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The map label for this gene is xanP [H]

Identifier: 50083925

GI number: 50083925

Start: 688754

End: 690127

Strand: Reverse

Name: xanP [H]

Synonym: ACIAD0702

Alternate gene names: 50083925

Gene position: 690127-688754 (Counterclockwise)

Preceding gene: 50083929

Following gene: 50083924

Centisome position: 19.18

GC content: 43.01

Gene sequence:

>1374_bases
ATGTCCGATCTCCCTCAATCTCCCCCAAAACGTCCCGAGCAACTCGATTTGATCTATGGTTTAGATGATCGACCTGCCCC
ATTCGTGTCCTTTTTGGCTGCATTACAGCATTTACTTGCTATTATTGTTCCAATTGTGACGCCAGGCTTGTTAATTTGTC
TGGCACTGGGTGTTTCTCGTGAAGAAACCAATATGATCTTGTCGATGTCATTGGTGATTTCTGGCGTCGCCACATTTTTA
CAATGTAAAAAAGTCGGTCCTTTAGGTGCTGGTCTTTTGATTGTTCAAGGCACCAGTTTTAACTTCATTGGCCCGATTAT
TGGCATCGGCTCTACAATGGTGGCAGCTGGAACTCCAGTCAATCAGGTGATGGCTGCCATTTTTGGTGTAGTGATTGCTG
GCTCGTTTATTGAAATGGGCGTTTCGCGTATTTTGCCCTGGATCAAAAAGCTGATTACCCCACTCGTCACTGGCATTGTA
GTATTACTGATTGGACTCACATTAATTAAAGAAGGCCTGATCAGTATGGGCGGTGGTTATCAAGCCATGCAGGATCAAAC
CTTTGCCAGCAGCGATAACCTGATTATGTCATGTACGGTTTTGGCAATTATTATTTTACTCAATCGTATTCAGGTGATCT
GGGTCAAAAGTTCTGCCATCCTGATTGCCTTGATCGTGGGATATATTCTTGCAGGTTTTATGGGACATTTAAATTTTTCA
GGTTTACATGAAACGCCTTTGATTCAGATTCCAACCCCAATGCATTTTGGACTGAGTTTTTCCTGGAGCCTATTTATTCC
AATGGCTTTTATCTATCTGGTGACGTCTCTTGAAGCGATTGGTGATATTACTGCTACCAGCAAGCTTTCTAATCAACCTG
TAGATGGCCCAGTATGGATGAAACGAATTAAAGGTGGTGTGCTGGTCAATGGTGCAAATTCATTTTTGGCGGGTCTATTT
AATACTTTCCCAAGCTCAGTGTTTGCACAAAACAATGGGGTGATTCAGCTCACAGGCGTTGCCAGTCGCTACGTAGGTAT
CTGGATCGCAGTGTTACTCATGTTGCTTGGATTATTTCCTGCTGTCGCAGGCATCATTCAAGCCGTACCACAAGCTGTTT
TAGGCGGTGCTGTGATGGTAATGTTTGGTGCAGTCGCAGCTTCTGGTATTAATATTTTGTCTGGTATTCATTTGGATCGA
CGTGCCTTACTCATTATTGCGATTTCATTGGCACTAGGTTTAGGTGTTGCACAAGTCCCGCAAATTTTAGAGCATTTACC
AGCGTTGTTTAAAAATATCTTTAGCTCTGGCGTAGCTACAGGTGGTATTGCAGCGCTGATACTGAATATTATATTGCCTG
AACACAAACAATAA

Upstream 100 bases:

>100_bases
TTAACGCGTTTTTTTTCATCCATCGCCTTTTATCTTTTATTATCAGTACTAACTCGATTAGAATACCGCCAACTTGTTGT
ACCAGACTTGATGATTTTAG

Downstream 100 bases:

>100_bases
CTTAGGTAATTCAACAGATTTGCCCAGTATTGACTGGGCTTTGTTATTCATGAGAGACACAAGATGGACCCACGTAGTGA
AGTGGTACTTCGGCAGCAAC

Product: transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MSDLPQSPPKRPEQLDLIYGLDDRPAPFVSFLAALQHLLAIIVPIVTPGLLICLALGVSREETNMILSMSLVISGVATFL
QCKKVGPLGAGLLIVQGTSFNFIGPIIGIGSTMVAAGTPVNQVMAAIFGVVIAGSFIEMGVSRILPWIKKLITPLVTGIV
VLLIGLTLIKEGLISMGGGYQAMQDQTFASSDNLIMSCTVLAIIILLNRIQVIWVKSSAILIALIVGYILAGFMGHLNFS
GLHETPLIQIPTPMHFGLSFSWSLFIPMAFIYLVTSLEAIGDITATSKLSNQPVDGPVWMKRIKGGVLVNGANSFLAGLF
NTFPSSVFAQNNGVIQLTGVASRYVGIWIAVLLMLLGLFPAVAGIIQAVPQAVLGGAVMVMFGAVAASGINILSGIHLDR
RALLIIAISLALGLGVAQVPQILEHLPALFKNIFSSGVATGGIAALILNIILPEHKQ

Sequences:

>Translated_457_residues
MSDLPQSPPKRPEQLDLIYGLDDRPAPFVSFLAALQHLLAIIVPIVTPGLLICLALGVSREETNMILSMSLVISGVATFL
QCKKVGPLGAGLLIVQGTSFNFIGPIIGIGSTMVAAGTPVNQVMAAIFGVVIAGSFIEMGVSRILPWIKKLITPLVTGIV
VLLIGLTLIKEGLISMGGGYQAMQDQTFASSDNLIMSCTVLAIIILLNRIQVIWVKSSAILIALIVGYILAGFMGHLNFS
GLHETPLIQIPTPMHFGLSFSWSLFIPMAFIYLVTSLEAIGDITATSKLSNQPVDGPVWMKRIKGGVLVNGANSFLAGLF
NTFPSSVFAQNNGVIQLTGVASRYVGIWIAVLLMLLGLFPAVAGIIQAVPQAVLGGAVMVMFGAVAASGINILSGIHLDR
RALLIIAISLALGLGVAQVPQILEHLPALFKNIFSSGVATGGIAALILNIILPEHKQ
>Mature_456_residues
SDLPQSPPKRPEQLDLIYGLDDRPAPFVSFLAALQHLLAIIVPIVTPGLLICLALGVSREETNMILSMSLVISGVATFLQ
CKKVGPLGAGLLIVQGTSFNFIGPIIGIGSTMVAAGTPVNQVMAAIFGVVIAGSFIEMGVSRILPWIKKLITPLVTGIVV
LLIGLTLIKEGLISMGGGYQAMQDQTFASSDNLIMSCTVLAIIILLNRIQVIWVKSSAILIALIVGYILAGFMGHLNFSG
LHETPLIQIPTPMHFGLSFSWSLFIPMAFIYLVTSLEAIGDITATSKLSNQPVDGPVWMKRIKGGVLVNGANSFLAGLFN
TFPSSVFAQNNGVIQLTGVASRYVGIWIAVLLMLLGLFPAVAGIIQAVPQAVLGGAVMVMFGAVAASGINILSGIHLDRR
ALLIIAISLALGLGVAQVPQILEHLPALFKNIFSSGVATGGIAALILNIILPEHKQ

Specific function: Specific, proton motive force-dependent high-affinity transporter for xanthine [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=523, Percent_Identity=22.3709369024857, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI44680148, Length=513, Percent_Identity=23.9766081871345, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI40316845, Length=513, Percent_Identity=23.9766081871345, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI44680143, Length=527, Percent_Identity=22.3908918406072, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1790087, Length=451, Percent_Identity=53.880266075388, Blast_Score=468, Evalue=1e-133,
Organism=Escherichia coli, GI87082178, Length=438, Percent_Identity=44.7488584474886, Blast_Score=351, Evalue=5e-98,
Organism=Escherichia coli, GI87082181, Length=462, Percent_Identity=31.1688311688312, Blast_Score=189, Evalue=4e-49,
Organism=Escherichia coli, GI1788843, Length=415, Percent_Identity=26.0240963855422, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI87081818, Length=282, Percent_Identity=28.3687943262411, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17558856, Length=456, Percent_Identity=21.2719298245614, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71993493, Length=222, Percent_Identity=27.027027027027, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 48094; Mature: 47962

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLPQSPPKRPEQLDLIYGLDDRPAPFVSFLAALQHLLAIIVPIVTPGLLICLALGVSR
CCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EETNMILSMSLVISGVATFLQCKKVGPLGAGLLIVQGTSFNFIGPIIGIGSTMVAAGTPV
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHCCCHHHCCCCCH
NQVMAAIFGVVIAGSFIEMGVSRILPWIKKLITPLVTGIVVLLIGLTLIKEGLISMGGGY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
QAMQDQTFASSDNLIMSCTVLAIIILLNRIQVIWVKSSAILIALIVGYILAGFMGHLNFS
HHHHCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCC
GLHETPLIQIPTPMHFGLSFSWSLFIPMAFIYLVTSLEAIGDITATSKLSNQPVDGPVWM
CCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCHHHH
KRIKGGVLVNGANSFLAGLFNTFPSSVFAQNNGVIQLTGVASRYVGIWIAVLLMLLGLFP
HHHCCCEEEECHHHHHHHHHHHCCHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHH
AVAGIIQAVPQAVLGGAVMVMFGAVAASGINILSGIHLDRRALLIIAISLALGLGVAQVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHH
QILEHLPALFKNIFSSGVATGGIAALILNIILPEHKQ
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SDLPQSPPKRPEQLDLIYGLDDRPAPFVSFLAALQHLLAIIVPIVTPGLLICLALGVSR
CCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EETNMILSMSLVISGVATFLQCKKVGPLGAGLLIVQGTSFNFIGPIIGIGSTMVAAGTPV
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHCCCHHHCCCCCH
NQVMAAIFGVVIAGSFIEMGVSRILPWIKKLITPLVTGIVVLLIGLTLIKEGLISMGGGY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
QAMQDQTFASSDNLIMSCTVLAIIILLNRIQVIWVKSSAILIALIVGYILAGFMGHLNFS
HHHHCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCC
GLHETPLIQIPTPMHFGLSFSWSLFIPMAFIYLVTSLEAIGDITATSKLSNQPVDGPVWM
CCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCHHHH
KRIKGGVLVNGANSFLAGLFNTFPSSVFAQNNGVIQLTGVASRYVGIWIAVLLMLLGLFP
HHHCCCEEEECHHHHHHHHHHHCCHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHH
AVAGIIQAVPQAVLGGAVMVMFGAVAASGINILSGIHLDRRALLIIAISLALGLGVAQVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHH
QILEHLPALFKNIFSSGVATGGIAALILNIILPEHKQ
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]