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The map label for this gene is hisZ

Identifier: 50084443

GI number: 50084443

Start: 1255511

End: 1256677

Strand: Direct

Name: hisZ

Synonym: ACIAD1257

Alternate gene names: 50084443

Gene position: 1255511-1256677 (Clockwise)

Preceding gene: 50084442

Following gene: 50084444

Centisome position: 34.89

GC content: 44.13

Gene sequence:

>1167_bases
ATGCCGATTTCAGAGACATGGTTGCTCCCTGACGGGGTAGCAGATGTATTGCCCGAACAAGCGCAAGTAGTAGAAACGCT
TCGCCGACAAGCTTTAGATTTCCTCGCATCTCGTGGTTATCAACTGGTATATACACCATTCATCGAATATATCGAATCTT
TATCTTTATTGTCAGAATCCAATCACGATCTTGATCTGGTTACATTCAAGGTGATTGACCAACTTTCTGGACGTTTGCTC
GGTGTTCGTGCAGACATGACCCCGCAGGTCGCGCGAATCGATGCGCATGTGCGCTCAATTGAAGGTGTGGCACGCTATTG
TTACGCTGGCACTGTGTTACACACAAAACCTCAAAACTTTAATTCATCTCGTGCACCTCTACAGTTAGGTGCGGAGCTTT
ATGGTCATCAAAGCCTTGAAGCGGATATTGAAATGGTTGATGTGATGCTGGGGTTGATTCAGCAGGCTCATAACCTTGAA
GGTTTGCATCTGGATCTGGGGCATGTGGGACTATTTCGTAGCTTGGTCAAACGTGCGGGTCTCAGTAAACAGGTAGAGCA
GGATTTATCTGATTTATATCAACGTAAAGCACTCCCAGAATTAGAAGAAGTGACGAAAACACTCGCGTTTGGTTCTGATT
TTTATGCCCTGGGACGTTATGCAAGTGATTTAAATGCGCTTGAGCAGCATTTGAGTCAGGATGTTTTGAATGATGCATCC
TTTAAAACGTCGCTTGATGATTTAAAAACAACGCTTTCACAAATACAAACACGTTGGCCAAATCTACGCATTGGTATTGA
TGTGGTTGAACTACGCAGTTATCACTATCATACGGGCTTGATGTACGCTGTGTATGCACCAAACCGTGCTGCTCCACTTG
CACAAGGTGGACGCTATGATGGTATTGGTGAACATTTTGGTCGTGCGCGTCCTGCTACAGGCTTCAGTTGTGACTTATAT
GCATTGTGTGTAGGACAATTTAAAGAGATTGAAACGATTGTCGCACCTGCTGGACAAGACCAGCAGCTTCTTGGCGCAAT
TGCTCAGGCACGTCAAAATGGCTTACGTGTGATTCAGTTATTGGGTAATGATGATTTAAGCTCTGTTCCTTATGCAACCC
ATAAAATGGAATTAGCACAAGATCAGTGGCAAATTAACAAGATTTAA

Upstream 100 bases:

>100_bases
CATGGTAATAACTATCGTGCTAGACTAGGAGAAATCGGGTGTGCTCCCGATTTTTTTATGCGGATTGAATACCGCTTTGA
CCAGATTTTAGGTTTGAAAC

Downstream 100 bases:

>100_bases
TGGTTTGTTTGTTCAATAAAGCAAACAAATGTTCACTTTTAACAGCATGATGTAATGAGGCTATTATGGGCAAAAATGTT
GTGGTACTTGGTACCCAATG

Product: ATP phosphoribosyltransferase regulatory subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MPISETWLLPDGVADVLPEQAQVVETLRRQALDFLASRGYQLVYTPFIEYIESLSLLSESNHDLDLVTFKVIDQLSGRLL
GVRADMTPQVARIDAHVRSIEGVARYCYAGTVLHTKPQNFNSSRAPLQLGAELYGHQSLEADIEMVDVMLGLIQQAHNLE
GLHLDLGHVGLFRSLVKRAGLSKQVEQDLSDLYQRKALPELEEVTKTLAFGSDFYALGRYASDLNALEQHLSQDVLNDAS
FKTSLDDLKTTLSQIQTRWPNLRIGIDVVELRSYHYHTGLMYAVYAPNRAAPLAQGGRYDGIGEHFGRARPATGFSCDLY
ALCVGQFKEIETIVAPAGQDQQLLGAIAQARQNGLRVIQLLGNDDLSSVPYATHKMELAQDQWQINKI

Sequences:

>Translated_388_residues
MPISETWLLPDGVADVLPEQAQVVETLRRQALDFLASRGYQLVYTPFIEYIESLSLLSESNHDLDLVTFKVIDQLSGRLL
GVRADMTPQVARIDAHVRSIEGVARYCYAGTVLHTKPQNFNSSRAPLQLGAELYGHQSLEADIEMVDVMLGLIQQAHNLE
GLHLDLGHVGLFRSLVKRAGLSKQVEQDLSDLYQRKALPELEEVTKTLAFGSDFYALGRYASDLNALEQHLSQDVLNDAS
FKTSLDDLKTTLSQIQTRWPNLRIGIDVVELRSYHYHTGLMYAVYAPNRAAPLAQGGRYDGIGEHFGRARPATGFSCDLY
ALCVGQFKEIETIVAPAGQDQQLLGAIAQARQNGLRVIQLLGNDDLSSVPYATHKMELAQDQWQINKI
>Mature_387_residues
PISETWLLPDGVADVLPEQAQVVETLRRQALDFLASRGYQLVYTPFIEYIESLSLLSESNHDLDLVTFKVIDQLSGRLLG
VRADMTPQVARIDAHVRSIEGVARYCYAGTVLHTKPQNFNSSRAPLQLGAELYGHQSLEADIEMVDVMLGLIQQAHNLEG
LHLDLGHVGLFRSLVKRAGLSKQVEQDLSDLYQRKALPELEEVTKTLAFGSDFYALGRYASDLNALEQHLSQDVLNDASF
KTSLDDLKTTLSQIQTRWPNLRIGIDVVELRSYHYHTGLMYAVYAPNRAAPLAQGGRYDGIGEHFGRARPATGFSCDLYA
LCVGQFKEIETIVAPAGQDQQLLGAIAQARQNGLRVIQLLGNDDLSSVPYATHKMELAQDQWQINKI

Specific function: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine

COG id: COG3705

COG function: function code E; ATP phosphoribosyltransferase involved in histidine biosynthesis

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISZ_ACIAD (Q6FCS8)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_045953.1
- ProteinModelPortal:   Q6FCS8
- SMR:   Q6FCS8
- STRING:   Q6FCS8
- GeneID:   2878932
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD1257
- NMPDR:   fig|62977.3.peg.326
- eggNOG:   COG3705
- HOGENOM:   HBG616575
- OMA:   LTHIDAG
- ProtClustDB:   PRK12421
- BioCyc:   ASP62977:ACIAD1257-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00125
- InterPro:   IPR004517
- InterPro:   IPR004516
- PANTHER:   PTHR11476
- PIRSF:   PIRSF001549
- TIGRFAMs:   TIGR00443

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 43162; Mature: 43030

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPISETWLLPDGVADVLPEQAQVVETLRRQALDFLASRGYQLVYTPFIEYIESLSLLSES
CCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHCC
NHDLDLVTFKVIDQLSGRLLGVRADMTPQVARIDAHVRSIEGVARYCYAGTVLHTKPQNF
CCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCC
NSSRAPLQLGAELYGHQSLEADIEMVDVMLGLIQQAHNLEGLHLDLGHVGLFRSLVKRAG
CCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHCC
LSKQVEQDLSDLYQRKALPELEEVTKTLAFGSDFYALGRYASDLNALEQHLSQDVLNDAS
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCH
FKTSLDDLKTTLSQIQTRWPNLRIGIDVVELRSYHYHTGLMYAVYAPNRAAPLAQGGRYD
HHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCC
GIGEHFGRARPATGFSCDLYALCVGQFKEIETIVAPAGQDQQLLGAIAQARQNGLRVIQL
CCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEE
LGNDDLSSVPYATHKMELAQDQWQINKI
ECCCCCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PISETWLLPDGVADVLPEQAQVVETLRRQALDFLASRGYQLVYTPFIEYIESLSLLSES
CCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHCC
NHDLDLVTFKVIDQLSGRLLGVRADMTPQVARIDAHVRSIEGVARYCYAGTVLHTKPQNF
CCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCC
NSSRAPLQLGAELYGHQSLEADIEMVDVMLGLIQQAHNLEGLHLDLGHVGLFRSLVKRAG
CCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHCC
LSKQVEQDLSDLYQRKALPELEEVTKTLAFGSDFYALGRYASDLNALEQHLSQDVLNDAS
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCH
FKTSLDDLKTTLSQIQTRWPNLRIGIDVVELRSYHYHTGLMYAVYAPNRAAPLAQGGRYD
HHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCC
GIGEHFGRARPATGFSCDLYALCVGQFKEIETIVAPAGQDQQLLGAIAQARQNGLRVIQL
CCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEE
LGNDDLSSVPYATHKMELAQDQWQINKI
ECCCCCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA