Click here to switch to the map view.

The map label for this gene is ispU

Identifier: 50084552

GI number: 50084552

Start: 1369305

End: 1370054

Strand: Direct

Name: ispU

Synonym: ACIAD1374

Alternate gene names: 50084552

Gene position: 1369305-1370054 (Clockwise)

Preceding gene: 50084551

Following gene: 50084553

Centisome position: 38.05

GC content: 39.07

Gene sequence:

>750_bases
ATGACCCTGTCTGAAGAAAGTCATCTTCCAAAACATGTTGCCATCATTATGGATGGCAACAATCGTTTTGCTAAAAAAAA
TCAGATGCAAAAAGGAGATGGGCACCGTGAAGGGAAAAACAGCTTAGATCCGATTGTTGAACATTGTTGTACTCGAGGTG
TTCAGGCGCTTACAGTTTTTGCTTTTTCCAGTGAAAATTGGAATCGTCCAGCTTTTGAGGTTGATCTATTAATGAAATTG
CTTGAAGAGGCAATTCATGAACAATTACCTCGAATGAGAAAGTTCAATATTGCCCTGCGTTTCATTGGTGATCGTTCAAA
ATTGTCAGAACATCTAACAGATTTGATGACTCACGCCGAAAATGAAACTGCTCATTTCACAAGTATGACTTTAACTATCG
CAATCAGTTATGGTGGCATGTGGGATATCACTGATGCTGCGAAGCAAATCGCGAAAGATGTCAGTGATGGAATTGTAGAT
ATAGAGCAAATCGATACACATTTATTTGGCCGATATGTAAGTTTGAATCAACTTCCTCCCGTCGATCTGTTAATTCGTAC
AGGTGGTGATTATCGCTTATCTAACTTTTTGCTTTGGCAAGCAGCTTATGCTGAGCTGTATTTTACTGAAACTTTGTGGC
CTGAGTTTTCAATAGATGAGTTTGACCATGCTTTAGCAGTGTTTGCTGGACGCGAACGCCGTTTTGGAAAAACTTCAGAG
CAAATCCAACAAGATAAAATTGAGAATTAA

Upstream 100 bases:

>100_bases
CGTGCAGGTGATGATATTCAAAAAATTACCGATAAATATGTTGCTGAAGTAGACAAGCGCTTAGCAGCAAAAGAAGCAGA
ACTGATGAAGGTCTAATTTG

Downstream 100 bases:

>100_bases
TAATGTTAGAGCGGATTGTAACCGCGTTGGTGTTAGTAGCAGTTGTTTTAATTTGTATGTTTGCTACCCAATCGCATTAT
CCAATGTTTGGATTAATGAT

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MTLSEESHLPKHVAIIMDGNNRFAKKNQMQKGDGHREGKNSLDPIVEHCCTRGVQALTVFAFSSENWNRPAFEVDLLMKL
LEEAIHEQLPRMRKFNIALRFIGDRSKLSEHLTDLMTHAENETAHFTSMTLTIAISYGGMWDITDAAKQIAKDVSDGIVD
IEQIDTHLFGRYVSLNQLPPVDLLIRTGGDYRLSNFLLWQAAYAELYFTETLWPEFSIDEFDHALAVFAGRERRFGKTSE
QIQQDKIEN

Sequences:

>Translated_249_residues
MTLSEESHLPKHVAIIMDGNNRFAKKNQMQKGDGHREGKNSLDPIVEHCCTRGVQALTVFAFSSENWNRPAFEVDLLMKL
LEEAIHEQLPRMRKFNIALRFIGDRSKLSEHLTDLMTHAENETAHFTSMTLTIAISYGGMWDITDAAKQIAKDVSDGIVD
IEQIDTHLFGRYVSLNQLPPVDLLIRTGGDYRLSNFLLWQAAYAELYFTETLWPEFSIDEFDHALAVFAGRERRFGKTSE
QIQQDKIEN
>Mature_248_residues
TLSEESHLPKHVAIIMDGNNRFAKKNQMQKGDGHREGKNSLDPIVEHCCTRGVQALTVFAFSSENWNRPAFEVDLLMKLL
EEAIHEQLPRMRKFNIALRFIGDRSKLSEHLTDLMTHAENETAHFTSMTLTIAISYGGMWDITDAAKQIAKDVSDGIVDI
EQIDTHLFGRYVSLNQLPPVDLLIRTGGDYRLSNFLLWQAAYAELYFTETLWPEFSIDEFDHALAVFAGRERRFGKTSEQ
IQQDKIEN

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580738, Length=223, Percent_Identity=35.4260089686099, Blast_Score=155, Evalue=3e-38,
Organism=Homo sapiens, GI45580742, Length=223, Percent_Identity=35.4260089686099, Blast_Score=155, Evalue=3e-38,
Organism=Escherichia coli, GI1786371, Length=238, Percent_Identity=48.3193277310924, Blast_Score=235, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI71993029, Length=214, Percent_Identity=38.3177570093458, Blast_Score=144, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6319474, Length=221, Percent_Identity=38.4615384615385, Blast_Score=130, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6323748, Length=219, Percent_Identity=32.8767123287671, Blast_Score=105, Evalue=7e-24,
Organism=Drosophila melanogaster, GI18857969, Length=235, Percent_Identity=34.468085106383, Blast_Score=130, Evalue=7e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_ACIAD (Q6FCH1)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_046062.1
- ProteinModelPortal:   Q6FCH1
- SMR:   Q6FCH1
- STRING:   Q6FCH1
- GeneID:   2879848
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD1374
- NMPDR:   fig|62977.3.peg.678
- eggNOG:   COG0020
- HOGENOM:   HBG627837
- OMA:   RVRWAGR
- PhylomeDB:   Q6FCH1
- ProtClustDB:   CLSK2516790
- BioCyc:   ASP62977:ACIAD1374-MONOMER
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 28504; Mature: 28372

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 18-18

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSEESHLPKHVAIIMDGNNRFAKKNQMQKGDGHREGKNSLDPIVEHCCTRGVQALTVF
CCCCCCCCCCCEEEEEEECCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEE
AFSSENWNRPAFEVDLLMKLLEEAIHEQLPRMRKFNIALRFIGDRSKLSEHLTDLMTHAE
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHHHCC
NETAHFTSMTLTIAISYGGMWDITDAAKQIAKDVSDGIVDIEQIDTHLFGRYVSLNQLPP
CCCEEEEEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHCCCCCCC
VDLLIRTGGDYRLSNFLLWQAAYAELYFTETLWPEFSIDEFDHALAVFAGRERRFGKTSE
CEEEEECCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCHH
QIQQDKIEN
HHHHHCCCC
>Mature Secondary Structure 
TLSEESHLPKHVAIIMDGNNRFAKKNQMQKGDGHREGKNSLDPIVEHCCTRGVQALTVF
CCCCCCCCCCEEEEEEECCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEE
AFSSENWNRPAFEVDLLMKLLEEAIHEQLPRMRKFNIALRFIGDRSKLSEHLTDLMTHAE
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHHHCC
NETAHFTSMTLTIAISYGGMWDITDAAKQIAKDVSDGIVDIEQIDTHLFGRYVSLNQLPP
CCCEEEEEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHCCCCCCC
VDLLIRTGGDYRLSNFLLWQAAYAELYFTETLWPEFSIDEFDHALAVFAGRERRFGKTSE
CEEEEECCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCHH
QIQQDKIEN
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA