Click here to switch to the map view.

The map label for this gene is moaA [H]

Identifier: 50085046

GI number: 50085046

Start: 1893611

End: 1894618

Strand: Reverse

Name: moaA [H]

Synonym: ACIAD1906

Alternate gene names: 50085046

Gene position: 1894618-1893611 (Counterclockwise)

Preceding gene: 50085047

Following gene: 50085045

Centisome position: 52.65

GC content: 38.89

Gene sequence:

>1008_bases
ATGAGTCCTGCGATATTCAGTGATCAATATGGTCGATACAAACGGAAACTTAGAATTTCTGTAACAGATCGCTGTAACTT
CAAATGCATGTATTGTATGCCTGAACATCCAGAATGGATTAAAAAGAAAGATTTGCTGGATTTTGAAGCACTTTACTTGT
TTTGCGAGTTTATGGTGCAAAATGGAATACAGAAAATCCGCATTACTGGTGGCGAGCCATTAATGCGACAAGGCGTGGTG
CATTTTGTACGAGATTTGCAAAAGTTACGTTCAATTGGTCTGAAACGTATTTCGATGACCACCAATGCACATTATCTTGC
CAAATATGCTTATGATCTTAAGCAGGCTGGACTGGATGACCTGAATATTAGTCTGGATAGTCTGGATGCTCAACAGTTTC
TTAAACTCACAAAGAAATCAATCGAACCAGTTTTGCAAGGCATACAAGCAGCCCAGTTGGTTGGTCTACCCTTTAAAATT
AATACCGTACTGATGAAAGGCAAGAACGATGACCAGATTTTACCTTTGGTCAATTGGGCCAAGGCGCATTCTATTCCTTT
AAGATTTATTGAGTTTATGCCACTAGATGGTGATGCACTTTGGCATAATCACGATGTGGTGACAGAGCAGGAAATTCTTT
CTGTTTTGGCGACACAGTTCGATCTACGTGAATTAAAACAAGAGCATGAACCAGCCAGATTGTATCGTTTAAATGATGAA
TATGATATTGGGATTATTTCAACCATTAGCCACTCTTTTTGTGGAGAATGTGACCGAATCCGTCTAACTGCTCAGGGTGA
ACTTTACAACTGTTTGTTTGCTCCCCAAGGTTTAATGCTTAAACCATTACTTGATCAAATTGTCGCTGAAAAAAATACGG
ATCTTCGCCAAACTTTACAACGTACCATTCATGAAAAAATTTCGGCTTATATCTGGCATAAAGCCAAAGGATTTCATAGC
TTGAACAAACAACCCCGAAAAATTAGCATGCATACATTAGGAGGCTAA

Upstream 100 bases:

>100_bases
CCCCCGAAATAATTTTGATATTGATTTTTATCCCATTTCAATGCGATAACGGGATAATAGGAAGTGAAATAGAGTGCATA
GCATGGAAGACAGCGCAAGC

Downstream 100 bases:

>100_bases
ATGAGCGCAGTACAGGTCACGATTGAAGGCTATGGTGCCATTCAACGTCAGCTTCCTTCCAAACTCATCTTGGACTATCC
ATCAGAGGTTTTGGTCAGTG

Product: molybdopterin biosynthesis, protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MSPAIFSDQYGRYKRKLRISVTDRCNFKCMYCMPEHPEWIKKKDLLDFEALYLFCEFMVQNGIQKIRITGGEPLMRQGVV
HFVRDLQKLRSIGLKRISMTTNAHYLAKYAYDLKQAGLDDLNISLDSLDAQQFLKLTKKSIEPVLQGIQAAQLVGLPFKI
NTVLMKGKNDDQILPLVNWAKAHSIPLRFIEFMPLDGDALWHNHDVVTEQEILSVLATQFDLRELKQEHEPARLYRLNDE
YDIGIISTISHSFCGECDRIRLTAQGELYNCLFAPQGLMLKPLLDQIVAEKNTDLRQTLQRTIHEKISAYIWHKAKGFHS
LNKQPRKISMHTLGG

Sequences:

>Translated_335_residues
MSPAIFSDQYGRYKRKLRISVTDRCNFKCMYCMPEHPEWIKKKDLLDFEALYLFCEFMVQNGIQKIRITGGEPLMRQGVV
HFVRDLQKLRSIGLKRISMTTNAHYLAKYAYDLKQAGLDDLNISLDSLDAQQFLKLTKKSIEPVLQGIQAAQLVGLPFKI
NTVLMKGKNDDQILPLVNWAKAHSIPLRFIEFMPLDGDALWHNHDVVTEQEILSVLATQFDLRELKQEHEPARLYRLNDE
YDIGIISTISHSFCGECDRIRLTAQGELYNCLFAPQGLMLKPLLDQIVAEKNTDLRQTLQRTIHEKISAYIWHKAKGFHS
LNKQPRKISMHTLGG
>Mature_334_residues
SPAIFSDQYGRYKRKLRISVTDRCNFKCMYCMPEHPEWIKKKDLLDFEALYLFCEFMVQNGIQKIRITGGEPLMRQGVVH
FVRDLQKLRSIGLKRISMTTNAHYLAKYAYDLKQAGLDDLNISLDSLDAQQFLKLTKKSIEPVLQGIQAAQLVGLPFKIN
TVLMKGKNDDQILPLVNWAKAHSIPLRFIEFMPLDGDALWHNHDVVTEQEILSVLATQFDLRELKQEHEPARLYRLNDEY
DIGIISTISHSFCGECDRIRLTAQGELYNCLFAPQGLMLKPLLDQIVAEKNTDLRQTLQRTIHEKISAYIWHKAKGFHSL
NKQPRKISMHTLGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=284, Percent_Identity=37.6760563380282, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI22027536, Length=294, Percent_Identity=37.0748299319728, Blast_Score=188, Evalue=5e-48,
Organism=Escherichia coli, GI1786999, Length=339, Percent_Identity=31.5634218289086, Blast_Score=160, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI32566331, Length=308, Percent_Identity=31.1688311688312, Blast_Score=177, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI32566329, Length=337, Percent_Identity=30.2670623145401, Blast_Score=177, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI17561210, Length=337, Percent_Identity=30.5637982195846, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI28574490, Length=345, Percent_Identity=33.6231884057971, Blast_Score=184, Evalue=9e-47,
Organism=Drosophila melanogaster, GI28574488, Length=292, Percent_Identity=35.2739726027397, Blast_Score=182, Evalue=3e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 38660; Mature: 38528

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPAIFSDQYGRYKRKLRISVTDRCNFKCMYCMPEHPEWIKKKDLLDFEALYLFCEFMVQ
CCCCCCCHHHHHEEEEEEEEEECCCCEEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHH
NGIQKIRITGGEPLMRQGVVHFVRDLQKLRSIGLKRISMTTNAHYLAKYAYDLKQAGLDD
CCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCCC
LNISLDSLDAQQFLKLTKKSIEPVLQGIQAAQLVGLPFKINTVLMKGKNDDQILPLVNWA
CCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCEECCCHHH
KAHSIPLRFIEFMPLDGDALWHNHDVVTEQEILSVLATQFDLRELKQEHEPARLYRLNDE
HHCCCCEEEHEEECCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
YDIGIISTISHSFCGECDRIRLTAQGELYNCLFAPQGLMLKPLLDQIVAEKNTDLRQTLQ
CCCCHHHHHHHHHCCCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHH
RTIHEKISAYIWHKAKGFHSLNKQPRKISMHTLGG
HHHHHHHHHHHHHHHCCCHHCCCCCCEEEEEECCC
>Mature Secondary Structure 
SPAIFSDQYGRYKRKLRISVTDRCNFKCMYCMPEHPEWIKKKDLLDFEALYLFCEFMVQ
CCCCCCHHHHHEEEEEEEEEECCCCEEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHH
NGIQKIRITGGEPLMRQGVVHFVRDLQKLRSIGLKRISMTTNAHYLAKYAYDLKQAGLDD
CCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCCC
LNISLDSLDAQQFLKLTKKSIEPVLQGIQAAQLVGLPFKINTVLMKGKNDDQILPLVNWA
CCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCEECCCHHH
KAHSIPLRFIEFMPLDGDALWHNHDVVTEQEILSVLATQFDLRELKQEHEPARLYRLNDE
HHCCCCEEEHEEECCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
YDIGIISTISHSFCGECDRIRLTAQGELYNCLFAPQGLMLKPLLDQIVAEKNTDLRQTLQ
CCCCHHHHHHHHHCCCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHH
RTIHEKISAYIWHKAKGFHSLNKQPRKISMHTLGG
HHHHHHHHHHHHHHHCCCHHCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12835416 [H]