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The map label for this gene is gsk [C]

Identifier: 50084531

GI number: 50084531

Start: 1344998

End: 1346002

Strand: Reverse

Name: gsk [C]

Synonym: ACIAD1351

Alternate gene names: 50084531

Gene position: 1346002-1344998 (Counterclockwise)

Preceding gene: 50084534

Following gene: 50084530

Centisome position: 37.4

GC content: 42.79

Gene sequence:

>1005_bases
ATGGCAACTGTTGATCTTTTTGCAATTGGTAATGCGCTTATTGACCAAGAATTTAAAGTGACTGATCAATTTCTTGGTGA
AGCAGGTTTGCAAAAAGGCACCATGCAATTGACAGATGGTGAAACACAGGCAGCGCTGTACGAAAAATTACAAGCCACAC
AAGACTATAAGGGTCAGGCAAGCGGCGGTTCGGCTGCAAATACCACGGTCGCCTTCAGCTCACTCGGTGGCTCAGCATTT
TATGGATGTCGTGTTGGAAATGATGAACTTGGCGCAATTTATCTCAATGGTTTGAATGATGCAGATATCGTAACGTCTGA
AAAATCACTAACTACAGGCACCACTGGAACGTGTATGGTGCTGATCAGTCCTGATACCGAACGAACCATGCATACCTATC
TTGGTATTACCACTGAATTATCAGAACAGCAAATCGACTATACATCACTAAAAACTGCTCAATGGCTTTATATCGAAGGT
TATCTTTCAACCAGTCCTACGGCCCGTCAAGCTGTGAAACAAGCGCGTAAAATCGCGCGTGAACATGGTGTAAAAATCGC
ACTTTCACTCTCAGATCCAGCTATGGTTCAATACGCACGCGAGGGTTTGGATGAAATGATCGATGATGGTGTCGATGTAT
TATTCTGTAATGAGCAAGAAGCCTTGATGTACACCGAAACTCAAACACTCGATGAAGCTTTTAGTCGTTTAAAACAAAAA
AATCATACTGTGGTTGTTACACAAAGTGCAAAAGGTGCATCTGTTTCAAATCCACATACACATTTTCATTTGAGTGGTCG
CCGTGTTACTGCAATCGATGCCAATGGAGCAGGCGATGCGTTTGCGGGTGCGTTCTTGTTTGCCTTGAATCATGGCATGT
CTCTTGAAGATGCTACTCAGCTTTCTATTCTGATTTCAAGTGAAGTTGTTTCGCAGTATGGTCCACGTTTGGCAGTTGAA
AGTTATGCTACACTGCTCAGAAACTTTCTAACTGAATGTGCTTAA

Upstream 100 bases:

>100_bases
ACTGTACATCAAACTCTGAGATGAATTTAATTCATCAATATACTGCTATTGTGAGCAATAGTGTAAAATTCGCGTTTTTA
AATTTAGATGTGAATATAAC

Downstream 100 bases:

>100_bases
AATGGAAAAGATTTGCATGACGGAAGACATTCCAGAACGTGAAGCGCGTGCATTTGATCATGTACACGGAGAAACCTTTT
TTATTACTCAGCGTGATGGC

Product: sugar kinase protein

Products: ADP; H+; IMP [C]

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MATVDLFAIGNALIDQEFKVTDQFLGEAGLQKGTMQLTDGETQAALYEKLQATQDYKGQASGGSAANTTVAFSSLGGSAF
YGCRVGNDELGAIYLNGLNDADIVTSEKSLTTGTTGTCMVLISPDTERTMHTYLGITTELSEQQIDYTSLKTAQWLYIEG
YLSTSPTARQAVKQARKIAREHGVKIALSLSDPAMVQYAREGLDEMIDDGVDVLFCNEQEALMYTETQTLDEAFSRLKQK
NHTVVVTQSAKGASVSNPHTHFHLSGRRVTAIDANGAGDAFAGAFLFALNHGMSLEDATQLSILISSEVVSQYGPRLAVE
SYATLLRNFLTECA

Sequences:

>Translated_334_residues
MATVDLFAIGNALIDQEFKVTDQFLGEAGLQKGTMQLTDGETQAALYEKLQATQDYKGQASGGSAANTTVAFSSLGGSAF
YGCRVGNDELGAIYLNGLNDADIVTSEKSLTTGTTGTCMVLISPDTERTMHTYLGITTELSEQQIDYTSLKTAQWLYIEG
YLSTSPTARQAVKQARKIAREHGVKIALSLSDPAMVQYAREGLDEMIDDGVDVLFCNEQEALMYTETQTLDEAFSRLKQK
NHTVVVTQSAKGASVSNPHTHFHLSGRRVTAIDANGAGDAFAGAFLFALNHGMSLEDATQLSILISSEVVSQYGPRLAVE
SYATLLRNFLTECA
>Mature_333_residues
ATVDLFAIGNALIDQEFKVTDQFLGEAGLQKGTMQLTDGETQAALYEKLQATQDYKGQASGGSAANTTVAFSSLGGSAFY
GCRVGNDELGAIYLNGLNDADIVTSEKSLTTGTTGTCMVLISPDTERTMHTYLGITTELSEQQIDYTSLKTAQWLYIEGY
LSTSPTARQAVKQARKIAREHGVKIALSLSDPAMVQYAREGLDEMIDDGVDVLFCNEQEALMYTETQTLDEAFSRLKQKN
HTVVVTQSAKGASVSNPHTHFHLSGRRVTAIDANGAGDAFAGAFLFALNHGMSLEDATQLSILISSEVVSQYGPRLAVES
YATLLRNFLTECA

Specific function: Unknown

COG id: COG0524

COG function: function code G; Sugar kinases, ribokinase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the carbohydrate kinase pfkB family [H]

Homologues:

Organism=Homo sapiens, GI32484973, Length=335, Percent_Identity=23.2835820895522, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI32484975, Length=335, Percent_Identity=23.2835820895522, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI11545855, Length=265, Percent_Identity=28.3018867924528, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1786684, Length=223, Percent_Identity=26.0089686098655, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI87081971, Length=248, Percent_Identity=27.0161290322581, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17541820, Length=332, Percent_Identity=25.9036144578313, Blast_Score=85, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6322565, Length=344, Percent_Identity=26.453488372093, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI28571668, Length=333, Percent_Identity=25.2252252252252, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21355521, Length=349, Percent_Identity=24.3553008595989, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011611
- InterPro:   IPR002173 [H]

Pfam domain/function: PF00294 PfkB [H]

EC number: 2.7.1.73 [C]

Molecular weight: Translated: 35978; Mature: 35846

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS00583 PFKB_KINASES_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATVDLFAIGNALIDQEFKVTDQFLGEAGLQKGTMQLTDGETQAALYEKLQATQDYKGQA
CCEEEEEECCHHHHCCHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCC
SGGSAANTTVAFSSLGGSAFYGCRVGNDELGAIYLNGLNDADIVTSEKSLTTGTTGTCMV
CCCCCCCCEEEEECCCCCEEEEEEECCCCEEEEEEECCCCCCEEECCCCCCCCCCCEEEE
LISPDTERTMHTYLGITTELSEQQIDYTSLKTAQWLYIEGYLSTSPTARQAVKQARKIAR
EECCCCCHHHHHHHCEEECCCHHHCCHHHCCCEEEEEEEEEECCCCHHHHHHHHHHHHHH
EHGVKIALSLSDPAMVQYAREGLDEMIDDGVDVLFCNEQEALMYTETQTLDEAFSRLKQK
HCCCEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEHHHHHHHHHHHHHHC
NHTVVVTQSAKGASVSNPHTHFHLSGRRVTAIDANGAGDAFAGAFLFALNHGMSLEDATQ
CCEEEEEECCCCCCCCCCCEEEEECCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCE
LSILISSEVVSQYGPRLAVESYATLLRNFLTECA
EEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ATVDLFAIGNALIDQEFKVTDQFLGEAGLQKGTMQLTDGETQAALYEKLQATQDYKGQA
CEEEEEECCHHHHCCHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCC
SGGSAANTTVAFSSLGGSAFYGCRVGNDELGAIYLNGLNDADIVTSEKSLTTGTTGTCMV
CCCCCCCCEEEEECCCCCEEEEEEECCCCEEEEEEECCCCCCEEECCCCCCCCCCCEEEE
LISPDTERTMHTYLGITTELSEQQIDYTSLKTAQWLYIEGYLSTSPTARQAVKQARKIAR
EECCCCCHHHHHHHCEEECCCHHHCCHHHCCCEEEEEEEEEECCCCHHHHHHHHHHHHHH
EHGVKIALSLSDPAMVQYAREGLDEMIDDGVDVLFCNEQEALMYTETQTLDEAFSRLKQK
HCCCEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEHHHHHHHHHHHHHHC
NHTVVVTQSAKGASVSNPHTHFHLSGRRVTAIDANGAGDAFAGAFLFALNHGMSLEDATQ
CCEEEEEECCCCCCCCCCCEEEEECCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCE
LSILISSEVVSQYGPRLAVESYATLLRNFLTECA
EEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; Inosine [C]

Specific reaction: ATP + Inosine --> ADP + H+ + IMP [C]

General reaction: Phospho group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]