Click here to switch to the map view.

The map label for this gene is moeA [H]

Identifier: 50085042

GI number: 50085042

Start: 1890678

End: 1891904

Strand: Reverse

Name: moeA [H]

Synonym: ACIAD1902

Alternate gene names: 50085042

Gene position: 1891904-1890678 (Counterclockwise)

Preceding gene: 50085043

Following gene: 50085041

Centisome position: 52.57

GC content: 40.34

Gene sequence:

>1227_bases
ATGTCGGCATGTGGTCATGAAAAAGACTTGATCAGCATTGATGAAGCGATTCAGTCTATTCTAAATACGGCAAAAAAATT
ATCAACAGAAACAATTTTTGTAAAAAATAGCCTAAGTAGATATTTGTCTGCACCTGTTTATTCGCCTGTAAATTTACCTG
GTTTTGATCAAAGTGCAGTTGATGGTTATGCACTGTGTACTTCTCATGCAGATGCTCAACATCAATCTTATGTGTTAATG
GGTGAGATACGTGCAGGTGTCGCAAGTGATTTGGCTTTACAAGAAGGACAGGCGATACGAATTTTTACAGGCGGTAAGTT
ACCTCAAGGTACGACCACAATCGCACGACAGGAAATTGTAGAAGTCGTTTCAGATACACAGATCCGCATTACGGATCCGT
TAATGGCACATACCGATATTCGCAGACGAGGAGAAGAACTTGCTGAAGGTCAATCACTTGCTGAAGCAGGTCAATTTATT
AATATCGGTAGTCTTGCTGCACTGAGTATGGCAGGCGTTCAAACAATAAGTGTATTTCGCCAACCAAAAGTTGCTGTCGT
CATTACAGGCGATGAAATTGCACTTGATCAAAATAGCCTAAGCGAAGCTCAAGTTTTTGATGCAAATGGACCTCTTTTAA
AGGCATGGTTCCAACAAAATGCAATTCAGGCCGAAATTATTCATGTATCAGATCAGTCTCAGGCCGTTACAGCATGTTTT
GAACAACTAAAATCGAAATATGATTTAATCATTACGACAGGTGGTGTTTCAGTCGGCGACTATGATTTTGTTCGTCCAAG
TTCATTCGATGCAGGGTTTGAACAAATTTTTTGGAAGGTGAAGCAAAAGCCTGGAAAACCCCTGTATTTTGCTCAATACC
AAAATCCAGAACATCACTGTTATCTGTTGGGGCTACCAGGTAATCCTGCGGCTGTTTATGTGTGTATGCAGGTGTACGGC
AAGTTGCTCATAGATGCCTTACAAGGACAACAACCTAAAACTGATACGTGGTTTACTGCAAAATTAACACATGGCATGAA
AGAAGATAAAAGGGAACGTTTTATTCGAATGCAAGCAAGTATAGTAAAAGGGGAGCTCAAGGTTTCAAGCCTTGCAAAGC
AACAGTCCCATATGTTAAGTAATTTAATGCAGGCCAATTGCCTCGTTCGTATTCCGGCAGAGGTAAAACCCGAAGCTGAA
ATGTTGGTTTCAGGCTTATTTATTTAA

Upstream 100 bases:

>100_bases
GCCGTGGTGGTGCTTCAGAATCCATGGCAGCACTCTTACCCGCAATTGTTCATATTTTTGATGTTTGTCGTGATTTACCA
CATCCAGGAGGTTATGAGTA

Downstream 100 bases:

>100_bases
GGAAGCAAAAATGTTAAAGAAAGTTGGGTTGCTTTCATTGATGTGCCTATGCACATTTCAGGCTTCTGCAGGAGAAGTGA
GAGTCTATGCTGCTGCTAGC

Product: molybdopterin biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MSACGHEKDLISIDEAIQSILNTAKKLSTETIFVKNSLSRYLSAPVYSPVNLPGFDQSAVDGYALCTSHADAQHQSYVLM
GEIRAGVASDLALQEGQAIRIFTGGKLPQGTTTIARQEIVEVVSDTQIRITDPLMAHTDIRRRGEELAEGQSLAEAGQFI
NIGSLAALSMAGVQTISVFRQPKVAVVITGDEIALDQNSLSEAQVFDANGPLLKAWFQQNAIQAEIIHVSDQSQAVTACF
EQLKSKYDLIITTGGVSVGDYDFVRPSSFDAGFEQIFWKVKQKPGKPLYFAQYQNPEHHCYLLGLPGNPAAVYVCMQVYG
KLLIDALQGQQPKTDTWFTAKLTHGMKEDKRERFIRMQASIVKGELKVSSLAKQQSHMLSNLMQANCLVRIPAEVKPEAE
MLVSGLFI

Sequences:

>Translated_408_residues
MSACGHEKDLISIDEAIQSILNTAKKLSTETIFVKNSLSRYLSAPVYSPVNLPGFDQSAVDGYALCTSHADAQHQSYVLM
GEIRAGVASDLALQEGQAIRIFTGGKLPQGTTTIARQEIVEVVSDTQIRITDPLMAHTDIRRRGEELAEGQSLAEAGQFI
NIGSLAALSMAGVQTISVFRQPKVAVVITGDEIALDQNSLSEAQVFDANGPLLKAWFQQNAIQAEIIHVSDQSQAVTACF
EQLKSKYDLIITTGGVSVGDYDFVRPSSFDAGFEQIFWKVKQKPGKPLYFAQYQNPEHHCYLLGLPGNPAAVYVCMQVYG
KLLIDALQGQQPKTDTWFTAKLTHGMKEDKRERFIRMQASIVKGELKVSSLAKQQSHMLSNLMQANCLVRIPAEVKPEAE
MLVSGLFI
>Mature_407_residues
SACGHEKDLISIDEAIQSILNTAKKLSTETIFVKNSLSRYLSAPVYSPVNLPGFDQSAVDGYALCTSHADAQHQSYVLMG
EIRAGVASDLALQEGQAIRIFTGGKLPQGTTTIARQEIVEVVSDTQIRITDPLMAHTDIRRRGEELAEGQSLAEAGQFIN
IGSLAALSMAGVQTISVFRQPKVAVVITGDEIALDQNSLSEAQVFDANGPLLKAWFQQNAIQAEIIHVSDQSQAVTACFE
QLKSKYDLIITTGGVSVGDYDFVRPSSFDAGFEQIFWKVKQKPGKPLYFAQYQNPEHHCYLLGLPGNPAAVYVCMQVYGK
LLIDALQGQQPKTDTWFTAKLTHGMKEDKRERFIRMQASIVKGELKVSSLAKQQSHMLSNLMQANCLVRIPAEVKPEAEM
LVSGLFI

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=403, Percent_Identity=27.0471464019851, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI66932975, Length=403, Percent_Identity=27.0471464019851, Blast_Score=138, Evalue=8e-33,
Organism=Escherichia coli, GI1787049, Length=391, Percent_Identity=30.690537084399, Blast_Score=176, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI25147659, Length=377, Percent_Identity=27.0557029177719, Blast_Score=124, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI17562606, Length=333, Percent_Identity=20.7207207207207, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17136978, Length=399, Percent_Identity=27.8195488721804, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24638841, Length=399, Percent_Identity=27.8195488721804, Blast_Score=131, Evalue=9e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44713; Mature: 44581

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSACGHEKDLISIDEAIQSILNTAKKLSTETIFVKNSLSRYLSAPVYSPVNLPGFDQSAV
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCCCCCCCCCCC
DGYALCTSHADAQHQSYVLMGEIRAGVASDLALQEGQAIRIFTGGKLPQGTTTIARQEIV
CCEEEECCCCCCCCCCEEEEEHHHCCHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHH
EVVSDTQIRITDPLMAHTDIRRRGEELAEGQSLAEAGQFINIGSLAALSMAGVQTISVFR
HHHCCCEEEEECCHHHHHHHHHHHHHHHHCHHHHHHCCEEECCHHHHHHHHHHHHHHHHC
QPKVAVVITGDEIALDQNSLSEAQVFDANGPLLKAWFQQNAIQAEIIHVSDQSQAVTACF
CCCEEEEEECCEEEECCCCCCCCEEECCCCCHHHHHHHCCCCEEEEEEECCCHHHHHHHH
EQLKSKYDLIITTGGVSVGDYDFVRPSSFDAGFEQIFWKVKQKPGKPLYFAQYQNPEHHC
HHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCE
YLLGLPGNPAAVYVCMQVYGKLLIDALQGQQPKTDTWFTAKLTHGMKEDKRERFIRMQAS
EEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHCCCHHHHHHHHHHHHHH
IVKGELKVSSLAKQQSHMLSNLMQANCLVRIPAEVKPEAEMLVSGLFI
HHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
SACGHEKDLISIDEAIQSILNTAKKLSTETIFVKNSLSRYLSAPVYSPVNLPGFDQSAV
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCCCCCCCCCCC
DGYALCTSHADAQHQSYVLMGEIRAGVASDLALQEGQAIRIFTGGKLPQGTTTIARQEIV
CCEEEECCCCCCCCCCEEEEEHHHCCHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHH
EVVSDTQIRITDPLMAHTDIRRRGEELAEGQSLAEAGQFINIGSLAALSMAGVQTISVFR
HHHCCCEEEEECCHHHHHHHHHHHHHHHHCHHHHHHCCEEECCHHHHHHHHHHHHHHHHC
QPKVAVVITGDEIALDQNSLSEAQVFDANGPLLKAWFQQNAIQAEIIHVSDQSQAVTACF
CCCEEEEEECCEEEECCCCCCCCEEECCCCCHHHHHHHCCCCEEEEEEECCCHHHHHHHH
EQLKSKYDLIITTGGVSVGDYDFVRPSSFDAGFEQIFWKVKQKPGKPLYFAQYQNPEHHC
HHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCE
YLLGLPGNPAAVYVCMQVYGKLLIDALQGQQPKTDTWFTAKLTHGMKEDKRERFIRMQAS
EEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHCCCHHHHHHHHHHHHHH
IVKGELKVSSLAKQQSHMLSNLMQANCLVRIPAEVKPEAEMLVSGLFI
HHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]