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The map label for this gene is paaG [H]

Identifier: 50084975

GI number: 50084975

Start: 1836465

End: 1837568

Strand: Direct

Name: paaG [H]

Synonym: ACIAD1829

Alternate gene names: 50084975

Gene position: 1836465-1837568 (Clockwise)

Preceding gene: 50084974

Following gene: 50084976

Centisome position: 51.03

GC content: 45.92

Gene sequence:

>1104_bases
ATGGAATTGGTGTATTCAAAACACGCAGGTATGCGTCTAGACGAACCTGAAAATTTTAAGGCATTTAAACTGGTGCTCGA
AGGATTTGAACTTGGCGAGCGACCCGCTATTGCTGATTTGGATTATGACAATAACGATCATGTTTGGATACCACCTTCAC
AAGTATTACAGTTTGCTAAGTCGGATGCATGGCGCTCGCAATTTCATAAAATGATTGAAGGTGCCGAAAAATATGGCTGG
ATTCATCCTGATACGCAAGCCATCAAGGCACATATCCAATGGCAATCAGCAAGCAATCTGCCAGAGCTGAATCAGGTGCC
CGAACAGTCTTTGGTTGTTGTTCGTCAAGAGCATGGCTATACCGTAATCACACTTAATCGTCCTGAAAAGCTCAATGCCT
TGACACGCCCGATGTTACAGGCCCTCAAAGATGCAGTTTTGGCTGCAACGCAAGACCACGCCTGTCGAGCAATTTTAATC
ACTGGAAATGGGCGTGGATTCTGCACTGGACAGGATCTAAATGAGCGACGTGATCTTGAGCAGGCCGTCGACTTGGGTGA
GTCTTTAATTCAATTTTATAATCCGATTATCACTGCAATTGACCAAGCAAATAAACCCGTGGTGTGTGCTGTCAATGGTG
TCGCTGCCGGAGCAGGCGTAGGACTTGCACTGGCATGCGATATTGTATTAGCAGCAGATGATGCTCGATTTATTCAATCT
TTTTCCAAAATTGGTTTGGCACCTGATGCTGGAATCAGTTGGCATTTACCTCGCTTGATTGGCTCTGCACGAACGAAAGC
ATTAACCATTTTGGCTGAGCCAATTAGCGCTGTTCAGGCGCAAGAATGGGGCATGATCTGGGCGACTTTGCCCAGTGAAA
AGCTACACAGTGAAGCGGAGGCACTGGTCAAACAATTGAGCCAACGCCCAACGTTATCCTTTGCAGCGATTAAACAGGCG
CATCGAAGTACAGCAATCAATACGTTACAGCAGCAGCTCGATCTAGAAGCCACCCTACAACAAAAGGTAGGATGGAGTGA
GGATTATAAACGCGGAGTACAAGCTTTTTTTGATGGCACTACTGCGCAATTTACTGGTCAATAA

Upstream 100 bases:

>100_bases
AATGGTGCAGCCGTCTATGTCGATGGTGGCTGGACTGCCTTCGGAAATGCAGGTGATGCATCATCGCCAAGCGCTATTTA
TAATTAAGGAGCACGACATC

Downstream 100 bases:

>100_bases
CGACAAATTCATATATCTGAATTTCAAGTCTAAATAAATGAAATATATAGAATATTATTTCCAATCTGCCTAGACTTAAA
CTTCAAGATCAACGCAAATT

Product: enoyl-CoA hydratase (PaaG-like)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MELVYSKHAGMRLDEPENFKAFKLVLEGFELGERPAIADLDYDNNDHVWIPPSQVLQFAKSDAWRSQFHKMIEGAEKYGW
IHPDTQAIKAHIQWQSASNLPELNQVPEQSLVVVRQEHGYTVITLNRPEKLNALTRPMLQALKDAVLAATQDHACRAILI
TGNGRGFCTGQDLNERRDLEQAVDLGESLIQFYNPIITAIDQANKPVVCAVNGVAAGAGVGLALACDIVLAADDARFIQS
FSKIGLAPDAGISWHLPRLIGSARTKALTILAEPISAVQAQEWGMIWATLPSEKLHSEAEALVKQLSQRPTLSFAAIKQA
HRSTAINTLQQQLDLEATLQQKVGWSEDYKRGVQAFFDGTTAQFTGQ

Sequences:

>Translated_367_residues
MELVYSKHAGMRLDEPENFKAFKLVLEGFELGERPAIADLDYDNNDHVWIPPSQVLQFAKSDAWRSQFHKMIEGAEKYGW
IHPDTQAIKAHIQWQSASNLPELNQVPEQSLVVVRQEHGYTVITLNRPEKLNALTRPMLQALKDAVLAATQDHACRAILI
TGNGRGFCTGQDLNERRDLEQAVDLGESLIQFYNPIITAIDQANKPVVCAVNGVAAGAGVGLALACDIVLAADDARFIQS
FSKIGLAPDAGISWHLPRLIGSARTKALTILAEPISAVQAQEWGMIWATLPSEKLHSEAEALVKQLSQRPTLSFAAIKQA
HRSTAINTLQQQLDLEATLQQKVGWSEDYKRGVQAFFDGTTAQFTGQ
>Mature_367_residues
MELVYSKHAGMRLDEPENFKAFKLVLEGFELGERPAIADLDYDNNDHVWIPPSQVLQFAKSDAWRSQFHKMIEGAEKYGW
IHPDTQAIKAHIQWQSASNLPELNQVPEQSLVVVRQEHGYTVITLNRPEKLNALTRPMLQALKDAVLAATQDHACRAILI
TGNGRGFCTGQDLNERRDLEQAVDLGESLIQFYNPIITAIDQANKPVVCAVNGVAAGAGVGLALACDIVLAADDARFIQS
FSKIGLAPDAGISWHLPRLIGSARTKALTILAEPISAVQAQEWGMIWATLPSEKLHSEAEALVKQLSQRPTLSFAAIKQA
HRSTAINTLQQQLDLEATLQQKVGWSEDYKRGVQAFFDGTTAQFTGQ

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=246, Percent_Identity=30.4878048780488, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI45643119, Length=217, Percent_Identity=29.0322580645161, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI260275230, Length=217, Percent_Identity=29.0322580645161, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI260274832, Length=217, Percent_Identity=29.0322580645161, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI31542718, Length=207, Percent_Identity=29.951690821256, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI70995211, Length=272, Percent_Identity=26.8382352941176, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4757968, Length=242, Percent_Identity=26.4462809917355, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI49355787, Length=242, Percent_Identity=26.4462809917355, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI25453481, Length=243, Percent_Identity=25.9259259259259, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI4757966, Length=243, Percent_Identity=25.9259259259259, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI51538573, Length=243, Percent_Identity=25.9259259259259, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI51538581, Length=243, Percent_Identity=25.9259259259259, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI116235487, Length=255, Percent_Identity=25.4901960784314, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI37594471, Length=152, Percent_Identity=33.5526315789474, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI37594469, Length=152, Percent_Identity=33.5526315789474, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI221307494, Length=240, Percent_Identity=24.5833333333333, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI221136756, Length=240, Percent_Identity=24.5833333333333, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI221136753, Length=240, Percent_Identity=24.5833333333333, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI157694516, Length=243, Percent_Identity=25.9259259259259, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI213417737, Length=243, Percent_Identity=25.9259259259259, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI4502327, Length=176, Percent_Identity=31.8181818181818, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI68989263, Length=196, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1787660, Length=253, Percent_Identity=47.8260869565217, Blast_Score=207, Evalue=7e-55,
Organism=Escherichia coli, GI1787659, Length=257, Percent_Identity=34.6303501945525, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI221142681, Length=208, Percent_Identity=32.2115384615385, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1788597, Length=290, Percent_Identity=26.8965517241379, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1790281, Length=192, Percent_Identity=27.6041666666667, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI87082183, Length=253, Percent_Identity=24.5059288537549, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788682, Length=194, Percent_Identity=25.7731958762887, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17554946, Length=260, Percent_Identity=31.1538461538462, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI25145438, Length=238, Percent_Identity=32.3529411764706, Blast_Score=121, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17535521, Length=335, Percent_Identity=25.3731343283582, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17549921, Length=218, Percent_Identity=29.8165137614679, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17534483, Length=243, Percent_Identity=28.8065843621399, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17540714, Length=228, Percent_Identity=29.3859649122807, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17536985, Length=210, Percent_Identity=29.5238095238095, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17560910, Length=226, Percent_Identity=24.3362831858407, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17540306, Length=181, Percent_Identity=25.414364640884, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6320241, Length=221, Percent_Identity=28.0542986425339, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI20129971, Length=251, Percent_Identity=31.0756972111554, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24653477, Length=251, Percent_Identity=31.0756972111554, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24653139, Length=172, Percent_Identity=31.9767441860465, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI19920382, Length=288, Percent_Identity=26.3888888888889, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24654903, Length=203, Percent_Identity=25.1231527093596, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI19922422, Length=252, Percent_Identity=25.7936507936508, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI21357171, Length=201, Percent_Identity=27.363184079602, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR011968 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 40454; Mature: 40454

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELVYSKHAGMRLDEPENFKAFKLVLEGFELGERPAIADLDYDNNDHVWIPPSQVLQFAK
CCCEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCEEEECHHHHHHHHH
SDAWRSQFHKMIEGAEKYGWIHPDTQAIKAHIQWQSASNLPELNQVPEQSLVVVRQEHGY
HHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEEEECCCCCCCHHHHCCCCCEEEEEECCCE
TVITLNRPEKLNALTRPMLQALKDAVLAATQDHACRAILITGNGRGFCTGQDLNERRDLE
EEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEECCCCCHHHHHHH
QAVDLGESLIQFYNPIITAIDQANKPVVCAVNGVAAGAGVGLALACDIVLAADDARFIQS
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHEEEEEECCHHHHHHH
FSKIGLAPDAGISWHLPRLIGSARTKALTILAEPISAVQAQEWGMIWATLPSEKLHSEAE
HHHCCCCCCCCCCEEHHHHHHHHHHHEEEEHHHHHHHHHHHHCCEEEEECCHHHHHHHHH
ALVKQLSQRPTLSFAAIKQAHRSTAINTLQQQLDLEATLQQKVGWSEDYKRGVQAFFDGT
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
TAQFTGQ
CEEECCC
>Mature Secondary Structure
MELVYSKHAGMRLDEPENFKAFKLVLEGFELGERPAIADLDYDNNDHVWIPPSQVLQFAK
CCCEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCEEEECHHHHHHHHH
SDAWRSQFHKMIEGAEKYGWIHPDTQAIKAHIQWQSASNLPELNQVPEQSLVVVRQEHGY
HHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEEEECCCCCCCHHHHCCCCCEEEEEECCCE
TVITLNRPEKLNALTRPMLQALKDAVLAATQDHACRAILITGNGRGFCTGQDLNERRDLE
EEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEECCCCCHHHHHHH
QAVDLGESLIQFYNPIITAIDQANKPVVCAVNGVAAGAGVGLALACDIVLAADDARFIQS
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHEEEEEECCHHHHHHH
FSKIGLAPDAGISWHLPRLIGSARTKALTILAEPISAVQAQEWGMIWATLPSEKLHSEAE
HHHCCCCCCCCCCEEHHHHHHHHHHHEEEEHHHHHHHHHHHHCCEEEEECCHHHHHHHHH
ALVKQLSQRPTLSFAAIKQAHRSTAINTLQQQLDLEATLQQKVGWSEDYKRGVQAFFDGT
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
TAQFTGQ
CEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]