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The map label for this gene is ethA [H]

Identifier: 50085845

GI number: 50085845

Start: 2742813

End: 2744345

Strand: Direct

Name: ethA [H]

Synonym: ACIAD2794

Alternate gene names: 50085845

Gene position: 2742813-2744345 (Clockwise)

Preceding gene: 50085822

Following gene: 50085846

Centisome position: 76.22

GC content: 39.01

Gene sequence:

>1533_bases
ATGAGTACATCAGATCAAATTGCTAGCTTCGATGTGCTAATCATTGGTGCAGGGATTTCAGGCATCAGCGCAGCTTATCA
CCTAAAGAAAAACCGTCCGAATGATACTTTTGCTATCCTAGAAGGACGAAATGCAATTGGTGGGACATGGAGCCAATTCA
AATATCCAGGTATTCGATCAGATTCAGATATGCCCTCTTTTGGTTTTGGTTTTAAGCCTTGGACGCATAAAAAAGCGATT
GCTCAAGCGAGTGTCATTTGTGACTATTTGCAAGAAACAATCCAAGAAAATGATATCTCTAAGCATATCTGCTTTGGATA
TCATGTAAATCAAGCTGAGTTTTCATCAGAAGAACAACTTTGGACCATTACGGCAGTAAAGCTTGAGGACAAATCGATTG
TTTCCTTTAAAGCTCGTTTTTTACTTTTAAATACTGGCTATTACGACTATCAAGAAGGTTTTTCACCTAAATTCGAAGGT
ACTGAAAAATTCAAGGGTCAAATCATTCACCCTCAGCACTGGCCTGAAAATTTAGATTATAGCAATAAAAAAGTCGTTGT
CATTGGAAGTGGGGCAACTGCTGTAACACTGTTGCCTTCAATGGCTGGAAAAGCGCAGCACGTTACAATGCTTCAACGTT
CTCCTACATATATGGTGTCATTTCCAGCTGTAGACCCGATTGCATGTATGTTGAATAAACTTTTGGGTTATGAAAAAGCT
TATCCAATTATCCGCAAAAAGAATATTGCCCTTAATCGCGCACTATATAAAGCTTGTCGTAACTATCCTCAAGTTATGAA
AAAGCTATTACTTGCAGATGTCCGTCGTCGACTACCTAAAGGCTATGATGTCGATACTCATTTCACTCCAAGATATAACC
CTTGGGACGAGCGTTTATGTTTAGTGCCTGATGGGGATTTATTCAAATCTATTTCAGAAGGAAAAGCATCTGTTGTGACG
GACCGTATCAAGCAATTCACCCAAGACGGTATTTTGCTTGAATCTGGTAAAAACCTTGATGCAGACATTATCGTGACTGC
AACTGGACTTAACATGCTGGCTTTTAGTCGAATTCAATTATCTGTTGACGGAAAAGAAGTCCAATATCCAGATACAACAA
TTTTCAAATCAATGATGCTGTCTGATGTACCAAACTTAGCATTTGCATTTGGCTATACCAATATTGCATGGACATTAAAA
GTTGATTTAGCCTGGGAACACTTCTGCCGACTATTAGACTATATGGATGCAAATGGATACAGCATATTTAAACCTGTAGT
GCATAATCCAGCAATGAAGCGAGTGCCATTTATTGATTTAAGTCCAGGTTATGTGCAAAGAGGTTTAGCACAATTTCCAA
TGGCTGGAACAGAAGGCCCCTGGACACTACAGCATGCTTATGAACATGATTTTGAAAGACTTCGTAATGGTCCTGTGTTT
GATAAAGAGCTGCAATTTACGAATATTGCTCAGAAAAATAAGTTAACTGTAGTCAAAGGCACTTGTGCCAAACCGTTGAA
AGCCCAAGCCTAA

Upstream 100 bases:

>100_bases
TCCATGGATTACGGAATTATGAATAACAAAAGAATCATCATTGTCTTAGCAAATCCGGCTGTTGCTCAATTTACTAAGAT
TTCAAAGAGAGGAGAATGAT

Downstream 100 bases:

>100_bases
TATAAGTCAAAAATTTAGTCTTCTATTATAATTTCTTTATCTAATTATAGAGGAGACTAAAGATGAATCGAGTAAGAACG
TTATGGAAAACATTAAATTT

Product: monooxygenase

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MSTSDQIASFDVLIIGAGISGISAAYHLKKNRPNDTFAILEGRNAIGGTWSQFKYPGIRSDSDMPSFGFGFKPWTHKKAI
AQASVICDYLQETIQENDISKHICFGYHVNQAEFSSEEQLWTITAVKLEDKSIVSFKARFLLLNTGYYDYQEGFSPKFEG
TEKFKGQIIHPQHWPENLDYSNKKVVVIGSGATAVTLLPSMAGKAQHVTMLQRSPTYMVSFPAVDPIACMLNKLLGYEKA
YPIIRKKNIALNRALYKACRNYPQVMKKLLLADVRRRLPKGYDVDTHFTPRYNPWDERLCLVPDGDLFKSISEGKASVVT
DRIKQFTQDGILLESGKNLDADIIVTATGLNMLAFSRIQLSVDGKEVQYPDTTIFKSMMLSDVPNLAFAFGYTNIAWTLK
VDLAWEHFCRLLDYMDANGYSIFKPVVHNPAMKRVPFIDLSPGYVQRGLAQFPMAGTEGPWTLQHAYEHDFERLRNGPVF
DKELQFTNIAQKNKLTVVKGTCAKPLKAQA

Sequences:

>Translated_510_residues
MSTSDQIASFDVLIIGAGISGISAAYHLKKNRPNDTFAILEGRNAIGGTWSQFKYPGIRSDSDMPSFGFGFKPWTHKKAI
AQASVICDYLQETIQENDISKHICFGYHVNQAEFSSEEQLWTITAVKLEDKSIVSFKARFLLLNTGYYDYQEGFSPKFEG
TEKFKGQIIHPQHWPENLDYSNKKVVVIGSGATAVTLLPSMAGKAQHVTMLQRSPTYMVSFPAVDPIACMLNKLLGYEKA
YPIIRKKNIALNRALYKACRNYPQVMKKLLLADVRRRLPKGYDVDTHFTPRYNPWDERLCLVPDGDLFKSISEGKASVVT
DRIKQFTQDGILLESGKNLDADIIVTATGLNMLAFSRIQLSVDGKEVQYPDTTIFKSMMLSDVPNLAFAFGYTNIAWTLK
VDLAWEHFCRLLDYMDANGYSIFKPVVHNPAMKRVPFIDLSPGYVQRGLAQFPMAGTEGPWTLQHAYEHDFERLRNGPVF
DKELQFTNIAQKNKLTVVKGTCAKPLKAQA
>Mature_509_residues
STSDQIASFDVLIIGAGISGISAAYHLKKNRPNDTFAILEGRNAIGGTWSQFKYPGIRSDSDMPSFGFGFKPWTHKKAIA
QASVICDYLQETIQENDISKHICFGYHVNQAEFSSEEQLWTITAVKLEDKSIVSFKARFLLLNTGYYDYQEGFSPKFEGT
EKFKGQIIHPQHWPENLDYSNKKVVVIGSGATAVTLLPSMAGKAQHVTMLQRSPTYMVSFPAVDPIACMLNKLLGYEKAY
PIIRKKNIALNRALYKACRNYPQVMKKLLLADVRRRLPKGYDVDTHFTPRYNPWDERLCLVPDGDLFKSISEGKASVVTD
RIKQFTQDGILLESGKNLDADIIVTATGLNMLAFSRIQLSVDGKEVQYPDTTIFKSMMLSDVPNLAFAFGYTNIAWTLKV
DLAWEHFCRLLDYMDANGYSIFKPVVHNPAMKRVPFIDLSPGYVQRGLAQFPMAGTEGPWTLQHAYEHDFERLRNGPVFD
KELQFTNIAQKNKLTVVKGTCAKPLKAQA

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI25150462, Length=354, Percent_Identity=23.4463276836158, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17555726, Length=285, Percent_Identity=22.8070175438596, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 57439; Mature: 57307

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSDQIASFDVLIIGAGISGISAAYHLKKNRPNDTFAILEGRNAIGGTWSQFKYPGIRS
CCCCCCCCEEEEEEEECCCCHHHHHHEECCCCCCCEEEEEECCCCCCCCHHHCCCCCCCC
DSDMPSFGFGFKPWTHKKAIAQASVICDYLQETIQENDISKHICFGYHVNQAEFSSEEQL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHCCCCCCE
WTITAVKLEDKSIVSFKARFLLLNTGYYDYQEGFSPKFEGTEKFKGQIIHPQHWPENLDY
EEEEEEEECCCCEEEEEEEEEEEECCCCCHHCCCCCCCCCCHHHCCEEECCCCCCCCCCC
SNKKVVVIGSGATAVTLLPSMAGKAQHVTMLQRSPTYMVSFPAVDPIACMLNKLLGYEKA
CCCEEEEEECCCCEEEEHHHHCCCCCEEEEEECCCCEEEECCCCCHHHHHHHHHHCHHHC
YPIIRKKNIALNRALYKACRNYPQVMKKLLLADVRRRLPKGYDVDTHFTPRYNPWDERLC
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCEEE
LVPDGDLFKSISEGKASVVTDRIKQFTQDGILLESGKNLDADIIVTATGLNMLAFSRIQL
ECCCCHHHHHHHCCHHHHHHHHHHHHHHCCEEEECCCCCCCEEEEEECCCCEEEEEEEEE
SVDGKEVQYPDTTIFKSMMLSDVPNLAFAFGYTNIAWTLKVDLAWEHFCRLLDYMDANGY
EECCCEEECCCHHHHHHHHHHCCCCCEEEECCCCEEEEEEEECCHHHHHHHHHHHCCCCC
SIFKPVVHNPAMKRVPFIDLSPGYVQRGLAQFPMAGTEGPWTLQHAYEHDFERLRNGPVF
EEEHHHHCCCCHHCCCEEECCCHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHCCCCC
DKELQFTNIAQKNKLTVVKGTCAKPLKAQA
CCCCCHHCCCCCCCEEEEECCCCCCCCCCC
>Mature Secondary Structure 
STSDQIASFDVLIIGAGISGISAAYHLKKNRPNDTFAILEGRNAIGGTWSQFKYPGIRS
CCCCCCCEEEEEEEECCCCHHHHHHEECCCCCCCEEEEEECCCCCCCCHHHCCCCCCCC
DSDMPSFGFGFKPWTHKKAIAQASVICDYLQETIQENDISKHICFGYHVNQAEFSSEEQL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHCCCCCCE
WTITAVKLEDKSIVSFKARFLLLNTGYYDYQEGFSPKFEGTEKFKGQIIHPQHWPENLDY
EEEEEEEECCCCEEEEEEEEEEEECCCCCHHCCCCCCCCCCHHHCCEEECCCCCCCCCCC
SNKKVVVIGSGATAVTLLPSMAGKAQHVTMLQRSPTYMVSFPAVDPIACMLNKLLGYEKA
CCCEEEEEECCCCEEEEHHHHCCCCCEEEEEECCCCEEEECCCCCHHHHHHHHHHCHHHC
YPIIRKKNIALNRALYKACRNYPQVMKKLLLADVRRRLPKGYDVDTHFTPRYNPWDERLC
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCEEE
LVPDGDLFKSISEGKASVVTDRIKQFTQDGILLESGKNLDADIIVTATGLNMLAFSRIQL
ECCCCHHHHHHHCCHHHHHHHHHHHHHHCCEEEECCCCCCCEEEEEECCCCEEEEEEEEE
SVDGKEVQYPDTTIFKSMMLSDVPNLAFAFGYTNIAWTLKVDLAWEHFCRLLDYMDANGY
EECCCEEECCCHHHHHHHHHHCCCCCEEEECCCCEEEEEEEECCHHHHHHHHHHHCCCCC
SIFKPVVHNPAMKRVPFIDLSPGYVQRGLAQFPMAGTEGPWTLQHAYEHDFERLRNGPVF
EEEHHHHCCCCHHCCCEEECCCHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHCCCCC
DKELQFTNIAQKNKLTVVKGTCAKPLKAQA
CCCCCHHCCCCCCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA