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The map label for this gene is mdh [H]

Identifier: 50085088

GI number: 50085088

Start: 1937790

End: 1938950

Strand: Direct

Name: mdh [H]

Synonym: ACIAD1950

Alternate gene names: 50085088

Gene position: 1937790-1938950 (Clockwise)

Preceding gene: 50085087

Following gene: 50085089

Centisome position: 53.85

GC content: 39.62

Gene sequence:

>1161_bases
ATGAGCCAATTTCAGTTTCAGACAGTATCTAATATCATCTCAGGTCTTGGCTCAATCCAGCAACTTCAGTCTATTCTTTT
AGAAACCCAATATAAAAAACTGCTTATTGTGACTGATGCAGGCATGATTCAGCATCAACTTCATTTACCTATCATTGAAA
TCTTAGAAGAACTCCAGATAAATTATTCGATTTTTTCCGACATACAAGCGGATCCTCCTGAATGTATTGTGCTCGACGCC
GCTAAATTTGCTAAAACACAAAAAATTGACGCTATTATTGGTTTTGGTGGTGGTAGCTCTATGGATGTTGCCAAAGTAAT
TGCACTCCTTACTCACCCACAACAAACTCAAAGTCTTGCAGAAATGTACGGTGTAAATAATGCCAAAGGCCCAAAACTTC
CTCTCATCTTGATTCCAACTACAGCAGGAACAGGTTCAGAAGTCACACCTATTTCAATTGTAACAACAGGAGAAACCACA
AAAACGGGCATTGTCTCACCTCAGCTTTATGCCGATATGGTTATTTTGGATGCGAATTTCACGCTACAATTACCAGCGCA
CATTACGGCTGCAACGGGTATTGATGCGATGGTTCATGCGATTGAAGCTTATACCTCAAAAAATAAGAAAAATTTTTATG
CCGATATGCTTGCCAAAAATGCCCTACGTTTACTCAATGACAATCTTCCAAAAGTTTTAAAAAATGCTCAGGATGCGCAA
GCACGCCAAAACATGTTAGTTGGCTCAATGTTGGCAGGTCAGGCGTTTGCTAATGCTCCAGTCGCTGCTGTACATGCGCT
TGCGTATCCACTTGGTGGACATTTTCATTTTTCTCATGGTCATACCAATGCATTGGTGCTGATTGAAGTCTTAAAGTTTA
ATGCACCACAAAGCAAACATCTCTATGCCGAACTTATGCAATGGCTTGACCCTAAAAGTAATGGCTGTGCAGACGGTTTG
TGCGATTTGTTTATCGACCATATGCAAAATCATCTGGATCATAGTGGCTTGATCCTCAAATTACAGGACTTAAATGTTCC
ACAAAACAGTTTAAAAATGCTGGCCAAAGATGCAATGTTACAAACACGGTTGCTACAAAACAATCCTAGAGAAATGACAG
AACAATCTGCTTTAGAAATTTATGAGGCGATTTACACATGA

Upstream 100 bases:

>100_bases
GTTCCAGTACAAAACATCTTTTTAAACTAAAGCTCGCTTGAACTCACCAAAATAATCAAGTAAATGTAAATCATGCTATC
AATTCAATAAGGATATTCTC

Downstream 100 bases:

>100_bases
ATAAAAAATCAATTAAAGCCACTCATAAAACTAGAGATCAGTTTTCTTTCTTTTTAAAAATACAAACGCGTTGGGCAGAT
AACGATTTATACGGCCACGT

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: MEDH [H]

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MSQFQFQTVSNIISGLGSIQQLQSILLETQYKKLLIVTDAGMIQHQLHLPIIEILEELQINYSIFSDIQADPPECIVLDA
AKFAKTQKIDAIIGFGGGSSMDVAKVIALLTHPQQTQSLAEMYGVNNAKGPKLPLILIPTTAGTGSEVTPISIVTTGETT
KTGIVSPQLYADMVILDANFTLQLPAHITAATGIDAMVHAIEAYTSKNKKNFYADMLAKNALRLLNDNLPKVLKNAQDAQ
ARQNMLVGSMLAGQAFANAPVAAVHALAYPLGGHFHFSHGHTNALVLIEVLKFNAPQSKHLYAELMQWLDPKSNGCADGL
CDLFIDHMQNHLDHSGLILKLQDLNVPQNSLKMLAKDAMLQTRLLQNNPREMTEQSALEIYEAIYT

Sequences:

>Translated_386_residues
MSQFQFQTVSNIISGLGSIQQLQSILLETQYKKLLIVTDAGMIQHQLHLPIIEILEELQINYSIFSDIQADPPECIVLDA
AKFAKTQKIDAIIGFGGGSSMDVAKVIALLTHPQQTQSLAEMYGVNNAKGPKLPLILIPTTAGTGSEVTPISIVTTGETT
KTGIVSPQLYADMVILDANFTLQLPAHITAATGIDAMVHAIEAYTSKNKKNFYADMLAKNALRLLNDNLPKVLKNAQDAQ
ARQNMLVGSMLAGQAFANAPVAAVHALAYPLGGHFHFSHGHTNALVLIEVLKFNAPQSKHLYAELMQWLDPKSNGCADGL
CDLFIDHMQNHLDHSGLILKLQDLNVPQNSLKMLAKDAMLQTRLLQNNPREMTEQSALEIYEAIYT
>Mature_385_residues
SQFQFQTVSNIISGLGSIQQLQSILLETQYKKLLIVTDAGMIQHQLHLPIIEILEELQINYSIFSDIQADPPECIVLDAA
KFAKTQKIDAIIGFGGGSSMDVAKVIALLTHPQQTQSLAEMYGVNNAKGPKLPLILIPTTAGTGSEVTPISIVTTGETTK
TGIVSPQLYADMVILDANFTLQLPAHITAATGIDAMVHAIEAYTSKNKKNFYADMLAKNALRLLNDNLPKVLKNAQDAQA
RQNMLVGSMLAGQAFANAPVAAVHALAYPLGGHFHFSHGHTNALVLIEVLKFNAPQSKHLYAELMQWLDPKSNGCADGLC
DLFIDHMQNHLDHSGLILKLQDLNVPQNSLKMLAKDAMLQTRLLQNNPREMTEQSALEIYEAIYT

Specific function: May Act On The Acetaldehyde Produced From The Degradation Of Ethanolamine. [C]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Integral Membrane Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=427, Percent_Identity=25.5269320843091, Blast_Score=105, Evalue=5e-23,
Organism=Escherichia coli, GI87082107, Length=375, Percent_Identity=32, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI48994951, Length=387, Percent_Identity=31.7829457364341, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1787493, Length=305, Percent_Identity=34.4262295081967, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1789163, Length=380, Percent_Identity=26.3157894736842, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1789386, Length=398, Percent_Identity=26.3819095477387, Blast_Score=89, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17537053, Length=422, Percent_Identity=24.6445497630332, Blast_Score=118, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6321181, Length=374, Percent_Identity=32.3529411764706, Blast_Score=171, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24657991, Length=424, Percent_Identity=25.7075471698113, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.244 [H]

Molecular weight: Translated: 42145; Mature: 42014

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQFQFQTVSNIISGLGSIQQLQSILLETQYKKLLIVTDAGMIQHQLHLPIIEILEELQI
CCCCHHHHHHHHHHHHCHHHHHHHHHHHHHCCEEEEEECCCHHHHHHCCCHHHHHHHHHC
NYSIFSDIQADPPECIVLDAAKFAKTQKIDAIIGFGGGSSMDVAKVIALLTHPQQTQSLA
CHHHHHCCCCCCCCEEEEECHHHHHHHCCEEEEEECCCCCHHHHHHHHHHCCCHHHHHHH
EMYGVNNAKGPKLPLILIPTTAGTGSEVTPISIVTTGETTKTGIVSPQLYADMVILDANF
HHHCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHCEEEEECCE
TLQLPAHITAATGIDAMVHAIEAYTSKNKKNFYADMLAKNALRLLNDNLPKVLKNAQDAQ
EEEECCCEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCHHHH
ARQNMLVGSMLAGQAFANAPVAAVHALAYPLGGHFHFSHGHTNALVLIEVLKFNAPQSKH
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEECCCCCCHHHEEEHHHCCCCCCHH
LYAELMQWLDPKSNGCADGLCDLFIDHMQNHLDHSGLILKLQDLNVPQNSLKMLAKDAML
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHH
QTRLLQNNPREMTEQSALEIYEAIYT
HHHHHHCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SQFQFQTVSNIISGLGSIQQLQSILLETQYKKLLIVTDAGMIQHQLHLPIIEILEELQI
CCCHHHHHHHHHHHHCHHHHHHHHHHHHHCCEEEEEECCCHHHHHHCCCHHHHHHHHHC
NYSIFSDIQADPPECIVLDAAKFAKTQKIDAIIGFGGGSSMDVAKVIALLTHPQQTQSLA
CHHHHHCCCCCCCCEEEEECHHHHHHHCCEEEEEECCCCCHHHHHHHHHHCCCHHHHHHH
EMYGVNNAKGPKLPLILIPTTAGTGSEVTPISIVTTGETTKTGIVSPQLYADMVILDANF
HHHCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHCEEEEECCE
TLQLPAHITAATGIDAMVHAIEAYTSKNKKNFYADMLAKNALRLLNDNLPKVLKNAQDAQ
EEEECCCEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCHHHH
ARQNMLVGSMLAGQAFANAPVAAVHALAYPLGGHFHFSHGHTNALVLIEVLKFNAPQSKH
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEECCCCCCHHHEEEHHHCCCCCCHH
LYAELMQWLDPKSNGCADGLCDLFIDHMQNHLDHSGLILKLQDLNVPQNSLKMLAKDAML
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHH
QTRLLQNNPREMTEQSALEIYEAIYT
HHHHHHCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1644761; 1995642 [H]