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The map label for this gene is hcaC [C]

Identifier: 50084878

GI number: 50084878

Start: 1731954

End: 1733828

Strand: Reverse

Name: hcaC [C]

Synonym: ACIAD1724

Alternate gene names: 50084878

Gene position: 1733828-1731954 (Counterclockwise)

Preceding gene: 50084879

Following gene: 50084877

Centisome position: 48.18

GC content: 42.83

Gene sequence:

>1875_bases
ATGAATGCCACTCAATCACAAGACAGAGAGCGCTTTGTAAAACTTGGACAACATGCAATTGACTATTTTTATAAAGGTCC
GGTTTTACATATTCAACCCAAAGAACAACTCAAGGCTTATCCGCAAAAACTGACCGATCGTTTGATTCATTTTGCTAAAG
TTAAGCCCTACCATACCTTTGCCGCTAAACGCAATACACAAGACGAATGGATCAGGCTCAGTTATGCAGAAACCTTGCAA
CGTGCTTGGCATATTGCACAAGCTTTGCATCAGCGCAACTTAAGCCAAGAACGACCTTTGGTAATTTTATCGGGAAATGA
TCTTGAACACTTAACGCTTTCGATGGGCGCGATGTTGGCAGGTGTACCATTTTCTGCTATTTCGCCAGCCTACTCACTGG
TATCTCAAGATTTTGGCAAATTAAAACATGTGTTTGATGTGCTCACCCCAGGCATGGTGTATGCAAATGATGGACAAGCT
TTTGCTAAAGCCATTCAAAGCTGTACGCAAGATCATATTGAAATTGTGACCAATAAAGGCATTATAGGTGATCAAGTCTG
TACATCGTTTCAGTCTTTATTAGATACCCCTGTGACCGATGTTCAAGAACATTATGAAACGCTAGATGAGCATCAGATTG
CCAAGTTTTTATTTACATCCGGTTCGACCAAGCTTCCAAAGGCTGTTCCGACCACACATTTGATGCTGTGTATCAATCAA
CAAATGCTACTTCAAACATTTCCAGAATTTGAAGACACACCGCCTGTCTTACTGGACTGGTTGTCTTGGCATCATACATT
CGGTGGAAGCCACAATGTTGGGATTGCGCTTTATAACGGCGGAACCATTTACATCGATGACGGTAAGCCCGTTCCGGGAA
AATTTGATGAAACGATTCGAAATTTAAAAGAAATTTCACCGACGGTTTATCTAAATGTACCCAAAGGCTGGGAAGAACTC
ACCGATGCACTTGAAAAAGATGCCGAACTCAGAGATCGCTTCTTTGCCAACGTTAAAATTTTGTTTTTTGCTGGTGCTGC
ATTATCTGAAGCAGGCTGGAACCGACTCGATAAAATTGCACAGGCACATTGCGGTGAAAAAATCCGCATCATGAGTGGCT
TGGGCATGACCGAAACGGCACCATCGTGCGCCTTTACCACAGGCCCACGGGTAATGGCTGGTTTTATTGGCTACCCTGCT
CCGGGCTGTGAAATCAAATTAGTTCCCTATGGTGACAAACTTGAATTTTGTGTTCGTGGCAAGCACGTCATGAAAGGTTA
CTGGCGCCTTAAGGCCGACCAGCAAAGCACAATTTTTGATGAAGACGGCTTTTTCCATACTGGCGATGCGGTACGTCTGG
TCGATCCAAACGACCCTGCACAGGGCCTGATGTACGACGGCCGTATTGCAGAAGATTTCAAACTCAACACGGGTACCTTT
GTGAATGTGGGCACTTTACGCAACAAGGCACTCATTCAAGGTAATTTGTTGATTCAAGATGTTTGTATTACCGGTTCAAA
TCTAAATGCGATTGGCTTCTTGGTTTTTCCTAAGCTTGATGCCTGTGCAGATTTTGCTGGTCTGAATATGAAAAATCATA
GCGCAATAGATATCTTGCAACACCCTAAAGTACAGCAGTGGTTTCGACAGTTTTTAATTCAGTACAACAAAGATGCCACG
GGCAGTTCAAATCGGGTATCAATGTTGTATTTAATGACTGAAGCACCACAGCTCGATGCAGGTGAAGTAACCGATAAAGG
CAATTTAAATCAGAGTAACATCTTAAAACGTCGTGCTGCACTGGTCGAAGAACTGTATAACAAACAAACAGATAATCCAT
TGATTGTACGTATACCCGTTTTAAATCACTCCTAA

Upstream 100 bases:

>100_bases
CCAATTTAACCATTGGGTATGGTTTTAAAAAATAACGATATAAAAATTGCATGATGCAAAAAAGTACAGCGATGTACAAC
ATGGAGTGAACGAAATGCAA

Downstream 100 bases:

>100_bases
GTTTATTTCTTGTTCTCAAGCTCATTTCGTATGGGGTTAGGCCTTGATCATGCTAAAAAAAGGTGAAATATGCAGCAAGA
TACTGATTTTGAATTGTTCC

Product: feruloyl-CoA synthase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 624; Mature: 624

Protein sequence:

>624_residues
MNATQSQDRERFVKLGQHAIDYFYKGPVLHIQPKEQLKAYPQKLTDRLIHFAKVKPYHTFAAKRNTQDEWIRLSYAETLQ
RAWHIAQALHQRNLSQERPLVILSGNDLEHLTLSMGAMLAGVPFSAISPAYSLVSQDFGKLKHVFDVLTPGMVYANDGQA
FAKAIQSCTQDHIEIVTNKGIIGDQVCTSFQSLLDTPVTDVQEHYETLDEHQIAKFLFTSGSTKLPKAVPTTHLMLCINQ
QMLLQTFPEFEDTPPVLLDWLSWHHTFGGSHNVGIALYNGGTIYIDDGKPVPGKFDETIRNLKEISPTVYLNVPKGWEEL
TDALEKDAELRDRFFANVKILFFAGAALSEAGWNRLDKIAQAHCGEKIRIMSGLGMTETAPSCAFTTGPRVMAGFIGYPA
PGCEIKLVPYGDKLEFCVRGKHVMKGYWRLKADQQSTIFDEDGFFHTGDAVRLVDPNDPAQGLMYDGRIAEDFKLNTGTF
VNVGTLRNKALIQGNLLIQDVCITGSNLNAIGFLVFPKLDACADFAGLNMKNHSAIDILQHPKVQQWFRQFLIQYNKDAT
GSSNRVSMLYLMTEAPQLDAGEVTDKGNLNQSNILKRRAALVEELYNKQTDNPLIVRIPVLNHS

Sequences:

>Translated_624_residues
MNATQSQDRERFVKLGQHAIDYFYKGPVLHIQPKEQLKAYPQKLTDRLIHFAKVKPYHTFAAKRNTQDEWIRLSYAETLQ
RAWHIAQALHQRNLSQERPLVILSGNDLEHLTLSMGAMLAGVPFSAISPAYSLVSQDFGKLKHVFDVLTPGMVYANDGQA
FAKAIQSCTQDHIEIVTNKGIIGDQVCTSFQSLLDTPVTDVQEHYETLDEHQIAKFLFTSGSTKLPKAVPTTHLMLCINQ
QMLLQTFPEFEDTPPVLLDWLSWHHTFGGSHNVGIALYNGGTIYIDDGKPVPGKFDETIRNLKEISPTVYLNVPKGWEEL
TDALEKDAELRDRFFANVKILFFAGAALSEAGWNRLDKIAQAHCGEKIRIMSGLGMTETAPSCAFTTGPRVMAGFIGYPA
PGCEIKLVPYGDKLEFCVRGKHVMKGYWRLKADQQSTIFDEDGFFHTGDAVRLVDPNDPAQGLMYDGRIAEDFKLNTGTF
VNVGTLRNKALIQGNLLIQDVCITGSNLNAIGFLVFPKLDACADFAGLNMKNHSAIDILQHPKVQQWFRQFLIQYNKDAT
GSSNRVSMLYLMTEAPQLDAGEVTDKGNLNQSNILKRRAALVEELYNKQTDNPLIVRIPVLNHS
>Mature_624_residues
MNATQSQDRERFVKLGQHAIDYFYKGPVLHIQPKEQLKAYPQKLTDRLIHFAKVKPYHTFAAKRNTQDEWIRLSYAETLQ
RAWHIAQALHQRNLSQERPLVILSGNDLEHLTLSMGAMLAGVPFSAISPAYSLVSQDFGKLKHVFDVLTPGMVYANDGQA
FAKAIQSCTQDHIEIVTNKGIIGDQVCTSFQSLLDTPVTDVQEHYETLDEHQIAKFLFTSGSTKLPKAVPTTHLMLCINQ
QMLLQTFPEFEDTPPVLLDWLSWHHTFGGSHNVGIALYNGGTIYIDDGKPVPGKFDETIRNLKEISPTVYLNVPKGWEEL
TDALEKDAELRDRFFANVKILFFAGAALSEAGWNRLDKIAQAHCGEKIRIMSGLGMTETAPSCAFTTGPRVMAGFIGYPA
PGCEIKLVPYGDKLEFCVRGKHVMKGYWRLKADQQSTIFDEDGFFHTGDAVRLVDPNDPAQGLMYDGRIAEDFKLNTGTF
VNVGTLRNKALIQGNLLIQDVCITGSNLNAIGFLVFPKLDACADFAGLNMKNHSAIDILQHPKVQQWFRQFLIQYNKDAT
GSSNRVSMLYLMTEAPQLDAGEVTDKGNLNQSNILKRRAALVEELYNKQTDNPLIVRIPVLNHS

Specific function: Esterification, Concomitant With Transport, Of Exogenous Long-Chain Fatty Acids Into Metabolically Active CoA Thioesters For Subsequent Degradation Or Incorporation Into Phospholipids. [C]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI57165412, Length=441, Percent_Identity=24.0362811791383, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI57165410, Length=442, Percent_Identity=24.2081447963801, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1788107, Length=247, Percent_Identity=25.5060728744939, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI161076582, Length=399, Percent_Identity=24.812030075188, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24653035, Length=399, Percent_Identity=24.812030075188, Blast_Score=80, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 69858; Mature: 69858

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNATQSQDRERFVKLGQHAIDYFYKGPVLHIQPKEQLKAYPQKLTDRLIHFAKVKPYHTF
CCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHH
AAKRNTQDEWIRLSYAETLQRAWHIAQALHQRNLSQERPLVILSGNDLEHLTLSMGAMLA
HHCCCCHHHHEEEHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHH
GVPFSAISPAYSLVSQDFGKLKHVFDVLTPGMVYANDGQAFAKAIQSCTQDHIEIVTNKG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHEEEECCC
IIGDQVCTSFQSLLDTPVTDVQEHYETLDEHQIAKFLFTSGSTKLPKAVPTTHLMLCINQ
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCH
QMLLQTFPEFEDTPPVLLDWLSWHHTFGGSHNVGIALYNGGTIYIDDGKPVPGKFDETIR
HHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCEEEECCCCCCCCCHHHHHH
NLKEISPTVYLNVPKGWEELTDALEKDAELRDRFFANVKILFFAGAALSEAGWNRLDKIA
HHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCEEEEEEECCHHHHHHHHHHHHHH
QAHCGEKIRIMSGLGMTETAPSCAFTTGPRVMAGFIGYPAPGCEIKLVPYGDKLEFCVRG
HHHCCCEEEEEECCCCCCCCCCCEECCCCHHHHHHCCCCCCCCEEEEEECCCCCHHHHCC
KHVMKGYWRLKADQQSTIFDEDGFFHTGDAVRLVDPNDPAQGLMYDGRIAEDFKLNTGTF
CHHHHHHHEEECCCCCCEECCCCCEECCCEEEEECCCCCCCCCEECCEECCCEECCCCCE
VNVGTLRNKALIQGNLLIQDVCITGSNLNAIGFLVFPKLDACADFAGLNMKNHSAIDILQ
EEECCCCCCEEEECCEEEEEEEEECCCCCEEEEEEECCHHHHHHHHCCCCCCCCHHHHHC
HPKVQQWFRQFLIQYNKDATGSSNRVSMLYLMTEAPQLDAGEVTDKGNLNQSNILKRRAA
CCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH
LVEELYNKQTDNPLIVRIPVLNHS
HHHHHHHCCCCCCEEEEEECCCCC
>Mature Secondary Structure
MNATQSQDRERFVKLGQHAIDYFYKGPVLHIQPKEQLKAYPQKLTDRLIHFAKVKPYHTF
CCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHH
AAKRNTQDEWIRLSYAETLQRAWHIAQALHQRNLSQERPLVILSGNDLEHLTLSMGAMLA
HHCCCCHHHHEEEHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHH
GVPFSAISPAYSLVSQDFGKLKHVFDVLTPGMVYANDGQAFAKAIQSCTQDHIEIVTNKG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHEEEECCC
IIGDQVCTSFQSLLDTPVTDVQEHYETLDEHQIAKFLFTSGSTKLPKAVPTTHLMLCINQ
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCH
QMLLQTFPEFEDTPPVLLDWLSWHHTFGGSHNVGIALYNGGTIYIDDGKPVPGKFDETIR
HHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCEEEECCCCCCCCCHHHHHH
NLKEISPTVYLNVPKGWEELTDALEKDAELRDRFFANVKILFFAGAALSEAGWNRLDKIA
HHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCEEEEEEECCHHHHHHHHHHHHHH
QAHCGEKIRIMSGLGMTETAPSCAFTTGPRVMAGFIGYPAPGCEIKLVPYGDKLEFCVRG
HHHCCCEEEEEECCCCCCCCCCCEECCCCHHHHHHCCCCCCCCEEEEEECCCCCHHHHCC
KHVMKGYWRLKADQQSTIFDEDGFFHTGDAVRLVDPNDPAQGLMYDGRIAEDFKLNTGTF
CHHHHHHHEEECCCCCCEECCCCCEECCCEEEEECCCCCCCCCEECCEECCCEECCCCCE
VNVGTLRNKALIQGNLLIQDVCITGSNLNAIGFLVFPKLDACADFAGLNMKNHSAIDILQ
EEECCCCCCEEEECCEEEEEEEEECCCCCEEEEEEECCHHHHHHHHCCCCCCCCHHHHHC
HPKVQQWFRQFLIQYNKDATGSSNRVSMLYLMTEAPQLDAGEVTDKGNLNQSNILKRRAA
CCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH
LVEELYNKQTDNPLIVRIPVLNHS
HHHHHHHCCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]