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The map label for this gene is yfnA [H]

Identifier: 50084462

GI number: 50084462

Start: 1276347

End: 1277831

Strand: Direct

Name: yfnA [H]

Synonym: ACIAD1276

Alternate gene names: 50084462

Gene position: 1276347-1277831 (Clockwise)

Preceding gene: 50084461

Following gene: 50084463

Centisome position: 35.47

GC content: 40.4

Gene sequence:

>1485_bases
ATGAAAAATCCCGTGACGTTTAGCCAACGTCTATTACGTAGAAAGCCGATTAATTTTTTAGTACAAGAAACTCAACAAGG
TGGAAAAACTTTAAAAAGATCGCTGACTTTATTTCAACTCACTATGTTTGGTGTCGGCGCGACAATTGGTACAGGTATTT
TTTTCGTACTAAGTGAACAGGTCCCTGTAGCAGGACCAGCAGTTTTAATTTCATTTATTCTTGCTGGAATTACAGCAGGC
TTAACGGCCTTATGTTATGCCGAATTAAGTTCAATGATTCCTGCATCAGGTTCTTCTTATTCATATGCTTATGCAACGCT
TGGTGAAGGTGTCGCATTTTTGGTCGCAGCGTGTCTTATTTTAGAATATGGGGTCTCGGCTGCTGCGGTTGCTATCGGTT
GGAGTGAATATCTTAATAATCTTATTCATAACGTTTTTGGCGTACATTTACCCAACTGGTTGCTTTCAGCTCCTTTTGTT
GCTGATGGATACAAATTACATTTAGGTGGCACCGGACTTATCAATTTACCTGCTGCAATTTTAGTCTTTTTATGCTGTAT
GTTGTTGATGCGTGGAGTAACAGAATCAGCGCGAATCAATGCAGTCATGGTTTTGATTAAACTATGTGTATTGATTTTAT
TTATTTCCATTGCTGCAACAGCATTTAACGCCGAGCATTTGACACCATTTTCTCCACATGGCTTTGCTGGAATTAGTGCA
GCGGCAGGTTCGATTTTTTTTACGTTTATTGGTCTGGATGCTGTATCTACCGCAGGTGAAGAAGTTGAAAATCCGCGTCG
GAATTTACCCTTAGCAATTATTAGTGCCTTATTTGTTGTCATTATTTTTTATATTCTGGTCGCATTAACAGCTTTAGGGG
CTCAAGAACAGGGTTTATTTAAAGGCCAGCAAGCTGGACTTGCGGTAATTTTGCAAGAAATAACAGGCTCTACTTGGCCT
GCAATTATTTTAGCAGCCGGTGCAGTTATTTCGGTATTTTCGATTACCCTTGTCGTTCTTTATGGTCAAACTCGTATTTT
ATTTGCAATGTCGCGTGATGGCCTTGCACCTAAAATCTTTCATCGTGTCAGTACCCAAACCTTAACTCCTAATGCGAATA
CACTCATTGTGGCAGTGATTGTATCAATCATCGCTGGGTTTGTTCCTGCTGATGTATTGTGGGATTTGACCAGTATGGGA
ACACTTATTGCTTTTACTGTAGTGTCCATTGGTGTTTTGGTATTGCGTTATCGCATGCCCGATGCACCACGGGGTTTTAA
GGTTCCTTTTTTTCCTGCACTGCCTGTTTTGAGTATCTGTGCATGTCTATATTTAATATCCAGTCTTTCTGCCATTGTTT
ACGTGATCGCGGCGATCTGGGCAGTTATTGCAGCAACTTATTATTTTTCATGTGCATCCAAAAACTCAGTGCTTGAAGCA
GGATCTGAAGCTTATTCGCATCAGAATGGAGACGATCACCAATGA

Upstream 100 bases:

>100_bases
GCCTAAAAATTGCTATTTGATTTATGGAAGAATCCAAGTTTTCGATATCTATTCAGATGTGTTGAAACTTGGGTAAGCGA
ATATGGATCCTGGGGGAAGT

Downstream 100 bases:

>100_bases
AATTTCTAGTCGGATATTCTAATGATTCAAGTGGTAAAGATGCCCTAAAGTTGGGTGTTGCACTCGCAGAAATGACTCAA
GGAAAGCTGATCGTTTGTCA

Product: amino acid transporter

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MKNPVTFSQRLLRRKPINFLVQETQQGGKTLKRSLTLFQLTMFGVGATIGTGIFFVLSEQVPVAGPAVLISFILAGITAG
LTALCYAELSSMIPASGSSYSYAYATLGEGVAFLVAACLILEYGVSAAAVAIGWSEYLNNLIHNVFGVHLPNWLLSAPFV
ADGYKLHLGGTGLINLPAAILVFLCCMLLMRGVTESARINAVMVLIKLCVLILFISIAATAFNAEHLTPFSPHGFAGISA
AAGSIFFTFIGLDAVSTAGEEVENPRRNLPLAIISALFVVIIFYILVALTALGAQEQGLFKGQQAGLAVILQEITGSTWP
AIILAAGAVISVFSITLVVLYGQTRILFAMSRDGLAPKIFHRVSTQTLTPNANTLIVAVIVSIIAGFVPADVLWDLTSMG
TLIAFTVVSIGVLVLRYRMPDAPRGFKVPFFPALPVLSICACLYLISSLSAIVYVIAAIWAVIAATYYFSCASKNSVLEA
GSEAYSHQNGDDHQ

Sequences:

>Translated_494_residues
MKNPVTFSQRLLRRKPINFLVQETQQGGKTLKRSLTLFQLTMFGVGATIGTGIFFVLSEQVPVAGPAVLISFILAGITAG
LTALCYAELSSMIPASGSSYSYAYATLGEGVAFLVAACLILEYGVSAAAVAIGWSEYLNNLIHNVFGVHLPNWLLSAPFV
ADGYKLHLGGTGLINLPAAILVFLCCMLLMRGVTESARINAVMVLIKLCVLILFISIAATAFNAEHLTPFSPHGFAGISA
AAGSIFFTFIGLDAVSTAGEEVENPRRNLPLAIISALFVVIIFYILVALTALGAQEQGLFKGQQAGLAVILQEITGSTWP
AIILAAGAVISVFSITLVVLYGQTRILFAMSRDGLAPKIFHRVSTQTLTPNANTLIVAVIVSIIAGFVPADVLWDLTSMG
TLIAFTVVSIGVLVLRYRMPDAPRGFKVPFFPALPVLSICACLYLISSLSAIVYVIAAIWAVIAATYYFSCASKNSVLEA
GSEAYSHQNGDDHQ
>Mature_494_residues
MKNPVTFSQRLLRRKPINFLVQETQQGGKTLKRSLTLFQLTMFGVGATIGTGIFFVLSEQVPVAGPAVLISFILAGITAG
LTALCYAELSSMIPASGSSYSYAYATLGEGVAFLVAACLILEYGVSAAAVAIGWSEYLNNLIHNVFGVHLPNWLLSAPFV
ADGYKLHLGGTGLINLPAAILVFLCCMLLMRGVTESARINAVMVLIKLCVLILFISIAATAFNAEHLTPFSPHGFAGISA
AAGSIFFTFIGLDAVSTAGEEVENPRRNLPLAIISALFVVIIFYILVALTALGAQEQGLFKGQQAGLAVILQEITGSTWP
AIILAAGAVISVFSITLVVLYGQTRILFAMSRDGLAPKIFHRVSTQTLTPNANTLIVAVIVSIIAGFVPADVLWDLTSMG
TLIAFTVVSIGVLVLRYRMPDAPRGFKVPFFPALPVLSICACLYLISSLSAIVYVIAAIWAVIAATYYFSCASKNSVLEA
GSEAYSHQNGDDHQ

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of Lysine. [C]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI258645169, Length=450, Percent_Identity=31.3333333333333, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI110347453, Length=421, Percent_Identity=34.6793349168646, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI258614003, Length=450, Percent_Identity=29.7777777777778, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI258614005, Length=450, Percent_Identity=29.7777777777778, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI114326544, Length=438, Percent_Identity=32.648401826484, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI114326550, Length=438, Percent_Identity=32.648401826484, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI4507047, Length=450, Percent_Identity=30.8888888888889, Blast_Score=170, Evalue=4e-42,
Organism=Homo sapiens, GI181337167, Length=435, Percent_Identity=30.8045977011494, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI186910308, Length=423, Percent_Identity=25.7683215130024, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI186910306, Length=423, Percent_Identity=25.7683215130024, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI186910304, Length=423, Percent_Identity=25.7683215130024, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI187423910, Length=453, Percent_Identity=25.1655629139073, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI7657591, Length=453, Percent_Identity=25.1655629139073, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI115648063, Length=448, Percent_Identity=26.5625, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI115648022, Length=448, Percent_Identity=26.5625, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI33286428, Length=418, Percent_Identity=23.6842105263158, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI7657683, Length=385, Percent_Identity=23.1168831168831, Blast_Score=73, Evalue=6e-13,
Organism=Escherichia coli, GI1788480, Length=488, Percent_Identity=25, Blast_Score=103, Evalue=4e-23,
Organism=Escherichia coli, GI87081869, Length=459, Percent_Identity=24.400871459695, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1786302, Length=427, Percent_Identity=24.5901639344262, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI87081708, Length=453, Percent_Identity=23.6203090507726, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI1786789, Length=354, Percent_Identity=24.8587570621469, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI87082023, Length=467, Percent_Identity=24.1970021413276, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI87081915, Length=460, Percent_Identity=23.695652173913, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87082250, Length=456, Percent_Identity=25, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI2367353, Length=354, Percent_Identity=23.728813559322, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1787890, Length=374, Percent_Identity=27.2727272727273, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=400, Percent_Identity=31.25, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17533459, Length=414, Percent_Identity=32.1256038647343, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17531343, Length=423, Percent_Identity=30.7328605200946, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17540018, Length=448, Percent_Identity=26.5625, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17568033, Length=450, Percent_Identity=26.2222222222222, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI32566699, Length=373, Percent_Identity=26.0053619302949, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71993915, Length=409, Percent_Identity=21.5158924205379, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71982608, Length=424, Percent_Identity=22.6415094339623, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71982612, Length=423, Percent_Identity=21.5130023640662, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17537453, Length=328, Percent_Identity=23.780487804878, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24668806, Length=436, Percent_Identity=34.6330275229358, Blast_Score=211, Evalue=8e-55,
Organism=Drosophila melanogaster, GI21356285, Length=436, Percent_Identity=34.6330275229358, Blast_Score=211, Evalue=8e-55,
Organism=Drosophila melanogaster, GI24668802, Length=436, Percent_Identity=34.6330275229358, Blast_Score=211, Evalue=8e-55,
Organism=Drosophila melanogaster, GI221512776, Length=431, Percent_Identity=32.4825986078886, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24666159, Length=431, Percent_Identity=32.2505800464037, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24667468, Length=422, Percent_Identity=31.9905213270142, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI281366235, Length=430, Percent_Identity=30.2325581395349, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI116007820, Length=430, Percent_Identity=30.2325581395349, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI116007818, Length=428, Percent_Identity=31.0747663551402, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI85725152, Length=428, Percent_Identity=31.0747663551402, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI161077963, Length=422, Percent_Identity=29.8578199052133, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI221331183, Length=452, Percent_Identity=25.2212389380531, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17647653, Length=452, Percent_Identity=25.2212389380531, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24664379, Length=452, Percent_Identity=25.2212389380531, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21357367, Length=437, Percent_Identity=25.629290617849, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24641995, Length=212, Percent_Identity=26.8867924528302, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24641993, Length=212, Percent_Identity=26.8867924528302, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR015606 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 52453; Mature: 52453

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNPVTFSQRLLRRKPINFLVQETQQGGKTLKRSLTLFQLTMFGVGATIGTGIFFVLSEQ
CCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
VPVAGPAVLISFILAGITAGLTALCYAELSSMIPASGSSYSYAYATLGEGVAFLVAACLI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHHHHHH
LEYGVSAAAVAIGWSEYLNNLIHNVFGVHLPNWLLSAPFVADGYKLHLGGTGLINLPAAI
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCEEECCEEEEECCCCHHHHHHHH
LVFLCCMLLMRGVTESARINAVMVLIKLCVLILFISIAATAFNAEHLTPFSPHGFAGISA
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHH
AAGSIFFTFIGLDAVSTAGEEVENPRRNLPLAIISALFVVIIFYILVALTALGAQEQGLF
HHHHHHHHHHHHHHHHHCHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KGQQAGLAVILQEITGSTWPAIILAAGAVISVFSITLVVLYGQTRILFAMSRDGLAPKIF
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHH
HRVSTQTLTPNANTLIVAVIVSIIAGFVPADVLWDLTSMGTLIAFTVVSIGVLVLRYRMP
HHHHCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DAPRGFKVPFFPALPVLSICACLYLISSLSAIVYVIAAIWAVIAATYYFSCASKNSVLEA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHC
GSEAYSHQNGDDHQ
CHHHHCCCCCCCCC
>Mature Secondary Structure
MKNPVTFSQRLLRRKPINFLVQETQQGGKTLKRSLTLFQLTMFGVGATIGTGIFFVLSEQ
CCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
VPVAGPAVLISFILAGITAGLTALCYAELSSMIPASGSSYSYAYATLGEGVAFLVAACLI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHHHHHH
LEYGVSAAAVAIGWSEYLNNLIHNVFGVHLPNWLLSAPFVADGYKLHLGGTGLINLPAAI
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCEEECCEEEEECCCCHHHHHHHH
LVFLCCMLLMRGVTESARINAVMVLIKLCVLILFISIAATAFNAEHLTPFSPHGFAGISA
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHH
AAGSIFFTFIGLDAVSTAGEEVENPRRNLPLAIISALFVVIIFYILVALTALGAQEQGLF
HHHHHHHHHHHHHHHHHCHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KGQQAGLAVILQEITGSTWPAIILAAGAVISVFSITLVVLYGQTRILFAMSRDGLAPKIF
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHH
HRVSTQTLTPNANTLIVAVIVSIIAGFVPADVLWDLTSMGTLIAFTVVSIGVLVLRYRMP
HHHHCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DAPRGFKVPFFPALPVLSICACLYLISSLSAIVYVIAAIWAVIAATYYFSCASKNSVLEA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHC
GSEAYSHQNGDDHQ
CHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9141694; 9384377 [H]