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The map label for this gene is yeaP [H]

Identifier: 50085347

GI number: 50085347

Start: 2213059

End: 2213997

Strand: Direct

Name: yeaP [H]

Synonym: ACIAD2242

Alternate gene names: 50085347

Gene position: 2213059-2213997 (Clockwise)

Preceding gene: 50085341

Following gene: 50085349

Centisome position: 61.5

GC content: 39.3

Gene sequence:

>939_bases
ATGACTTCCATTTCATTTAAAAATTTTCATGAAGCAGGAAAAGCGGTATTACATTTTTTACATCAAAAATTTGGATTTGA
TTTATGGATGATTACCCGTGTAGAAGGTAATGACTGGATCGTATTACAGTCTGAAGATCATGGTTATAATGTCAAACCAG
GCCGTGTTTTTAATTGGGCTGATTCGTTTTGTTCACATATGGTGTTAGGTAATGCGCCAAGAATCGCACCTTATTCTGAA
GAAATTCCACTTTATGCATCAGCTCCAATTGCCAAACAAGTCGATATCAAAGCCTATATTGGCCAACCGCTTTTAAATGA
AGATGGAAGTTTATTTGGTACATTATGTGCAATTGATCCACAACCCAAATCTAGAAAAATCATTGAAGATGAAGATTTAA
TTGAGTTGTTTGGTAATCTTCTAAGCCATATATTACAACGTGAAATTCGGGAGAATGAACAAATTCGGCTGCACGAGCGT
TTAAGAAGCGAAGCCGTAATTGACGCGCTAACAGGTATTTATAATCGGCGGGGTTGGAATCAATTTATCGAAGCAGAGGA
GCAACGTTGCAAACAGTATGGATACCCCGCTGCCATTTTTATGATTGATCTGAATGATTTAAAGTTAATGAATGATCAAA
GAGGCCATGCCGAAGGAGATCGGCTCCTCCAGCAAGCCGCGACTATATTAAAAAACACCTTACGTCAGGAAGATCTTGTT
GCACGTCTGGGTGGAGATGAGTTTGGAATACTCACCCTCGGGCATGACATACATCGTATTGAGCAACTCAAAAATCGGAT
TATTGCAGCTCTTAAAGCTGCCAAAATTAGTGCAGCGATTGGTTATGCCATACGTCATCCAAGTTTTGATCTGGAAAGCG
CATGTGCTCATGCAGATGAACAAATGTATCAACATAAGCGTCGCAACAAGAGACATTAA

Upstream 100 bases:

>100_bases
TCATTTATGATGTATTTTTTAGTCATTAAAAATAAAGAGTGATAGCCAGTCAGATAAAATTGTTTTAAAGTTCAATTAAA
TTTCACTATTAAAACGAGCA

Downstream 100 bases:

>100_bases
CTTTCACTTTCTTGATCAAAAAATCCAACTACCTCAACATTCTGATCATTGACTTTAAAGTGAATATCGAATTGATCGAA
CTTCATTTTATAAATCCGGT

Product: hypothetical protein

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MTSISFKNFHEAGKAVLHFLHQKFGFDLWMITRVEGNDWIVLQSEDHGYNVKPGRVFNWADSFCSHMVLGNAPRIAPYSE
EIPLYASAPIAKQVDIKAYIGQPLLNEDGSLFGTLCAIDPQPKSRKIIEDEDLIELFGNLLSHILQREIRENEQIRLHER
LRSEAVIDALTGIYNRRGWNQFIEAEEQRCKQYGYPAAIFMIDLNDLKLMNDQRGHAEGDRLLQQAATILKNTLRQEDLV
ARLGGDEFGILTLGHDIHRIEQLKNRIIAALKAAKISAAIGYAIRHPSFDLESACAHADEQMYQHKRRNKRH

Sequences:

>Translated_312_residues
MTSISFKNFHEAGKAVLHFLHQKFGFDLWMITRVEGNDWIVLQSEDHGYNVKPGRVFNWADSFCSHMVLGNAPRIAPYSE
EIPLYASAPIAKQVDIKAYIGQPLLNEDGSLFGTLCAIDPQPKSRKIIEDEDLIELFGNLLSHILQREIRENEQIRLHER
LRSEAVIDALTGIYNRRGWNQFIEAEEQRCKQYGYPAAIFMIDLNDLKLMNDQRGHAEGDRLLQQAATILKNTLRQEDLV
ARLGGDEFGILTLGHDIHRIEQLKNRIIAALKAAKISAAIGYAIRHPSFDLESACAHADEQMYQHKRRNKRH
>Mature_311_residues
TSISFKNFHEAGKAVLHFLHQKFGFDLWMITRVEGNDWIVLQSEDHGYNVKPGRVFNWADSFCSHMVLGNAPRIAPYSEE
IPLYASAPIAKQVDIKAYIGQPLLNEDGSLFGTLCAIDPQPKSRKIIEDEDLIELFGNLLSHILQREIRENEQIRLHERL
RSEAVIDALTGIYNRRGWNQFIEAEEQRCKQYGYPAAIFMIDLNDLKLMNDQRGHAEGDRLLQQAATILKNTLRQEDLVA
RLGGDEFGILTLGHDIHRIEQLKNRIIAALKAAKISAAIGYAIRHPSFDLESACAHADEQMYQHKRRNKRH

Specific function: Catalyzes the condensation of two GTP molecules to the cyclic dinucleotide di-GMP (c-di-GMP), which acts as a secondary messenger (Probable). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria [H]

COG id: COG2203

COG function: function code T; FOG: GAF domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI87081977, Length=266, Percent_Identity=28.5714285714286, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI87081974, Length=183, Percent_Identity=33.879781420765, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082007, Length=185, Percent_Identity=28.6486486486486, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI145693134, Length=159, Percent_Identity=31.4465408805031, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1786584, Length=95, Percent_Identity=35.7894736842105, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788381, Length=173, Percent_Identity=30.0578034682081, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787262, Length=100, Percent_Identity=35, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081881, Length=164, Percent_Identity=30.4878048780488, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787541, Length=165, Percent_Identity=29.6969696969697, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788085, Length=99, Percent_Identity=34.3434343434343, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR003018 [H]

Pfam domain/function: PF01590 GAF; PF00990 GGDEF [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 35693; Mature: 35562

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSISFKNFHEAGKAVLHFLHQKFGFDLWMITRVEGNDWIVLQSEDHGYNVKPGRVFNWA
CCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEECCCCCCCCCCCCEEHHH
DSFCSHMVLGNAPRIAPYSEEIPLYASAPIAKQVDIKAYIGQPLLNEDGSLFGTLCAIDP
HHHHHHHHHCCCCCCCCCCCCCCEEECCCCCHHCCHHHHHCCCCCCCCCCEEEEEEECCC
QPKSRKIIEDEDLIELFGNLLSHILQREIRENEQIRLHERLRSEAVIDALTGIYNRRGWN
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
QFIEAEEQRCKQYGYPAAIFMIDLNDLKLMNDQRGHAEGDRLLQQAATILKNTLRQEDLV
HHHHHHHHHHHHCCCCEEEEEEECCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ARLGGDEFGILTLGHDIHRIEQLKNRIIAALKAAKISAAIGYAIRHPSFDLESACAHADE
HHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
QMYQHKRRNKRH
HHHHHHHHCCCC
>Mature Secondary Structure 
TSISFKNFHEAGKAVLHFLHQKFGFDLWMITRVEGNDWIVLQSEDHGYNVKPGRVFNWA
CCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEECCCCCCCCCCCCEEHHH
DSFCSHMVLGNAPRIAPYSEEIPLYASAPIAKQVDIKAYIGQPLLNEDGSLFGTLCAIDP
HHHHHHHHHCCCCCCCCCCCCCCEEECCCCCHHCCHHHHHCCCCCCCCCCEEEEEEECCC
QPKSRKIIEDEDLIELFGNLLSHILQREIRENEQIRLHERLRSEAVIDALTGIYNRRGWN
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
QFIEAEEQRCKQYGYPAAIFMIDLNDLKLMNDQRGHAEGDRLLQQAATILKNTLRQEDLV
HHHHHHHHHHHHCCCCEEEEEEECCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ARLGGDEFGILTLGHDIHRIEQLKNRIIAALKAAKISAAIGYAIRHPSFDLESACAHADE
HHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
QMYQHKRRNKRH
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]