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The map label for this gene is irgA [H]

Identifier: 50084254

GI number: 50084254

Start: 1047677

End: 1049914

Strand: Direct

Name: irgA [H]

Synonym: ACIAD1054

Alternate gene names: 50084254

Gene position: 1047677-1049914 (Clockwise)

Preceding gene: 50084253

Following gene: 50084256

Centisome position: 29.11

GC content: 35.88

Gene sequence:

>2238_bases
ATGTCCAAACGGATTACACGTACAGCATTGTCTTTAGCTATTTTAACCAGCATATTTCATGCAACTTATGCTGCAGAAGA
AAGTAAAACCCCCAATAATAATGTTGAAAATACCACCAAGTTGCAGACAATAGTGGTTACTGCTGCTGGTTATGAACAAA
ATGTAAAAGATGCAGCAGCATCGATTAGTGTGATTAGCCGCGATGATATTGAAAAGAAAAATGCAACCAACGTTGCAGAT
TTACTCACAGATATTCCAGGTGTTGATGTTAGAAATGGAACAGGTAAAACAGGCAATCTTGAAGTAGAAATGCGAGGGAT
GGGTGCGCAATATACGCTTATTTTGATTGATGGTAAGCGTCAAAATACCAATACTGATATTGCACCAAATGGGTTTGGAT
CTGGATTACGTTCATTTTTACCACCTTTAGCGAGTATTGAACGTATCGAAGTTATTCGAGGTCCAATGTCTACGATGTAT
GGATCAGATGCAATGGGTGGAGTGATTAATATCATTACCAAAAAGGTATCGAATGAGTGGCATGGTAATTTGACAGTTTC
AGGTAATGTCACTGAAAGTAATAAGGAAGCCAATTCATTAACTACCAGTTTTGCGCTAAATGGTCCTCTGGTCAATGATA
AGTTAGGTATACAACTACGTGGCAGTTACATGGATCGGGGAACAGCCGATCGTGTGGATGAAAGTAGTAATTTACGAGAT
CCTAGACCAAATAAAGCACATAACTATGATGTAGGCGCAAAACTGACTTATAAATTAGATAATAAAAATTCGTTTTGGAT
CGATGGCTTTACAGCCGATCAAATCTACAAAAATATCAATAATGTTCTTGGGACTAAAGATACTGATACAACAGTTAACT
CTTATAGCCAATCTGGTGAGATGGAGTATCTTCGTAATCAAGTGTCGATTGGTCATGATGGTGATTATGATTTTGGTAAA
TGGTCTACTTATGTATTACAAAATAATACTCAAGTTAAAGGGAGAACATTACCAAGTACTTATATTCCAGTTGAATTACG
TGGTGCTGAAAGAAGATTAAAAAATGACGATTTTCTGGCACATACTGATATTACAAGCCAATTAGGGATGCATAAAGTTA
CTGGTGGCATCGAATACCAAAAATCTGAAACAACAGATACATTACGTAATCAAAATCCAAAATTAGAAACCGAATCTACA
GCAATTTTTATAGAAGATGAATGGCGGTTGTTTAATCCTTTAGCCTTTACCTTTGGTGGGCGTTATGAAGATCATTCTGG
TTTTGGTGGACATTTTAGTCCACGAGGATATTTGGTTTGGACACCCTCAGATACATTAACGATTAAAGGTGGTGTAAGTA
CAGGATATAAGGTGCCAACTGCTGCACAATTATATGATGGCGTAACAGGTGTAAGTGTTATTTCTTATAATGGTGTAAGT
CTAGGTCAAGGTTCTGGCTTAACGATTGGAACACCTGGATTAAAACCTGAGGAATCGAAAAACTATGAATTAGGTGTTAA
TTTTGATAATGGTGAGAATTTTGAAGTTAGTGTTACAGGATATTTAAACAAGATTAAAAACCTAATTTCTTCTGATGGAT
ATGTATATAGTTGCACTTTCATTGATTCACCAAATCGCTCAGGTTGTATTACAGTTGCTGGTGCTTCAATTTATCAAGAT
ACTTTTTCTCAATCAATGAATGCGAATTCTGCAGAAACGAAAGGTGTAGAGGTTGCATTAAAGTATAAGATTATTCCAGA
GTGGGATATTAAAACTGCATATACATGGGCGGATACCGAAGTAACGTCGGGAACAAATGACGGTTTTGCTTATACTATGT
TGCCCAAACATGCTATAAATACTACTTCAACTTGGCATATTAATGATGCCATAGATGTTTACCTGCAGCATGAATATAAA
TCCAGTCGTAAACGTTTTGCTTCTGTACCAACAGGAACGAATGCGACAGCAAGAAATAATCTTGAAATCTATAATATGAC
AGATAACAAGTTTAAGGCTTATAACTTATTTAATTTAGGTACAAGCTACCGTTACAGTGATCATATGCGTATAAATTTCG
CGGTAAATAATTTGCTTGATAAAGATTTTACCAAAATTATTGGAAAAACAGCGACCTCACAAACAACAGTCTATGAATAT
ATTGCCATGGGCTCAACCAATGATGGAACGTATATTTCTGGACGTAATTATTGGTTGTCATTGTCTTATGACTTTTAA

Upstream 100 bases:

>100_bases
ATAATGAGAATTATTTTTAATACTATTTTAATTTTTATTTTTTTGATAAAATTGTAAAAATAAGTTAAACCTAATTTATC
GTCGAAAACGAGAGTAAATA

Downstream 100 bases:

>100_bases
AATCTTTAGGTTCTGTTAAAAAAAAAGATCCGCAATTCAGATATTGCGGATCTTTTTTTTAATATTTACTTTAATATTTG
CTGAATTTGCTCTGAATAAT

Product: ferric siderophore receptor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 745; Mature: 744

Protein sequence:

>745_residues
MSKRITRTALSLAILTSIFHATYAAEESKTPNNNVENTTKLQTIVVTAAGYEQNVKDAAASISVISRDDIEKKNATNVAD
LLTDIPGVDVRNGTGKTGNLEVEMRGMGAQYTLILIDGKRQNTNTDIAPNGFGSGLRSFLPPLASIERIEVIRGPMSTMY
GSDAMGGVINIITKKVSNEWHGNLTVSGNVTESNKEANSLTTSFALNGPLVNDKLGIQLRGSYMDRGTADRVDESSNLRD
PRPNKAHNYDVGAKLTYKLDNKNSFWIDGFTADQIYKNINNVLGTKDTDTTVNSYSQSGEMEYLRNQVSIGHDGDYDFGK
WSTYVLQNNTQVKGRTLPSTYIPVELRGAERRLKNDDFLAHTDITSQLGMHKVTGGIEYQKSETTDTLRNQNPKLETEST
AIFIEDEWRLFNPLAFTFGGRYEDHSGFGGHFSPRGYLVWTPSDTLTIKGGVSTGYKVPTAAQLYDGVTGVSVISYNGVS
LGQGSGLTIGTPGLKPEESKNYELGVNFDNGENFEVSVTGYLNKIKNLISSDGYVYSCTFIDSPNRSGCITVAGASIYQD
TFSQSMNANSAETKGVEVALKYKIIPEWDIKTAYTWADTEVTSGTNDGFAYTMLPKHAINTTSTWHINDAIDVYLQHEYK
SSRKRFASVPTGTNATARNNLEIYNMTDNKFKAYNLFNLGTSYRYSDHMRINFAVNNLLDKDFTKIIGKTATSQTTVYEY
IAMGSTNDGTYISGRNYWLSLSYDF

Sequences:

>Translated_745_residues
MSKRITRTALSLAILTSIFHATYAAEESKTPNNNVENTTKLQTIVVTAAGYEQNVKDAAASISVISRDDIEKKNATNVAD
LLTDIPGVDVRNGTGKTGNLEVEMRGMGAQYTLILIDGKRQNTNTDIAPNGFGSGLRSFLPPLASIERIEVIRGPMSTMY
GSDAMGGVINIITKKVSNEWHGNLTVSGNVTESNKEANSLTTSFALNGPLVNDKLGIQLRGSYMDRGTADRVDESSNLRD
PRPNKAHNYDVGAKLTYKLDNKNSFWIDGFTADQIYKNINNVLGTKDTDTTVNSYSQSGEMEYLRNQVSIGHDGDYDFGK
WSTYVLQNNTQVKGRTLPSTYIPVELRGAERRLKNDDFLAHTDITSQLGMHKVTGGIEYQKSETTDTLRNQNPKLETEST
AIFIEDEWRLFNPLAFTFGGRYEDHSGFGGHFSPRGYLVWTPSDTLTIKGGVSTGYKVPTAAQLYDGVTGVSVISYNGVS
LGQGSGLTIGTPGLKPEESKNYELGVNFDNGENFEVSVTGYLNKIKNLISSDGYVYSCTFIDSPNRSGCITVAGASIYQD
TFSQSMNANSAETKGVEVALKYKIIPEWDIKTAYTWADTEVTSGTNDGFAYTMLPKHAINTTSTWHINDAIDVYLQHEYK
SSRKRFASVPTGTNATARNNLEIYNMTDNKFKAYNLFNLGTSYRYSDHMRINFAVNNLLDKDFTKIIGKTATSQTTVYEY
IAMGSTNDGTYISGRNYWLSLSYDF
>Mature_744_residues
SKRITRTALSLAILTSIFHATYAAEESKTPNNNVENTTKLQTIVVTAAGYEQNVKDAAASISVISRDDIEKKNATNVADL
LTDIPGVDVRNGTGKTGNLEVEMRGMGAQYTLILIDGKRQNTNTDIAPNGFGSGLRSFLPPLASIERIEVIRGPMSTMYG
SDAMGGVINIITKKVSNEWHGNLTVSGNVTESNKEANSLTTSFALNGPLVNDKLGIQLRGSYMDRGTADRVDESSNLRDP
RPNKAHNYDVGAKLTYKLDNKNSFWIDGFTADQIYKNINNVLGTKDTDTTVNSYSQSGEMEYLRNQVSIGHDGDYDFGKW
STYVLQNNTQVKGRTLPSTYIPVELRGAERRLKNDDFLAHTDITSQLGMHKVTGGIEYQKSETTDTLRNQNPKLETESTA
IFIEDEWRLFNPLAFTFGGRYEDHSGFGGHFSPRGYLVWTPSDTLTIKGGVSTGYKVPTAAQLYDGVTGVSVISYNGVSL
GQGSGLTIGTPGLKPEESKNYELGVNFDNGENFEVSVTGYLNKIKNLISSDGYVYSCTFIDSPNRSGCITVAGASIYQDT
FSQSMNANSAETKGVEVALKYKIIPEWDIKTAYTWADTEVTSGTNDGFAYTMLPKHAINTTSTWHINDAIDVYLQHEYKS
SRKRFASVPTGTNATARNNLEIYNMTDNKFKAYNLFNLGTSYRYSDHMRINFAVNNLLDKDFTKIIGKTATSQTTVYEYI
AMGSTNDGTYISGRNYWLSLSYDF

Specific function: Involved in the initial step of iron uptake by binding ferric vibriobactin, an iron chelatin siderophore that allows V.cholerae to extract iron from the environment [H]

COG id: COG4771

COG function: function code P; Outer membrane receptor for ferrienterochelin and colicins

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

Organism=Escherichia coli, GI1788478, Length=679, Percent_Identity=30.780559646539, Blast_Score=268, Evalue=8e-73,
Organism=Escherichia coli, GI1786798, Length=800, Percent_Identity=25.125, Blast_Score=162, Evalue=1e-40,
Organism=Escherichia coli, GI1790405, Length=715, Percent_Identity=24.8951048951049, Blast_Score=122, Evalue=1e-28,
Organism=Escherichia coli, GI1790743, Length=212, Percent_Identity=26.8867924528302, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1787723, Length=136, Percent_Identity=35.2941176470588, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010916
- InterPro:   IPR010917 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 82174; Mature: 82043

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRITRTALSLAILTSIFHATYAAEESKTPNNNVENTTKLQTIVVTAAGYEQNVKDAAA
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCCCHHHHHH
SISVISRDDIEKKNATNVADLLTDIPGVDVRNGTGKTGNLEVEMRGMGAQYTLILIDGKR
EEEEEECCCCCCCCCCCHHHHHHCCCCCEECCCCCCCCEEEEEEECCCCEEEEEEEECCC
QNTNTDIAPNGFGSGLRSFLPPLASIERIEVIRGPMSTMYGSDAMGGVINIITKKVSNEW
CCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHCCCC
HGNLTVSGNVTESNKEANSLTTSFALNGPLVNDKLGIQLRGSYMDRGTADRVDESSNLRD
CCEEEEECCCCCCCCCCCCEEEEEEECCCEECCCCCEEEECCCCCCCCCCCCCCCCCCCC
PRPNKAHNYDVGAKLTYKLDNKNSFWIDGFTADQIYKNINNVLGTKDTDTTVNSYSQSGE
CCCCCCCCCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHCCCCC
MEYLRNQVSIGHDGDYDFGKWSTYVLQNNTQVKGRTLPSTYIPVELRGAERRLKNDDFLA
HHHHHHHCCCCCCCCCCCCCEEEEEEECCCEECCEECCCEEEEEEECCHHHHCCCCCEEE
HTDITSQLGMHKVTGGIEYQKSETTDTLRNQNPKLETESTAIFIEDEWRLFNPLAFTFGG
ECCHHHHCCCEECCCCEEECCCCCHHHHHCCCCCCCCCCEEEEEECCCEEECCEEEEECC
RYEDHSGFGGHFSPRGYLVWTPSDTLTIKGGVSTGYKVPTAAQLYDGVTGVSVISYNGVS
CCCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCCCCCCCHHHHHCCCCCEEEEEECCEE
LGQGSGLTIGTPGLKPEESKNYELGVNFDNGENFEVSVTGYLNKIKNLISSDGYVYSCTF
ECCCCCEEEECCCCCCCCCCCEEEEEEECCCCCEEEEEHHHHHHHHHHHCCCCEEEEEEE
IDSPNRSGCITVAGASIYQDTFSQSMNANSAETKGVEVALKYKIIPEWDIKTAYTWADTE
ECCCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCCCCEEEEECCCE
VTSGTNDGFAYTMLPKHAINTTSTWHINDAIDVYLQHEYKSSRKRFASVPTGTNATARNN
ECCCCCCCEEEEECCCCCCCCCEEEEECCEEEEEEEEHHHHHHHHEECCCCCCCCCCCCC
LEIYNMTDNKFKAYNLFNLGTSYRYSDHMRINFAVNNLLDKDFTKIIGKTATSQTTVYEY
EEEEECCCCCEEEEEEEECCCCCEECCCEEEEEEEHHHHHHHHHHHHCCCCCCCCEEEEE
IAMGSTNDGTYISGRNYWLSLSYDF
EEECCCCCCCEECCCEEEEEEEECC
>Mature Secondary Structure 
SKRITRTALSLAILTSIFHATYAAEESKTPNNNVENTTKLQTIVVTAAGYEQNVKDAAA
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCCCHHHHHH
SISVISRDDIEKKNATNVADLLTDIPGVDVRNGTGKTGNLEVEMRGMGAQYTLILIDGKR
EEEEEECCCCCCCCCCCHHHHHHCCCCCEECCCCCCCCEEEEEEECCCCEEEEEEEECCC
QNTNTDIAPNGFGSGLRSFLPPLASIERIEVIRGPMSTMYGSDAMGGVINIITKKVSNEW
CCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHCCCC
HGNLTVSGNVTESNKEANSLTTSFALNGPLVNDKLGIQLRGSYMDRGTADRVDESSNLRD
CCEEEEECCCCCCCCCCCCEEEEEEECCCEECCCCCEEEECCCCCCCCCCCCCCCCCCCC
PRPNKAHNYDVGAKLTYKLDNKNSFWIDGFTADQIYKNINNVLGTKDTDTTVNSYSQSGE
CCCCCCCCCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHCCCCC
MEYLRNQVSIGHDGDYDFGKWSTYVLQNNTQVKGRTLPSTYIPVELRGAERRLKNDDFLA
HHHHHHHCCCCCCCCCCCCCEEEEEEECCCEECCEECCCEEEEEEECCHHHHCCCCCEEE
HTDITSQLGMHKVTGGIEYQKSETTDTLRNQNPKLETESTAIFIEDEWRLFNPLAFTFGG
ECCHHHHCCCEECCCCEEECCCCCHHHHHCCCCCCCCCCEEEEEECCCEEECCEEEEECC
RYEDHSGFGGHFSPRGYLVWTPSDTLTIKGGVSTGYKVPTAAQLYDGVTGVSVISYNGVS
CCCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCCCCCCCHHHHHCCCCCEEEEEECCEE
LGQGSGLTIGTPGLKPEESKNYELGVNFDNGENFEVSVTGYLNKIKNLISSDGYVYSCTF
ECCCCCEEEECCCCCCCCCCCEEEEEEECCCCCEEEEEHHHHHHHHHHHCCCCEEEEEEE
IDSPNRSGCITVAGASIYQDTFSQSMNANSAETKGVEVALKYKIIPEWDIKTAYTWADTE
ECCCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCCCCEEEEECCCE
VTSGTNDGFAYTMLPKHAINTTSTWHINDAIDVYLQHEYKSSRKRFASVPTGTNATARNN
ECCCCCCCEEEEECCCCCCCCCEEEEECCEEEEEEEEHHHHHHHHEECCCCCCCCCCCCC
LEIYNMTDNKFKAYNLFNLGTSYRYSDHMRINFAVNNLLDKDFTKIIGKTATSQTTVYEY
EEEEECCCCCEEEEEEEECCCCCEECCCEEEEEEEHHHHHHHHHHHHCCCCCCCCEEEEE
IAMGSTNDGTYISGRNYWLSLSYDF
EEECCCCCCCEECCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1406279; 2174861 [H]