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The map label for this gene is gcdH [H]

Identifier: 50084817

GI number: 50084817

Start: 1658940

End: 1660166

Strand: Direct

Name: gcdH [H]

Synonym: ACIAD1660

Alternate gene names: 50084817

Gene position: 1658940-1660166 (Clockwise)

Preceding gene: 50084815

Following gene: 50084818

Centisome position: 46.1

GC content: 41.73

Gene sequence:

>1227_bases
ATGAATCAAATGGTCGATAAAGTAACAAAATCAGGACGTGTTCATTTTAATTGGGAAGATCCCTTTTTGCTTGAGCAACA
ATTATCAGAAGAAGAACGTATGATTCGTGATAGTGCCTTTGCATATTGTCAAGATAAATTGATGCAGCGTGTACTAGAAC
AATTTCGTCATGAAAAAACTGATCCAAATATTTTTCGTGAAATGGGAGAGCTTGGTCTACTTGGACCAACAATTCCCGAA
CAATATGGTGGGGCTGGTTTAAACTATGTCAGTTATGGATTGATCGCTCGTGAAATTGAACGTGTTGACTCTGGTTATCG
CTCCATGGCAAGTGTACAAAGCTCTTTGGTGATGGTTCCAATTAACGAGTTTGGTACAGAAGAACAAAAACAGAAATATT
TACCTAAATTGGCTACAGGTGAATATATTGGATGTTTTGGTTTAACCGAACCAGATCATGGCTCCGATCCAGGAAGTATG
ATCACACGCGCCAAAAAAGTAGAGGGTGGATACCGACTTACAGGGGCGAAAATGTGGATTACAAATAGTCCAATCGCCGA
TGTATTTGTGGTGTGGGCAAAAGAAGTATCGAGTGAAGGTCATGTGGGTGAAATTCGTGGCTTTATTTTAGAGAAAGGAT
GGGATGGACTTTCTGCACCAGCCATACATGGCAAGGTTGGTTTACGAGCGTCAATTACAGGCGAAATTGTAATGGATAAT
GTATTTGTGCCTGAAGAAAATGCATTTCCCGAAGTTCGTGGACTAAAAGGTCCCTTTACCTGTTTAAACAGTGCCCGCTA
TGGAATTGCCTGGGGAGCAATGGGAGCCGCCGAATTCTGTTGGCATACTGCACGCCAATATACACTTGATCGTAAACAAT
TTGGCCGCCCATTGGCCGCAAACCAACTAATTCAGAAAAAGCTTGCCGATATGCAGACTGAAATTAGTCTGGGATTACAA
GTAGCTTTGCGTTTTGGGCGTATGAAAGATGAAGGTATTGCAGCGGTTGAGGGTACTTCTTTAATTAAGCGTAACAATTG
TGGGAAAGCATTAGAAATTGCTCGTCTGGCAAGAGATATGATGGGCGGGAATGGAATCAGTGATGAATTTGGTGTAGCAC
GTCATCTTGTTAATCTTGAAGTTGTAAATACTTATGAGGGAACACACGATGTACATGCACTTATTCTTGGGCGTGCCCAA
ACGGGTATCGCTGCTTTTAGTAACTAA

Upstream 100 bases:

>100_bases
ATGTGTAAATGGAATAACTGTATGCGAAATTAACGTTTGCTATGAGAAATTTGAAATCGTAATATGAGGCTATAACTTAA
TTGAATACGCTAGGGAAGCA

Downstream 100 bases:

>100_bases
ATCCATTTAAATAATCAAGATTCAATGATTAGGGATTCACAAAGACATGTGAATCCCTAAATTTCATTTGAGTAAACAAG
ATTAGCTTCGACATATTTTT

Product: glutaryl-CoA dehydrogenase

Products: crotonoyl-CoA; CO2; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MNQMVDKVTKSGRVHFNWEDPFLLEQQLSEEERMIRDSAFAYCQDKLMQRVLEQFRHEKTDPNIFREMGELGLLGPTIPE
QYGGAGLNYVSYGLIAREIERVDSGYRSMASVQSSLVMVPINEFGTEEQKQKYLPKLATGEYIGCFGLTEPDHGSDPGSM
ITRAKKVEGGYRLTGAKMWITNSPIADVFVVWAKEVSSEGHVGEIRGFILEKGWDGLSAPAIHGKVGLRASITGEIVMDN
VFVPEENAFPEVRGLKGPFTCLNSARYGIAWGAMGAAEFCWHTARQYTLDRKQFGRPLAANQLIQKKLADMQTEISLGLQ
VALRFGRMKDEGIAAVEGTSLIKRNNCGKALEIARLARDMMGGNGISDEFGVARHLVNLEVVNTYEGTHDVHALILGRAQ
TGIAAFSN

Sequences:

>Translated_408_residues
MNQMVDKVTKSGRVHFNWEDPFLLEQQLSEEERMIRDSAFAYCQDKLMQRVLEQFRHEKTDPNIFREMGELGLLGPTIPE
QYGGAGLNYVSYGLIAREIERVDSGYRSMASVQSSLVMVPINEFGTEEQKQKYLPKLATGEYIGCFGLTEPDHGSDPGSM
ITRAKKVEGGYRLTGAKMWITNSPIADVFVVWAKEVSSEGHVGEIRGFILEKGWDGLSAPAIHGKVGLRASITGEIVMDN
VFVPEENAFPEVRGLKGPFTCLNSARYGIAWGAMGAAEFCWHTARQYTLDRKQFGRPLAANQLIQKKLADMQTEISLGLQ
VALRFGRMKDEGIAAVEGTSLIKRNNCGKALEIARLARDMMGGNGISDEFGVARHLVNLEVVNTYEGTHDVHALILGRAQ
TGIAAFSN
>Mature_408_residues
MNQMVDKVTKSGRVHFNWEDPFLLEQQLSEEERMIRDSAFAYCQDKLMQRVLEQFRHEKTDPNIFREMGELGLLGPTIPE
QYGGAGLNYVSYGLIAREIERVDSGYRSMASVQSSLVMVPINEFGTEEQKQKYLPKLATGEYIGCFGLTEPDHGSDPGSM
ITRAKKVEGGYRLTGAKMWITNSPIADVFVVWAKEVSSEGHVGEIRGFILEKGWDGLSAPAIHGKVGLRASITGEIVMDN
VFVPEENAFPEVRGLKGPFTCLNSARYGIAWGAMGAAEFCWHTARQYTLDRKQFGRPLAANQLIQKKLADMQTEISLGLQ
VALRFGRMKDEGIAAVEGTSLIKRNNCGKALEIARLARDMMGGNGISDEFGVARHLVNLEVVNTYEGTHDVHALILGRAQ
TGIAAFSN

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=404, Percent_Identity=64.3564356435644, Blast_Score=522, Evalue=1e-148,
Organism=Homo sapiens, GI7669494, Length=383, Percent_Identity=63.4464751958225, Blast_Score=486, Evalue=1e-137,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=33.2446808510638, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI226958414, Length=344, Percent_Identity=33.4302325581395, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI4557233, Length=373, Percent_Identity=31.3672922252011, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI4501859, Length=368, Percent_Identity=30.1630434782609, Blast_Score=175, Evalue=9e-44,
Organism=Homo sapiens, GI76496475, Length=396, Percent_Identity=30.8080808080808, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI4557235, Length=396, Percent_Identity=30.8080808080808, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI21361497, Length=342, Percent_Identity=33.0409356725146, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI7656849, Length=376, Percent_Identity=30.5851063829787, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI4557231, Length=375, Percent_Identity=28.8, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI187960098, Length=375, Percent_Identity=28.8, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI4501857, Length=384, Percent_Identity=27.6041666666667, Blast_Score=127, Evalue=1e-29,
Organism=Escherichia coli, GI1786223, Length=344, Percent_Identity=26.7441860465116, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI87081958, Length=378, Percent_Identity=25.1322751322751, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI87081702, Length=154, Percent_Identity=32.4675324675325, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17534353, Length=405, Percent_Identity=61.4814814814815, Blast_Score=505, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI17508101, Length=390, Percent_Identity=32.8205128205128, Blast_Score=190, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI17506239, Length=366, Percent_Identity=31.6939890710383, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17538396, Length=341, Percent_Identity=34.0175953079179, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71990804, Length=289, Percent_Identity=35.2941176470588, Blast_Score=164, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17569725, Length=379, Percent_Identity=29.8153034300792, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71985184, Length=369, Percent_Identity=30.6233062330623, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17534899, Length=375, Percent_Identity=29.0666666666667, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI32563615, Length=232, Percent_Identity=35.7758620689655, Blast_Score=142, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI71985192, Length=298, Percent_Identity=31.5436241610738, Blast_Score=141, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=31.3868613138686, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17570075, Length=378, Percent_Identity=26.4550264550265, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17533517, Length=377, Percent_Identity=25.4641909814324, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17505929, Length=383, Percent_Identity=25.065274151436, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17551932, Length=379, Percent_Identity=24.2744063324538, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI19920834, Length=410, Percent_Identity=59.5121951219512, Blast_Score=481, Evalue=1e-136,
Organism=Drosophila melanogaster, GI24666513, Length=372, Percent_Identity=32.258064516129, Blast_Score=195, Evalue=4e-50,
Organism=Drosophila melanogaster, GI21356377, Length=371, Percent_Identity=31.5363881401617, Blast_Score=191, Evalue=7e-49,
Organism=Drosophila melanogaster, GI24646207, Length=373, Percent_Identity=31.6353887399464, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI21355753, Length=377, Percent_Identity=31.5649867374005, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI281363737, Length=355, Percent_Identity=31.830985915493, Blast_Score=158, Evalue=6e-39,
Organism=Drosophila melanogaster, GI24660351, Length=383, Percent_Identity=31.0704960835509, Blast_Score=152, Evalue=6e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.7

Molecular weight: Translated: 45144; Mature: 45144

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQMVDKVTKSGRVHFNWEDPFLLEQQLSEEERMIRDSAFAYCQDKLMQRVLEQFRHEKT
CCHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DPNIFREMGELGLLGPTIPEQYGGAGLNYVSYGLIAREIERVDSGYRSMASVQSSLVMVP
CHHHHHHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEE
INEFGTEEQKQKYLPKLATGEYIGCFGLTEPDHGSDPGSMITRAKKVEGGYRLTGAKMWI
CHHHCCHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCEEEECEEEEE
TNSPIADVFVVWAKEVSSEGHVGEIRGFILEKGWDGLSAPAIHGKVGLRASITGEIVMDN
ECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCEEEECC
VFVPEENAFPEVRGLKGPFTCLNSARYGIAWGAMGAAEFCWHTARQYTLDRKQFGRPLAA
EECCCCCCCCHHCCCCCCHHHHCCCCCCEEECCCHHHHHHHHHHHHHCCCHHHHCCCHHH
NQLIQKKLADMQTEISLGLQVALRFGRMKDEGIAAVEGTSLIKRNNCGKALEIARLARDM
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCHHHHCCCCCHHHHHHHHHHHH
MGGNGISDEFGVARHLVNLEVVNTYEGTHDVHALILGRAQTGIAAFSN
HCCCCCCHHHHHHHHHHEEEEEECCCCCHHEEHHEEECCCCCCCCCCC
>Mature Secondary Structure
MNQMVDKVTKSGRVHFNWEDPFLLEQQLSEEERMIRDSAFAYCQDKLMQRVLEQFRHEKT
CCHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DPNIFREMGELGLLGPTIPEQYGGAGLNYVSYGLIAREIERVDSGYRSMASVQSSLVMVP
CHHHHHHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEE
INEFGTEEQKQKYLPKLATGEYIGCFGLTEPDHGSDPGSMITRAKKVEGGYRLTGAKMWI
CHHHCCHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCEEEECEEEEE
TNSPIADVFVVWAKEVSSEGHVGEIRGFILEKGWDGLSAPAIHGKVGLRASITGEIVMDN
ECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCEEEECC
VFVPEENAFPEVRGLKGPFTCLNSARYGIAWGAMGAAEFCWHTARQYTLDRKQFGRPLAA
EECCCCCCCCHHCCCCCCHHHHCCCCCCEEECCCHHHHHHHHHHHHHCCCHHHHCCCHHH
NQLIQKKLADMQTEISLGLQVALRFGRMKDEGIAAVEGTSLIKRNNCGKALEIARLARDM
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCHHHHCCCCCHHHHHHHHHHHH
MGGNGISDEFGVARHLVNLEVVNTYEGTHDVHALILGRAQTGIAAFSN
HCCCCCCHHHHHHHHHHEEEEEECCCCCHHEEHHEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutaryl-CoA; acceptor

Specific reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]