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The map label for this gene is nrdB [H]

Identifier: 50083944

GI number: 50083944

Start: 705843

End: 707126

Strand: Reverse

Name: nrdB [H]

Synonym: ACIAD0722

Alternate gene names: 50083944

Gene position: 707126-705843 (Counterclockwise)

Preceding gene: 50083945

Following gene: 50083936

Centisome position: 19.65

GC content: 45.79

Gene sequence:

>1284_bases
ATGTCTATCCTGAGTTGGGACGATTTAGAAGATGATTCGCAAAAACCGGCTGCACATGAACACAAGCCTGCGCCCGTCGA
TACGCAAAAAGCGCCAGCTGCGCCGTTGGTATCTGATGCAGAGCCATCATCGCCGCGTGTGGCAACTGCACAATCCTCTG
GAACCGATTCCATGCGATCAACAGATCCAACCGATCCGGTGGCTCGAGCATCTGAGTCCCTAAAACATCTGGACATTACG
GCTGGTCTGCAAGAGATTGAAACTGGTGCCGCACGTGTACAGGTTGATGATAAAGCCATGATCAACTGCCGTGCAGACTT
AAACCAGCTTGTACCATTTAAATACGAATGGGCTTGGCAGAAGTATCTGGATGGTTGCGCCAACCACTGGATGCCACAAG
AAGTTAACATGAACCACGACATCGCACTCTGGAAGTCTGAAAATGGCTTAACCGAAGATGAACGTGTGATTGTAAAACGT
AATCTTGGCTTCTTCTCTACTGCAGACTCACTGGTTGCAAATAATCTGGTTCTTGCGATCTATCGCCTCATTACCAACCC
CGAATGCCGTCAGTATATTTTGCGTCAGGCATTTGAAGAAGCCATTCATACACATGCATACCAGTACTGTATCGAATCTT
TGGGTATGGATGAAGGCGAAATCTTCAATATGTATCACGAGATTCCAAGTGTTGCACGCAAAGCAGCATGGGGCTTGAAA
TATACACAATCTTTGAGCGATCCAAAGTTTGAAACAGGAACCCCTGAAACAGATCAGCAGCTTTTGCGTAACCTGATTGC
ATTCTACTGCGTACTTGAAGGGATCTTCTTCTATTGTGGCTTTACTCAAATTTTGAGTATGGGCCGTCGTAATAAGATGA
ATGGTGTTTCTGAGCAATTCCAGTACATCTTGCGTGACGAATCAATGCATGTAAACTTCGGGATCGACATGATCAACCAG
ATCAAGATCGAAAACCCGCACTTGTGGACAGCAGAGTTCCAACAAGAAGTGATTCAGATGATTGTGGAAGGTACATTACT
TGAAATCGAATATGCACGTGACACCATGCCACGTGGTGTATTAGGTATGAATGCTGCCATGATGGAAGAGTACTTGAAGT
TTATCTGTAACCGCCGTTTGGCACAGCTTGGTTTGCCAGAGCAATATCGTGGCGTGAACAACCCATTTCAGTGGATGTCT
GAAATGATGGACTTACGTAAAGAGAAGAATTTCTTCGAAACGCGCGTAACAGACTATCAGACAGGTGGCGCTTTGAGTTG
GTGA

Upstream 100 bases:

>100_bases
TCGACAAAACTTAATTTTGCTTACACATAATAAGCGTATAGTAATGGCATCTTCGTAGAAAGGTGTCGATAACGATATTA
ACAACGAAGAGAGAATTGAG

Downstream 100 bases:

>100_bases
AATAAGTTATTGATAATATTCAAAAAAACCGTCTTTTAATAGGCGGTTTTTTCATACTTAATTTCTTAGTTATTTAAAAT
GATCAAGATCATCCTGAATT

Product: ribonucleotide-diphosphate reductase subunit beta

Products: NA

Alternate protein names: Ribonucleotide reductase small subunit [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MSILSWDDLEDDSQKPAAHEHKPAPVDTQKAPAAPLVSDAEPSSPRVATAQSSGTDSMRSTDPTDPVARASESLKHLDIT
AGLQEIETGAARVQVDDKAMINCRADLNQLVPFKYEWAWQKYLDGCANHWMPQEVNMNHDIALWKSENGLTEDERVIVKR
NLGFFSTADSLVANNLVLAIYRLITNPECRQYILRQAFEEAIHTHAYQYCIESLGMDEGEIFNMYHEIPSVARKAAWGLK
YTQSLSDPKFETGTPETDQQLLRNLIAFYCVLEGIFFYCGFTQILSMGRRNKMNGVSEQFQYILRDESMHVNFGIDMINQ
IKIENPHLWTAEFQQEVIQMIVEGTLLEIEYARDTMPRGVLGMNAAMMEEYLKFICNRRLAQLGLPEQYRGVNNPFQWMS
EMMDLRKEKNFFETRVTDYQTGGALSW

Sequences:

>Translated_427_residues
MSILSWDDLEDDSQKPAAHEHKPAPVDTQKAPAAPLVSDAEPSSPRVATAQSSGTDSMRSTDPTDPVARASESLKHLDIT
AGLQEIETGAARVQVDDKAMINCRADLNQLVPFKYEWAWQKYLDGCANHWMPQEVNMNHDIALWKSENGLTEDERVIVKR
NLGFFSTADSLVANNLVLAIYRLITNPECRQYILRQAFEEAIHTHAYQYCIESLGMDEGEIFNMYHEIPSVARKAAWGLK
YTQSLSDPKFETGTPETDQQLLRNLIAFYCVLEGIFFYCGFTQILSMGRRNKMNGVSEQFQYILRDESMHVNFGIDMINQ
IKIENPHLWTAEFQQEVIQMIVEGTLLEIEYARDTMPRGVLGMNAAMMEEYLKFICNRRLAQLGLPEQYRGVNNPFQWMS
EMMDLRKEKNFFETRVTDYQTGGALSW
>Mature_426_residues
SILSWDDLEDDSQKPAAHEHKPAPVDTQKAPAAPLVSDAEPSSPRVATAQSSGTDSMRSTDPTDPVARASESLKHLDITA
GLQEIETGAARVQVDDKAMINCRADLNQLVPFKYEWAWQKYLDGCANHWMPQEVNMNHDIALWKSENGLTEDERVIVKRN
LGFFSTADSLVANNLVLAIYRLITNPECRQYILRQAFEEAIHTHAYQYCIESLGMDEGEIFNMYHEIPSVARKAAWGLKY
TQSLSDPKFETGTPETDQQLLRNLIAFYCVLEGIFFYCGFTQILSMGRRNKMNGVSEQFQYILRDESMHVNFGIDMINQI
KIENPHLWTAEFQQEVIQMIVEGTLLEIEYARDTMPRGVLGMNAAMMEEYLKFICNRRLAQLGLPEQYRGVNNPFQWMSE
MMDLRKEKNFFETRVTDYQTGGALSW

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0208

COG function: function code F; Ribonucleotide reductase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribonucleoside diphosphate reductase small chain family [H]

Homologues:

Organism=Homo sapiens, GI4557845, Length=413, Percent_Identity=28.0871670702179, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI260064013, Length=396, Percent_Identity=28.2828282828283, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI289177074, Length=349, Percent_Identity=27.7936962750716, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI42544136, Length=343, Percent_Identity=27.6967930029155, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI289177076, Length=296, Percent_Identity=29.7297297297297, Blast_Score=137, Evalue=1e-32,
Organism=Escherichia coli, GI1788567, Length=293, Percent_Identity=23.5494880546075, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17551968, Length=319, Percent_Identity=29.7805642633229, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI193206379, Length=304, Percent_Identity=24.6710526315789, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17567153, Length=224, Percent_Identity=26.3392857142857, Blast_Score=86, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6322434, Length=331, Percent_Identity=31.4199395770393, Blast_Score=173, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6321619, Length=320, Percent_Identity=23.75, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI18079279, Length=400, Percent_Identity=26, Blast_Score=157, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009078
- InterPro:   IPR012348
- InterPro:   IPR000358 [H]

Pfam domain/function: PF00268 Ribonuc_red_sm [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 48842; Mature: 48711

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILSWDDLEDDSQKPAAHEHKPAPVDTQKAPAAPLVSDAEPSSPRVATAQSSGTDSMRS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCC
TDPTDPVARASESLKHLDITAGLQEIETGAARVQVDDKAMINCRADLNQLVPFKYEWAWQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHEEEHHHHHHCCCCCCHHHHH
KYLDGCANHWMPQEVNMNHDIALWKSENGLTEDERVIVKRNLGFFSTADSLVANNLVLAI
HHHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHEEEEECCCCHHHHHHHHHHHHHHHH
YRLITNPECRQYILRQAFEEAIHTHAYQYCIESLGMDEGEIFNMYHEIPSVARKAAWGLK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCH
YTQSLSDPKFETGTPETDQQLLRNLIAFYCVLEGIFFYCGFTQILSMGRRNKMNGVSEQF
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
QYILRDESMHVNFGIDMINQIKIENPHLWTAEFQQEVIQMIVEGTLLEIEYARDTMPRGV
HHHHHCCCEEEEECCCCHHHEEECCCCEEHHHHHHHHHHHHHCCHHEEEEHHHHCCCCCH
LGMNAAMMEEYLKFICNRRLAQLGLPEQYRGVNNPFQWMSEMMDLRKEKNFFETRVTDYQ
HHCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
TGGALSW
CCCCCCC
>Mature Secondary Structure 
SILSWDDLEDDSQKPAAHEHKPAPVDTQKAPAAPLVSDAEPSSPRVATAQSSGTDSMRS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCC
TDPTDPVARASESLKHLDITAGLQEIETGAARVQVDDKAMINCRADLNQLVPFKYEWAWQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHEEEHHHHHHCCCCCCHHHHH
KYLDGCANHWMPQEVNMNHDIALWKSENGLTEDERVIVKRNLGFFSTADSLVANNLVLAI
HHHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHEEEEECCCCHHHHHHHHHHHHHHHH
YRLITNPECRQYILRQAFEEAIHTHAYQYCIESLGMDEGEIFNMYHEIPSVARKAAWGLK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCH
YTQSLSDPKFETGTPETDQQLLRNLIAFYCVLEGIFFYCGFTQILSMGRRNKMNGVSEQF
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
QYILRDESMHVNFGIDMINQIKIENPHLWTAEFQQEVIQMIVEGTLLEIEYARDTMPRGV
HHHHHCCCEEEEECCCCHHHEEECCCCEEHHHHHHHHHHHHHCCHHEEEEHHHHCCCCCH
LGMNAAMMEEYLKFICNRRLAQLGLPEQYRGVNNPFQWMSEMMDLRKEKNFFETRVTDYQ
HHCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
TGGALSW
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]