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The map label for this gene is silR [H]

Identifier: 50084792

GI number: 50084792

Start: 1631169

End: 1631855

Strand: Reverse

Name: silR [H]

Synonym: ACIAD1634

Alternate gene names: 50084792

Gene position: 1631855-1631169 (Counterclockwise)

Preceding gene: 50084793

Following gene: 50084782

Centisome position: 45.35

GC content: 41.05

Gene sequence:

>687_bases
ATGGGTCAGCATTTTATTCTTATTGTCGAAGATCATTTCGAACTAGCTGCAACGGTATGTGAATTTCTGGAAACACATGG
TTATGTCGTTGATCATGCGCGCAATTTAGATGCAGCCCGCACGCGATTAAAATCACAGCCTTATCATTTATTACTTTTAG
ACATCAATTTACCTGATGGTTCAGGATATAGTCTATGTGACTGGTTACGTGTCGAGCAAGGACTGGATTTGCCTGTATTG
ATGCTGACAGCCCGAGATACTGTCGGTGATAAACTTAAAGGTTTCTCAGCAGGTGCTGACGATTACTTGGTCAAACCTTT
TGATTTTAATGAACTGGTTGCCCGTATTCGTGCGCTCATCAAACGCGCTTCAGGTGAAGTGTCTAACACTCAGCTCAAGA
TTCACGATCTTGTATTAGATACCTCGACTCAAACTTTAACCCGAATGGGGCAAACTATCGAACTGCCCCCGATACAATTT
AAATTATTGAAAATCCTGATGCGCCATTCGCCCAAAGTTATTACCAAACAGGAACTTATTATGGAACTTTGGGGCGAAGA
AGAGCCAGAAAGTGATGCCTTACGTAGTCATATCTATAATTTACGTAAAATGATCGATAAACCGTTTCAACAAAAATTGC
TGCATACGGTCTCTGGTGTAGGTTTAAAAATTGCGTTGGACTCTTGA

Upstream 100 bases:

>100_bases
GCTCATGCAAATCATTACTTTAAAATCTGGTTTGGCAGTACTCCATTTAATGTTAAGTTAAAACAACAACTACTAAACTG
ATGAGATAAAAGATTAAGTT

Downstream 100 bases:

>100_bases
GCTTATACAATATTTAGCAGAGATAGACCACCACGATCAATCCTGTGGTATGTGCAAGATTTAATTCCGAATGCGTAGAT
AAATAATATTCACGATCAAA

Product: two-component system sensor protein (ColR-like)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MGQHFILIVEDHFELAATVCEFLETHGYVVDHARNLDAARTRLKSQPYHLLLLDINLPDGSGYSLCDWLRVEQGLDLPVL
MLTARDTVGDKLKGFSAGADDYLVKPFDFNELVARIRALIKRASGEVSNTQLKIHDLVLDTSTQTLTRMGQTIELPPIQF
KLLKILMRHSPKVITKQELIMELWGEEEPESDALRSHIYNLRKMIDKPFQQKLLHTVSGVGLKIALDS

Sequences:

>Translated_228_residues
MGQHFILIVEDHFELAATVCEFLETHGYVVDHARNLDAARTRLKSQPYHLLLLDINLPDGSGYSLCDWLRVEQGLDLPVL
MLTARDTVGDKLKGFSAGADDYLVKPFDFNELVARIRALIKRASGEVSNTQLKIHDLVLDTSTQTLTRMGQTIELPPIQF
KLLKILMRHSPKVITKQELIMELWGEEEPESDALRSHIYNLRKMIDKPFQQKLLHTVSGVGLKIALDS
>Mature_227_residues
GQHFILIVEDHFELAATVCEFLETHGYVVDHARNLDAARTRLKSQPYHLLLLDINLPDGSGYSLCDWLRVEQGLDLPVLM
LTARDTVGDKLKGFSAGADDYLVKPFDFNELVARIRALIKRASGEVSNTQLKIHDLVLDTSTQTLTRMGQTIELPPIQFK
LLKILMRHSPKVITKQELIMELWGEEEPESDALRSHIYNLRKMIDKPFQQKLLHTVSGVGLKIALDS

Specific function: Component of the sil cation-efflux system that confers resistance to silver. Probable member of a two-component regulatory system silS/silR [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=217, Percent_Identity=35.9447004608295, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=34.6846846846847, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=34.8623853211009, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=33.4841628959276, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1790552, Length=217, Percent_Identity=35.9447004608295, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=33.4821428571429, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1787375, Length=217, Percent_Identity=32.7188940092166, Blast_Score=110, Evalue=5e-26,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=30.5309734513274, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1789809, Length=224, Percent_Identity=29.9107142857143, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI2367329, Length=225, Percent_Identity=36.4444444444444, Blast_Score=100, Evalue=6e-23,
Organism=Escherichia coli, GI1790860, Length=204, Percent_Identity=30.3921568627451, Blast_Score=94, Evalue=6e-21,
Organism=Escherichia coli, GI1790863, Length=232, Percent_Identity=30.6034482758621, Blast_Score=87, Evalue=6e-19,
Organism=Escherichia coli, GI1787229, Length=230, Percent_Identity=28.695652173913, Blast_Score=87, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25841; Mature: 25710

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQHFILIVEDHFELAATVCEFLETHGYVVDHARNLDAARTRLKSQPYHLLLLDINLPDG
CCCEEEEEEECHHHHHHHHHHHHHHCCEEEEHHCCCHHHHHHHCCCCEEEEEEEEECCCC
SGYSLCDWLRVEQGLDLPVLMLTARDTVGDKLKGFSAGADDYLVKPFDFNELVARIRALI
CCCHHHHHHHHHCCCCCCEEEEEECCHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHH
KRASGEVSNTQLKIHDLVLDTSTQTLTRMGQTIELPPIQFKLLKILMRHSPKVITKQELI
HHHCCCCCCCEEEEEEEEECCCHHHHHHCCCEECCCCHHHHHHHHHHHCCCCCHHHHHHH
MELWGEEEPESDALRSHIYNLRKMIDKPFQQKLLHTVSGVGLKIALDS
HHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEECC
>Mature Secondary Structure 
GQHFILIVEDHFELAATVCEFLETHGYVVDHARNLDAARTRLKSQPYHLLLLDINLPDG
CCEEEEEEECHHHHHHHHHHHHHHCCEEEEHHCCCHHHHHHHCCCCEEEEEEEEECCCC
SGYSLCDWLRVEQGLDLPVLMLTARDTVGDKLKGFSAGADDYLVKPFDFNELVARIRALI
CCCHHHHHHHHHCCCCCCEEEEEECCHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHH
KRASGEVSNTQLKIHDLVLDTSTQTLTRMGQTIELPPIQFKLLKILMRHSPKVITKQELI
HHHCCCCCCCEEEEEEEEECCCHHHHHHCCCEECCCCHHHHHHHHHHHCCCCCHHHHHHH
MELWGEEEPESDALRSHIYNLRKMIDKPFQQKLLHTVSGVGLKIALDS
HHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9930866 [H]