Click here to switch to the map view.

The map label for this gene is fabB [H]

Identifier: 50084090

GI number: 50084090

Start: 861789

End: 863018

Strand: Reverse

Name: fabB [H]

Synonym: ACIAD0879

Alternate gene names: 50084090

Gene position: 863018-861789 (Counterclockwise)

Preceding gene: 50084098

Following gene: 50084089

Centisome position: 23.98

GC content: 43.82

Gene sequence:

>1230_bases
ATGAAACGTGTTGTAATCACTGGTATGGGTATCAACTCATGTATTGGTAACACTTTAGAAGATGTAACGCATTCACTTCA
AAATGGAATCTCGGGCACACGTTTTAACCCAACTTATGCAGAACTCAACTTCAAAAGTCATGTGAGTGCTGCAGCAGAAC
AAAATTTTGACAATATTGATCGCAAATTAAAACGGTTTATGGGCGTATGTGCAATGTACGCTTACAACTCAGCAGTCGCT
GCAGTTGAACATGCAGGCTTAACAGCAGCAGACCTTGAAGGTAATCCTCGCTACGGTATCGTAGGCGGAAGTGGTGGTGG
TTCTACCGCATCTGTTGTAGAAATGCAGGAATTACTTGAAACCAAAGGTGCGCGTAAAGTCGGTCCTTTCTTTGTACCCC
GTAACATGACCAATACCATTACTGCAAACGTAGGCGTAGCATTCAAGTTACAGGGTGTTTCACATTCTATTGCCAGCGCG
TGTGCAACTTCTGCTGATGCAATTGGTTATGCTTATAATTTAATCCAGCTAGGCAAACAAGATCTTATCTTGGCAGGTGG
TGGTGAAGAAGACCACTGGTCACAAAGCTTATTGTTTGATGCCATGGGCGCGTTGTGCTCAAAATACAACGATACACCTG
AAACTGCATCTCGCCCTTACTCTAAAGACCGCGATGGTTTCGTCATCGCAGGTGGTGGTGGTTTCTTGGTACTTGAGTCA
CTTGAACATGCTCAAGCACGCGGTGCCAACATTCTGGCTGAGATTGTAGCTTATGCTGCAAATGCCGATGGTGCAGACAT
GGTTGCACCAAGTGGTGAAGGCGCAACTCGCTGTATCCTCATGGCGCTTGAAGAAGCCAAGCAACATGGTGTTGATTCTC
TAGATTATGTCAACACACATGGTACATCGACTCCTGCTGGTGATATCACCGAGCTTAAAGCCATGGAACGTGCATTTGGT
GAAGGTAAAGTTCCTGCTTTTAGTTCTACCAAATCTATGACAGGCCATAGCTTGGGTGCTGCGGGTGTTCATGAAGCGAT
TTATTCTGTGTTAATGCTTCAAAATGAATTTATTGCACCAAACATCAATGTGACTGAACTCGATGAAGGCGCTAAAGGTT
TTGATATTGTTTTAGAAAAACGTGATACAAAACTCAATGCTGTAATGAGCAACAGCTTTGGTTTTGGCGGCGTAAATGCA
TGCTTGATCTTCAAAAAATGGGATCAATAA

Upstream 100 bases:

>100_bases
CAAACAATGAGTCACACGATGTTTCGTTTCGCCTTACCTTGCGCGTAAAGGACGACGTATTTATTCAGACTCAAGACTAT
CACCAATAAGGGATCTCTAA

Downstream 100 bases:

>100_bases
TTTCTTTTTAAAGCTTTAAAGCATTTTTTAAAAGATACATCCATTACAAATAAGCGGATATATATTTCCGCTTATTTTTT
AATTTAGGTTTTAACTCTGC

Product: beta-ketoacyl-ACP synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MKRVVITGMGINSCIGNTLEDVTHSLQNGISGTRFNPTYAELNFKSHVSAAAEQNFDNIDRKLKRFMGVCAMYAYNSAVA
AVEHAGLTAADLEGNPRYGIVGGSGGGSTASVVEMQELLETKGARKVGPFFVPRNMTNTITANVGVAFKLQGVSHSIASA
CATSADAIGYAYNLIQLGKQDLILAGGGEEDHWSQSLLFDAMGALCSKYNDTPETASRPYSKDRDGFVIAGGGGFLVLES
LEHAQARGANILAEIVAYAANADGADMVAPSGEGATRCILMALEEAKQHGVDSLDYVNTHGTSTPAGDITELKAMERAFG
EGKVPAFSSTKSMTGHSLGAAGVHEAIYSVLMLQNEFIAPNINVTELDEGAKGFDIVLEKRDTKLNAVMSNSFGFGGVNA
CLIFKKWDQ

Sequences:

>Translated_409_residues
MKRVVITGMGINSCIGNTLEDVTHSLQNGISGTRFNPTYAELNFKSHVSAAAEQNFDNIDRKLKRFMGVCAMYAYNSAVA
AVEHAGLTAADLEGNPRYGIVGGSGGGSTASVVEMQELLETKGARKVGPFFVPRNMTNTITANVGVAFKLQGVSHSIASA
CATSADAIGYAYNLIQLGKQDLILAGGGEEDHWSQSLLFDAMGALCSKYNDTPETASRPYSKDRDGFVIAGGGGFLVLES
LEHAQARGANILAEIVAYAANADGADMVAPSGEGATRCILMALEEAKQHGVDSLDYVNTHGTSTPAGDITELKAMERAFG
EGKVPAFSSTKSMTGHSLGAAGVHEAIYSVLMLQNEFIAPNINVTELDEGAKGFDIVLEKRDTKLNAVMSNSFGFGGVNA
CLIFKKWDQ
>Mature_409_residues
MKRVVITGMGINSCIGNTLEDVTHSLQNGISGTRFNPTYAELNFKSHVSAAAEQNFDNIDRKLKRFMGVCAMYAYNSAVA
AVEHAGLTAADLEGNPRYGIVGGSGGGSTASVVEMQELLETKGARKVGPFFVPRNMTNTITANVGVAFKLQGVSHSIASA
CATSADAIGYAYNLIQLGKQDLILAGGGEEDHWSQSLLFDAMGALCSKYNDTPETASRPYSKDRDGFVIAGGGGFLVLES
LEHAQARGANILAEIVAYAANADGADMVAPSGEGATRCILMALEEAKQHGVDSLDYVNTHGTSTPAGDITELKAMERAFG
EGKVPAFSSTKSMTGHSLGAAGVHEAIYSVLMLQNEFIAPNINVTELDEGAKGFDIVLEKRDTKLNAVMSNSFGFGGVNA
CLIFKKWDQ

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=423, Percent_Identity=34.7517730496454, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI223972627, Length=166, Percent_Identity=38.5542168674699, Blast_Score=89, Evalue=5e-18,
Organism=Escherichia coli, GI1788663, Length=409, Percent_Identity=54.7677261613692, Blast_Score=425, Evalue=1e-120,
Organism=Escherichia coli, GI1787337, Length=413, Percent_Identity=38.9830508474576, Blast_Score=241, Evalue=9e-65,
Organism=Caenorhabditis elegans, GI71983541, Length=417, Percent_Identity=34.5323741007194, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI71983535, Length=267, Percent_Identity=38.5767790262172, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17550940, Length=282, Percent_Identity=28.7234042553192, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI212642053, Length=393, Percent_Identity=25.4452926208651, Blast_Score=91, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6320904, Length=449, Percent_Identity=33.4075723830735, Blast_Score=212, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24644341, Length=419, Percent_Identity=36.2768496420048, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI221330659, Length=426, Percent_Identity=24.1784037558685, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19920632, Length=426, Percent_Identity=24.6478873239437, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 43144; Mature: 43144

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVVITGMGINSCIGNTLEDVTHSLQNGISGTRFNPTYAELNFKSHVSAAAEQNFDNID
CCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECHHHHHHHHHHCCHHHHH
RKLKRFMGVCAMYAYNSAVAAVEHAGLTAADLEGNPRYGIVGGSGGGSTASVVEMQELLE
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHH
TKGARKVGPFFVPRNMTNTITANVGVAFKLQGVSHSIASACATSADAIGYAYNLIQLGKQ
HCCCCCCCCEECCCCCCCEEEECCCEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHCCCC
DLILAGGGEEDHWSQSLLFDAMGALCSKYNDTPETASRPYSKDRDGFVIAGGGGFLVLES
CEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCEEEECCCCEEEEHH
LEHAQARGANILAEIVAYAANADGADMVAPSGEGATRCILMALEEAKQHGVDSLDYVNTH
HHHHHHCCHHHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHHHHCCCCCCCEECCC
GTSTPAGDITELKAMERAFGEGKVPAFSSTKSMTGHSLGAAGVHEAIYSVLMLQNEFIAP
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
NINVTELDEGAKGFDIVLEKRDTKLNAVMSNSFGFGGVNACLIFKKWDQ
CCCCEECCCCCCCEEEEEECCCCEEEHEECCCCCCCCCEEEEEEEECCC
>Mature Secondary Structure
MKRVVITGMGINSCIGNTLEDVTHSLQNGISGTRFNPTYAELNFKSHVSAAAEQNFDNID
CCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECHHHHHHHHHHCCHHHHH
RKLKRFMGVCAMYAYNSAVAAVEHAGLTAADLEGNPRYGIVGGSGGGSTASVVEMQELLE
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHH
TKGARKVGPFFVPRNMTNTITANVGVAFKLQGVSHSIASACATSADAIGYAYNLIQLGKQ
HCCCCCCCCEECCCCCCCEEEECCCEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHCCCC
DLILAGGGEEDHWSQSLLFDAMGALCSKYNDTPETASRPYSKDRDGFVIAGGGGFLVLES
CEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCEEEECCCCEEEEHH
LEHAQARGANILAEIVAYAANADGADMVAPSGEGATRCILMALEEAKQHGVDSLDYVNTH
HHHHHHCCHHHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHHHHCCCCCCCEECCC
GTSTPAGDITELKAMERAFGEGKVPAFSSTKSMTGHSLGAAGVHEAIYSVLMLQNEFIAP
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
NINVTELDEGAKGFDIVLEKRDTKLNAVMSNSFGFGGVNACLIFKKWDQ
CCCCEECCCCCCCEEEEEECCCCEEEHEECCCCCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]