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The map label for this gene is fumC [H]

Identifier: 50085031

GI number: 50085031

Start: 1882037

End: 1883431

Strand: Reverse

Name: fumC [H]

Synonym: ACIAD1890

Alternate gene names: 50085031

Gene position: 1883431-1882037 (Counterclockwise)

Preceding gene: 50085032

Following gene: 50085030

Centisome position: 52.34

GC content: 42.44

Gene sequence:

>1395_bases
ATGCAAACTCGAATTGAACACGACACCATGGGTGAGGTTGAGGTCCCAAACGATGCACTTTGGGGAGCTCAGACGCAACG
CAGTTTGCAAAATTTTAAGATCGGTCAGGAAAGACTCCCACGAGCGATGATTCGTGCAATGGGACTTGTCAAGAAGGCAG
CAGCGATTACCAATGCAGAACTCGGGCAGTTGCCAGAGGATCTGAGCCAATATATCGTTGGTGCGGCAGAAGAAGTAATT
GCAGGTGACTGGGACTCGCAATTTCCTTTGGTGGTCTGGCAAACGGGTTCAGGCACACAAAGTAATATGAATTGTAATGA
AGTGATTGCCAATATTGCGAACCAAAAATTAGGAAATGCTTTAGGTTCTCAATCACCTGTGCATCCGAACGATCATGTCA
ATCGTGCTCAGTCGACAAACGATTCTTTCCCAACTGCCATACATGTTGCTGCATCATTACAAATCAACGAATTGCTTATT
CCCGCTGTAAAAAGCCTAAAAGAGACCTTGAAGAAAAAATCAGATGAATTTTCTGATATTGTCAAAATTGGTCGCACGCA
TTTACAGGATGCAACACCGTTAACATTAGGGCAAGAGTTTAGTGGGTATGTATCGCAGCTCGATCATGGGTTAAAGCGAT
TACAGCAAGCGCTTGAGGGTTTATACGAGCTTCCGTTAGGTGGAACGGCTGTGGGTACAGGTTTAAATGCACATCCTGAT
TATGCAGTGAATGCAGCTCAACAACTTGCTAAACTGACAAGTCTGCCATTCGTTACGGCACCTAATAAATTTGAAGCTTT
AGCTGGACGTGATGCTGCGGTATTTGCATCTGGTGCACTGAAAACTCTCGCTGTAAGCTTAAACAAAATTGCAAATGATA
TTCGTTGGCTGGCAAGTGGTCCGCGTTGCGGATTTGGTGAAATTCGTATTCCAGAAAACGAACCAGGCTCAAGCATTATG
CCAGGCAAAGTAAATCCAACGCAAAGTGAAGCTATGACGATGGTGGTTGCGCAGGTGTTAGGCAATGATACAACGATCAA
TGTTGCAGGTGCTTCTGGTAACTTTGAACTGAATGTCTTCATGCCTGTAATCGCATTTAATCTTCTTCAGTCAATTCAGC
TTCTAGGTGATGCTTGTAATAGTTTTAACGAACATTGTGCAGTAGGTATCGAGCCAAATAGAGAAAAGATTGATTATTTT
CTGCATAATTCATTAATGTTGGTGACGGCATTGAATCCTGTTATTGGTTATGAAAACGCTGCAAAAGTAGCAAAAACGGC
TTACAAAGAAAATAAAACGTTAAAACAGGTTGCTGTAGAACTAAATTTAGTCACAGAACAGCAGTTTGATGAAATCGTTC
GTCCTGAAAAGATGGTATCTCCAAATACCAAGTAA

Upstream 100 bases:

>100_bases
AAAATTGTTGTGCTTGATTAGTATCATCTCACTAGCCAAGTAATGATTACAATTGCTCAGCCCGTAATGTCTTAAATTAT
GATGAATATTAGAGGTTTAT

Downstream 100 bases:

>100_bases
TCATGATTTGAACTGAATTCTGCTATCAGCAGTTTTTATCTGGATGAGTTATGCGTACAATAGCCAATCCAGATTAAGAC
TGCTGATGAAAACCTATGCT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MQTRIEHDTMGEVEVPNDALWGAQTQRSLQNFKIGQERLPRAMIRAMGLVKKAAAITNAELGQLPEDLSQYIVGAAEEVI
AGDWDSQFPLVVWQTGSGTQSNMNCNEVIANIANQKLGNALGSQSPVHPNDHVNRAQSTNDSFPTAIHVAASLQINELLI
PAVKSLKETLKKKSDEFSDIVKIGRTHLQDATPLTLGQEFSGYVSQLDHGLKRLQQALEGLYELPLGGTAVGTGLNAHPD
YAVNAAQQLAKLTSLPFVTAPNKFEALAGRDAAVFASGALKTLAVSLNKIANDIRWLASGPRCGFGEIRIPENEPGSSIM
PGKVNPTQSEAMTMVVAQVLGNDTTINVAGASGNFELNVFMPVIAFNLLQSIQLLGDACNSFNEHCAVGIEPNREKIDYF
LHNSLMLVTALNPVIGYENAAKVAKTAYKENKTLKQVAVELNLVTEQQFDEIVRPEKMVSPNTK

Sequences:

>Translated_464_residues
MQTRIEHDTMGEVEVPNDALWGAQTQRSLQNFKIGQERLPRAMIRAMGLVKKAAAITNAELGQLPEDLSQYIVGAAEEVI
AGDWDSQFPLVVWQTGSGTQSNMNCNEVIANIANQKLGNALGSQSPVHPNDHVNRAQSTNDSFPTAIHVAASLQINELLI
PAVKSLKETLKKKSDEFSDIVKIGRTHLQDATPLTLGQEFSGYVSQLDHGLKRLQQALEGLYELPLGGTAVGTGLNAHPD
YAVNAAQQLAKLTSLPFVTAPNKFEALAGRDAAVFASGALKTLAVSLNKIANDIRWLASGPRCGFGEIRIPENEPGSSIM
PGKVNPTQSEAMTMVVAQVLGNDTTINVAGASGNFELNVFMPVIAFNLLQSIQLLGDACNSFNEHCAVGIEPNREKIDYF
LHNSLMLVTALNPVIGYENAAKVAKTAYKENKTLKQVAVELNLVTEQQFDEIVRPEKMVSPNTK
>Mature_464_residues
MQTRIEHDTMGEVEVPNDALWGAQTQRSLQNFKIGQERLPRAMIRAMGLVKKAAAITNAELGQLPEDLSQYIVGAAEEVI
AGDWDSQFPLVVWQTGSGTQSNMNCNEVIANIANQKLGNALGSQSPVHPNDHVNRAQSTNDSFPTAIHVAASLQINELLI
PAVKSLKETLKKKSDEFSDIVKIGRTHLQDATPLTLGQEFSGYVSQLDHGLKRLQQALEGLYELPLGGTAVGTGLNAHPD
YAVNAAQQLAKLTSLPFVTAPNKFEALAGRDAAVFASGALKTLAVSLNKIANDIRWLASGPRCGFGEIRIPENEPGSSIM
PGKVNPTQSEAMTMVVAQVLGNDTTINVAGASGNFELNVFMPVIAFNLLQSIQLLGDACNSFNEHCAVGIEPNREKIDYF
LHNSLMLVTALNPVIGYENAAKVAKTAYKENKTLKQVAVELNLVTEQQFDEIVRPEKMVSPNTK

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=460, Percent_Identity=59.1304347826087, Blast_Score=554, Evalue=1e-158,
Organism=Homo sapiens, GI266458395, Length=77, Percent_Identity=48.0519480519481, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1787896, Length=456, Percent_Identity=62.9385964912281, Blast_Score=583, Evalue=1e-168,
Organism=Escherichia coli, GI87082375, Length=464, Percent_Identity=42.4568965517241, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI1790398, Length=212, Percent_Identity=31.6037735849057, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17553882, Length=462, Percent_Identity=59.3073593073593, Blast_Score=560, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI32565146, Length=326, Percent_Identity=59.5092024539877, Blast_Score=407, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6324993, Length=460, Percent_Identity=60, Blast_Score=548, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6321806, Length=316, Percent_Identity=25.6329113924051, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24640179, Length=461, Percent_Identity=59.4360086767896, Blast_Score=565, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24640177, Length=461, Percent_Identity=59.4360086767896, Blast_Score=564, Evalue=1e-161,
Organism=Drosophila melanogaster, GI78710009, Length=462, Percent_Identity=57.7922077922078, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24662684, Length=466, Percent_Identity=58.1545064377682, Blast_Score=548, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24583245, Length=463, Percent_Identity=52.4838012958963, Blast_Score=498, Evalue=1e-141,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50146; Mature: 50146

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTRIEHDTMGEVEVPNDALWGAQTQRSLQNFKIGQERLPRAMIRAMGLVKKAAAITNAE
CCCCCCCCCCCCEECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCH
LGQLPEDLSQYIVGAAEEVIAGDWDSQFPLVVWQTGSGTQSNMNCNEVIANIANQKLGNA
HHCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
LGSQSPVHPNDHVNRAQSTNDSFPTAIHVAASLQINELLIPAVKSLKETLKKKSDEFSDI
HCCCCCCCCCHHHHHHCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
VKIGRTHLQDATPLTLGQEFSGYVSQLDHGLKRLQQALEGLYELPLGGTAVGTGLNAHPD
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCC
YAVNAAQQLAKLTSLPFVTAPNKFEALAGRDAAVFASGALKTLAVSLNKIANDIRWLASG
HHHHHHHHHHHHHCCCEEECCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PRCGFGEIRIPENEPGSSIMPGKVNPTQSEAMTMVVAQVLGNDTTINVAGASGNFELNVF
CCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEH
MPVIAFNLLQSIQLLGDACNSFNEHCAVGIEPNREKIDYFLHNSLMLVTALNPVIGYENA
HHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHCCEEEEEHHHHHHCCCHH
AKVAKTAYKENKTLKQVAVELNLVTEQQFDEIVRPEKMVSPNTK
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCC
>Mature Secondary Structure
MQTRIEHDTMGEVEVPNDALWGAQTQRSLQNFKIGQERLPRAMIRAMGLVKKAAAITNAE
CCCCCCCCCCCCEECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCH
LGQLPEDLSQYIVGAAEEVIAGDWDSQFPLVVWQTGSGTQSNMNCNEVIANIANQKLGNA
HHCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
LGSQSPVHPNDHVNRAQSTNDSFPTAIHVAASLQINELLIPAVKSLKETLKKKSDEFSDI
HCCCCCCCCCHHHHHHCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
VKIGRTHLQDATPLTLGQEFSGYVSQLDHGLKRLQQALEGLYELPLGGTAVGTGLNAHPD
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCC
YAVNAAQQLAKLTSLPFVTAPNKFEALAGRDAAVFASGALKTLAVSLNKIANDIRWLASG
HHHHHHHHHHHHHCCCEEECCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PRCGFGEIRIPENEPGSSIMPGKVNPTQSEAMTMVVAQVLGNDTTINVAGASGNFELNVF
CCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEH
MPVIAFNLLQSIQLLGDACNSFNEHCAVGIEPNREKIDYFLHNSLMLVTALNPVIGYENA
HHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHCCEEEEEHHHHHHCCCHH
AKVAKTAYKENKTLKQVAVELNLVTEQQFDEIVRPEKMVSPNTK
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]