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The map label for this gene is uvrB

Identifier: 50085644

GI number: 50085644

Start: 2527299

End: 2529326

Strand: Reverse

Name: uvrB

Synonym: ACIAD2569

Alternate gene names: 50085644

Gene position: 2529326-2527299 (Counterclockwise)

Preceding gene: 50085645

Following gene: 50085643

Centisome position: 70.29

GC content: 43.1

Gene sequence:

>2028_bases
GTGCGTGTGAACGACAACCAACCTTTTGATTTAGTCACAAACTACCAACCTGCTGGTGATCAGCCACAGGCAATTAAAAA
GTTGGTCAGCGGAATTGAGCAGGGCAATCGTAATCAGCTTTTGCTGGGCGTTACAGGTTCGGGTAAGACCTATACCATGG
CCAATGTTATCGCACAGACTCAGCGTCCGACCATTGTCATGGCACACAACAAAACTCTGGCTGCACAGCTCTATGGCGAG
TTCAAGGCATTTTTTCCAAATAATGCAGTGGAATACTTTGTCAGCTATTACGATTATTACCAGCCTGAAGCCTATGTACC
ATCTTCAGATACTTTTATCGAAAAAGATGCTGCCATCAACGATCATATCGATCAAATGCGACTTTCTGCAACACGTGCCT
TACTTGAGCGCCGTGATGCCATTATTGTGGCATCGGTTTCGGCCATTTATGGTTTGGGTGATCCAGAAGCCTACATGAAA
ATGTTACTGCATGTAGTGGAGGGTGATCGTATAAATCGTGATGATTTGATTCGCCGTTTGGTCGAAATGCAATATACGCG
TAATGAACTTGAATTTTTACGCGGTACTTACCGAATTCGTGGCGAAATACTGGATGTATTTCCTGCCGAATCTGATCAAT
TTGCCATTCGGATTGAACTGTTTGACGATGAGGTCGATTCAATTCGCTGGTTTGATCCTCTGACTGGAAAGATGCAACGT
AAAGTACCGCGTGTCACGATTTATCCAAAAAGTCATTATGTGACGCCCAAAGATAATCTTTCCAGAGCAATTGAAACCAT
TAAGGATGAGTTGCAGGATCAGCTTAAATTTTTCCGAGAGCATGACAAATTGCTTGAGGCGCAGCGAATAGAGCAGCGTA
CACGTTATGATCTGGAAATGATGCAACAGCTTGGCTATACCAACGGTATCGAAAACTACTCCCGTCATTTATCTGGCCGA
AGCCCTGGCGCAGCACCGCCGACATTATTTGATTATATTCCAGAAGATGCATTGCTCATTATTGATGAATCTCATGTGAC
CGTACCGCAAATTGGTGCAATGTATAAAGGTGACCGTTCCCGTAAAGAAAATCTGGTGAATTACGGCTTTCGTTTACCCA
GCGCACTTGATAACCGACCAATGAAATTCGAAGAATGGGAACGAATTGTTCCAACCACGGTATTTGTGAGTGCGACACCA
GCAAAATATGAGCTTGAAAAATCAGATCAAATCGTAGAGCAAGTGGTTCGACCAACTGGATTGATTGACCCTGAAATCGA
GATTCGACCCGTCTTGACCCAAGTGGATGATGTGCTGTCTGAAATCAATATTCGTAAAGAAATGGACGAACGCGTATTGA
TTACCACGCTAACAAAGCGAATGGCAGAAGATCTGACTTCATATTTGAAAGAATATGGCGTTAAGGTGGCTTATCTACAC
TCAGATATTGACACGGTCGAGCGCGTTAAAATTATTCATGAACTACGCACTGGTGTTTATGACGTATTGGTTGGCATTAA
TTTGCTACGTGAAGGTCTGGATATGCCAGAAGTGTCACTGGTCGCCATTTTGGATGCAGATAAGGAAGGATTCTTGCGTT
CGGAGCGGTCTTTAATTCAGACCATTGGTCGTGCTGCGCGTAATATTAAAGGCAAGGCAATTTTGTATGCAGACCGAATG
ACAGACTCTATGCAAAAAGCGATTGATGAAACTGAACGACGTCGTGAAAAACAAATCGAATTTAATAAAATTCACGGCAT
TACCCCACGCAGTGCTGTACGTCAAAAAGTAAAAGAAATTGACACTGGCGAAGTCTTTAACGACGATGACATTGAAGGCA
AGATTTCGGAACAGGCGCGAGCACTAAGTGCAGATGAGCGCCATATTTTGGCTGATCCTAAGTTGTTTGCAAAACATATG
AGCAAACTTGAGAAGGAAATGCTAAAAGCATCTAAAGAATTACAGTTTGAGCAAGCTGCGCGATTACGTGATGAAATTTT
ACGCCTGAAAGCACAAATGCTGCATTAA

Upstream 100 bases:

>100_bases
GCAGTGTTATTGCATATTGAATGCGATGGCTAAGCCTTGAAAAATCAGAATTTGACCAGATTAATGTTATAAATCCAATT
TAATTTTTTAATCATAGAGA

Downstream 100 bases:

>100_bases
TCTGCTCATGATGTAGAAATAACGTTAAGTGCTACATATTTCTACATTATCTGCATAAAAAACAAGCTAATGTAGCAACT
AGATCTTTATAAGATATGGT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 675; Mature: 675

Protein sequence:

>675_residues
MRVNDNQPFDLVTNYQPAGDQPQAIKKLVSGIEQGNRNQLLLGVTGSGKTYTMANVIAQTQRPTIVMAHNKTLAAQLYGE
FKAFFPNNAVEYFVSYYDYYQPEAYVPSSDTFIEKDAAINDHIDQMRLSATRALLERRDAIIVASVSAIYGLGDPEAYMK
MLLHVVEGDRINRDDLIRRLVEMQYTRNELEFLRGTYRIRGEILDVFPAESDQFAIRIELFDDEVDSIRWFDPLTGKMQR
KVPRVTIYPKSHYVTPKDNLSRAIETIKDELQDQLKFFREHDKLLEAQRIEQRTRYDLEMMQQLGYTNGIENYSRHLSGR
SPGAAPPTLFDYIPEDALLIIDESHVTVPQIGAMYKGDRSRKENLVNYGFRLPSALDNRPMKFEEWERIVPTTVFVSATP
AKYELEKSDQIVEQVVRPTGLIDPEIEIRPVLTQVDDVLSEINIRKEMDERVLITTLTKRMAEDLTSYLKEYGVKVAYLH
SDIDTVERVKIIHELRTGVYDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNIKGKAILYADRM
TDSMQKAIDETERRREKQIEFNKIHGITPRSAVRQKVKEIDTGEVFNDDDIEGKISEQARALSADERHILADPKLFAKHM
SKLEKEMLKASKELQFEQAARLRDEILRLKAQMLH

Sequences:

>Translated_675_residues
MRVNDNQPFDLVTNYQPAGDQPQAIKKLVSGIEQGNRNQLLLGVTGSGKTYTMANVIAQTQRPTIVMAHNKTLAAQLYGE
FKAFFPNNAVEYFVSYYDYYQPEAYVPSSDTFIEKDAAINDHIDQMRLSATRALLERRDAIIVASVSAIYGLGDPEAYMK
MLLHVVEGDRINRDDLIRRLVEMQYTRNELEFLRGTYRIRGEILDVFPAESDQFAIRIELFDDEVDSIRWFDPLTGKMQR
KVPRVTIYPKSHYVTPKDNLSRAIETIKDELQDQLKFFREHDKLLEAQRIEQRTRYDLEMMQQLGYTNGIENYSRHLSGR
SPGAAPPTLFDYIPEDALLIIDESHVTVPQIGAMYKGDRSRKENLVNYGFRLPSALDNRPMKFEEWERIVPTTVFVSATP
AKYELEKSDQIVEQVVRPTGLIDPEIEIRPVLTQVDDVLSEINIRKEMDERVLITTLTKRMAEDLTSYLKEYGVKVAYLH
SDIDTVERVKIIHELRTGVYDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNIKGKAILYADRM
TDSMQKAIDETERRREKQIEFNKIHGITPRSAVRQKVKEIDTGEVFNDDDIEGKISEQARALSADERHILADPKLFAKHM
SKLEKEMLKASKELQFEQAARLRDEILRLKAQMLH
>Mature_675_residues
MRVNDNQPFDLVTNYQPAGDQPQAIKKLVSGIEQGNRNQLLLGVTGSGKTYTMANVIAQTQRPTIVMAHNKTLAAQLYGE
FKAFFPNNAVEYFVSYYDYYQPEAYVPSSDTFIEKDAAINDHIDQMRLSATRALLERRDAIIVASVSAIYGLGDPEAYMK
MLLHVVEGDRINRDDLIRRLVEMQYTRNELEFLRGTYRIRGEILDVFPAESDQFAIRIELFDDEVDSIRWFDPLTGKMQR
KVPRVTIYPKSHYVTPKDNLSRAIETIKDELQDQLKFFREHDKLLEAQRIEQRTRYDLEMMQQLGYTNGIENYSRHLSGR
SPGAAPPTLFDYIPEDALLIIDESHVTVPQIGAMYKGDRSRKENLVNYGFRLPSALDNRPMKFEEWERIVPTTVFVSATP
AKYELEKSDQIVEQVVRPTGLIDPEIEIRPVLTQVDDVLSEINIRKEMDERVLITTLTKRMAEDLTSYLKEYGVKVAYLH
SDIDTVERVKIIHELRTGVYDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNIKGKAILYADRM
TDSMQKAIDETERRREKQIEFNKIHGITPRSAVRQKVKEIDTGEVFNDDDIEGKISEQARALSADERHILADPKLFAKHM
SKLEKEMLKASKELQFEQAARLRDEILRLKAQMLH

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=666, Percent_Identity=63.5135135135135, Blast_Score=870, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=307, Percent_Identity=24.7557003257329, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_ACIAD (Q6F9D2)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_047154.1
- ProteinModelPortal:   Q6F9D2
- STRING:   Q6F9D2
- GeneID:   2879210
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD2569
- NMPDR:   fig|62977.3.peg.2347
- eggNOG:   COG0556
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- PhylomeDB:   Q6F9D2
- ProtClustDB:   PRK05298
- BioCyc:   ASP62977:ACIAD2569-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 77686; Mature: 77686

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVNDNQPFDLVTNYQPAGDQPQAIKKLVSGIEQGNRNQLLLGVTGSGKTYTMANVIAQT
CCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCEEHHHHHHHHC
QRPTIVMAHNKTLAAQLYGEFKAFFPNNAVEYFVSYYDYYQPEAYVPSSDTFIEKDAAIN
CCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCHH
DHIDQMRLSATRALLERRDAIIVASVSAIYGLGDPEAYMKMLLHVVEGDRINRDDLIRRL
HHHHHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHH
VEMQYTRNELEFLRGTYRIRGEILDVFPAESDQFAIRIELFDDEVDSIRWFDPLTGKMQR
HHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEEEEEECCCCCCEECCCCCCHHHHH
KVPRVTIYPKSHYVTPKDNLSRAIETIKDELQDQLKFFREHDKLLEAQRIEQRTRYDLEM
CCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MQQLGYTNGIENYSRHLSGRSPGAAPPTLFDYIPEDALLIIDESHVTVPQIGAMYKGDRS
HHHCCCCCCHHHHHHHCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCH
RKENLVNYGFRLPSALDNRPMKFEEWERIVPTTVFVSATPAKYELEKSDQIVEQVVRPTG
HHHHHHHHCCCCCHHHCCCCCCHHHHHHHCCEEEEEECCCCCEECCHHHHHHHHHHCCCC
LIDPEIEIRPVLTQVDDVLSEINIRKEMDERVLITTLTKRMAEDLTSYLKEYGVKVAYLH
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEE
SDIDTVERVKIIHELRTGVYDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHH
TIGRAARNIKGKAILYADRMTDSMQKAIDETERRREKQIEFNKIHGITPRSAVRQKVKEI
HHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHC
DTGEVFNDDDIEGKISEQARALSADERHILADPKLFAKHMSKLEKEMLKASKELQFEQAA
CCCCCCCCCCCCCHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLRDEILRLKAQMLH
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MRVNDNQPFDLVTNYQPAGDQPQAIKKLVSGIEQGNRNQLLLGVTGSGKTYTMANVIAQT
CCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCEEHHHHHHHHC
QRPTIVMAHNKTLAAQLYGEFKAFFPNNAVEYFVSYYDYYQPEAYVPSSDTFIEKDAAIN
CCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCHH
DHIDQMRLSATRALLERRDAIIVASVSAIYGLGDPEAYMKMLLHVVEGDRINRDDLIRRL
HHHHHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHH
VEMQYTRNELEFLRGTYRIRGEILDVFPAESDQFAIRIELFDDEVDSIRWFDPLTGKMQR
HHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEEEEEECCCCCCEECCCCCCHHHHH
KVPRVTIYPKSHYVTPKDNLSRAIETIKDELQDQLKFFREHDKLLEAQRIEQRTRYDLEM
CCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MQQLGYTNGIENYSRHLSGRSPGAAPPTLFDYIPEDALLIIDESHVTVPQIGAMYKGDRS
HHHCCCCCCHHHHHHHCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCH
RKENLVNYGFRLPSALDNRPMKFEEWERIVPTTVFVSATPAKYELEKSDQIVEQVVRPTG
HHHHHHHHCCCCCHHHCCCCCCHHHHHHHCCEEEEEECCCCCEECCHHHHHHHHHHCCCC
LIDPEIEIRPVLTQVDDVLSEINIRKEMDERVLITTLTKRMAEDLTSYLKEYGVKVAYLH
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEE
SDIDTVERVKIIHELRTGVYDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHH
TIGRAARNIKGKAILYADRMTDSMQKAIDETERRREKQIEFNKIHGITPRSAVRQKVKEI
HHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHC
DTGEVFNDDDIEGKISEQARALSADERHILADPKLFAKHMSKLEKEMLKASKELQFEQAA
CCCCCCCCCCCCCHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLRDEILRLKAQMLH
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA