Click here to switch to the map view.

The map label for this gene is mutM

Identifier: 50083930

GI number: 50083930

Start: 693723

End: 694541

Strand: Reverse

Name: mutM

Synonym: ACIAD0707

Alternate gene names: 50083930

Gene position: 694541-693723 (Counterclockwise)

Preceding gene: 50083934

Following gene: 50083929

Centisome position: 19.3

GC content: 42.25

Gene sequence:

>819_bases
ATGCCTGAATTACCTGAAGTTGAAACGACAAAAACAAGCCTGTTACCTTTACTGAACCAACGTGTCAAATCTGTGCAAGT
CAGAGACTCCCGATTACGCTGGCCTATTCCCGAAGATATTTCTCGTCTTGCTGGACAGCGTTTAACGAGTCTAAAGCGAC
GCTCCAAATATATTTTGGCCGAATTTGAAACAGATCAAATGCTGTGGCATTTAGGCATGTCAGGCAGCTTTCGTGTGGCG
ACAGCAGCAGATGAACTACGTAAACATGATCATCTGATTTTAACATTCGATGATGGCACCGAGTTGCGTTATCACGATCC
ACGGCGTTTTGGCTGCATTTTATGGCTGAATGAAGAATCACAAAGCAAGCTACTTAATCCACTTGGCCCAGAGCCTTTAA
GTGAAGATTTTAATGCAGACTATCTTTACCAAAAGTTAAAATCCAAGCAAGTCGGCATAAAAATTGCACTTATGGATAAT
CATGTCGTGGTAGGCGTAGGTAATATTTACGCGACAGAAAGCCTGTTTAATTTAGGAATTCACCCTGCCCAGCCTGCCAG
TAGTTTGAGTAAGCCTCAAATTCTGGCTTTAGTTCAAGAAATCAAACGTATTTTAAAATTTGCGATTGAGCTGGGTGGTT
CAACTTTACGAGACTATACCAATGCAATGGGCGAAAACGGTTATTTCCAGCAAACACTTTTGGCTTATGGCCGTGCAGGT
GAAATGTGCGTAAACTGCGAAACACCTTTAGAAAATCTAAAACTTGGACAACGCGCCAGTGTGTTCTGCCCTCAATGTCA
GCCATTAAAGCGAAAATAA

Upstream 100 bases:

>100_bases
GACATAAGCCTATACATATTAGAGGCTACAATGCGCCCCATCCTTTACAATGGACAAGATCGCCCCCATATTAGCGTTGG
TTGATAGAGTTGAGCTAAAG

Downstream 100 bases:

>100_bases
TGTGTATCTTTAAGATCACAAGCGAGGTTTAATTCATGCAAACAGCCATCGTGCGACATATTTTAGTTAAAGACAAAGAT
TTGGCCGATCAGCTAAAAAA

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MPELPEVETTKTSLLPLLNQRVKSVQVRDSRLRWPIPEDISRLAGQRLTSLKRRSKYILAEFETDQMLWHLGMSGSFRVA
TAADELRKHDHLILTFDDGTELRYHDPRRFGCILWLNEESQSKLLNPLGPEPLSEDFNADYLYQKLKSKQVGIKIALMDN
HVVVGVGNIYATESLFNLGIHPAQPASSLSKPQILALVQEIKRILKFAIELGGSTLRDYTNAMGENGYFQQTLLAYGRAG
EMCVNCETPLENLKLGQRASVFCPQCQPLKRK

Sequences:

>Translated_272_residues
MPELPEVETTKTSLLPLLNQRVKSVQVRDSRLRWPIPEDISRLAGQRLTSLKRRSKYILAEFETDQMLWHLGMSGSFRVA
TAADELRKHDHLILTFDDGTELRYHDPRRFGCILWLNEESQSKLLNPLGPEPLSEDFNADYLYQKLKSKQVGIKIALMDN
HVVVGVGNIYATESLFNLGIHPAQPASSLSKPQILALVQEIKRILKFAIELGGSTLRDYTNAMGENGYFQQTLLAYGRAG
EMCVNCETPLENLKLGQRASVFCPQCQPLKRK
>Mature_271_residues
PELPEVETTKTSLLPLLNQRVKSVQVRDSRLRWPIPEDISRLAGQRLTSLKRRSKYILAEFETDQMLWHLGMSGSFRVAT
AADELRKHDHLILTFDDGTELRYHDPRRFGCILWLNEESQSKLLNPLGPEPLSEDFNADYLYQKLKSKQVGIKIALMDNH
VVVGVGNIYATESLFNLGIHPAQPASSLSKPQILALVQEIKRILKFAIELGGSTLRDYTNAMGENGYFQQTLLAYGRAGE
MCVNCETPLENLKLGQRASVFCPQCQPLKRK

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=268, Percent_Identity=50, Blast_Score=260, Evalue=5e-71,
Organism=Escherichia coli, GI1786932, Length=282, Percent_Identity=23.758865248227, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_ACIAD (Q6FE90)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_045440.1
- ProteinModelPortal:   Q6FE90
- SMR:   Q6FE90
- STRING:   Q6FE90
- GeneID:   2880562
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD0707
- NMPDR:   fig|62977.3.peg.454
- eggNOG:   COG0266
- HOGENOM:   HBG690070
- OMA:   RMTGQLL
- PhylomeDB:   Q6FE90
- ProtClustDB:   CLSK707047
- BioCyc:   ASP62977:ACIAD0707-MONOMER
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 30825; Mature: 30694

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2; PS00070 ALDEHYDE_DEHYDR_CYS

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 56-56 ACT_SITE 258-258 BINDING 89-89 BINDING 108-108 BINDING 149-149

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETTKTSLLPLLNQRVKSVQVRDSRLRWPIPEDISRLAGQRLTSLKRRSKYILA
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEE
EFETDQMLWHLGMSGSFRVATAADELRKHDHLILTFDDGTELRYHDPRRFGCILWLNEES
EECHHHHHEEECCCCCEEEEHHHHHHHHCCCEEEEECCCCCEEECCCCCEEEEEEECCCH
QSKLLNPLGPEPLSEDFNADYLYQKLKSKQVGIKIALMDNHVVVGVGNIYATESLFNLGI
HHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCEEEEEECCHHHHHHHHHCCC
HPAQPASSLSKPQILALVQEIKRILKFAIELGGSTLRDYTNAMGENGYFQQTLLAYGRAG
CCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHCCCC
EMCVNCETPLENLKLGQRASVFCPQCQPLKRK
CEEEECCCCHHHCCCCCCCCEECCCCCCCCCC
>Mature Secondary Structure 
PELPEVETTKTSLLPLLNQRVKSVQVRDSRLRWPIPEDISRLAGQRLTSLKRRSKYILA
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEE
EFETDQMLWHLGMSGSFRVATAADELRKHDHLILTFDDGTELRYHDPRRFGCILWLNEES
EECHHHHHEEECCCCCEEEEHHHHHHHHCCCEEEEECCCCCEEECCCCCEEEEEEECCCH
QSKLLNPLGPEPLSEDFNADYLYQKLKSKQVGIKIALMDNHVVVGVGNIYATESLFNLGI
HHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCEEEEEECCHHHHHHHHHCCC
HPAQPASSLSKPQILALVQEIKRILKFAIELGGSTLRDYTNAMGENGYFQQTLLAYGRAG
CCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHCCCC
EMCVNCETPLENLKLGQRASVFCPQCQPLKRK
CEEEECCCCHHHCCCCCCCCEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA