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The map label for this gene is paaF [H]

Identifier: 50085679

GI number: 50085679

Start: 2560661

End: 2561461

Strand: Direct

Name: paaF [H]

Synonym: ACIAD2607

Alternate gene names: 50085679

Gene position: 2560661-2561461 (Clockwise)

Preceding gene: 50085676

Following gene: 50085680

Centisome position: 71.16

GC content: 41.57

Gene sequence:

>801_bases
ATGACACTACAATGTATTCAACAACCTCACCCACATTTAAATGCAAATTTAGAAAATGGAGTGCTGACACTGGCATTGAA
TCGCGCTGAAACTAAAAATGCGCTTTATGGCGAACTCTATCTATGGCTTGCCCAAGCACTTGATGATGCCGATCAATCGA
ATGATGTGAGAGTGGTGATATTACGTGGTGCAGATCGTGATTTTACTGCTGGCAATGATATGAAAGACTTTATGGGATTT
ATTCAAAAGCCGTATGAAGGCAAAGCTGGCGATCAGCCGCCATTTGTATTATTAAAGTCGGCAGCGAAATTTTCAAAACC
ACTGATCGTCGCTATTCAGGGGGTTGCTATCGGAATTGGAGTCACTATTTTGCTGCATGCCGATCTAGTCTATGCCGATC
AGACTGCTTTGTTCCAGATCCCATTTGTCAGCTTAGGATTGTCACCTGAAGGTGCAGCAAGTCGTTTACTGGTGAAACAG
GCAGGCTATCATCGCGCGGCAGAATTACTATTTACAGCAAAGAAATTTAATGCAGAACTGGCAGAAAAAGCGGGTTTAAT
CAATCAAATCAGTGATGATGTCTATACACAAGCCCATCAGATAGCGTTGCAATTAGCTGCTTTACCTTTAGCATCCATTA
AACAATCTAAAGCTTTAATGAAGCAGGATCTTGCCGACATCATAAAATGTATTGATGATGAAGCAGAAATTTTCATGCAA
CGTGTACGCTCACCCGAAATGAAAGAAGCCGTTCAGGCCTTTATGCAAAAACGTCAACCAGACTTTTCTCAATTTAGCTA
G

Upstream 100 bases:

>100_bases
TAAATCAACTTAACTTCCATGAACTCATCAGTTGCTCTTTTAGAGCAGTTTTAAGACATAATGCGTTACATGATCTTGAG
AAACAAGCAAGGATAGTACG

Downstream 100 bases:

>100_bases
TTTTGAGATTAACACCATACCCACCAAAGGATAAATCCTGTGATACATGTTTTGAACAACACAGGATTTATTGAATGATA
TGCTCGCTTTAAATTTCTAT

Product: enoyl-CoA hydratase/isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MTLQCIQQPHPHLNANLENGVLTLALNRAETKNALYGELYLWLAQALDDADQSNDVRVVILRGADRDFTAGNDMKDFMGF
IQKPYEGKAGDQPPFVLLKSAAKFSKPLIVAIQGVAIGIGVTILLHADLVYADQTALFQIPFVSLGLSPEGAASRLLVKQ
AGYHRAAELLFTAKKFNAELAEKAGLINQISDDVYTQAHQIALQLAALPLASIKQSKALMKQDLADIIKCIDDEAEIFMQ
RVRSPEMKEAVQAFMQKRQPDFSQFS

Sequences:

>Translated_266_residues
MTLQCIQQPHPHLNANLENGVLTLALNRAETKNALYGELYLWLAQALDDADQSNDVRVVILRGADRDFTAGNDMKDFMGF
IQKPYEGKAGDQPPFVLLKSAAKFSKPLIVAIQGVAIGIGVTILLHADLVYADQTALFQIPFVSLGLSPEGAASRLLVKQ
AGYHRAAELLFTAKKFNAELAEKAGLINQISDDVYTQAHQIALQLAALPLASIKQSKALMKQDLADIIKCIDDEAEIFMQ
RVRSPEMKEAVQAFMQKRQPDFSQFS
>Mature_265_residues
TLQCIQQPHPHLNANLENGVLTLALNRAETKNALYGELYLWLAQALDDADQSNDVRVVILRGADRDFTAGNDMKDFMGFI
QKPYEGKAGDQPPFVLLKSAAKFSKPLIVAIQGVAIGIGVTILLHADLVYADQTALFQIPFVSLGLSPEGAASRLLVKQA
GYHRAAELLFTAKKFNAELAEKAGLINQISDDVYTQAHQIALQLAALPLASIKQSKALMKQDLADIIKCIDDEAEIFMQR
VRSPEMKEAVQAFMQKRQPDFSQFS

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI260274832, Length=248, Percent_Identity=30.241935483871, Blast_Score=107, Evalue=8e-24,
Organism=Homo sapiens, GI45643119, Length=249, Percent_Identity=30.1204819277108, Blast_Score=107, Evalue=8e-24,
Organism=Homo sapiens, GI260275230, Length=249, Percent_Identity=30.1204819277108, Blast_Score=107, Evalue=8e-24,
Organism=Homo sapiens, GI4757968, Length=251, Percent_Identity=26.6932270916335, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI49355787, Length=251, Percent_Identity=26.6932270916335, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI25453481, Length=251, Percent_Identity=26.6932270916335, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI51538573, Length=251, Percent_Identity=26.6932270916335, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI4757966, Length=212, Percent_Identity=29.2452830188679, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI51538581, Length=212, Percent_Identity=29.2452830188679, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI221136756, Length=244, Percent_Identity=25.8196721311475, Blast_Score=91, Evalue=9e-19,
Organism=Homo sapiens, GI221136753, Length=244, Percent_Identity=25.8196721311475, Blast_Score=91, Evalue=9e-19,
Organism=Homo sapiens, GI221307494, Length=243, Percent_Identity=25.9259259259259, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI194097323, Length=254, Percent_Identity=28.740157480315, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI116235487, Length=216, Percent_Identity=25.462962962963, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI70995211, Length=189, Percent_Identity=29.6296296296296, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI4502327, Length=257, Percent_Identity=26.4591439688716, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI31542718, Length=264, Percent_Identity=24.6212121212121, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787659, Length=245, Percent_Identity=30.2040816326531, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1787660, Length=256, Percent_Identity=34.375, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI87082183, Length=261, Percent_Identity=27.5862068965517, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788597, Length=268, Percent_Identity=25.3731343283582, Blast_Score=79, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17535521, Length=258, Percent_Identity=30.6201550387597, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17554946, Length=247, Percent_Identity=26.7206477732794, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI25145438, Length=251, Percent_Identity=24.3027888446215, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17549921, Length=212, Percent_Identity=29.7169811320755, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17560910, Length=188, Percent_Identity=27.1276595744681, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17540714, Length=178, Percent_Identity=28.6516853932584, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24654903, Length=261, Percent_Identity=25.2873563218391, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI20129971, Length=248, Percent_Identity=25.8064516129032, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24653477, Length=248, Percent_Identity=25.8064516129032, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI19920382, Length=211, Percent_Identity=27.0142180094787, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24653139, Length=251, Percent_Identity=27.8884462151394, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 29284; Mature: 29153

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLQCIQQPHPHLNANLENGVLTLALNRAETKNALYGELYLWLAQALDDADQSNDVRVVI
CCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
LRGADRDFTAGNDMKDFMGFIQKPYEGKAGDQPPFVLLKSAAKFSKPLIVAIQGVAIGIG
EECCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECHHHHHH
VTILLHADLVYADQTALFQIPFVSLGLSPEGAASRLLVKQAGYHRAAELLFTAKKFNAEL
HHHHHHHHHHEECCCEEEEECCEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
AEKAGLINQISDDVYTQAHQIALQLAALPLASIKQSKALMKQDLADIIKCIDDEAEIFMQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
RVRSPEMKEAVQAFMQKRQPDFSQFS
HHCCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TLQCIQQPHPHLNANLENGVLTLALNRAETKNALYGELYLWLAQALDDADQSNDVRVVI
CCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
LRGADRDFTAGNDMKDFMGFIQKPYEGKAGDQPPFVLLKSAAKFSKPLIVAIQGVAIGIG
EECCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECHHHHHH
VTILLHADLVYADQTALFQIPFVSLGLSPEGAASRLLVKQAGYHRAAELLFTAKKFNAEL
HHHHHHHHHHEECCCEEEEECCEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
AEKAGLINQISDDVYTQAHQIALQLAALPLASIKQSKALMKQDLADIIKCIDDEAEIFMQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
RVRSPEMKEAVQAFMQKRQPDFSQFS
HHCCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]