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The map label for this gene is tmk

Identifier: 50085662

GI number: 50085662

Start: 2546790

End: 2547398

Strand: Reverse

Name: tmk

Synonym: ACIAD2588

Alternate gene names: 50085662

Gene position: 2547398-2546790 (Counterclockwise)

Preceding gene: 50085663

Following gene: 50085660

Centisome position: 70.79

GC content: 44.99

Gene sequence:

>609_bases
ATGTTTATTAGTTTTGAAGGCACGGAAGGTGTAGGTAAAACCACGCTGATTCGTAAGTTGTATGAACATTTCGAAGCTTC
AGGAAAACAGGTTGTTTTGACCCGTGAGCCAGGTGGAACACCGCTGGCAGAGCAGATTCGTAGTCTGTTACTTGCGGTAA
ATCATGATGAGCCGATGAGTTCAGATACTGAGCTATTACTGATGTATGCAGCGCGTGCCCAGCACTTACAGCAAGTCATT
GTACCTGCATTGGCAGATGAAAAATTAGTATTGAGTGATCGCTTTACTGATGCCAGCTATGCCTATCAATGTGTAGGTCG
GGGATTGAGTAAAGATAAACTGAATACCCTCAATCAGACTTTTGTTTCCCATATGCCAGACATTACCTTCTGGCTAGATG
CACCCATTGAATTAGGCATGTCGCGAGCGCGTGAGCGGGGTGCTCTTGATCGCTTTGAGCAGGAAAAAGTTGAGTTTTTT
CAACGTGTAAGACAGGGATATCAGCAGTTGCATGAATTATATCCCGAGCGTATCAAACGTCTGGATGCGACACAGGCCCC
TGAAATTGTTTTTCAGGAAGCGCTTGAGCATATACAGGCACTGGTATAA

Upstream 100 bases:

>100_bases
AGGTAATGGCGGACATAAATTTAGCGCCAATTTACAAGACCATAATCAAGCGGTTCAACAATACTTGTCCGTGTTAAGAT
CGAAAAATTAAGGAGCCTGC

Downstream 100 bases:

>100_bases
ATACAGCGCCTGTATATCCGTTAAAGCGTATTGACCGGAATTTGTTTAACTTCAAAATTTGGCGGTGTTAAAACCGTCTT
TTTGAGTTGTTGTTCAAGCT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MFISFEGTEGVGKTTLIRKLYEHFEASGKQVVLTREPGGTPLAEQIRSLLLAVNHDEPMSSDTELLLMYAARAQHLQQVI
VPALADEKLVLSDRFTDASYAYQCVGRGLSKDKLNTLNQTFVSHMPDITFWLDAPIELGMSRARERGALDRFEQEKVEFF
QRVRQGYQQLHELYPERIKRLDATQAPEIVFQEALEHIQALV

Sequences:

>Translated_202_residues
MFISFEGTEGVGKTTLIRKLYEHFEASGKQVVLTREPGGTPLAEQIRSLLLAVNHDEPMSSDTELLLMYAARAQHLQQVI
VPALADEKLVLSDRFTDASYAYQCVGRGLSKDKLNTLNQTFVSHMPDITFWLDAPIELGMSRARERGALDRFEQEKVEFF
QRVRQGYQQLHELYPERIKRLDATQAPEIVFQEALEHIQALV
>Mature_202_residues
MFISFEGTEGVGKTTLIRKLYEHFEASGKQVVLTREPGGTPLAEQIRSLLLAVNHDEPMSSDTELLLMYAARAQHLQQVI
VPALADEKLVLSDRFTDASYAYQCVGRGLSKDKLNTLNQTFVSHMPDITFWLDAPIELGMSRARERGALDRFEQEKVEFF
QRVRQGYQQLHELYPERIKRLDATQAPEIVFQEALEHIQALV

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=194, Percent_Identity=43.8144329896907, Blast_Score=143, Evalue=9e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_ACIAD (Q6F9B5)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_047172.1
- ProteinModelPortal:   Q6F9B5
- SMR:   Q6F9B5
- STRING:   Q6F9B5
- GeneID:   2880756
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD2588
- NMPDR:   fig|62977.3.peg.2365
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- PhylomeDB:   Q6F9B5
- ProtClustDB:   PRK00698
- BioCyc:   ASP62977:ACIAD2588-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23050; Mature: 23050

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFISFEGTEGVGKTTLIRKLYEHFEASGKQVVLTREPGGTPLAEQIRSLLLAVNHDEPMS
CEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCC
SDTELLLMYAARAQHLQQVIVPALADEKLVLSDRFTDASYAYQCVGRGLSKDKLNTLNQT
CCHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHCCCCCHHHHHHHHHCCCCHHHHHHHHHH
FVSHMPDITFWLDAPIELGMSRARERGALDRFEQEKVEFFQRVRQGYQQLHELYPERIKR
HHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDATQAPEIVFQEALEHIQALV
CCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFISFEGTEGVGKTTLIRKLYEHFEASGKQVVLTREPGGTPLAEQIRSLLLAVNHDEPMS
CEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCC
SDTELLLMYAARAQHLQQVIVPALADEKLVLSDRFTDASYAYQCVGRGLSKDKLNTLNQT
CCHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHCCCCCHHHHHHHHHCCCCHHHHHHHHHH
FVSHMPDITFWLDAPIELGMSRARERGALDRFEQEKVEFFQRVRQGYQQLHELYPERIKR
HHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDATQAPEIVFQEALEHIQALV
CCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA