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The map label for this gene is livM [H]

Identifier: 50084918

GI number: 50084918

Start: 1774686

End: 1775756

Strand: Direct

Name: livM [H]

Synonym: ACIAD1767

Alternate gene names: 50084918

Gene position: 1774686-1775756 (Clockwise)

Preceding gene: 50084917

Following gene: 50084919

Centisome position: 49.32

GC content: 41.46

Gene sequence:

>1071_bases
ATGAAGATCGCCACTTTGTTTTCTGATAAACCCTATAGTGCTGTACTCATAGCGCTATGTTTTCTGGTTGTTATGATTTT
GCCATGGCTACATCTGGTTCCATCAGATTCACCATTTTATCTGTCTGCCTACTGGGTTACTTTGATTGGCAAAATTATGT
GTCTGGCACTGGTTGCTTTATCGCTTGATCTAGTTTGGGGCTACGCTGGCATATTGAGTTTAGGGCATGGTCTTTATTTT
GCCTTAGGTGGATATGCCTTTGGGATGTATCTGATGCGACAATCTGCAGGTGATGGCTTGCCAGACTTTATGCGGTTTTT
AAGCTGGAATGAGCTACCTTGGTTTTGGGTGGGTACAGAGCACTTTATTTGGGCCGTCCTCTTGGTTGTTTTAGTACCAG
GTGTTATTGCTTTTATTTTCGGATTCTTTGCATTTAGATCAAAAATTAAGGGCGTTTATTTTTCAATTATTACGCAGGCC
ATGACTTTTGCTGCTGCATTATTATTTTTTAGAAACGAAACAGGATTTGGTGGCAATAACGGATTTACGGGATTTAAAAC
CATTCTGGGATTTGACATTACGTCTTCAATGACCCGAGCAGTTTTATGTTTTGTGACAGCATTGATATTAATGCTGTGCT
TTATCGGATTACGTATCTTGATGAATCAGCCTTATGGCAGAGTACTTGGCGCAATCCGTGATAGTGAAAATAGATTGCAG
TATCTTGGCTATCGTACGCTTTGGTACAAGCTTTCTGCATGGGTACTGTCAGCGGTTATTGCTGGAATCGCAGGCGCTTT
GTATGTACCGCAGGCTGGCATTATCAATCCAAGTGAAATGAATCCCGTGAATTCTATTGAAATGGCGGTTTGGGTAGCAG
CAGGAGGACGAGGTACCTTGATCGGCCCGATTCTTGGCGCTGGTTTAATTAACGGACTTAAAACCTATTTTACGGTCGCA
GCACCAGAGTTCTGGTTAATTATTTTGGGTGCATTGTTTATTGTGGTGACACTGTTCTTACCGAAAGGTGTAATTGGTCT
GTTTGATCGCTTTAAAAAGGAGAAAAATTAA

Upstream 100 bases:

>100_bases
ATTGGCCAAAATTATTCTGTTGGTTCTTGTGATTTTGTTTATTCAAAAACGTCCACAAGGTTTATTTGCAATCAAAGGCC
GTTTTGTGGAGTAAATAACA

Downstream 100 bases:

>100_bases
ATGAGCGAACATGTTGCAAATATACATCAGCATGGTGGTCAATTTGGTGAAGGCTATGGCAGAGCAAAGTCGGAAGGTGC
AGATTTTAGTCATGGGGTTG

Product: branched chain amino acid ABC transporter permease

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MKIATLFSDKPYSAVLIALCFLVVMILPWLHLVPSDSPFYLSAYWVTLIGKIMCLALVALSLDLVWGYAGILSLGHGLYF
ALGGYAFGMYLMRQSAGDGLPDFMRFLSWNELPWFWVGTEHFIWAVLLVVLVPGVIAFIFGFFAFRSKIKGVYFSIITQA
MTFAAALLFFRNETGFGGNNGFTGFKTILGFDITSSMTRAVLCFVTALILMLCFIGLRILMNQPYGRVLGAIRDSENRLQ
YLGYRTLWYKLSAWVLSAVIAGIAGALYVPQAGIINPSEMNPVNSIEMAVWVAAGGRGTLIGPILGAGLINGLKTYFTVA
APEFWLIILGALFIVVTLFLPKGVIGLFDRFKKEKN

Sequences:

>Translated_356_residues
MKIATLFSDKPYSAVLIALCFLVVMILPWLHLVPSDSPFYLSAYWVTLIGKIMCLALVALSLDLVWGYAGILSLGHGLYF
ALGGYAFGMYLMRQSAGDGLPDFMRFLSWNELPWFWVGTEHFIWAVLLVVLVPGVIAFIFGFFAFRSKIKGVYFSIITQA
MTFAAALLFFRNETGFGGNNGFTGFKTILGFDITSSMTRAVLCFVTALILMLCFIGLRILMNQPYGRVLGAIRDSENRLQ
YLGYRTLWYKLSAWVLSAVIAGIAGALYVPQAGIINPSEMNPVNSIEMAVWVAAGGRGTLIGPILGAGLINGLKTYFTVA
APEFWLIILGALFIVVTLFLPKGVIGLFDRFKKEKN
>Mature_356_residues
MKIATLFSDKPYSAVLIALCFLVVMILPWLHLVPSDSPFYLSAYWVTLIGKIMCLALVALSLDLVWGYAGILSLGHGLYF
ALGGYAFGMYLMRQSAGDGLPDFMRFLSWNELPWFWVGTEHFIWAVLLVVLVPGVIAFIFGFFAFRSKIKGVYFSIITQA
MTFAAALLFFRNETGFGGNNGFTGFKTILGFDITSSMTRAVLCFVTALILMLCFIGLRILMNQPYGRVLGAIRDSENRLQ
YLGYRTLWYKLSAWVLSAVIAGIAGALYVPQAGIINPSEMNPVNSIEMAVWVAAGGRGTLIGPILGAGLINGLKTYFTVA
APEFWLIILGALFIVVTLFLPKGVIGLFDRFKKEKN

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=341, Percent_Identity=24.9266862170088, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 39270; Mature: 39270

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIATLFSDKPYSAVLIALCFLVVMILPWLHLVPSDSPFYLSAYWVTLIGKIMCLALVAL
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
SLDLVWGYAGILSLGHGLYFALGGYAFGMYLMRQSAGDGLPDFMRFLSWNELPWFWVGTE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEECHH
HFIWAVLLVVLVPGVIAFIFGFFAFRSKIKGVYFSIITQAMTFAAALLFFRNETGFGGNN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GFTGFKTILGFDITSSMTRAVLCFVTALILMLCFIGLRILMNQPYGRVLGAIRDSENRLQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHH
YLGYRTLWYKLSAWVLSAVIAGIAGALYVPQAGIINPSEMNPVNSIEMAVWVAAGGRGTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHEEEEEEECCCCCC
IGPILGAGLINGLKTYFTVAAPEFWLIILGALFIVVTLFLPKGVIGLFDRFKKEKN
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIATLFSDKPYSAVLIALCFLVVMILPWLHLVPSDSPFYLSAYWVTLIGKIMCLALVAL
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
SLDLVWGYAGILSLGHGLYFALGGYAFGMYLMRQSAGDGLPDFMRFLSWNELPWFWVGTE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEECHH
HFIWAVLLVVLVPGVIAFIFGFFAFRSKIKGVYFSIITQAMTFAAALLFFRNETGFGGNN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GFTGFKTILGFDITSSMTRAVLCFVTALILMLCFIGLRILMNQPYGRVLGAIRDSENRLQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHH
YLGYRTLWYKLSAWVLSAVIAGIAGALYVPQAGIINPSEMNPVNSIEMAVWVAAGGRGTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHEEEEEEECCCCCC
IGPILGAGLINGLKTYFTVAAPEFWLIILGALFIVVTLFLPKGVIGLFDRFKKEKN
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]