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The map label for this gene is xdhB [H]

Identifier: 50085549

GI number: 50085549

Start: 2427833

End: 2430214

Strand: Reverse

Name: xdhB [H]

Synonym: ACIAD2467

Alternate gene names: 50085549

Gene position: 2430214-2427833 (Counterclockwise)

Preceding gene: 50085550

Following gene: 50085548

Centisome position: 67.53

GC content: 45.13

Gene sequence:

>2382_bases
ATGAATCAGTCCGTAGAACATTTAAACATTCAAAAAAAATCGGCGAAAGCTGGGGACTCGATTCCACACGAAAGCGCACA
TCTACATGTGACGGGTCAAGCCACTTATATCGATGACTTACCAGAACTTGAAAATACACTGCATCTGGCAGTGGGTTTCT
CGCAATGTGCAAAGGGTAAAATTGTCCAATTTGATTTAGATGCAGTGCGTCAGGCAGAAGGTGTTTATGCTGTTTATACT
GCAGCAGATATAGCAGTCAAAAATAATTGGGGCCCAATTGTCAATGACGATCCAATTTTTGCTGATGGCGAAGTTGAGTT
TTATGGTCAGGCACTGTTTGTGGTGGCAGCTAAAACCTATCAGCAGGCAAGACGTGCAGTACGACTGGCCAAAATCGAAT
ATGAAGCAGAAACCCCCATTTTAAGTATTCAAGATGCGATTGAGCAGCAATCTTGGGTCTTGCCACCTGTCGATTTTAGT
CATGGCGAAGTGGAACAAGCCTTTCAAACCGCATCGCATCAGTTAAGTGGTTCAATTGAGCTCGGCGGGCAAGAGCATTT
TTATCTGGAAGGCCAGATTTCTTATGCGGTGCCACAAGAAGATCAGACACTGAAGGTTTATTGTTCAACCCAACATCCAA
CCGAGATGCAATTACTTATCTGCCATGCATTGGGCTACCACATGCATCAGGTCAGTGTTGAAGCACGTCGTATGGGCGGT
GGATTTGGTGGGAAAGAATCGCAATCGGCACAATGGGCGTGTATTGCTTCGCTCGCCGCACAACTTTCGGGGCATCCATG
TAAACTGCGTCTGGATCGTGATGATGATATGAGTTCGACGGGTAAGCGACATGGCTTTGCGTATGAATGGTCAGTTGCAT
TTGATGAATTGGGTGTATTACAGGGATTAAAAGTGCAATTGGCATCCAATTGTGGTTTTTCTGCAGATTTATCAGGCCCT
GTCAATGAACGTGCTATTTGTCATATTGGTAATGCGTATTATCTAAATGCGGTTCAGTTGCGCAATTTACGCTGTAAGAC
CAATACCGTATCGAATACAGCGTATCGAGGATTTGGCGGCCCTCAAGGCATGTTTGTCATTGAGAATATTTTGGATGATA
TTGCCCGTTATTTAAAGTGTGATCCTGTTTTGGTGCGTCAGCGTAATTTTTTTGCAGAAAAGCCAGGCAATGGTCGTGAT
CATATGCATTATGGTGCTGAAGTTCGAGATAATGTTGCGCCCAAAATTGTAGACGAATTACTGGCGACAAGTCATTACCA
CGCACGTCGAGCCTCAATTGCGCAATTTAATCAGCACAATGCAATCATTAAACGTGGTATTGCTTTAACACCACTCATGT
TTGGGATCTCTTTTAATGCTGTTCATTACAATCAGGCTGGTGCGCTGGTCTATGTGTATATGGATGGCACGGTCGCAATC
ACGCATGGTGGTACAGAGATGGGTCAAGGGCTTTATACCAAAGTTCGTCAGGTTGCCGCACATGAATTAGGACTACCGAT
TGATCGGGTACGTTTAATTGCCACCGATACCTCTCGTGTTCCGAATACTTCCGCCACAGCCGCTTCGAGTGGTGCAGATT
TAAACGGGAAGGCGGTACAAAATGCGTGTATTAAGATTCGTGAACGTTTAGCCAAACTTGCGGCTGAAATTAGCCAAAGT
GATGCAGACCAGATTCACTTTGAAAATAGTACGGTGACTACAAATAATGGACAATCATGGAGTTTTAATGATTTGGTCAA
TCGTGCCTATATGGCGCGGGTACAATTGTGGGATAGCGGTTTTTATAAGACCCCTGAAATTCACTATGATCAAGTCAACC
ATTTAGGTCGTCCATTTTTTTACTATGCATATGGCGCTGCGGTCAGTGAAGTTGCAATTGATACTTTGACGGGGGAAATG
AAAGTCTTACGTACCGATATTCTTCATGATGTCGGACGTTCGATTAACCCTGCGATAGACATTGGGCAGATTGAAGGTGG
GTTTATTCAAGGCATGGGATGGTTAACCACTGAAGAACTGTATTGGCAACCGCAAGGGCCGCATGCTGGGCGATTATTTA
CGCATGCACCATCGACCTATAAGATTCCGACCAGTGCCGATATTCCGCATGTCTTTAATGTCAAATTATTTGATAACCAG
AATGCTGCTGATACCATTTATCGTTCCAAAGCTGTGGGTGAGCCGCCGTTTATGTTAGGGCTATCGGTATTCTCTGCGAT
TCGCCAAGCGGTTCAGGCGGCAATTCCTGAGGATGCACCGCTTGAGTTAAATGCACCTGCAACAGCAGAAGAAATCCTGC
GCGCGATTGCGATTGGTCGTGGGCAGGCACTTGCAGATCAGCCACAGCCAAGATTACGCTAG

Upstream 100 bases:

>100_bases
CAAGTCGCACAAAACTGTTTGCAACGTTTTTATCTTGAAAAGATTGAAGATACACCGATGACCCGTGTTGATGATTTGAT
TGCTTTGGTGGAGGTGTAAC

Downstream 100 bases:

>100_bases
TTGGAAAGGTAATCATGCATCAACATTTACAATGGTGGCAAGATCTAGTGCTTTGGCATTCAGATCAGTCATCCATGATT
TTAGTGACTGTGGTTCGTGC

Product: xanthine dehydrogenase, large subunit

Products: NA

Alternate protein names: XDHase subunit D [H]

Number of amino acids: Translated: 793; Mature: 793

Protein sequence:

>793_residues
MNQSVEHLNIQKKSAKAGDSIPHESAHLHVTGQATYIDDLPELENTLHLAVGFSQCAKGKIVQFDLDAVRQAEGVYAVYT
AADIAVKNNWGPIVNDDPIFADGEVEFYGQALFVVAAKTYQQARRAVRLAKIEYEAETPILSIQDAIEQQSWVLPPVDFS
HGEVEQAFQTASHQLSGSIELGGQEHFYLEGQISYAVPQEDQTLKVYCSTQHPTEMQLLICHALGYHMHQVSVEARRMGG
GFGGKESQSAQWACIASLAAQLSGHPCKLRLDRDDDMSSTGKRHGFAYEWSVAFDELGVLQGLKVQLASNCGFSADLSGP
VNERAICHIGNAYYLNAVQLRNLRCKTNTVSNTAYRGFGGPQGMFVIENILDDIARYLKCDPVLVRQRNFFAEKPGNGRD
HMHYGAEVRDNVAPKIVDELLATSHYHARRASIAQFNQHNAIIKRGIALTPLMFGISFNAVHYNQAGALVYVYMDGTVAI
THGGTEMGQGLYTKVRQVAAHELGLPIDRVRLIATDTSRVPNTSATAASSGADLNGKAVQNACIKIRERLAKLAAEISQS
DADQIHFENSTVTTNNGQSWSFNDLVNRAYMARVQLWDSGFYKTPEIHYDQVNHLGRPFFYYAYGAAVSEVAIDTLTGEM
KVLRTDILHDVGRSINPAIDIGQIEGGFIQGMGWLTTEELYWQPQGPHAGRLFTHAPSTYKIPTSADIPHVFNVKLFDNQ
NAADTIYRSKAVGEPPFMLGLSVFSAIRQAVQAAIPEDAPLELNAPATAEEILRAIAIGRGQALADQPQPRLR

Sequences:

>Translated_793_residues
MNQSVEHLNIQKKSAKAGDSIPHESAHLHVTGQATYIDDLPELENTLHLAVGFSQCAKGKIVQFDLDAVRQAEGVYAVYT
AADIAVKNNWGPIVNDDPIFADGEVEFYGQALFVVAAKTYQQARRAVRLAKIEYEAETPILSIQDAIEQQSWVLPPVDFS
HGEVEQAFQTASHQLSGSIELGGQEHFYLEGQISYAVPQEDQTLKVYCSTQHPTEMQLLICHALGYHMHQVSVEARRMGG
GFGGKESQSAQWACIASLAAQLSGHPCKLRLDRDDDMSSTGKRHGFAYEWSVAFDELGVLQGLKVQLASNCGFSADLSGP
VNERAICHIGNAYYLNAVQLRNLRCKTNTVSNTAYRGFGGPQGMFVIENILDDIARYLKCDPVLVRQRNFFAEKPGNGRD
HMHYGAEVRDNVAPKIVDELLATSHYHARRASIAQFNQHNAIIKRGIALTPLMFGISFNAVHYNQAGALVYVYMDGTVAI
THGGTEMGQGLYTKVRQVAAHELGLPIDRVRLIATDTSRVPNTSATAASSGADLNGKAVQNACIKIRERLAKLAAEISQS
DADQIHFENSTVTTNNGQSWSFNDLVNRAYMARVQLWDSGFYKTPEIHYDQVNHLGRPFFYYAYGAAVSEVAIDTLTGEM
KVLRTDILHDVGRSINPAIDIGQIEGGFIQGMGWLTTEELYWQPQGPHAGRLFTHAPSTYKIPTSADIPHVFNVKLFDNQ
NAADTIYRSKAVGEPPFMLGLSVFSAIRQAVQAAIPEDAPLELNAPATAEEILRAIAIGRGQALADQPQPRLR
>Mature_793_residues
MNQSVEHLNIQKKSAKAGDSIPHESAHLHVTGQATYIDDLPELENTLHLAVGFSQCAKGKIVQFDLDAVRQAEGVYAVYT
AADIAVKNNWGPIVNDDPIFADGEVEFYGQALFVVAAKTYQQARRAVRLAKIEYEAETPILSIQDAIEQQSWVLPPVDFS
HGEVEQAFQTASHQLSGSIELGGQEHFYLEGQISYAVPQEDQTLKVYCSTQHPTEMQLLICHALGYHMHQVSVEARRMGG
GFGGKESQSAQWACIASLAAQLSGHPCKLRLDRDDDMSSTGKRHGFAYEWSVAFDELGVLQGLKVQLASNCGFSADLSGP
VNERAICHIGNAYYLNAVQLRNLRCKTNTVSNTAYRGFGGPQGMFVIENILDDIARYLKCDPVLVRQRNFFAEKPGNGRD
HMHYGAEVRDNVAPKIVDELLATSHYHARRASIAQFNQHNAIIKRGIALTPLMFGISFNAVHYNQAGALVYVYMDGTVAI
THGGTEMGQGLYTKVRQVAAHELGLPIDRVRLIATDTSRVPNTSATAASSGADLNGKAVQNACIKIRERLAKLAAEISQS
DADQIHFENSTVTTNNGQSWSFNDLVNRAYMARVQLWDSGFYKTPEIHYDQVNHLGRPFFYYAYGAAVSEVAIDTLTGEM
KVLRTDILHDVGRSINPAIDIGQIEGGFIQGMGWLTTEELYWQPQGPHAGRLFTHAPSTYKIPTSADIPHVFNVKLFDNQ
NAADTIYRSKAVGEPPFMLGLSVFSAIRQAVQAAIPEDAPLELNAPATAEEILRAIAIGRGQALADQPQPRLR

Specific function: Oxidizes hypoxanthine and xanthine to uric acid [H]

COG id: COG4631

COG function: function code F; Xanthine dehydrogenase, molybdopterin-binding subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=772, Percent_Identity=40.9326424870466, Blast_Score=571, Evalue=1e-162,
Organism=Homo sapiens, GI71773480, Length=763, Percent_Identity=37.4836173001311, Blast_Score=473, Evalue=1e-133,
Organism=Escherichia coli, GI1789230, Length=747, Percent_Identity=26.6398929049531, Blast_Score=213, Evalue=4e-56,
Organism=Escherichia coli, GI1789246, Length=668, Percent_Identity=24.5508982035928, Blast_Score=163, Evalue=5e-41,
Organism=Escherichia coli, GI1786478, Length=758, Percent_Identity=26.1213720316623, Blast_Score=147, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17540638, Length=768, Percent_Identity=40.4947916666667, Blast_Score=526, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI32566215, Length=773, Percent_Identity=31.1772315653299, Blast_Score=343, Evalue=3e-94,
Organism=Caenorhabditis elegans, GI17539860, Length=761, Percent_Identity=31.5374507227332, Blast_Score=333, Evalue=3e-91,
Organism=Drosophila melanogaster, GI17737937, Length=778, Percent_Identity=41.6452442159383, Blast_Score=583, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24647193, Length=793, Percent_Identity=30.5170239596469, Blast_Score=315, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24647199, Length=793, Percent_Identity=29.5081967213115, Blast_Score=312, Evalue=5e-85,
Organism=Drosophila melanogaster, GI24647195, Length=808, Percent_Identity=28.8366336633663, Blast_Score=289, Evalue=5e-78,
Organism=Drosophila melanogaster, GI24647201, Length=766, Percent_Identity=31.0704960835509, Blast_Score=289, Evalue=7e-78,
Organism=Drosophila melanogaster, GI24647197, Length=782, Percent_Identity=29.156010230179, Blast_Score=288, Evalue=8e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR017609 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 87152; Mature: 87152

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQSVEHLNIQKKSAKAGDSIPHESAHLHVTGQATYIDDLPELENTLHLAVGFSQCAKGK
CCCCCCCCEEEHHCCCCCCCCCCCCCEEEEEECEEECCCCHHHHHHEEEEEEHHHHCCCC
IVQFDLDAVRQAEGVYAVYTAADIAVKNNWGPIVNDDPIFADGEVEFYGQALFVVAAKTY
EEEEEHHHHHHCCCEEEEEEEEEEEEECCCCCCCCCCCEEECCCEEEECCEEEEEEHHHH
QQARRAVRLAKIEYEAETPILSIQDAIEQQSWVLPPVDFSHGEVEQAFQTASHQLSGSIE
HHHHHHHHHHEEEECCCCCEEEHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEE
LGGQEHFYLEGQISYAVPQEDQTLKVYCSTQHPTEMQLLICHALGYHMHQVSVEARRMGG
ECCCEEEEEEEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
GFGGKESQSAQWACIASLAAQLSGHPCKLRLDRDDDMSSTGKRHGFAYEWSVAFDELGVL
CCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEEEEEEHHHHHHHH
QGLKVQLASNCGFSADLSGPVNERAICHIGNAYYLNAVQLRNLRCKTNTVSNTAYRGFGG
CCCEEEEECCCCCCCCCCCCCCCCEEEEECCEEEEEEEEEECEEEECCCCCCCCCCCCCC
PQGMFVIENILDDIARYLKCDPVLVRQRNFFAEKPGNGRDHMHYGAEVRDNVAPKIVDEL
CCCHHHHHHHHHHHHHHHCCCCEEEECCCHHCCCCCCCCCCCEECCHHHCCCCHHHHHHH
LATSHYHARRASIAQFNQHNAIIKRGIALTPLMFGISFNAVHYNQAGALVYVYMDGTVAI
HHHCHHHHHHHHHHHHHHCHHHHHCCCCHHHHEECEEEEEEEECCCCEEEEEEECCEEEE
THGGTEMGQGLYTKVRQVAAHELGLPIDRVRLIATDTSRVPNTSATAASSGADLNGKAVQ
EECCHHHCCHHHHHHHHHHHHHHCCCHHHEEEEEECCCCCCCCCCCCCCCCCCCCCHHHH
NACIKIRERLAKLAAEISQSDADQIHFENSTVTTNNGQSWSFNDLVNRAYMARVQLWDSG
HHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEECCCCCCCCHHHHHHHHHHHHEEEECCC
FYKTPEIHYDQVNHLGRPFFYYAYGAAVSEVAIDTLTGEMKVLRTDILHDVGRSINPAID
CCCCCCCCHHHHHHCCCCEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEE
IGQIEGGFIQGMGWLTTEELYWQPQGPHAGRLFTHAPSTYKIPTSADIPHVFNVKLFDNQ
EECCCCCEEECCCCEEEHHEEECCCCCCCCCEEEECCCCEECCCCCCCCCEEEEEEECCC
NAADTIYRSKAVGEPPFMLGLSVFSAIRQAVQAAIPEDAPLELNAPATAEEILRAIAIGR
CHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHCC
GQALADQPQPRLR
CCCCCCCCCCCCC
>Mature Secondary Structure
MNQSVEHLNIQKKSAKAGDSIPHESAHLHVTGQATYIDDLPELENTLHLAVGFSQCAKGK
CCCCCCCCEEEHHCCCCCCCCCCCCCEEEEEECEEECCCCHHHHHHEEEEEEHHHHCCCC
IVQFDLDAVRQAEGVYAVYTAADIAVKNNWGPIVNDDPIFADGEVEFYGQALFVVAAKTY
EEEEEHHHHHHCCCEEEEEEEEEEEEECCCCCCCCCCCEEECCCEEEECCEEEEEEHHHH
QQARRAVRLAKIEYEAETPILSIQDAIEQQSWVLPPVDFSHGEVEQAFQTASHQLSGSIE
HHHHHHHHHHEEEECCCCCEEEHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEE
LGGQEHFYLEGQISYAVPQEDQTLKVYCSTQHPTEMQLLICHALGYHMHQVSVEARRMGG
ECCCEEEEEEEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
GFGGKESQSAQWACIASLAAQLSGHPCKLRLDRDDDMSSTGKRHGFAYEWSVAFDELGVL
CCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEEEEEEHHHHHHHH
QGLKVQLASNCGFSADLSGPVNERAICHIGNAYYLNAVQLRNLRCKTNTVSNTAYRGFGG
CCCEEEEECCCCCCCCCCCCCCCCEEEEECCEEEEEEEEEECEEEECCCCCCCCCCCCCC
PQGMFVIENILDDIARYLKCDPVLVRQRNFFAEKPGNGRDHMHYGAEVRDNVAPKIVDEL
CCCHHHHHHHHHHHHHHHCCCCEEEECCCHHCCCCCCCCCCCEECCHHHCCCCHHHHHHH
LATSHYHARRASIAQFNQHNAIIKRGIALTPLMFGISFNAVHYNQAGALVYVYMDGTVAI
HHHCHHHHHHHHHHHHHHCHHHHHCCCCHHHHEECEEEEEEEECCCCEEEEEEECCEEEE
THGGTEMGQGLYTKVRQVAAHELGLPIDRVRLIATDTSRVPNTSATAASSGADLNGKAVQ
EECCHHHCCHHHHHHHHHHHHHHCCCHHHEEEEEECCCCCCCCCCCCCCCCCCCCCHHHH
NACIKIRERLAKLAAEISQSDADQIHFENSTVTTNNGQSWSFNDLVNRAYMARVQLWDSG
HHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEECCCCCCCCHHHHHHHHHHHHEEEECCC
FYKTPEIHYDQVNHLGRPFFYYAYGAAVSEVAIDTLTGEMKVLRTDILHDVGRSINPAID
CCCCCCCCHHHHHHCCCCEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEE
IGQIEGGFIQGMGWLTTEELYWQPQGPHAGRLFTHAPSTYKIPTSADIPHVFNVKLFDNQ
EECCCCCEEECCCCEEEHHEEECCCCCCCCCEEEECCCCEECCCCCCCCCEEEEEEECCC
NAADTIYRSKAVGEPPFMLGLSVFSAIRQAVQAAIPEDAPLELNAPATAEEILRAIAIGR
CHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHCC
GQALADQPQPRLR
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 11344136 [H]