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The map label for this gene is aro [H]

Identifier: 50085423

GI number: 50085423

Start: 2293501

End: 2294613

Strand: Direct

Name: aro [H]

Synonym: ACIAD2330

Alternate gene names: 50085423

Gene position: 2293501-2294613 (Clockwise)

Preceding gene: 50085422

Following gene: 50085425

Centisome position: 63.73

GC content: 41.96

Gene sequence:

>1113_bases
ATGATCCAATCAGTGACAGCAATGAATACTTTACAGTCCAATCCAGTTTCACAGCCAGATATCGATGATGTTAACATCAA
AAGCATCCAGCCTCTTGTTACGCCTGCCGAGTTAAAAGCAGAGCTTCCACTGACAGAAAGTGCTTATCAAACCGTACTCC
ACGGTCGTGAAACCATTCGCAACATTCTTGATGGTACAGACAAACGTATTTTTGTTGTCATTGGGCCATGCTCTATTCAC
GACCCTAAAGCAGCGCATGAATACGCAACACGCTTAAAAGTACTCAGCGAAAAAGTAAAAGACAGTTTGTATATTGTGAT
GCGTGTTTATTTTGAAAAACCACGTACAACAGTAGGCTGGAAAGGTTTGATTAATGATCCTGATATGAATGACTCATTCA
ATATTGAAAAAGGTCTGCGTATTGGACGTAAATTACTCCTTGAACTAAACGAACAAGGTCTACCTTGTGCTACAGAAGCG
CTTGATCCAAACTCTCCTCAGTATTATCAAGATCTGATTTCATGGTCGGCTATTGGCGCTCGTACCACTGAAAGTCAGAC
ACATCGTGAGATGTCATCTGGATTATCATCACCAGTTGGCTTTAAAAACGGAACAGATGGTGGGCTTACAGTCGCAACAA
ATGCGATGCAATCTGTCAAACACGGTCACAGCTTTTTAGGTTTGAATGAAGCTGGTCAGGTTTCTGTCATTCATACCAGT
GGGAATCCATATGCACACGTTGTATTACGTGGCGGTAACGGAAAGCCAAACTATGATGCAGGGTCAGTCGCAGAAGCTGA
AAATGCACTGGCAAAAGCAAAAGTCAGCACTAAAATCATGATTGATGCCAGCCATGCCAATTCAAATAAAGACCCATACT
TACAGCCACTTGTACTCAAAAATGTAACCGAGCAAATCATCGACGGTAATAAGTCAATAGTGGGTGTCATGGTTGAAAGT
CACCTCAAAGGCGGACGTCAGGATATTCCTGAAAACCTATGTGATCTTGAATACGGCAAGTCTGTTACCGATGGCTGTAT
TGATTGGGAAACCACAGAAAATGTTTTGCTTGAAATGCATGAAGCACTCAAAGATGTTTTAGCTCAGCGTTAA

Upstream 100 bases:

>100_bases
CGATATAACGGGTTAATCGATCTTTTTAAATGATTAATCCGTCTTAAATATGCGTTGCTGAATATGGTTTCGTGGTATAT
TCAGTAAACAGAAAACTAGT

Downstream 100 bases:

>100_bases
TAACCACTTTCAATTTAAAAAGCTCTCATTTGAGAGCTTTTTTATACAATGGATAAAATTAATCCACTGGATAGACAATT
TTAACCATTTTAATCCGATT

Product: phospho-2-dehydro-3-deoxyheptonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase; DAHP synthase; Phospho-2-keto-3-deoxyheptonate aldolase [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MIQSVTAMNTLQSNPVSQPDIDDVNIKSIQPLVTPAELKAELPLTESAYQTVLHGRETIRNILDGTDKRIFVVIGPCSIH
DPKAAHEYATRLKVLSEKVKDSLYIVMRVYFEKPRTTVGWKGLINDPDMNDSFNIEKGLRIGRKLLLELNEQGLPCATEA
LDPNSPQYYQDLISWSAIGARTTESQTHREMSSGLSSPVGFKNGTDGGLTVATNAMQSVKHGHSFLGLNEAGQVSVIHTS
GNPYAHVVLRGGNGKPNYDAGSVAEAENALAKAKVSTKIMIDASHANSNKDPYLQPLVLKNVTEQIIDGNKSIVGVMVES
HLKGGRQDIPENLCDLEYGKSVTDGCIDWETTENVLLEMHEALKDVLAQR

Sequences:

>Translated_370_residues
MIQSVTAMNTLQSNPVSQPDIDDVNIKSIQPLVTPAELKAELPLTESAYQTVLHGRETIRNILDGTDKRIFVVIGPCSIH
DPKAAHEYATRLKVLSEKVKDSLYIVMRVYFEKPRTTVGWKGLINDPDMNDSFNIEKGLRIGRKLLLELNEQGLPCATEA
LDPNSPQYYQDLISWSAIGARTTESQTHREMSSGLSSPVGFKNGTDGGLTVATNAMQSVKHGHSFLGLNEAGQVSVIHTS
GNPYAHVVLRGGNGKPNYDAGSVAEAENALAKAKVSTKIMIDASHANSNKDPYLQPLVLKNVTEQIIDGNKSIVGVMVES
HLKGGRQDIPENLCDLEYGKSVTDGCIDWETTENVLLEMHEALKDVLAQR
>Mature_370_residues
MIQSVTAMNTLQSNPVSQPDIDDVNIKSIQPLVTPAELKAELPLTESAYQTVLHGRETIRNILDGTDKRIFVVIGPCSIH
DPKAAHEYATRLKVLSEKVKDSLYIVMRVYFEKPRTTVGWKGLINDPDMNDSFNIEKGLRIGRKLLLELNEQGLPCATEA
LDPNSPQYYQDLISWSAIGARTTESQTHREMSSGLSSPVGFKNGTDGGLTVATNAMQSVKHGHSFLGLNEAGQVSVIHTS
GNPYAHVVLRGGNGKPNYDAGSVAEAENALAKAKVSTKIMIDASHANSNKDPYLQPLVLKNVTEQIIDGNKSIVGVMVES
HLKGGRQDIPENLCDLEYGKSVTDGCIDWETTENVLLEMHEALKDVLAQR

Specific function: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) [H]

COG id: COG0722

COG function: function code E; 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I DAHP synthase family [H]

Homologues:

Organism=Escherichia coli, GI1788953, Length=350, Percent_Identity=56.2857142857143, Blast_Score=412, Evalue=1e-116,
Organism=Escherichia coli, GI1786969, Length=343, Percent_Identity=56.268221574344, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI1787996, Length=342, Percent_Identity=48.8304093567251, Blast_Score=340, Evalue=1e-94,
Organism=Saccharomyces cerevisiae, GI6319726, Length=350, Percent_Identity=52.5714285714286, Blast_Score=365, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6320240, Length=351, Percent_Identity=50.1424501424501, Blast_Score=355, Evalue=4e-99,

Paralogues:

None

Copy number: 2,200 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006219 [H]

Pfam domain/function: PF00793 DAHP_synth_1 [H]

EC number: =2.5.1.54 [H]

Molecular weight: Translated: 40412; Mature: 40412

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQSVTAMNTLQSNPVSQPDIDDVNIKSIQPLVTPAELKAELPLTESAYQTVLHGRETIR
CCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHH
NILDGTDKRIFVVIGPCSIHDPKAAHEYATRLKVLSEKVKDSLYIVMRVYFEKPRTTVGW
HHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KGLINDPDMNDSFNIEKGLRIGRKLLLELNEQGLPCATEALDPNSPQYYQDLISWSAIGA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCHHHHHHHHHHHCCC
RTTESQTHREMSSGLSSPVGFKNGTDGGLTVATNAMQSVKHGHSFLGLNEAGQVSVIHTS
CCCHHHHHHHHHHCCCCCCCCCCCCCCCEEHHHHHHHHHHCCCCEECCCCCCCEEEEEEC
GNPYAHVVLRGGNGKPNYDAGSVAEAENALAKAKVSTKIMIDASHANSNKDPYLQPLVLK
CCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCEEEEEEEECCCCCCCCCCCCHHHHH
NVTEQIIDGNKSIVGVMVESHLKGGRQDIPENLCDLEYGKSVTDGCIDWETTENVLLEMH
HHHHHHHCCCCCEEEEEHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
EALKDVLAQR
HHHHHHHCCC
>Mature Secondary Structure
MIQSVTAMNTLQSNPVSQPDIDDVNIKSIQPLVTPAELKAELPLTESAYQTVLHGRETIR
CCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHH
NILDGTDKRIFVVIGPCSIHDPKAAHEYATRLKVLSEKVKDSLYIVMRVYFEKPRTTVGW
HHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KGLINDPDMNDSFNIEKGLRIGRKLLLELNEQGLPCATEALDPNSPQYYQDLISWSAIGA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCHHHHHHHHHHHCCC
RTTESQTHREMSSGLSSPVGFKNGTDGGLTVATNAMQSVKHGHSFLGLNEAGQVSVIHTS
CCCHHHHHHHHHHCCCCCCCCCCCCCCCEEHHHHHHHHHHCCCCEECCCCCCCEEEEEEC
GNPYAHVVLRGGNGKPNYDAGSVAEAENALAKAKVSTKIMIDASHANSNKDPYLQPLVLK
CCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCEEEEEEEECCCCCCCCCCCCHHHHH
NVTEQIIDGNKSIVGVMVESHLKGGRQDIPENLCDLEYGKSVTDGCIDWETTENVLLEMH
HHHHHHHCCCCCEEEEEHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
EALKDVLAQR
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6146618; 6396419; 9205837; 9278503; 1977738; 6104668; 2857723; 9056491 [H]