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The map label for this gene is yiaY [H]

Identifier: 50085150

GI number: 50085150

Start: 2006956

End: 2008128

Strand: Direct

Name: yiaY [H]

Synonym: ACIAD2015

Alternate gene names: 50085150

Gene position: 2006956-2008128 (Clockwise)

Preceding gene: 50085146

Following gene: 50085151

Centisome position: 55.77

GC content: 43.99

Gene sequence:

>1173_bases
ATGGCTTTTAAAAATATTGCTGACCAAACAAACGGTTTTTATATCCCTTGTGTCTCCCTTTTTGGCCCTGGTTGTGCCAA
AGAAATTGGTACCAAAGCACAAAATTTAGGTGCAAAAAAAGCACTCATCGTGACTGATGCTGGTTTATTTAAATTTGGTG
TAGCTGACACTATCGCAGCATACCTTAAAGAAGCTGGCGTAGACAGTCATATTTTCCCAGGCGCTGAACCCAATCCGACA
GATAAAAACGTACATAATGGCGTTGATGCATATAATACCAATGGATGTGACTTTATTGTATCGCTCGGTGGTGGATCATC
TCACGACTGTGCAAAAGGTATTGGATTAGTTACCGCAGGCGGTGGTCACATTCGTGATTACGAAGGAATTGATAAAAGTA
CTGTTCCAATGACGCCGTTAATTGCAGTCAATACCACTGCAGGCACAGCATCTGAAATGACACGTTTCTGTATTATTACC
AATACAGATACACATGTAAAAATGGCGATTGTAGATTGGCGTTGTACCCCACTGATTGCCATTGATGACCCTAAGCTCAT
GATTGCTAAGCCTGCAAGCCTGACTGCTGCGACTGGTATGGATGCGCTGACACATGCTGTCGAAGCTTATGTATCTACTG
CTGCGAACCCAATCACAGACGCCTGTGCCGAAAAAGCAATCAGCATGATCAGTGAATGGCTCAGCCCAGCTGTTGCCAAT
GGTGAAAACCTTGAAGCACGTGATGCAATGAGCTATGCCCAATATCTTGCAGGTATGGCATTTAACAATGCGTCATTAGG
TTATGTTCATGCCATGGCGCACCAACTTGGCGGTTTCTACAATCTGCCACACGGCGTATGTAATGCGGTATTGTTGCCAC
ACGTTTGTGAGTTCAACCTGATTGCTTGCCCAGAGCGTTATGCACGTATCGCAGAATTAATGGGCGTAAATACACACGGC
CTTACGGTGACTGAAGCTGCATATGCTGCAATCGATGCAATTCGTACATTATCAAAATCAATTGGTATCCCATCTGGCTT
GACCGAGCTTGGTGTAAAAACTGAAGATCTTGCAGTAATGGCCGAAAATGCACAAAAAGACGCGTGTATGTTGACTAATC
CACGCAAAGCAAATCACGCTCAAGTTGTAGATATTTTCACAGCAGCATTGTAA

Upstream 100 bases:

>100_bases
TTTGGTAGGTAGGAAAAGAAAAGCGTTCTGAGAATACTAGGCTCATGGTGAAGATCACCTAGATAACAAACAATGGATTA
ATGGAAGAAGGAATCACTCC

Downstream 100 bases:

>100_bases
ACCAGCCCTTATCTGCTCCAAATTTCCTCTCTAAGTAAGTCTTCTCTCCAACAGACTTACTCAGTTTTGGGAATATCAGT
CCGGTGATATTCCCTTTTTT

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MAFKNIADQTNGFYIPCVSLFGPGCAKEIGTKAQNLGAKKALIVTDAGLFKFGVADTIAAYLKEAGVDSHIFPGAEPNPT
DKNVHNGVDAYNTNGCDFIVSLGGGSSHDCAKGIGLVTAGGGHIRDYEGIDKSTVPMTPLIAVNTTAGTASEMTRFCIIT
NTDTHVKMAIVDWRCTPLIAIDDPKLMIAKPASLTAATGMDALTHAVEAYVSTAANPITDACAEKAISMISEWLSPAVAN
GENLEARDAMSYAQYLAGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAVLLPHVCEFNLIACPERYARIAELMGVNTHG
LTVTEAAYAAIDAIRTLSKSIGIPSGLTELGVKTEDLAVMAENAQKDACMLTNPRKANHAQVVDIFTAAL

Sequences:

>Translated_390_residues
MAFKNIADQTNGFYIPCVSLFGPGCAKEIGTKAQNLGAKKALIVTDAGLFKFGVADTIAAYLKEAGVDSHIFPGAEPNPT
DKNVHNGVDAYNTNGCDFIVSLGGGSSHDCAKGIGLVTAGGGHIRDYEGIDKSTVPMTPLIAVNTTAGTASEMTRFCIIT
NTDTHVKMAIVDWRCTPLIAIDDPKLMIAKPASLTAATGMDALTHAVEAYVSTAANPITDACAEKAISMISEWLSPAVAN
GENLEARDAMSYAQYLAGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAVLLPHVCEFNLIACPERYARIAELMGVNTHG
LTVTEAAYAAIDAIRTLSKSIGIPSGLTELGVKTEDLAVMAENAQKDACMLTNPRKANHAQVVDIFTAAL
>Mature_389_residues
AFKNIADQTNGFYIPCVSLFGPGCAKEIGTKAQNLGAKKALIVTDAGLFKFGVADTIAAYLKEAGVDSHIFPGAEPNPTD
KNVHNGVDAYNTNGCDFIVSLGGGSSHDCAKGIGLVTAGGGHIRDYEGIDKSTVPMTPLIAVNTTAGTASEMTRFCIITN
TDTHVKMAIVDWRCTPLIAIDDPKLMIAKPASLTAATGMDALTHAVEAYVSTAANPITDACAEKAISMISEWLSPAVANG
ENLEARDAMSYAQYLAGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAVLLPHVCEFNLIACPERYARIAELMGVNTHGL
TVTEAAYAAIDAIRTLSKSIGIPSGLTELGVKTEDLAVMAENAQKDACMLTNPRKANHAQVVDIFTAAL

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=380, Percent_Identity=28.1578947368421, Blast_Score=140, Evalue=3e-33,
Organism=Escherichia coli, GI48994951, Length=378, Percent_Identity=58.7301587301587, Blast_Score=441, Evalue=1e-125,
Organism=Escherichia coli, GI1789163, Length=373, Percent_Identity=39.4101876675603, Blast_Score=274, Evalue=6e-75,
Organism=Escherichia coli, GI87082107, Length=382, Percent_Identity=35.6020942408377, Blast_Score=224, Evalue=7e-60,
Organism=Escherichia coli, GI1787493, Length=370, Percent_Identity=35.6756756756757, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1789386, Length=358, Percent_Identity=27.3743016759777, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17537053, Length=425, Percent_Identity=26.3529411764706, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6321181, Length=378, Percent_Identity=51.5873015873016, Blast_Score=383, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24657991, Length=409, Percent_Identity=27.1393643031785, Blast_Score=154, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 40941; Mature: 40810

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2 ; PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFKNIADQTNGFYIPCVSLFGPGCAKEIGTKAQNLGAKKALIVTDAGLFKFGVADTIAA
CCCCHHHHCCCCEEEEEHHHCCCCHHHHHCCHHHHCCCCEEEEEECCCHHHHHHHHHHHH
YLKEAGVDSHIFPGAEPNPTDKNVHNGVDAYNTNGCDFIVSLGGGSSHDCAKGIGLVTAG
HHHHCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCEEEEECCCCCCCCHHCCCEEEECC
GGHIRDYEGIDKSTVPMTPLIAVNTTAGTASEMTRFCIITNTDTHVKMAIVDWRCTPLIA
CCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHCEEEEEEECCCCEEEEEEEEECCCEEEE
IDDPKLMIAKPASLTAATGMDALTHAVEAYVSTAANPITDACAEKAISMISEWLSPAVAN
ECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCHHHCC
GENLEARDAMSYAQYLAGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAVLLPHVCEFNL
CCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCE
IACPERYARIAELMGVNTHGLTVTEAAYAAIDAIRTLSKSIGIPSGLTELGVKTEDLAVM
EECCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCHHHHEE
AENAQKDACMLTNPRKANHAQVVDIFTAAL
ECCCCCCEEEECCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
AFKNIADQTNGFYIPCVSLFGPGCAKEIGTKAQNLGAKKALIVTDAGLFKFGVADTIAA
CCCHHHHCCCCEEEEEHHHCCCCHHHHHCCHHHHCCCCEEEEEECCCHHHHHHHHHHHH
YLKEAGVDSHIFPGAEPNPTDKNVHNGVDAYNTNGCDFIVSLGGGSSHDCAKGIGLVTAG
HHHHCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCEEEEECCCCCCCCHHCCCEEEECC
GGHIRDYEGIDKSTVPMTPLIAVNTTAGTASEMTRFCIITNTDTHVKMAIVDWRCTPLIA
CCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHCEEEEEEECCCCEEEEEEEEECCCEEEE
IDDPKLMIAKPASLTAATGMDALTHAVEAYVSTAANPITDACAEKAISMISEWLSPAVAN
ECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCHHHCC
GENLEARDAMSYAQYLAGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAVLLPHVCEFNL
CCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCE
IACPERYARIAELMGVNTHGLTVTEAAYAAIDAIRTLSKSIGIPSGLTELGVKTEDLAVM
EECCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCHHHHEE
AENAQKDACMLTNPRKANHAQVVDIFTAAL
ECCCCCCEEEECCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7768815 [H]