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The map label for this gene is gap [H]

Identifier: 50085641

GI number: 50085641

Start: 2523832

End: 2525289

Strand: Reverse

Name: gap [H]

Synonym: ACIAD2565

Alternate gene names: 50085641

Gene position: 2525289-2523832 (Counterclockwise)

Preceding gene: 50085642

Following gene: 50085640

Centisome position: 70.17

GC content: 41.02

Gene sequence:

>1458_bases
GTGAGCAAAGAAACCATCATCGCCCTACATGCAGACCATCAAGGACGTTGGAAGAATCGCGAAGAAATTGCAGAGCATAT
GATCGCCTTGATCGGTCAGTTATATCGCGAAAAGAATATTGTTGTTTCTGTTTATGGTCGTTCTTTAATCAACCGTTCAG
TGATTCAGATCCTGAAATCTCATCGCCGCACACGTGTGGTGGATGTTGAACTTTCAGTGGTAAATACTTTCCCTATTCTT
GAAGCATTGGCAAAAGTAGATAACATTGGTTCAGCAGAAGTAGATATCGGTAAATTGGCTGTTGAATACAAACAGCATGG
TGGCGATATTGATGCTTTTGTTGCTCAAGCTGTTGAGTCAATTAAAGGCAATGCATGCTCTGAAGAGCCAAAAGATGTGG
TGCTTTATGGTTTTGGCCGTATTGGTCGTATCTTGGCACGTCTCATCATTAGCCAGTCTGGTATGGGTCGTGGCCTAGGG
CTTAAAGCAATTGTTGTGCGTAAAAGCTCAGATGGTGATTTGGCAAAACGTGCGTCATTACTACGTCGTGACTCAATTCA
TGGTTCATTTGACGGTACAATTTCAATTGATGAAGAAAATGAAGCAATCATTGCAAATGGTAACTTTATTAAAGTCATTT
ATGCCTCTAGCCCGTCTGAAGTTGACTATACCGCCTATGGTATTGACAATGCACTTTTAATTGATAATACAGGTAAATGG
CGTGATCTTGATGGTCTAAGCCAGCATCTTAAATGTCCTGGCGTTGCACGTGTTGTGTTGACTGCACCAGGTAAAGGTGA
CATGAAAAACGTTGTATTTGGTGTAAACCAAGCTGATATTTTAGATGAAGACAAAATCATCTCTGCGGCAAGCTGTACAA
CAAACGCAATCACTGGTGTACTCAAAGTGATTGATGATAAATATAAAATTTTAAATGGTCATGTTGAAACTGTTCATTCA
TTTACCAATGATCAGAACCTGATTGATAATTACCACAAGGCAGATCGTCGTGGTCGTGCTGCAACACTGAACATGGTGAT
TACAGAAACGGGTGCAGCGAAAGCAGTTGCTAAGGCTTTACCAGCGCTTAAAGGTAAATTGACAGGTAATTCGGTACGTG
TACCTACACCAAACGTATCTTTAGCCATTCTGAATTTGACACTTGAAAAAGAAGTTGATCGCGACGAAGTGAATGAATAC
ATTCGCCAGATTTCAATCAATTCAAATTTACAAGGTCAGATTGGTTATACCAATTCAACAGAAGTCGTTTCAAGTGACTT
TATCGGTTCGCGTACAGCAGGTGTATATGATGCACAGGCAACGATTGCCTCTGGTACTCATTTGACCGCTTATGTGTGGT
ATGACAATGAAGTAGGCTATAGCTGTCAGGTTCTACGCATTGCAGAGAAAATGTGCGGCGTAAGCTATCCAAAAGTACCT
ACGCAAATGACAGCTTAA

Upstream 100 bases:

>100_bases
GCATATCGTTAAGTGCTGGATTTAATCTTGGCGCTATTTGATTTACAATTATCGCGTTTTCAAATTCACGCCTAGATAAC
ATTAATTAGAGGACGTATCT

Downstream 100 bases:

>100_bases
TCACGTAATCAATAGATTTAAAAGCTCAGTTTCGACTGAGCTTTTTTGTCAAATGTACATAGTCCTTCATATTTGACACA
AAACCCAAGCTGAAACGCCA

Product: glyceraldehyde-3-phosphate dehydrogenase

Products: NA

Alternate protein names: GAPDH [H]

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MSKETIIALHADHQGRWKNREEIAEHMIALIGQLYREKNIVVSVYGRSLINRSVIQILKSHRRTRVVDVELSVVNTFPIL
EALAKVDNIGSAEVDIGKLAVEYKQHGGDIDAFVAQAVESIKGNACSEEPKDVVLYGFGRIGRILARLIISQSGMGRGLG
LKAIVVRKSSDGDLAKRASLLRRDSIHGSFDGTISIDEENEAIIANGNFIKVIYASSPSEVDYTAYGIDNALLIDNTGKW
RDLDGLSQHLKCPGVARVVLTAPGKGDMKNVVFGVNQADILDEDKIISAASCTTNAITGVLKVIDDKYKILNGHVETVHS
FTNDQNLIDNYHKADRRGRAATLNMVITETGAAKAVAKALPALKGKLTGNSVRVPTPNVSLAILNLTLEKEVDRDEVNEY
IRQISINSNLQGQIGYTNSTEVVSSDFIGSRTAGVYDAQATIASGTHLTAYVWYDNEVGYSCQVLRIAEKMCGVSYPKVP
TQMTA

Sequences:

>Translated_485_residues
MSKETIIALHADHQGRWKNREEIAEHMIALIGQLYREKNIVVSVYGRSLINRSVIQILKSHRRTRVVDVELSVVNTFPIL
EALAKVDNIGSAEVDIGKLAVEYKQHGGDIDAFVAQAVESIKGNACSEEPKDVVLYGFGRIGRILARLIISQSGMGRGLG
LKAIVVRKSSDGDLAKRASLLRRDSIHGSFDGTISIDEENEAIIANGNFIKVIYASSPSEVDYTAYGIDNALLIDNTGKW
RDLDGLSQHLKCPGVARVVLTAPGKGDMKNVVFGVNQADILDEDKIISAASCTTNAITGVLKVIDDKYKILNGHVETVHS
FTNDQNLIDNYHKADRRGRAATLNMVITETGAAKAVAKALPALKGKLTGNSVRVPTPNVSLAILNLTLEKEVDRDEVNEY
IRQISINSNLQGQIGYTNSTEVVSSDFIGSRTAGVYDAQATIASGTHLTAYVWYDNEVGYSCQVLRIAEKMCGVSYPKVP
TQMTA
>Mature_484_residues
SKETIIALHADHQGRWKNREEIAEHMIALIGQLYREKNIVVSVYGRSLINRSVIQILKSHRRTRVVDVELSVVNTFPILE
ALAKVDNIGSAEVDIGKLAVEYKQHGGDIDAFVAQAVESIKGNACSEEPKDVVLYGFGRIGRILARLIISQSGMGRGLGL
KAIVVRKSSDGDLAKRASLLRRDSIHGSFDGTISIDEENEAIIANGNFIKVIYASSPSEVDYTAYGIDNALLIDNTGKWR
DLDGLSQHLKCPGVARVVLTAPGKGDMKNVVFGVNQADILDEDKIISAASCTTNAITGVLKVIDDKYKILNGHVETVHSF
TNDQNLIDNYHKADRRGRAATLNMVITETGAAKAVAKALPALKGKLTGNSVRVPTPNVSLAILNLTLEKEVDRDEVNEYI
RQISINSNLQGQIGYTNSTEVVSSDFIGSRTAGVYDAQATIASGTHLTAYVWYDNEVGYSCQVLRIAEKMCGVSYPKVPT
QMTA

Specific function: Second phase of glycolysis; first step. [C]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7669492, Length=338, Percent_Identity=37.5739644970414, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI7657116, Length=338, Percent_Identity=34.9112426035503, Blast_Score=182, Evalue=5e-46,
Organism=Escherichia coli, GI1788079, Length=333, Percent_Identity=37.5375375375375, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1789295, Length=346, Percent_Identity=32.6589595375723, Blast_Score=172, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI17568413, Length=345, Percent_Identity=35.3623188405797, Blast_Score=181, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI32566163, Length=337, Percent_Identity=35.3115727002967, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17534677, Length=342, Percent_Identity=33.3333333333333, Blast_Score=171, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17534679, Length=342, Percent_Identity=33.3333333333333, Blast_Score=170, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6322468, Length=344, Percent_Identity=37.2093023255814, Blast_Score=199, Evalue=7e-52,
Organism=Saccharomyces cerevisiae, GI6322409, Length=341, Percent_Identity=38.1231671554252, Blast_Score=199, Evalue=9e-52,
Organism=Saccharomyces cerevisiae, GI6321631, Length=342, Percent_Identity=37.4269005847953, Blast_Score=197, Evalue=3e-51,
Organism=Drosophila melanogaster, GI19922412, Length=333, Percent_Identity=37.8378378378378, Blast_Score=198, Evalue=6e-51,
Organism=Drosophila melanogaster, GI17933600, Length=337, Percent_Identity=36.7952522255193, Blast_Score=195, Evalue=7e-50,
Organism=Drosophila melanogaster, GI18110149, Length=337, Percent_Identity=36.7952522255193, Blast_Score=195, Evalue=7e-50,
Organism=Drosophila melanogaster, GI85725000, Length=337, Percent_Identity=36.7952522255193, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI22023983, Length=337, Percent_Identity=36.7952522255193, Blast_Score=193, Evalue=2e-49,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 740 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1660 Molecules/Cell In: Growth Phase, Min

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.12 [H]

Molecular weight: Translated: 52754; Mature: 52623

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00071 GAPDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKETIIALHADHQGRWKNREEIAEHMIALIGQLYREKNIVVSVYGRSLINRSVIQILKS
CCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHH
HRRTRVVDVELSVVNTFPILEALAKVDNIGSAEVDIGKLAVEYKQHGGDIDAFVAQAVES
CCCEEEEEEEEEEEHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHCCCCHHHHHHHHHHH
IKGNACSEEPKDVVLYGFGRIGRILARLIISQSGMGRGLGLKAIVVRKSSDGDLAKRASL
HCCCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCHHHHHHH
LRRDSIHGSFDGTISIDEENEAIIANGNFIKVIYASSPSEVDYTAYGIDNALLIDNTGKW
HHHHCCCCCCCCEEEECCCCCEEEECCCEEEEEEECCCCCCCEEEECCCCEEEEECCCCC
RDLDGLSQHLKCPGVARVVLTAPGKGDMKNVVFGVNQADILDEDKIISAASCTTNAITGV
CCCHHHHHHCCCCCEEEEEEECCCCCCCCCEEEECCCHHCCCCCCEEEHHCCHHHHHHHH
LKVIDDKYKILNGHVETVHSFTNDQNLIDNYHKADRRGRAATLNMVITETGAAKAVAKAL
HHHHCCHHHHHCCHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHHH
PALKGKLTGNSVRVPTPNVSLAILNLTLEKEVDRDEVNEYIRQISINSNLQGQIGYTNST
HHHHCCCCCCEEECCCCCCEEEEEEEEECCCCCHHHHHHHHHHEECCCCCCEEECCCCCC
EVVSSDFIGSRTAGVYDAQATIASGTHLTAYVWYDNEVGYSCQVLRIAEKMCGVSYPKVP
HHHHHCCCCCCCCCEEECCEEEECCCEEEEEEEECCCCCCEEHHHHHHHHHHCCCCCCCC
TQMTA
CCCCC
>Mature Secondary Structure 
SKETIIALHADHQGRWKNREEIAEHMIALIGQLYREKNIVVSVYGRSLINRSVIQILKS
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHH
HRRTRVVDVELSVVNTFPILEALAKVDNIGSAEVDIGKLAVEYKQHGGDIDAFVAQAVES
CCCEEEEEEEEEEEHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHCCCCHHHHHHHHHHH
IKGNACSEEPKDVVLYGFGRIGRILARLIISQSGMGRGLGLKAIVVRKSSDGDLAKRASL
HCCCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCHHHHHHH
LRRDSIHGSFDGTISIDEENEAIIANGNFIKVIYASSPSEVDYTAYGIDNALLIDNTGKW
HHHHCCCCCCCCEEEECCCCCEEEECCCEEEEEEECCCCCCCEEEECCCCEEEEECCCCC
RDLDGLSQHLKCPGVARVVLTAPGKGDMKNVVFGVNQADILDEDKIISAASCTTNAITGV
CCCHHHHHHCCCCCEEEEEEECCCCCCCCCEEEECCCHHCCCCCCEEEHHCCHHHHHHHH
LKVIDDKYKILNGHVETVHSFTNDQNLIDNYHKADRRGRAATLNMVITETGAAKAVAKAL
HHHHCCHHHHHCCHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHHH
PALKGKLTGNSVRVPTPNVSLAILNLTLEKEVDRDEVNEYIRQISINSNLQGQIGYTNST
HHHHCCCCCCEEECCCCCCEEEEEEEEECCCCCHHHHHHHHHHEECCCCCCEEECCCCCC
EVVSSDFIGSRTAGVYDAQATIASGTHLTAYVWYDNEVGYSCQVLRIAEKMCGVSYPKVP
HHHHHCCCCCCCCCEEECCEEEECCCEEEEEEEECCCCCCEEHHHHHHHHHHCCCCCCCC
TQMTA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8508805; 10360571; 2401296; 7877172 [H]