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The map label for this gene is cbh [H]

Identifier: 50085161

GI number: 50085161

Start: 2016482

End: 2017552

Strand: Direct

Name: cbh [H]

Synonym: ACIAD2026

Alternate gene names: 50085161

Gene position: 2016482-2017552 (Clockwise)

Preceding gene: 50085160

Following gene: 50085162

Centisome position: 56.03

GC content: 39.22

Gene sequence:

>1071_bases
TTGCAGGACGGTATCATGTTCAAACAATTATTACTCAGTTCTTTGATTTTTTCATCAACACTTGCAGCTTCTTTTGCTGT
GCAAGCCTGTACACGCGTTGTATACAAAGGAAGCAATCAAAATATCATGACTGCAAGATCGATGGATTGGAAATCTGATG
TTGGAACCAATTTGTGGATCTTGCCAAGTGGAGTCAAACGTAGTGGTAATGCAGGCAAAGACTCAATTCACTGGACATCT
AAATACGGCAGTGTAGTTGCAACTGGGTATGATATTTCCACAACCGATGGTGTCAACGAAGTAGGACTCAACGCAAATTT
ATTGTGGTTAGTAGAATCACAATACCCTGATGTCTCTCAATCTAAAAAACCCAAACTGACTATTGCAGCATGGGCACAAT
ATGTTCTAGATAATTTTGCTACGGTAGATGAGGCTGTAAAAGCTTTACAGAAAGAACCATTTATCATTGTGAGTGATGCT
GTTCCTGGTGAACAACGTCTGACCACACTGCACCTATCAATCTCGGATGCAACCGGTGACAGTGCGATTATCGAATATAT
TAACGGTAAACAAGTCATTCATCATAACCCTGACTATCAGGTGATGACCAATTCTCCCATATTTGAAGAGCAACTTGCAT
TAAATGAGTATTGGAAAAAAATTGGAGGAACAACGTTCTTACCAGGAACCAATCGAGCAGCCGACCGCTTTGCACGTGCA
TCATTTTATATCAATGCCATTCCTAAAGATGCAGACTCAAAGGCAACTTTAGCATCTGTATTTAGCGTGATCCGCAACGT
CTCTGTTCCTTATGGATTAAATACAGAAGAAGAGCCGAATATCTCCTCCACCCGATGGAGAGCGGTGGTCGATCACAAAC
GAAAACTTTATTTTTTTGAATCTGCACTTTCTCCTAATATTTTTTGGGTAGATTTAAAGCAGATTAACTTTAAAGATGGT
ATAACTCGCAAGCTTGATTTAGGAAAAAATCAGGAAAATATTTATTCGGGTGATGCTACCGCAAAATTTAAACCATCGAC
ACCTTTTCATTTTTTAGGTATAGACGATTAA

Upstream 100 bases:

>100_bases
CAGATCTATTACATTGAAATATGTATCAGGGCACCAGAAAAGCTGATCATTGTGTTCAATTAACTTGAATTATAAATCAT
TCTAACAATTATGCGATATT

Downstream 100 bases:

>100_bases
ACGAGTCACATCTCTCAAACGATCAGAATCATGAGGACAAGAAATGAGAAAAATATTTGGTCTGTTTACTACAATATTGT
TTTTACATGGATGTGCTACT

Product: choloylglycine hydrolase protein

Products: NA

Alternate protein names: Bile salt hydrolase; Conjugated bile acid hydrolase; CBAH [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MQDGIMFKQLLLSSLIFSSTLAASFAVQACTRVVYKGSNQNIMTARSMDWKSDVGTNLWILPSGVKRSGNAGKDSIHWTS
KYGSVVATGYDISTTDGVNEVGLNANLLWLVESQYPDVSQSKKPKLTIAAWAQYVLDNFATVDEAVKALQKEPFIIVSDA
VPGEQRLTTLHLSISDATGDSAIIEYINGKQVIHHNPDYQVMTNSPIFEEQLALNEYWKKIGGTTFLPGTNRAADRFARA
SFYINAIPKDADSKATLASVFSVIRNVSVPYGLNTEEEPNISSTRWRAVVDHKRKLYFFESALSPNIFWVDLKQINFKDG
ITRKLDLGKNQENIYSGDATAKFKPSTPFHFLGIDD

Sequences:

>Translated_356_residues
MQDGIMFKQLLLSSLIFSSTLAASFAVQACTRVVYKGSNQNIMTARSMDWKSDVGTNLWILPSGVKRSGNAGKDSIHWTS
KYGSVVATGYDISTTDGVNEVGLNANLLWLVESQYPDVSQSKKPKLTIAAWAQYVLDNFATVDEAVKALQKEPFIIVSDA
VPGEQRLTTLHLSISDATGDSAIIEYINGKQVIHHNPDYQVMTNSPIFEEQLALNEYWKKIGGTTFLPGTNRAADRFARA
SFYINAIPKDADSKATLASVFSVIRNVSVPYGLNTEEEPNISSTRWRAVVDHKRKLYFFESALSPNIFWVDLKQINFKDG
ITRKLDLGKNQENIYSGDATAKFKPSTPFHFLGIDD
>Mature_356_residues
MQDGIMFKQLLLSSLIFSSTLAASFAVQACTRVVYKGSNQNIMTARSMDWKSDVGTNLWILPSGVKRSGNAGKDSIHWTS
KYGSVVATGYDISTTDGVNEVGLNANLLWLVESQYPDVSQSKKPKLTIAAWAQYVLDNFATVDEAVKALQKEPFIIVSDA
VPGEQRLTTLHLSISDATGDSAIIEYINGKQVIHHNPDYQVMTNSPIFEEQLALNEYWKKIGGTTFLPGTNRAADRFARA
SFYINAIPKDADSKATLASVFSVIRNVSVPYGLNTEEEPNISSTRWRAVVDHKRKLYFFESALSPNIFWVDLKQINFKDG
ITRKLDLGKNQENIYSGDATAKFKPSTPFHFLGIDD

Specific function: The enzyme catalyzes the degradation of conjugated bile acids in the mammalian gut [H]

COG id: COG3049

COG function: function code M; Penicillin V acylase and related amidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C59 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003199 [H]

Pfam domain/function: PF02275 CBAH [H]

EC number: =3.5.1.24 [H]

Molecular weight: Translated: 39510; Mature: 39510

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDGIMFKQLLLSSLIFSSTLAASFAVQACTRVVYKGSNQNIMTARSMDWKSDVGTNLWI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCEEEE
LPSGVKRSGNAGKDSIHWTSKYGSVVATGYDISTTDGVNEVGLNANLLWLVESQYPDVSQ
EECCCCCCCCCCCCCEEEECCCCCEEEECCCCCCCCCCHHCCCCCEEEEEEECCCCCCCC
SKKPKLTIAAWAQYVLDNFATVDEAVKALQKEPFIIVSDAVPGEQRLTTLHLSISDATGD
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEEEEECCCCC
SAIIEYINGKQVIHHNPDYQVMTNSPIFEEQLALNEYWKKIGGTTFLPGTNRAADRFARA
HHHEEECCCCEEEEECCCEEEEECCCCHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHH
SFYINAIPKDADSKATLASVFSVIRNVSVPYGLNTEEEPNISSTRWRAVVDHKRKLYFFE
EEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEE
SALSPNIFWVDLKQINFKDGITRKLDLGKNQENIYSGDATAKFKPSTPFHFLGIDD
CCCCCCEEEEEEEEECCCCCCCEEECCCCCCCCEECCCCCEEECCCCCEEEEECCC
>Mature Secondary Structure
MQDGIMFKQLLLSSLIFSSTLAASFAVQACTRVVYKGSNQNIMTARSMDWKSDVGTNLWI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCEEEE
LPSGVKRSGNAGKDSIHWTSKYGSVVATGYDISTTDGVNEVGLNANLLWLVESQYPDVSQ
EECCCCCCCCCCCCCEEEECCCCCEEEECCCCCCCCCCHHCCCCCEEEEEEECCCCCCCC
SKKPKLTIAAWAQYVLDNFATVDEAVKALQKEPFIIVSDAVPGEQRLTTLHLSISDATGD
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEEEEECCCCC
SAIIEYINGKQVIHHNPDYQVMTNSPIFEEQLALNEYWKKIGGTTFLPGTNRAADRFARA
HHHEEECCCCEEEEECCCEEEEECCCCHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHH
SFYINAIPKDADSKATLASVFSVIRNVSVPYGLNTEEEPNISSTRWRAVVDHKRKLYFFE
EEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEE
SALSPNIFWVDLKQINFKDGITRKLDLGKNQENIYSGDATAKFKPSTPFHFLGIDD
CCCCCCEEEEEEEEECCCCCCCEEECCCCCCCCEECCCCCEEECCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7618863; 11792842 [H]