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The map label for this gene is xdhA [H]

Identifier: 50085550

GI number: 50085550

Start: 2430216

End: 2431712

Strand: Reverse

Name: xdhA [H]

Synonym: ACIAD2468

Alternate gene names: 50085550

Gene position: 2431712-2430216 (Counterclockwise)

Preceding gene: 50085554

Following gene: 50085549

Centisome position: 67.57

GC content: 43.95

Gene sequence:

>1497_bases
ATGTCACAACGCCCAGTCACTTTCTTTTTCCGTGGGAAAACCCAGCAGGTAGCGGGTGTCGCGCCAGTGATGACGGTTTT
GCAGTTTTTGCGTGAGCATGGTGGCCTAGATCAGGTTCGTCAAACAGGAACCAAAGAAGGATGTGCAGAAGGCGATTGCG
GTGCATGTACAGTGGTGATCGGTGAGTTAGTCAATGATCAGCTACAGCTCCGCAGTGTTAATGCATGTATTCAATTTTTA
CCTACACTTGACGGTAAAGCACTTTTTACTGTTGAGGACTTAAAAACATTAACCTTGAGCTCTGAGTCTGTATTACACCC
TGTACAGCAGGCGATGGTTGAACACCACGGTTCACAGTGTGGTTTTTGTACACCTGGTTTTATTATGTCGCTATGGTCGA
TGTATGAAAATGAATCACATGCACCCGATAAAGCCAAGGTCAGTGATTATTTGTCTGGTAATTTATGTCGCTGTACAGGT
TATCGCCCGATTCTGGATGCTGCGCAAAAGGCTTTTGATTATCCAAAAGTCATGTTGGAGCGACAAAACATCATTGAGGC
GCTCAAGCAGATTCAGGCTTTACCAAGCTTGCAACTTGAATATCAAGGACAACAGTTTTTTGCACCCAAAACCGTGCAGG
AGTTTGCAGCTTTGCGTCAACAGTATCCACAAGCACGTATTGTTGCTGGCAGCACCGATGTAGGGCTTTGGGTGACCAAG
CTTGGGCGTGATCTAGGCGACATGCTATATATTGGTCAAGTACAAGAATTAAAAAGCATCGATATTGACCAGAATATGCT
ACATATTGGTGCAAATGTAAGCTTAAGTGATGCGCTGTCTAAAATATCAGACATTTATCCAGATTTTGAAGAGTTACAAC
GCCGTTTCGCCTCGATGCCAATCAAAAACGCAGGCACGTTGGGTGGCAATATTGCCAATGGTTCTCCTATTGGGGATTCG
ATGCCAGCATTAATAACACTAGATACAATATTACGTTTACGCAGTGGTGAACAGCGTCGAGACATTGCATTGGCGGATTA
TTATCTGGATTATCAAAAGACTGCTTTACAGGCAGGCGAGTTTGTCGAAGCAATTCTGATTCCTATTCATTCATCCAAAA
CATTTAAATTTGCCACATATAAAATCTCAAAACGTTTTGAGCAAGATATTTCGGCGGTCTGTGCGGCCTTTAGTTGTGAG
TTGGATGAAAATAAGGTCGTGCAATCTATCAACATTGCGTTTGGGGGAATGGCGGCAATTCCGAAACGTGCGGTACAGGC
AGAAGCGGTGCTATTAGGGAAAGTGATGTCTGCCGAATTAATTCAGCATGCACAAGTGGCTTTAGCACAGGACTTTCAAC
CTTTAAGTGATGGTCGGGCAAGCAGTGCGTACCGTTTGCAAGTCGCACAAAACTGTTTGCAACGTTTTTATCTTGAAAAG
ATTGAAGATACACCGATGACCCGTGTTGATGATTTGATTGCTTTGGTGGAGGTGTAA

Upstream 100 bases:

>100_bases
TATTCAAAGTCAAATAGATCAACAGGATAGCACTTTGATGGCACTAAATTTGCAAAAATACTCTTTAGTAGAGTTATGAA
GTTAAGCTTAAGGATAGAAC

Downstream 100 bases:

>100_bases
CATGAATCAGTCCGTAGAACATTTAAACATTCAAAAAAAATCGGCGAAAGCTGGGGACTCGATTCCACACGAAAGCGCAC
ATCTACATGTGACGGGTCAA

Product: xanthine dehydrogenase, small subunit

Products: NA

Alternate protein names: CO dehydrogenase subunit S; CO-DH S [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MSQRPVTFFFRGKTQQVAGVAPVMTVLQFLREHGGLDQVRQTGTKEGCAEGDCGACTVVIGELVNDQLQLRSVNACIQFL
PTLDGKALFTVEDLKTLTLSSESVLHPVQQAMVEHHGSQCGFCTPGFIMSLWSMYENESHAPDKAKVSDYLSGNLCRCTG
YRPILDAAQKAFDYPKVMLERQNIIEALKQIQALPSLQLEYQGQQFFAPKTVQEFAALRQQYPQARIVAGSTDVGLWVTK
LGRDLGDMLYIGQVQELKSIDIDQNMLHIGANVSLSDALSKISDIYPDFEELQRRFASMPIKNAGTLGGNIANGSPIGDS
MPALITLDTILRLRSGEQRRDIALADYYLDYQKTALQAGEFVEAILIPIHSSKTFKFATYKISKRFEQDISAVCAAFSCE
LDENKVVQSINIAFGGMAAIPKRAVQAEAVLLGKVMSAELIQHAQVALAQDFQPLSDGRASSAYRLQVAQNCLQRFYLEK
IEDTPMTRVDDLIALVEV

Sequences:

>Translated_498_residues
MSQRPVTFFFRGKTQQVAGVAPVMTVLQFLREHGGLDQVRQTGTKEGCAEGDCGACTVVIGELVNDQLQLRSVNACIQFL
PTLDGKALFTVEDLKTLTLSSESVLHPVQQAMVEHHGSQCGFCTPGFIMSLWSMYENESHAPDKAKVSDYLSGNLCRCTG
YRPILDAAQKAFDYPKVMLERQNIIEALKQIQALPSLQLEYQGQQFFAPKTVQEFAALRQQYPQARIVAGSTDVGLWVTK
LGRDLGDMLYIGQVQELKSIDIDQNMLHIGANVSLSDALSKISDIYPDFEELQRRFASMPIKNAGTLGGNIANGSPIGDS
MPALITLDTILRLRSGEQRRDIALADYYLDYQKTALQAGEFVEAILIPIHSSKTFKFATYKISKRFEQDISAVCAAFSCE
LDENKVVQSINIAFGGMAAIPKRAVQAEAVLLGKVMSAELIQHAQVALAQDFQPLSDGRASSAYRLQVAQNCLQRFYLEK
IEDTPMTRVDDLIALVEV
>Mature_497_residues
SQRPVTFFFRGKTQQVAGVAPVMTVLQFLREHGGLDQVRQTGTKEGCAEGDCGACTVVIGELVNDQLQLRSVNACIQFLP
TLDGKALFTVEDLKTLTLSSESVLHPVQQAMVEHHGSQCGFCTPGFIMSLWSMYENESHAPDKAKVSDYLSGNLCRCTGY
RPILDAAQKAFDYPKVMLERQNIIEALKQIQALPSLQLEYQGQQFFAPKTVQEFAALRQQYPQARIVAGSTDVGLWVTKL
GRDLGDMLYIGQVQELKSIDIDQNMLHIGANVSLSDALSKISDIYPDFEELQRRFASMPIKNAGTLGGNIANGSPIGDSM
PALITLDTILRLRSGEQRRDIALADYYLDYQKTALQAGEFVEAILIPIHSSKTFKFATYKISKRFEQDISAVCAAFSCEL
DENKVVQSINIAFGGMAAIPKRAVQAEAVLLGKVMSAELIQHAQVALAQDFQPLSDGRASSAYRLQVAQNCLQRFYLEKI
EDTPMTRVDDLIALVEV

Specific function: Catalyzes the oxidation of carbon monoxide to carbon dioxide [H]

COG id: COG4630

COG function: function code F; Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=548, Percent_Identity=28.2846715328467, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI71773480, Length=475, Percent_Identity=25.2631578947368, Blast_Score=150, Evalue=4e-36,
Organism=Escherichia coli, GI1786480, Length=181, Percent_Identity=36.4640883977901, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1789231, Length=262, Percent_Identity=25.9541984732824, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1789232, Length=148, Percent_Identity=35.1351351351351, Blast_Score=82, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17540638, Length=162, Percent_Identity=42.5925925925926, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI17539860, Length=480, Percent_Identity=26.25, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI32566215, Length=414, Percent_Identity=26.0869565217391, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI17737937, Length=556, Percent_Identity=30.7553956834532, Blast_Score=212, Evalue=5e-55,
Organism=Drosophila melanogaster, GI24647199, Length=496, Percent_Identity=29.0322580645161, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24647197, Length=503, Percent_Identity=30.6163021868787, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24647201, Length=514, Percent_Identity=27.6264591439689, Blast_Score=175, Evalue=7e-44,
Organism=Drosophila melanogaster, GI24647195, Length=323, Percent_Identity=34.6749226006192, Blast_Score=161, Evalue=9e-40,
Organism=Drosophila melanogaster, GI24647193, Length=493, Percent_Identity=28.1947261663286, Blast_Score=151, Evalue=9e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.2.99.2 [H]

Molecular weight: Translated: 54966; Mature: 54835

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQRPVTFFFRGKTQQVAGVAPVMTVLQFLREHGGLDQVRQTGTKEGCAEGDCGACTVVI
CCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCHHHHHH
GELVNDQLQLRSVNACIQFLPTLDGKALFTVEDLKTLTLSSESVLHPVQQAMVEHHGSQC
HHHHCHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHCCCCHHHHHHHHHHHHHHCCCCC
GFCTPGFIMSLWSMYENESHAPDKAKVSDYLSGNLCRCTGYRPILDAAQKAFDYPKVMLE
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHCCCHHHHHH
RQNIIEALKQIQALPSLQLEYQGQQFFAPKTVQEFAALRQQYPQARIVAGSTDVGLWVTK
HHHHHHHHHHHHHCCCCEEEECCCEECCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHH
LGRDLGDMLYIGQVQELKSIDIDQNMLHIGANVSLSDALSKISDIYPDFEELQRRFASMP
HHHHHHHHHHHCCHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHCC
IKNAGTLGGNIANGSPIGDSMPALITLDTILRLRSGEQRRDIALADYYLDYQKTALQAGE
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHH
FVEAILIPIHSSKTFKFATYKISKRFEQDISAVCAAFSCELDENKVVQSINIAFGGMAAI
HHHHHEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHH
PKRAVQAEAVLLGKVMSAELIQHAQVALAQDFQPLSDGRASSAYRLQVAQNCLQRFYLEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
IEDTPMTRVDDLIALVEV
HCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SQRPVTFFFRGKTQQVAGVAPVMTVLQFLREHGGLDQVRQTGTKEGCAEGDCGACTVVI
CCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCHHHHHH
GELVNDQLQLRSVNACIQFLPTLDGKALFTVEDLKTLTLSSESVLHPVQQAMVEHHGSQC
HHHHCHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHCCCCHHHHHHHHHHHHHHCCCCC
GFCTPGFIMSLWSMYENESHAPDKAKVSDYLSGNLCRCTGYRPILDAAQKAFDYPKVMLE
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHCCCHHHHHH
RQNIIEALKQIQALPSLQLEYQGQQFFAPKTVQEFAALRQQYPQARIVAGSTDVGLWVTK
HHHHHHHHHHHHHCCCCEEEECCCEECCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHH
LGRDLGDMLYIGQVQELKSIDIDQNMLHIGANVSLSDALSKISDIYPDFEELQRRFASMP
HHHHHHHHHHHCCHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHCC
IKNAGTLGGNIANGSPIGDSMPALITLDTILRLRSGEQRRDIALADYYLDYQKTALQAGE
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHH
FVEAILIPIHSSKTFKFATYKISKRFEQDISAVCAAFSCELDENKVVQSINIAFGGMAAI
HHHHHEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHH
PKRAVQAEAVLLGKVMSAELIQHAQVALAQDFQPLSDGRASSAYRLQVAQNCLQRFYLEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
IEDTPMTRVDDLIALVEV
HCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10482497; 2818128; 10966817; 11076018 [H]