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The map label for this gene is degP [H]

Identifier: 50085660

GI number: 50085660

Start: 2543522

End: 2544925

Strand: Reverse

Name: degP [H]

Synonym: ACIAD2586

Alternate gene names: 50085660

Gene position: 2544925-2543522 (Counterclockwise)

Preceding gene: 50085662

Following gene: 50085659

Centisome position: 70.72

GC content: 42.95

Gene sequence:

>1404_bases
TTGTGCATGGGTATGGTTTTTATGAAAAGCGGTTTTCTACAAAAAGGGATGTATGCGGTTGCTTTCACCATGGTCACTGT
ACAGGCCGAAGCAGCAGCACCAGTTGACTTTTCAAATTTGGTTGAGCAGGTGAGTCCTGCGGTGGTCAGTGTCAGTGTTG
TCAAAAAAATGACCCAAGAAGAACTATTACAGCAGCAAGTTCCTGAAATATTACGTCGTTTTTTTGGCAATCAGGTTGTG
ATTCCACAGCAGCAAGCACCTCAAGAAAAAACAGGTTATGGCAGTGCCTTCTTTATTAGTAAAGATGGATATTTGCTCAC
CAATCATCATGTTGTAGAAGATGCTTCACGTATCACCATTACTTTAAATGACCGTCGCGAAATAGATGCTAAAGTTGTGG
GAAGTGACGAGCGTACAGACGTTGCATTACTTAAAGTCGAAGGAAACAATTATCCTGCTTTAAAAATTGGCAATGTGGAT
CAATTAAAAGTCGGACAGCCCGTTTTGGCGATTGGTTCGCCTTTTGGATTTGACTACTCTGCATCGGCTGGAATCGTGAG
TGCTAAATCAAGAAATATGATTGGAGAAACCTCAGTTCCTTTTATTCAAACTGATGTTGCTTTAAACCCAGGTAATTCGG
GGGGGCCGTTGTTTAATCAACAGGGTGAAGTGGTTGGTGTGAATTCCAGAATCTTTAGTGGTACTGGTGGGTATATGGGA
CTTTCGTTTTCTATCCCAATCGATGTGGCAATGGATGTTGCGCAACAGTTAAAAACTACGGGTAAAGTGACGCGTTCGTA
TTTGGGTGTGATGCTGCAAGATATTGATCGCAATTTGGCAGATGCCTACAACTTACCGAAACCAGAAGGTTCACTGATCA
ATCAGGTCGCGCCAAACTCTCCAGCAGCCAAAGCTGGTCTAAAAGCAGGCGATATTATTATGAAATATAATGGTAGCCCA
ATTTCAAGAACATCACAGTTGTTAAATTATCTAAATCGTACCATGCCAAAACAGGTGATACAGCTAGAAATACTGCGTGA
TGGTAAACCATATAATATTTCCGCAACATTGACCACAGCACCTGATGACACACCAGCGACAGGTGAAAAAGCATCTGCTG
CAAATGGCCCGCTGTTGGGTATGGCAATCCGTAATCTGACTGAAACCGAACAGGCGCGCCTGGATGTTCGGGGAGGAATC
TTTGTAGAGGATGTCACACGTGGTGGTTTAGCTGCAATGTCTAATATCATGCCTAGGGATGTAATCACGCAAGTAAATAG
TACCGCGATTCTTAACACCAATGATTTTTCTAAAGCAGTGGCGACTTTACCCAAAAATTCAGTAGCTCGTATCGCCTTAA
TTCGTCAGGGACAAAGGGCAATGCTCGGTTTACGTATCAAGTAA

Upstream 100 bases:

>100_bases
TGTAACGGAAAACTAAGGTGTTGTTTTGTCGATACTAATTAAACATATTATTACGGAAATGAATGAAATCTTATGATAAA
AACAATTTCAATCAAGTAAA

Downstream 100 bases:

>100_bases
ATATGTGTATTCAGATGAAAAAGCCACTTTTAAAAGTGGCTTTTTCATAAAAAAAATCGCGTAAGATAGTGCTCAGTTAT
AAAGTTTACCAAGCGATAGA

Product: serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MCMGMVFMKSGFLQKGMYAVAFTMVTVQAEAAAPVDFSNLVEQVSPAVVSVSVVKKMTQEELLQQQVPEILRRFFGNQVV
IPQQQAPQEKTGYGSAFFISKDGYLLTNHHVVEDASRITITLNDRREIDAKVVGSDERTDVALLKVEGNNYPALKIGNVD
QLKVGQPVLAIGSPFGFDYSASAGIVSAKSRNMIGETSVPFIQTDVALNPGNSGGPLFNQQGEVVGVNSRIFSGTGGYMG
LSFSIPIDVAMDVAQQLKTTGKVTRSYLGVMLQDIDRNLADAYNLPKPEGSLINQVAPNSPAAKAGLKAGDIIMKYNGSP
ISRTSQLLNYLNRTMPKQVIQLEILRDGKPYNISATLTTAPDDTPATGEKASAANGPLLGMAIRNLTETEQARLDVRGGI
FVEDVTRGGLAAMSNIMPRDVITQVNSTAILNTNDFSKAVATLPKNSVARIALIRQGQRAMLGLRIK

Sequences:

>Translated_467_residues
MCMGMVFMKSGFLQKGMYAVAFTMVTVQAEAAAPVDFSNLVEQVSPAVVSVSVVKKMTQEELLQQQVPEILRRFFGNQVV
IPQQQAPQEKTGYGSAFFISKDGYLLTNHHVVEDASRITITLNDRREIDAKVVGSDERTDVALLKVEGNNYPALKIGNVD
QLKVGQPVLAIGSPFGFDYSASAGIVSAKSRNMIGETSVPFIQTDVALNPGNSGGPLFNQQGEVVGVNSRIFSGTGGYMG
LSFSIPIDVAMDVAQQLKTTGKVTRSYLGVMLQDIDRNLADAYNLPKPEGSLINQVAPNSPAAKAGLKAGDIIMKYNGSP
ISRTSQLLNYLNRTMPKQVIQLEILRDGKPYNISATLTTAPDDTPATGEKASAANGPLLGMAIRNLTETEQARLDVRGGI
FVEDVTRGGLAAMSNIMPRDVITQVNSTAILNTNDFSKAVATLPKNSVARIALIRQGQRAMLGLRIK
>Mature_467_residues
MCMGMVFMKSGFLQKGMYAVAFTMVTVQAEAAAPVDFSNLVEQVSPAVVSVSVVKKMTQEELLQQQVPEILRRFFGNQVV
IPQQQAPQEKTGYGSAFFISKDGYLLTNHHVVEDASRITITLNDRREIDAKVVGSDERTDVALLKVEGNNYPALKIGNVD
QLKVGQPVLAIGSPFGFDYSASAGIVSAKSRNMIGETSVPFIQTDVALNPGNSGGPLFNQQGEVVGVNSRIFSGTGGYMG
LSFSIPIDVAMDVAQQLKTTGKVTRSYLGVMLQDIDRNLADAYNLPKPEGSLINQVAPNSPAAKAGLKAGDIIMKYNGSP
ISRTSQLLNYLNRTMPKQVIQLEILRDGKPYNISATLTTAPDDTPATGEKASAANGPLLGMAIRNLTETEQARLDVRGGI
FVEDVTRGGLAAMSNIMPRDVITQVNSTAILNTNDFSKAVATLPKNSVARIALIRQGQRAMLGLRIK

Specific function: Protease With A Shared Specificity With Degp. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=318, Percent_Identity=29.2452830188679, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI24308541, Length=310, Percent_Identity=30.3225806451613, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI22129776, Length=311, Percent_Identity=29.903536977492, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI7019477, Length=295, Percent_Identity=30.8474576271186, Blast_Score=121, Evalue=1e-27,
Organism=Escherichia coli, GI1789629, Length=456, Percent_Identity=35.5263157894737, Blast_Score=249, Evalue=4e-67,
Organism=Escherichia coli, GI1786356, Length=431, Percent_Identity=34.338747099768, Blast_Score=221, Evalue=7e-59,
Organism=Escherichia coli, GI1789630, Length=273, Percent_Identity=32.6007326007326, Blast_Score=152, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24646839, Length=292, Percent_Identity=30.1369863013699, Blast_Score=126, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 50157; Mature: 50157

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCMGMVFMKSGFLQKGMYAVAFTMVTVQAEAAAPVDFSNLVEQVSPAVVSVSVVKKMTQE
CCEEHHHHHCCCHHCCHHEEEEEEEEEEECCCCCCCHHHHHHHHCHHHHHHHHHHHHHHH
ELLQQQVPEILRRFFGNQVVIPQQQAPQEKTGYGSAFFISKDGYLLTNHHVVEDASRITI
HHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCEEEEECCCEEEECCEEECCCCEEEE
TLNDRREIDAKVVGSDERTDVALLKVEGNNYPALKIGNVDQLKVGQPVLAIGSPFGFDYS
EECCCCCCCEEEECCCCCCCEEEEEEECCCCCEEEECCCCCEECCCCEEEECCCCCCCCC
ASAGIVSAKSRNMIGETSVPFIQTDVALNPGNSGGPLFNQQGEVVGVNSRIFSGTGGYMG
CCCCEEECCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCEEEECCEEEECCCCCEE
LSFSIPIDVAMDVAQQLKTTGKVTRSYLGVMLQDIDRNLADAYNLPKPEGSLINQVAPNS
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCC
PAAKAGLKAGDIIMKYNGSPISRTSQLLNYLNRTMPKQVIQLEILRDGKPYNISATLTTA
CHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEEEEEC
PDDTPATGEKASAANGPLLGMAIRNLTETEQARLDVRGGIFVEDVTRGGLAAMSNIMPRD
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEECCCEEEEHHCCCCHHHHHHCCCHH
VITQVNSTAILNTNDFSKAVATLPKNSVARIALIRQGQRAMLGLRIK
HHHHCCCEEEEECCCHHHHHHHCCCCCCEEEEEHHCCCHHEEEEECC
>Mature Secondary Structure
MCMGMVFMKSGFLQKGMYAVAFTMVTVQAEAAAPVDFSNLVEQVSPAVVSVSVVKKMTQE
CCEEHHHHHCCCHHCCHHEEEEEEEEEEECCCCCCCHHHHHHHHCHHHHHHHHHHHHHHH
ELLQQQVPEILRRFFGNQVVIPQQQAPQEKTGYGSAFFISKDGYLLTNHHVVEDASRITI
HHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCEEEEECCCEEEECCEEECCCCEEEE
TLNDRREIDAKVVGSDERTDVALLKVEGNNYPALKIGNVDQLKVGQPVLAIGSPFGFDYS
EECCCCCCCEEEECCCCCCCEEEEEEECCCCCEEEECCCCCEECCCCEEEECCCCCCCCC
ASAGIVSAKSRNMIGETSVPFIQTDVALNPGNSGGPLFNQQGEVVGVNSRIFSGTGGYMG
CCCCEEECCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCEEEECCEEEECCCCCEE
LSFSIPIDVAMDVAQQLKTTGKVTRSYLGVMLQDIDRNLADAYNLPKPEGSLINQVAPNS
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCC
PAAKAGLKAGDIIMKYNGSPISRTSQLLNYLNRTMPKQVIQLEILRDGKPYNISATLTTA
CHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEEEEEC
PDDTPATGEKASAANGPLLGMAIRNLTETEQARLDVRGGIFVEDVTRGGLAAMSNIMPRD
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEECCCEEEEHHCCCCHHHHHHCCCHH
VITQVNSTAILNTNDFSKAVATLPKNSVARIALIRQGQRAMLGLRIK
HHHHCCCEEEEECCCHHHHHHHCCCCCCEEEEEHHCCCHHEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]