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The map label for this gene is ytfL [H]

Identifier: 50084279

GI number: 50084279

Start: 1076846

End: 1078168

Strand: Reverse

Name: ytfL [H]

Synonym: ACIAD1081

Alternate gene names: 50084279

Gene position: 1078168-1076846 (Counterclockwise)

Preceding gene: 50084280

Following gene: 50084273

Centisome position: 29.96

GC content: 38.1

Gene sequence:

>1323_bases
GTGAGCCTTTTTCAAAATGCTATCATCATTATATTATTGATCGTTGCGGCTGGTTTCTTATCGCTTACCGAAATTGCACT
CGCTGGCGCAAGAAAAGTTAAACTCAAGATTCTGGCCGAATCTGGTGATGAACGCGCCCAGAAAGTTTTAGATTTACAAG
CGCAGTCTGCCGACTTCTTTGCTGCATCACAAATCGGTTTAAATGCTGTGGCGATTTTAGGCGGTATTTTGGGTGAAGCT
GCATTTCGACCTTTTTTTGTTGAATTGATTGATCGTTTCTACGATGGACCATGGACACAAAATATTGGCTTTATTTTGTC
TTTTACTTTTGTGACGTCCTTATTCATTTTATTTGCAGATCTGATGCCAAAACGTTTGGCGATGATTGCACCTGAAAAAA
TTGCTGTTTCAGTCATAGATCCTATTCAAATTTTTATCAAAATCTGTAAACCACTTGCTTGGTTTATAAATGCGATTGCC
AATCTTCTATTTCGCCTTTTTAAGGTGAATACCATACGTGATGATAATATCACCTTTGATGATATTTCTGCGGTGATGGA
AGCAGGTGCACAAGCCGGCGTTCTGCAAAAACAAGAACATCATTTTATTGAAAATGTGTTTGAACTTGAAGAACGTACTG
TTCCCTCGAGCATGACTACACGTGAAAATATCGTGTATTTTACGCTTGATGAATCAGATGAAAGTATTCGTCAAAAGCTT
GCCGAGTATCCCTACTCGAAATTTTTGGTTTGTAATGAAACCATCGATCAAGTGATTGGTTATGTGGATGCCAAAGATAT
TCTGATCAGAATCTTAAATAGTCAATCGCTCATCCATTTGAAAGAAAATACTATTCGTACTGTTCTCACTCTTCCAGATG
CTCTCACTTTATCTGAGGTTTTAGATCGCTTCCGCTCAACCAAAGAAAAATTTGCAGTTGTCATCAACGAATATGCTTTG
GTGGTTGGCGTCATCACACTAAGTGACATCATGATCACAGTCATGGGCGACTGGGTCACTCCAATTGAAGAAGATCAACA
AATTATCAAACGTGATAATAACTCTTGGTTGATTGATGGCAGTACGCCAATCGAAGATCTGAAACATGCCTTAGAAATTG
ACGATATGCCAGATGAAGAAAATTATGAAACTCTGGCTGGTTTTATGATGTATCAACTGCGTAAAATTCCAAGACCTGCG
GATACGGTTGAGTTTTCAGGATTTAAATTTGAGGTGGTCGATGTTGATCACTATAAAATTGACCAGCTTTTGGTGACAAG
AATTCTAGAAAAACTGGAAGATCAAAATATTATTGAAGACTAA

Upstream 100 bases:

>100_bases
CTTTTTTCAAGCTTATACTAATTTTATCTGGAGGTAGTCCTATCTGCCTCCCCGCTTTCTATTTAAATTTTCGCACAATA
ACGAATATAACAGGTGAATT

Downstream 100 bases:

>100_bases
ACACATTTAGAAAATAAAGATGCTGTGTCGGGTTAAATTGTTTATTTTCTGCGTCTTAATTAAGCATTCTGTTTATTGAT
TTACGCTGAAAAAAGGAGGG

Product: hemolysin-related protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MSLFQNAIIIILLIVAAGFLSLTEIALAGARKVKLKILAESGDERAQKVLDLQAQSADFFAASQIGLNAVAILGGILGEA
AFRPFFVELIDRFYDGPWTQNIGFILSFTFVTSLFILFADLMPKRLAMIAPEKIAVSVIDPIQIFIKICKPLAWFINAIA
NLLFRLFKVNTIRDDNITFDDISAVMEAGAQAGVLQKQEHHFIENVFELEERTVPSSMTTRENIVYFTLDESDESIRQKL
AEYPYSKFLVCNETIDQVIGYVDAKDILIRILNSQSLIHLKENTIRTVLTLPDALTLSEVLDRFRSTKEKFAVVINEYAL
VVGVITLSDIMITVMGDWVTPIEEDQQIIKRDNNSWLIDGSTPIEDLKHALEIDDMPDEENYETLAGFMMYQLRKIPRPA
DTVEFSGFKFEVVDVDHYKIDQLLVTRILEKLEDQNIIED

Sequences:

>Translated_440_residues
MSLFQNAIIIILLIVAAGFLSLTEIALAGARKVKLKILAESGDERAQKVLDLQAQSADFFAASQIGLNAVAILGGILGEA
AFRPFFVELIDRFYDGPWTQNIGFILSFTFVTSLFILFADLMPKRLAMIAPEKIAVSVIDPIQIFIKICKPLAWFINAIA
NLLFRLFKVNTIRDDNITFDDISAVMEAGAQAGVLQKQEHHFIENVFELEERTVPSSMTTRENIVYFTLDESDESIRQKL
AEYPYSKFLVCNETIDQVIGYVDAKDILIRILNSQSLIHLKENTIRTVLTLPDALTLSEVLDRFRSTKEKFAVVINEYAL
VVGVITLSDIMITVMGDWVTPIEEDQQIIKRDNNSWLIDGSTPIEDLKHALEIDDMPDEENYETLAGFMMYQLRKIPRPA
DTVEFSGFKFEVVDVDHYKIDQLLVTRILEKLEDQNIIED
>Mature_439_residues
SLFQNAIIIILLIVAAGFLSLTEIALAGARKVKLKILAESGDERAQKVLDLQAQSADFFAASQIGLNAVAILGGILGEAA
FRPFFVELIDRFYDGPWTQNIGFILSFTFVTSLFILFADLMPKRLAMIAPEKIAVSVIDPIQIFIKICKPLAWFINAIAN
LLFRLFKVNTIRDDNITFDDISAVMEAGAQAGVLQKQEHHFIENVFELEERTVPSSMTTRENIVYFTLDESDESIRQKLA
EYPYSKFLVCNETIDQVIGYVDAKDILIRILNSQSLIHLKENTIRTVLTLPDALTLSEVLDRFRSTKEKFAVVINEYALV
VGVITLSDIMITVMGDWVTPIEEDQQIIKRDNNSWLIDGSTPIEDLKHALEIDDMPDEENYETLAGFMMYQLRKIPRPAD
TVEFSGFKFEVVDVDHYKIDQLLVTRILEKLEDQNIIED

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=381, Percent_Identity=24.9343832020997, Blast_Score=135, Evalue=5e-32,
Organism=Escherichia coli, GI1790664, Length=427, Percent_Identity=57.1428571428571, Blast_Score=516, Evalue=1e-147,
Organism=Escherichia coli, GI145693175, Length=419, Percent_Identity=23.6276849642005, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI87082033, Length=254, Percent_Identity=29.5275590551181, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788119, Length=235, Percent_Identity=24.6808510638298, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1786879, Length=248, Percent_Identity=23.7903225806452, Blast_Score=79, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 49827; Mature: 49696

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLFQNAIIIILLIVAAGFLSLTEIALAGARKVKLKILAESGDERAQKVLDLQAQSADFF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHCCCCHH
AASQIGLNAVAILGGILGEAAFRPFFVELIDRFYDGPWTQNIGFILSFTFVTSLFILFAD
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
LMPKRLAMIAPEKIAVSVIDPIQIFIKICKPLAWFINAIANLLFRLFKVNTIRDDNITFD
HHHHHHHHHCCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
DISAVMEAGAQAGVLQKQEHHFIENVFELEERTVPSSMTTRENIVYFTLDESDESIRQKL
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHH
AEYPYSKFLVCNETIDQVIGYVDAKDILIRILNSQSLIHLKENTIRTVLTLPDALTLSEV
HHCCCCEEEEEHHHHHHHHCCCCHHHHHHHHHCCCCEEEECCCCCEEEEECCCHHHHHHH
LDRFRSTKEKFAVVINEYALVVGVITLSDIMITVMGDWVTPIEEDQQIIKRDNNSWLIDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCEEEEC
STPIEDLKHALEIDDMPDEENYETLAGFMMYQLRKIPRPADTVEFSGFKFEVVDVDHYKI
CCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCEEEEEEECCHHHH
DQLLVTRILEKLEDQNIIED
HHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SLFQNAIIIILLIVAAGFLSLTEIALAGARKVKLKILAESGDERAQKVLDLQAQSADFF
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHCCCCHH
AASQIGLNAVAILGGILGEAAFRPFFVELIDRFYDGPWTQNIGFILSFTFVTSLFILFAD
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
LMPKRLAMIAPEKIAVSVIDPIQIFIKICKPLAWFINAIANLLFRLFKVNTIRDDNITFD
HHHHHHHHHCCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
DISAVMEAGAQAGVLQKQEHHFIENVFELEERTVPSSMTTRENIVYFTLDESDESIRQKL
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHH
AEYPYSKFLVCNETIDQVIGYVDAKDILIRILNSQSLIHLKENTIRTVLTLPDALTLSEV
HHCCCCEEEEEHHHHHHHHCCCCHHHHHHHHHCCCCEEEECCCCCEEEEECCCHHHHHHH
LDRFRSTKEKFAVVINEYALVVGVITLSDIMITVMGDWVTPIEEDQQIIKRDNNSWLIDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCEEEEC
STPIEDLKHALEIDDMPDEENYETLAGFMMYQLRKIPRPADTVEFSGFKFEVVDVDHYKI
CCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCEEEEEEECCHHHH
DQLLVTRILEKLEDQNIIED
HHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]