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The map label for this gene is dcaS [H]

Identifier: 50084840

GI number: 50084840

Start: 1688853

End: 1689698

Strand: Direct

Name: dcaS [H]

Synonym: ACIAD1684

Alternate gene names: 50084840

Gene position: 1688853-1689698 (Clockwise)

Preceding gene: 50084839

Following gene: 50084842

Centisome position: 46.93

GC content: 41.61

Gene sequence:

>846_bases
ATGACAGATTTAAATGAAACAGAGCAAACCGAAAAATTATTAGTGCCTTCACGACATGAATTGCTCCATCCAATTGAAGA
CATGCAGGATGAAGATGATCGTCAGTTTATTACTGCGCTTGCGCGCGGTCTGGAGCTTTTACGCTGTTTTTCTGCCAAGC
AACCGCATTTGGGAAATCAGGAATTATCGCAAATGACGGGTTTGCCAAAGCCGACCATTACACGCCTGACACATACTTTG
TCGCGTCTGGGTTATATTCGTCAAGTTCCTAATTCTACTAAATTTCAATTATCAGTGGGGGTCTTGGCATTTGGCTACTC
GATGTTATCCAATGTCTCGATTCGTTCGATAGCACAGCCCTATATGAAAGAGCTGGCAGATTATGCAGGCGCTGCGGTAG
CGATGTCTACTCGTGACCGACTAAATATGATCTATCTGGATGTCGTACAGGGCAAAGGCAATGTCACTATGCGTCGTCAG
GTGGGAACTTATTTGCCCATTCATTTAAGTTCAATGGGGCGTGCCTGTTTAGCCGCTATGCCTGAGGATGAGCGTGATTT
TTTATTAAATGCAATTCGTCATAAGCATAAAGAAGACTGGATTAAAATTAACCGTGATCTAGATAAAGCGTTTAAAGATT
ATCAAGATTTTGGCTACTGTTTTTCGATTGGTGATTGGCATAAAGATGTCAATTCAGTTGCGGTACCTTTATTACACGAA
CAACATGGCTTATTAGTCTTTAACTGTGGTGGGCCAAGCTTCATAATGAAACGTGAAAAACTGGAAGAAGATATCGCACC
ACGTCTATTGCACATGGTCAACAACATTAAAACCGAAATTAGTTAA

Upstream 100 bases:

>100_bases
ATTATACGTTTTATTACGTGCTTGTTTTGCTATGACAACAACAAATAGATTATAATTTTCGCAATGCGAAATATTAATTG
AGTTGAGTATACTCTTTCCT

Downstream 100 bases:

>100_bases
AAAATATCGCAAAATGCGTACGCCAGTAATATTCCATTCAATATTACTGGTTTTTATTTAATGGAACATGAGATATTGGT
GCAAGCCTTGCATCACGAAA

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MTDLNETEQTEKLLVPSRHELLHPIEDMQDEDDRQFITALARGLELLRCFSAKQPHLGNQELSQMTGLPKPTITRLTHTL
SRLGYIRQVPNSTKFQLSVGVLAFGYSMLSNVSIRSIAQPYMKELADYAGAAVAMSTRDRLNMIYLDVVQGKGNVTMRRQ
VGTYLPIHLSSMGRACLAAMPEDERDFLLNAIRHKHKEDWIKINRDLDKAFKDYQDFGYCFSIGDWHKDVNSVAVPLLHE
QHGLLVFNCGGPSFIMKREKLEEDIAPRLLHMVNNIKTEIS

Sequences:

>Translated_281_residues
MTDLNETEQTEKLLVPSRHELLHPIEDMQDEDDRQFITALARGLELLRCFSAKQPHLGNQELSQMTGLPKPTITRLTHTL
SRLGYIRQVPNSTKFQLSVGVLAFGYSMLSNVSIRSIAQPYMKELADYAGAAVAMSTRDRLNMIYLDVVQGKGNVTMRRQ
VGTYLPIHLSSMGRACLAAMPEDERDFLLNAIRHKHKEDWIKINRDLDKAFKDYQDFGYCFSIGDWHKDVNSVAVPLLHE
QHGLLVFNCGGPSFIMKREKLEEDIAPRLLHMVNNIKTEIS
>Mature_280_residues
TDLNETEQTEKLLVPSRHELLHPIEDMQDEDDRQFITALARGLELLRCFSAKQPHLGNQELSQMTGLPKPTITRLTHTLS
RLGYIRQVPNSTKFQLSVGVLAFGYSMLSNVSIRSIAQPYMKELADYAGAAVAMSTRDRLNMIYLDVVQGKGNVTMRRQV
GTYLPIHLSSMGRACLAAMPEDERDFLLNAIRHKHKEDWIKINRDLDKAFKDYQDFGYCFSIGDWHKDVNSVAVPLLHEQ
HGLLVFNCGGPSFIMKREKLEEDIAPRLLHMVNNIKTEIS

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1786468, Length=203, Percent_Identity=25.615763546798, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI87082359, Length=192, Percent_Identity=28.6458333333333, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788131, Length=223, Percent_Identity=23.7668161434978, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI145693096, Length=223, Percent_Identity=25.1121076233184, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1789999, Length=155, Percent_Identity=29.0322580645161, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 32026; Mature: 31895

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLNETEQTEKLLVPSRHELLHPIEDMQDEDDRQFITALARGLELLRCFSAKQPHLGNQ
CCCCCCHHHHHHHCCCCHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
ELSQMTGLPKPTITRLTHTLSRLGYIRQVPNSTKFQLSVGVLAFGYSMLSNVSIRSIAQP
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHCCHHHHHHHH
YMKELADYAGAAVAMSTRDRLNMIYLDVVQGKGNVTMRRQVGTYLPIHLSSMGRACLAAM
HHHHHHHHCCCEEEECCHHHCEEEEEEEEECCCCEEEHHHCCCCCCEEHHHHHHHHHHCC
PEDERDFLLNAIRHKHKEDWIKINRDLDKAFKDYQDFGYCFSIGDWHKDVNSVAVPLLHE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHEEC
QHGLLVFNCGGPSFIMKREKLEEDIAPRLLHMVNNIKTEIS
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TDLNETEQTEKLLVPSRHELLHPIEDMQDEDDRQFITALARGLELLRCFSAKQPHLGNQ
CCCCCHHHHHHHCCCCHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
ELSQMTGLPKPTITRLTHTLSRLGYIRQVPNSTKFQLSVGVLAFGYSMLSNVSIRSIAQP
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHCCHHHHHHHH
YMKELADYAGAAVAMSTRDRLNMIYLDVVQGKGNVTMRRQVGTYLPIHLSSMGRACLAAM
HHHHHHHHCCCEEEECCHHHCEEEEEEEEECCCCEEEHHHCCCCCCEEHHHHHHHHHHCC
PEDERDFLLNAIRHKHKEDWIKINRDLDKAFKDYQDFGYCFSIGDWHKDVNSVAVPLLHE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHEEC
QHGLLVFNCGGPSFIMKREKLEEDIAPRLLHMVNNIKTEIS
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]