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The map label for this gene is wecB [H]

Identifier: 50084366

GI number: 50084366

Start: 1171946

End: 1173079

Strand: Direct

Name: wecB [H]

Synonym: ACIAD1175

Alternate gene names: 50084366

Gene position: 1171946-1173079 (Clockwise)

Preceding gene: 50084365

Following gene: 50084375

Centisome position: 32.57

GC content: 38.8

Gene sequence:

>1134_bases
ATGACAAAACAACTTATTTCTATTGTTTTTGGTACACGGCCAGAGCTGATAAAGCTCGCTCCTGTTATTTTAATGGCCCA
GCAGGATTCTCGATTTGAGGTAGAAGTTTTATTTACAGGTCAGCACGATGAACTCGTTCGTGATGCCATAGAATTTTTTA
ACATCAAAATTGATCGGCGATTAAGTATGATGCATGCTGGGCAATCATTAAATCAGCTATTAATTCAGGGATTAACACAG
ATAGAACAAGTATTTAAGGATGGACGCACGCGACACGCAATTATTATACAAGGTGATACAACTACAGTTTTGGCAGCTGG
TCTGGTTGCATTTTCGATGAAAATTCCTGTTGCTCATGTGGAGGCTGGGTTACGCTCTTATGATATGGATCAACCGTTTC
CAGAAGAGGGAAACCGCCAGCTTGTTTCCAGAGTAGCTAAATGGCATTTTGCACCAACAGAAAAATCAAAAGATAATTTA
TTAAATGAACATATTGAAGCTGACGCAATTAGCGTAACAGGTAATACCATTGTAGACGCGGTCTATCTTGGACGTGAGTT
AATCAAGAGCAAACAGGCTGGTCAGGATCTGCTTAAGCAATTGGGTATTCATCTTGATCCAACAGATAAAGTTATTTTAA
TTACGGCGCATCGTCGTGAAAATTTTGGCCAAGGAATTCAAAATATTTGTGATGCAGTCAGTGCGCTGATCGAACAATAT
CCTGAGTTACATTTTATCTGGCCAGTTCATCTTAACCCAGCCGTACATGATGTTATTCATAATCGTTTTGATGACCACAA
GCGAGTTCATTTAGTGAAGCCTTTGGATTATCCAAACCTTTTGGCCGTTATTGAAAGATCATATTTTATTATGACTGATT
CGGGCGGGATTCAAGAAGAAAGTCCATCATTTCATAAACCAGTTTTGATTTTAAGAGAGACTACAGAACGGCCTGAGGTC
ATTTCAGTGGGTGCAGGGGTGTTGGTTGGAACAGACACACCATTAATTGTTAAAGAAGCCCAACATTTACTCAATGATGT
AAGTCATTATCATAAAATGTCGAATGTAGAAAATCCATTTGGAGATGGGCATGCATCTCAACGAATTTTAGATAAAATTG
CCACATCATATTGA

Upstream 100 bases:

>100_bases
GAGCAGAACGGTTATATGGTTTTTATTTTAAAGATTATAACGATAAGAATCGTTACAACAATACTCGTTTCGAAATGGTT
TTTTATAAGGATTTCTAATA

Downstream 100 bases:

>100_bases
AAAATTAGGCTTTATTTGGATGCGAATTTGCATAATAGACTTTATACCAGAGTGAAATAATTAAAACAGAGGTGCGATTT
AAATAATGAGGACCATCAAA

Product: UDP-N-acetyl glucosamine-2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MTKQLISIVFGTRPELIKLAPVILMAQQDSRFEVEVLFTGQHDELVRDAIEFFNIKIDRRLSMMHAGQSLNQLLIQGLTQ
IEQVFKDGRTRHAIIIQGDTTTVLAAGLVAFSMKIPVAHVEAGLRSYDMDQPFPEEGNRQLVSRVAKWHFAPTEKSKDNL
LNEHIEADAISVTGNTIVDAVYLGRELIKSKQAGQDLLKQLGIHLDPTDKVILITAHRRENFGQGIQNICDAVSALIEQY
PELHFIWPVHLNPAVHDVIHNRFDDHKRVHLVKPLDYPNLLAVIERSYFIMTDSGGIQEESPSFHKPVLILRETTERPEV
ISVGAGVLVGTDTPLIVKEAQHLLNDVSHYHKMSNVENPFGDGHASQRILDKIATSY

Sequences:

>Translated_377_residues
MTKQLISIVFGTRPELIKLAPVILMAQQDSRFEVEVLFTGQHDELVRDAIEFFNIKIDRRLSMMHAGQSLNQLLIQGLTQ
IEQVFKDGRTRHAIIIQGDTTTVLAAGLVAFSMKIPVAHVEAGLRSYDMDQPFPEEGNRQLVSRVAKWHFAPTEKSKDNL
LNEHIEADAISVTGNTIVDAVYLGRELIKSKQAGQDLLKQLGIHLDPTDKVILITAHRRENFGQGIQNICDAVSALIEQY
PELHFIWPVHLNPAVHDVIHNRFDDHKRVHLVKPLDYPNLLAVIERSYFIMTDSGGIQEESPSFHKPVLILRETTERPEV
ISVGAGVLVGTDTPLIVKEAQHLLNDVSHYHKMSNVENPFGDGHASQRILDKIATSY
>Mature_376_residues
TKQLISIVFGTRPELIKLAPVILMAQQDSRFEVEVLFTGQHDELVRDAIEFFNIKIDRRLSMMHAGQSLNQLLIQGLTQI
EQVFKDGRTRHAIIIQGDTTTVLAAGLVAFSMKIPVAHVEAGLRSYDMDQPFPEEGNRQLVSRVAKWHFAPTEKSKDNLL
NEHIEADAISVTGNTIVDAVYLGRELIKSKQAGQDLLKQLGIHLDPTDKVILITAHRRENFGQGIQNICDAVSALIEQYP
ELHFIWPVHLNPAVHDVIHNRFDDHKRVHLVKPLDYPNLLAVIERSYFIMTDSGGIQEESPSFHKPVLILRETTERPEVI
SVGAGVLVGTDTPLIVKEAQHLLNDVSHYHKMSNVENPFGDGHASQRILDKIATSY

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=371, Percent_Identity=42.0485175202156, Blast_Score=295, Evalue=4e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 42376; Mature: 42245

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKQLISIVFGTRPELIKLAPVILMAQQDSRFEVEVLFTGQHDELVRDAIEFFNIKIDRR
CCHHHHHHHHCCCCCHHHHCCEEEEECCCCCEEEEEEEECCHHHHHHHHHHHHCCCHHHH
LSMMHAGQSLNQLLIQGLTQIEQVFKDGRTRHAIIIQGDTTTVLAAGLVAFSMKIPVAHV
HHHHHHCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHCCCHHHH
EAGLRSYDMDQPFPEEGNRQLVSRVAKWHFAPTEKSKDNLLNEHIEADAISVTGNTIVDA
HHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEECCHHHHHH
VYLGRELIKSKQAGQDLLKQLGIHLDPTDKVILITAHRRENFGQGIQNICDAVSALIEQY
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHC
PELHFIWPVHLNPAVHDVIHNRFDDHKRVHLVKPLDYPNLLAVIERSYFIMTDSGGIQEE
CCEEEEEEEECCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHCCEEEEECCCCCCCC
SPSFHKPVLILRETTERPEVISVGAGVLVGTDTPLIVKEAQHLLNDVSHYHKMSNVENPF
CCCCCCCEEEEECCCCCCCEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
GDGHASQRILDKIATSY
CCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TKQLISIVFGTRPELIKLAPVILMAQQDSRFEVEVLFTGQHDELVRDAIEFFNIKIDRR
CHHHHHHHHCCCCCHHHHCCEEEEECCCCCEEEEEEEECCHHHHHHHHHHHHCCCHHHH
LSMMHAGQSLNQLLIQGLTQIEQVFKDGRTRHAIIIQGDTTTVLAAGLVAFSMKIPVAHV
HHHHHHCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHCCCHHHH
EAGLRSYDMDQPFPEEGNRQLVSRVAKWHFAPTEKSKDNLLNEHIEADAISVTGNTIVDA
HHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEECCHHHHHH
VYLGRELIKSKQAGQDLLKQLGIHLDPTDKVILITAHRRENFGQGIQNICDAVSALIEQY
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHC
PELHFIWPVHLNPAVHDVIHNRFDDHKRVHLVKPLDYPNLLAVIERSYFIMTDSGGIQEE
CCEEEEEEEECCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHCCEEEEECCCCCCCC
SPSFHKPVLILRETTERPEVISVGAGVLVGTDTPLIVKEAQHLLNDVSHYHKMSNVENPF
CCCCCCCEEEEECCCCCCCEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
GDGHASQRILDKIATSY
CCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]