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The map label for this gene is hapE [H]

Identifier: 50084886

GI number: 50084886

Start: 1741220

End: 1742749

Strand: Direct

Name: hapE [H]

Synonym: ACIAD1733

Alternate gene names: 50084886

Gene position: 1741220-1742749 (Clockwise)

Preceding gene: 50084885

Following gene: 50084887

Centisome position: 48.39

GC content: 39.28

Gene sequence:

>1530_bases
ATGACAGCTCAAGCAAAAAAATTAGATTCGGCTGATCGTAAAGCATTGCCTTCACACATCTATGATAGTTTTATTGTGGG
TGCAGGTATCTCGGGTATTGCAGCAGCAATACGACTAGATCAGGTTGGCTATGCAAACTACAAAATCATTGAAAAAGCAA
GCCGTGTAGGCGGTACATGGCGTGAAAATACGTATCCTGGTTGTGGTTGTGATGTACCATCAGCTTTATATTCATATTCA
TTTGCTCCGAGTGCTCAATGGAGTCATTTATTTGCACGTCAGCCAGAAATACTAAATTATTTGGAAGATGTCAGTCATAA
ATTTAACATTAACGAAAAAATTGAATTTGAAACTGAGCTTAATAAAGCTGCATGGGATAATGAGCGTAATTTGTGGGTAT
TAGATACCAACAAGGGACAGTTTTTATCTCGTACTGTCGTATTTGCAACAGGCCCAATTACAGAAGCCCAAATTCCAAAA
CTTGATGGCCTTGACAGTTTTAAAGGAGAGATGTTTCACTCGGCCAGATGGAATCATGACTATGATTTGAGTGGTAAACG
TATTGCGGTGATTGGTACAGGTGCCTCAGCGATTCAGTTTGTGCCACAAATCCAGCCTTTAGCAAAAGAACTTTTTGTTT
TTCAGCGTACTGCACCATGGGTAGTTCCAAAACCAGATATGGAGCTGGGCGACTTTAGTAAATCGGTGATTGCAAAGTTA
CCTATTATTCAATCCACTTGGCGAAAAGCCGTTGCACAGTCCTTAAATGCGATCAATTTTGGTCTACGTAATCCAGCAGT
TTTAAAGCCAGTTGGGGAGTTATTTAAACAAGTACTTAAATCACAGGTGAAAGATCCTGAATTATTGAAAGCTGTGATAC
CTGATTTCACTATCGGTTGTAAGCGTTTATTGTTTGCCAATAATTACTATCCTGCATTGCAAGCCAGTAATACTAAGCTT
ATTCCACACGGTTTGGTTAAGGTCGAAGGGAATACCGTGATTGCAGCCAATGGCGAGCGTCATGAAGTCGATGTGATTAT
CTGGGGAACAGGCTTTGAAGTATCACATCCACCTATTGGACGCCGTGTTTATAATGATAAAGGTGAATGCCTAAACGATT
TGTGGAAACAGAGCTCTCCAGAAGCATATTTGGGCACCAATATTGAAAATGTGCCGAATGCCTTTTTGGTGCTGGGGCCA
AATGTCTTGGTGTATGACTCATTTATTGGTTTGGCAGAAGCACAATTGGACTATATTGTGGATGGTTTGCAAAAAATTAA
AAAGCACAATATTTCAAAATTAACTATTAAACCACAAGTAATCCATGCACATAATGAACGGGTACAAAAGCATTTAAAAA
CCACAGTATTTAATGCAGGCGGTTGTAAGAGCTATTATCTGGATGCCAATGGTCGTAACTTTGCAGCATGGCCATGGTCA
TTGAAAAAATTAAGACAACGTCTGAAAAGCTTGAATATTCGTGACTACGATGTAACTTATCAAACCACAACAAATAAAAT
AGATGCATGA

Upstream 100 bases:

>100_bases
ATCAAATGAGCCCAAAATTTTGGTGACTTATGATCAAATTGAGATGAACACTCAATCAAAGATTGGTTTAAAAATATTTT
TAAGTAAAAGGATATTCTGA

Downstream 100 bases:

>100_bases
TTGAATAGAAGATGGATTGCTCAAGATGGCTTTTTATAACCATCTTGATTTTGATCTTATTTAATGTAGAGATGTGTATG
AAGAAAGGACAATATAGCCG

Product: flavin-binding monooxygenase

Products: NA

Alternate protein names: HAPMO; Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MTAQAKKLDSADRKALPSHIYDSFIVGAGISGIAAAIRLDQVGYANYKIIEKASRVGGTWRENTYPGCGCDVPSALYSYS
FAPSAQWSHLFARQPEILNYLEDVSHKFNINEKIEFETELNKAAWDNERNLWVLDTNKGQFLSRTVVFATGPITEAQIPK
LDGLDSFKGEMFHSARWNHDYDLSGKRIAVIGTGASAIQFVPQIQPLAKELFVFQRTAPWVVPKPDMELGDFSKSVIAKL
PIIQSTWRKAVAQSLNAINFGLRNPAVLKPVGELFKQVLKSQVKDPELLKAVIPDFTIGCKRLLFANNYYPALQASNTKL
IPHGLVKVEGNTVIAANGERHEVDVIIWGTGFEVSHPPIGRRVYNDKGECLNDLWKQSSPEAYLGTNIENVPNAFLVLGP
NVLVYDSFIGLAEAQLDYIVDGLQKIKKHNISKLTIKPQVIHAHNERVQKHLKTTVFNAGGCKSYYLDANGRNFAAWPWS
LKKLRQRLKSLNIRDYDVTYQTTTNKIDA

Sequences:

>Translated_509_residues
MTAQAKKLDSADRKALPSHIYDSFIVGAGISGIAAAIRLDQVGYANYKIIEKASRVGGTWRENTYPGCGCDVPSALYSYS
FAPSAQWSHLFARQPEILNYLEDVSHKFNINEKIEFETELNKAAWDNERNLWVLDTNKGQFLSRTVVFATGPITEAQIPK
LDGLDSFKGEMFHSARWNHDYDLSGKRIAVIGTGASAIQFVPQIQPLAKELFVFQRTAPWVVPKPDMELGDFSKSVIAKL
PIIQSTWRKAVAQSLNAINFGLRNPAVLKPVGELFKQVLKSQVKDPELLKAVIPDFTIGCKRLLFANNYYPALQASNTKL
IPHGLVKVEGNTVIAANGERHEVDVIIWGTGFEVSHPPIGRRVYNDKGECLNDLWKQSSPEAYLGTNIENVPNAFLVLGP
NVLVYDSFIGLAEAQLDYIVDGLQKIKKHNISKLTIKPQVIHAHNERVQKHLKTTVFNAGGCKSYYLDANGRNFAAWPWS
LKKLRQRLKSLNIRDYDVTYQTTTNKIDA
>Mature_508_residues
TAQAKKLDSADRKALPSHIYDSFIVGAGISGIAAAIRLDQVGYANYKIIEKASRVGGTWRENTYPGCGCDVPSALYSYSF
APSAQWSHLFARQPEILNYLEDVSHKFNINEKIEFETELNKAAWDNERNLWVLDTNKGQFLSRTVVFATGPITEAQIPKL
DGLDSFKGEMFHSARWNHDYDLSGKRIAVIGTGASAIQFVPQIQPLAKELFVFQRTAPWVVPKPDMELGDFSKSVIAKLP
IIQSTWRKAVAQSLNAINFGLRNPAVLKPVGELFKQVLKSQVKDPELLKAVIPDFTIGCKRLLFANNYYPALQASNTKLI
PHGLVKVEGNTVIAANGERHEVDVIIWGTGFEVSHPPIGRRVYNDKGECLNDLWKQSSPEAYLGTNIENVPNAFLVLGPN
VLVYDSFIGLAEAQLDYIVDGLQKIKKHNISKLTIKPQVIHAHNERVQKHLKTTVFNAGGCKSYYLDANGRNFAAWPWSL
KKLRQRLKSLNIRDYDVTYQTTTNKIDA

Specific function: Catalyzes a Baeyer-Villiger oxidation reaction, i.e., the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Can oxidize a wide range of acetophenone derivatives. Highest activity occurs with co

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Homo sapiens, GI4503755, Length=368, Percent_Identity=22.2826086956522, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI4503757, Length=353, Percent_Identity=24.929178470255, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25145785, Length=210, Percent_Identity=25.7142857142857, Blast_Score=79, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI193202226, Length=229, Percent_Identity=27.5109170305677, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR020946 [H]

Pfam domain/function: PF00743 FMO-like [H]

EC number: =1.14.13.84 [H]

Molecular weight: Translated: 56915; Mature: 56783

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAQAKKLDSADRKALPSHIYDSFIVGAGISGIAAAIRLDQVGYANYKIIEKASRVGGTW
CCCCCHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCC
RENTYPGCGCDVPSALYSYSFAPSAQWSHLFARQPEILNYLEDVSHKFNINEKIEFETEL
CCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEHHHH
NKAAWDNERNLWVLDTNKGQFLSRTVVFATGPITEAQIPKLDGLDSFKGEMFHSARWNHD
CHHHCCCCCCEEEEECCCCCEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCC
YDLSGKRIAVIGTGASAIQFVPQIQPLAKELFVFQRTAPWVVPKPDMELGDFSKSVIAKL
CCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHC
PIIQSTWRKAVAQSLNAINFGLRNPAVLKPVGELFKQVLKSQVKDPELLKAVIPDFTIGC
CHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHH
KRLLFANNYYPALQASNTKLIPHGLVKVEGNTVIAANGERHEVDVIIWGTGFEVSHPPIG
HHHHHCCCCCCCEECCCCEECCCCEEEECCCEEEEECCCCEEEEEEEEECCCCCCCCCCC
RRVYNDKGECLNDLWKQSSPEAYLGTNIENVPNAFLVLGPNVLVYDSFIGLAEAQLDYIV
CHHCCCCHHHHHHHHHCCCCCEEECCCCCCCCCEEEEECCCEEEEECHHHHHHHHHHHHH
DGLQKIKKHNISKLTIKPQVIHAHNERVQKHLKTTVFNAGGCKSYYLDANGRNFAAWPWS
HHHHHHHHCCCEEEEECCCEEEHHHHHHHHHHHHHEECCCCCEEEEEECCCCEEEECCHH
LKKLRQRLKSLNIRDYDVTYQTTTNKIDA
HHHHHHHHHHCCCCEEEEEEEECCCCCCC
>Mature Secondary Structure 
TAQAKKLDSADRKALPSHIYDSFIVGAGISGIAAAIRLDQVGYANYKIIEKASRVGGTW
CCCCHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCC
RENTYPGCGCDVPSALYSYSFAPSAQWSHLFARQPEILNYLEDVSHKFNINEKIEFETEL
CCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEHHHH
NKAAWDNERNLWVLDTNKGQFLSRTVVFATGPITEAQIPKLDGLDSFKGEMFHSARWNHD
CHHHCCCCCCEEEEECCCCCEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCC
YDLSGKRIAVIGTGASAIQFVPQIQPLAKELFVFQRTAPWVVPKPDMELGDFSKSVIAKL
CCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHC
PIIQSTWRKAVAQSLNAINFGLRNPAVLKPVGELFKQVLKSQVKDPELLKAVIPDFTIGC
CHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHH
KRLLFANNYYPALQASNTKLIPHGLVKVEGNTVIAANGERHEVDVIIWGTGFEVSHPPIG
HHHHHCCCCCCCEECCCCEECCCCEEEECCCEEEEECCCCEEEEEEEEECCCCCCCCCCC
RRVYNDKGECLNDLWKQSSPEAYLGTNIENVPNAFLVLGPNVLVYDSFIGLAEAQLDYIV
CHHCCCCHHHHHHHHHCCCCCEEECCCCCCCCCEEEEECCCEEEEECHHHHHHHHHHHHH
DGLQKIKKHNISKLTIKPQVIHAHNERVQKHLKTTVFNAGGCKSYYLDANGRNFAAWPWS
HHHHHHHHCCCEEEEECCCEEEHHHHHHHHHHHHHEECCCCCEEEEEECCCCEEEECCHH
LKKLRQRLKSLNIRDYDVTYQTTTNKIDA
HHHHHHHHHHCCCCEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11322873 [H]