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The map label for this gene is ahpC [H]

Identifier: 50085223

GI number: 50085223

Start: 2093160

End: 2093723

Strand: Direct

Name: ahpC [H]

Synonym: ACIAD2103

Alternate gene names: 50085223

Gene position: 2093160-2093723 (Clockwise)

Preceding gene: 50085220

Following gene: 50085228

Centisome position: 58.17

GC content: 41.31

Gene sequence:

>564_bases
ATGAGCTTAATTAATACTGAAGTTAAACCATTTAAAGCAACTGCTTACCACAACGGTCAATTTGTTGAAGTGACTGAAGC
TGACCTTAAAGGCAAATGGTCTGTTGTATTCTTCTATCCAGCTGACTTCACTTTTGTTTGCCCAACTGAACTTGAGGACT
TAGCTGACAACTATGCTGAATTTCAAAAGCTAGGTGTTGAAATTTACGGTGTTTCGACTGATACACATTTCACGCACAAA
GCATGGCATGACACTTCAGAAGCAATCAAAAAAATCCAGTATCCACTTGTTGGCGATCCAACTTGGACACTTTCTAAAAA
CTTTGAAGTGTTAATCGAAGCTGCTGGCTTAGCTGACCGTGGTACTTTCGTAATCGATCCTGAAGGTAAAATCCAGATCG
TTGAAATCAACGCTGGCGGTATTGGCCGTGATGCTCAAGAACTTCTTCGTAAAGTGAAAGCAGCTCAATACGTTCACTCT
CATCCAGGTGAAGTATGCCCTGCTAAATGGAAAGAAGGTGAAGCGACGCTTGCTCCATCTATCGACTTAGTGGGTAAAAT
CTAA

Upstream 100 bases:

>100_bases
TATGCAAAAATACTATTTCCCCAATAAATAAAAGTTCTTTATTCTAAATCAAGTTTTAAAGTTAACGATAATGTCCAATT
CATGAATCATGGAGAAAATG

Downstream 100 bases:

>100_bases
TTTTTTAGATGTTATCTATAAAAATAGTCACCTTATAGGTGGCTATTTTTTATTTGTAATTTATTCAATTGATCAGAACT
TACTTTATTCATCTAACTTA

Product: alkyl hydroperoxide reductase

Products: NA

Alternate protein names: Alkyl hydroperoxide reductase protein C22; Peroxiredoxin; SCRP-23; Sulfate starvation-induced protein 8; SSI8; Thioredoxin peroxidase [H]

Number of amino acids: Translated: 187; Mature: 186

Protein sequence:

>187_residues
MSLINTEVKPFKATAYHNGQFVEVTEADLKGKWSVVFFYPADFTFVCPTELEDLADNYAEFQKLGVEIYGVSTDTHFTHK
AWHDTSEAIKKIQYPLVGDPTWTLSKNFEVLIEAAGLADRGTFVIDPEGKIQIVEINAGGIGRDAQELLRKVKAAQYVHS
HPGEVCPAKWKEGEATLAPSIDLVGKI

Sequences:

>Translated_187_residues
MSLINTEVKPFKATAYHNGQFVEVTEADLKGKWSVVFFYPADFTFVCPTELEDLADNYAEFQKLGVEIYGVSTDTHFTHK
AWHDTSEAIKKIQYPLVGDPTWTLSKNFEVLIEAAGLADRGTFVIDPEGKIQIVEINAGGIGRDAQELLRKVKAAQYVHS
HPGEVCPAKWKEGEATLAPSIDLVGKI
>Mature_186_residues
SLINTEVKPFKATAYHNGQFVEVTEADLKGKWSVVFFYPADFTFVCPTELEDLADNYAEFQKLGVEIYGVSTDTHFTHKA
WHDTSEAIKKIQYPLVGDPTWTLSKNFEVLIEAAGLADRGTFVIDPEGKIQIVEINAGGIGRDAQELLRKVKAAQYVHSH
PGEVCPAKWKEGEATLAPSIDLVGKI

Specific function: Directly reduces organic hydroperoxides in its reduced dithiol form [H]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32483377, Length=173, Percent_Identity=45.6647398843931, Blast_Score=160, Evalue=6e-40,
Organism=Homo sapiens, GI5802974, Length=173, Percent_Identity=45.6647398843931, Blast_Score=160, Evalue=6e-40,
Organism=Homo sapiens, GI32189392, Length=175, Percent_Identity=46.2857142857143, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI4505591, Length=175, Percent_Identity=43.4285714285714, Blast_Score=152, Evalue=1e-37,
Organism=Homo sapiens, GI32455266, Length=175, Percent_Identity=43.4285714285714, Blast_Score=152, Evalue=1e-37,
Organism=Homo sapiens, GI32455264, Length=175, Percent_Identity=43.4285714285714, Blast_Score=152, Evalue=1e-37,
Organism=Homo sapiens, GI5453549, Length=180, Percent_Identity=41.6666666666667, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI33188454, Length=74, Percent_Identity=55.4054054054054, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI4758638, Length=166, Percent_Identity=28.3132530120482, Blast_Score=68, Evalue=6e-12,
Organism=Escherichia coli, GI1786822, Length=187, Percent_Identity=71.1229946524064, Blast_Score=295, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI17554494, Length=177, Percent_Identity=42.3728813559322, Blast_Score=150, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI193204376, Length=183, Percent_Identity=39.344262295082, Blast_Score=144, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI32565831, Length=183, Percent_Identity=39.344262295082, Blast_Score=144, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI25153706, Length=164, Percent_Identity=27.4390243902439, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320661, Length=181, Percent_Identity=35.9116022099448, Blast_Score=126, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323613, Length=182, Percent_Identity=36.8131868131868, Blast_Score=124, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6319407, Length=163, Percent_Identity=30.6748466257669, Blast_Score=84, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17738015, Length=177, Percent_Identity=41.2429378531073, Blast_Score=153, Evalue=8e-38,
Organism=Drosophila melanogaster, GI24656348, Length=182, Percent_Identity=40.6593406593407, Blast_Score=149, Evalue=9e-37,
Organism=Drosophila melanogaster, GI17864676, Length=182, Percent_Identity=40.6593406593407, Blast_Score=149, Evalue=9e-37,
Organism=Drosophila melanogaster, GI17157991, Length=180, Percent_Identity=40, Blast_Score=147, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24641739, Length=180, Percent_Identity=40, Blast_Score=147, Evalue=3e-36,
Organism=Drosophila melanogaster, GI21357347, Length=182, Percent_Identity=38.4615384615385, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24581278, Length=154, Percent_Identity=33.7662337662338, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24652436, Length=163, Percent_Identity=30.0613496932515, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI17975518, Length=158, Percent_Identity=29.746835443038, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24652434, Length=158, Percent_Identity=29.746835443038, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017559
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 20728; Mature: 20596

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLINTEVKPFKATAYHNGQFVEVTEADLKGKWSVVFFYPADFTFVCPTELEDLADNYAE
CCCCCCCCCCEEEEEEECCEEEEEEECCCCCCEEEEEEECCCEEEECCCHHHHHHHHHHH
FQKLGVEIYGVSTDTHFTHKAWHDTSEAIKKIQYPLVGDPTWTLSKNFEVLIEAAGLADR
HHHCCEEEEEECCCCCEEHHHHCCHHHHHHHHCCCCCCCCCEEECCCEEEEEEECCCCCC
GTFVIDPEGKIQIVEINAGGIGRDAQELLRKVKAAQYVHSHPGEVCPAKWKEGEATLAPS
CEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCC
IDLVGKI
EEEEECC
>Mature Secondary Structure 
SLINTEVKPFKATAYHNGQFVEVTEADLKGKWSVVFFYPADFTFVCPTELEDLADNYAE
CCCCCCCCCEEEEEEECCEEEEEEECCCCCCEEEEEEECCCEEEECCCHHHHHHHHHHH
FQKLGVEIYGVSTDTHFTHKAWHDTSEAIKKIQYPLVGDPTWTLSKNFEVLIEAAGLADR
HHHCCEEEEEECCCCCEEHHHHCCHHHHHHHHCCCCCCCCCEEECCCEEEEEEECCCCCC
GTFVIDPEGKIQIVEINAGGIGRDAQELLRKVKAAQYVHSHPGEVCPAKWKEGEATLAPS
CEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCC
IDLVGKI
EEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]