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The map label for this gene is hemE

Identifier: 50085555

GI number: 50085555

Start: 2435553

End: 2436629

Strand: Reverse

Name: hemE

Synonym: ACIAD2474

Alternate gene names: 50085555

Gene position: 2436629-2435553 (Counterclockwise)

Preceding gene: 50085558

Following gene: 50085554

Centisome position: 67.71

GC content: 44.1

Gene sequence:

>1077_bases
ATGACGGCCTTAAAAAATGATCGTTTTCTACGCGCTTTGCTCCGTGAACCAGTCGATACCACACCTGTATGGATGATGCG
TCAGGCAGGTCGTTATTTACCAGAATATCGTGAAACGCGTGCTCAGGCTGGAGATTTCCTGTCTTTATGTAAAAATACCG
AGTTTGCCTGTGAAGTCACTTTGCAGCCGCTACGTCGTTATGATTTAGATGCTGCAATTTTATTTTCCGATATTCTGACC
ATACCCGATGCATTGGGTTTAGGGTTGTATTTTGAAACAGGTGAAGGACCAAAATTTAAAAAAACCATTCGTACAGAACA
AGATGTTTTAAATCTACCCAATTTTAATGCCAAGTCGGATTTAGATTATGTCATGAATGCGGTGACAACCATTCATTCGG
CATTAGGTGGGCAAGTTCCACTGATTGGTTTCTCTGGAAGCCCGTGGACGTTGGCAACCTATATGGTAGAGGGCGGTTCC
AGTAAAGATTTCCGTTATACCAAGCATATGATGTATTCGCAGCCAGAAGTATTACATGCCTTATTAGATCGTCTTGCAGT
GGCAGTGATTGATTATCTAAATGCTCAAATTGATGCAGGCGCACAGGCAGTTCAAATCTTTGATAGTTGGGGTGGGGCAC
TGGCACACCGTGAATATACCGAATTTTCTCTTAACTACATGCGTAAAATCGTAGCTGGATTACAGCGTGAAAAAGATGGA
CGCCGTATTCCTGTCATTTTATTTACCAAAGGTGGCGGTCAATGGCTAGAACCGATGATTGCAACAGGTGCAGATGCGAT
TGGTCTAGACTGGACAACACCGCTTAATGTGGCACGGAAAACGGTTGCAGGACGAGTCGCGCTACAAGGCAACCTTGATC
CTGCAGTACTGTATGGCTCAGCAGCCAGCATTGAAAAATCAGTAAAAGCCATGCTAGATGATGCTTACGCCAATGGTGAA
ACCACTGGTTATATCGCAAATCTTGGGCACGGTATCACTCAATGGGTTGATCCATCCCAGCCGAAAATTTTTGTCGATAC
CGTACACGAATACAGCGCCAAATATTTAGGATCGTGA

Upstream 100 bases:

>100_bases
TTGATGTAGACAAATCTGATTTTATATGTCGAGCCCTTATTAATTTACAACCCTTTTTGTTATGATGCGGTGAAGATAAA
TATTTAGATTGAGACAGTGA

Downstream 100 bases:

>100_bases
TGCAGTGTATCTCCTAAGATTTACCAGTTTATTTGTATTTAAGGCAGCTTCGGCTGCCTTGTTTGGTTTGTTACTGCTGA
TTGCTTTTGCTGTAACAGCA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MTALKNDRFLRALLREPVDTTPVWMMRQAGRYLPEYRETRAQAGDFLSLCKNTEFACEVTLQPLRRYDLDAAILFSDILT
IPDALGLGLYFETGEGPKFKKTIRTEQDVLNLPNFNAKSDLDYVMNAVTTIHSALGGQVPLIGFSGSPWTLATYMVEGGS
SKDFRYTKHMMYSQPEVLHALLDRLAVAVIDYLNAQIDAGAQAVQIFDSWGGALAHREYTEFSLNYMRKIVAGLQREKDG
RRIPVILFTKGGGQWLEPMIATGADAIGLDWTTPLNVARKTVAGRVALQGNLDPAVLYGSAASIEKSVKAMLDDAYANGE
TTGYIANLGHGITQWVDPSQPKIFVDTVHEYSAKYLGS

Sequences:

>Translated_358_residues
MTALKNDRFLRALLREPVDTTPVWMMRQAGRYLPEYRETRAQAGDFLSLCKNTEFACEVTLQPLRRYDLDAAILFSDILT
IPDALGLGLYFETGEGPKFKKTIRTEQDVLNLPNFNAKSDLDYVMNAVTTIHSALGGQVPLIGFSGSPWTLATYMVEGGS
SKDFRYTKHMMYSQPEVLHALLDRLAVAVIDYLNAQIDAGAQAVQIFDSWGGALAHREYTEFSLNYMRKIVAGLQREKDG
RRIPVILFTKGGGQWLEPMIATGADAIGLDWTTPLNVARKTVAGRVALQGNLDPAVLYGSAASIEKSVKAMLDDAYANGE
TTGYIANLGHGITQWVDPSQPKIFVDTVHEYSAKYLGS
>Mature_357_residues
TALKNDRFLRALLREPVDTTPVWMMRQAGRYLPEYRETRAQAGDFLSLCKNTEFACEVTLQPLRRYDLDAAILFSDILTI
PDALGLGLYFETGEGPKFKKTIRTEQDVLNLPNFNAKSDLDYVMNAVTTIHSALGGQVPLIGFSGSPWTLATYMVEGGSS
KDFRYTKHMMYSQPEVLHALLDRLAVAVIDYLNAQIDAGAQAVQIFDSWGGALAHREYTEFSLNYMRKIVAGLQREKDGR
RIPVILFTKGGGQWLEPMIATGADAIGLDWTTPLNVARKTVAGRVALQGNLDPAVLYGSAASIEKSVKAMLDDAYANGET
TGYIANLGHGITQWVDPSQPKIFVDTVHEYSAKYLGS

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=354, Percent_Identity=48.8700564971751, Blast_Score=320, Evalue=1e-87,
Organism=Escherichia coli, GI2367337, Length=355, Percent_Identity=66.4788732394366, Blast_Score=483, Evalue=1e-138,
Organism=Saccharomyces cerevisiae, GI6320252, Length=360, Percent_Identity=42.2222222222222, Blast_Score=294, Evalue=2e-80,
Organism=Drosophila melanogaster, GI19921920, Length=351, Percent_Identity=43.3048433048433, Blast_Score=280, Evalue=9e-76,
Organism=Drosophila melanogaster, GI221330099, Length=351, Percent_Identity=43.3048433048433, Blast_Score=280, Evalue=1e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_ACIAD (Q6F9M1)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_047065.1
- HSSP:   P06132
- ProteinModelPortal:   Q6F9M1
- SMR:   Q6F9M1
- STRING:   Q6F9M1
- GeneID:   2879990
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD2474
- NMPDR:   fig|62977.3.peg.2074
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- PhylomeDB:   Q6F9M1
- ProtClustDB:   PRK00115
- BioCyc:   ASP62977:ACIAD2474-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 39559; Mature: 39427

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 77-77 BINDING 154-154 BINDING 209-209 BINDING 330-330

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALKNDRFLRALLREPVDTTPVWMMRQAGRYLPEYRETRAQAGDFLSLCKNTEFACEVT
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEEE
LQPLRRYDLDAAILFSDILTIPDALGLGLYFETGEGPKFKKTIRTEQDVLNLPNFNAKSD
HHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHCHHHHHCCCCCCCCCH
LDYVMNAVTTIHSALGGQVPLIGFSGSPWTLATYMVEGGSSKDFRYTKHMMYSQPEVLHA
HHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHCCCHHHHHH
LLDRLAVAVIDYLNAQIDAGAQAVQIFDSWGGALAHREYTEFSLNYMRKIVAGLQREKDG
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RRIPVILFTKGGGQWLEPMIATGADAIGLDWTTPLNVARKTVAGRVALQGNLDPAVLYGS
CEEEEEEEECCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCEEEEECCCCCEEEECC
AASIEKSVKAMLDDAYANGETTGYIANLGHGITQWVDPSQPKIFVDTVHEYSAKYLGS
HHHHHHHHHHHHHHHHCCCCCCEEHHHHCCCHHHCCCCCCCEEEEEHHHHHHHHHCCC
>Mature Secondary Structure 
TALKNDRFLRALLREPVDTTPVWMMRQAGRYLPEYRETRAQAGDFLSLCKNTEFACEVT
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEEE
LQPLRRYDLDAAILFSDILTIPDALGLGLYFETGEGPKFKKTIRTEQDVLNLPNFNAKSD
HHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHCHHHHHCCCCCCCCCH
LDYVMNAVTTIHSALGGQVPLIGFSGSPWTLATYMVEGGSSKDFRYTKHMMYSQPEVLHA
HHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHCCCHHHHHH
LLDRLAVAVIDYLNAQIDAGAQAVQIFDSWGGALAHREYTEFSLNYMRKIVAGLQREKDG
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RRIPVILFTKGGGQWLEPMIATGADAIGLDWTTPLNVARKTVAGRVALQGNLDPAVLYGS
CEEEEEEEECCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCEEEEECCCCCEEEECC
AASIEKSVKAMLDDAYANGETTGYIANLGHGITQWVDPSQPKIFVDTVHEYSAKYLGS
HHHHHHHHHHHHHHHHCCCCCCEEHHHHCCCHHHCCCCCCCEEEEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA