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The map label for this gene is pcoA [H]

Identifier: 50083914

GI number: 50083914

Start: 677061

End: 678821

Strand: Direct

Name: pcoA [H]

Synonym: ACIAD0687

Alternate gene names: 50083914

Gene position: 677061-678821 (Clockwise)

Preceding gene: 50083913

Following gene: 50083915

Centisome position: 18.81

GC content: 42.82

Gene sequence:

>1761_bases
ATGCGACGTGTATTACAACAGTTATGGGCTGTTGGGATTTGCCTGACTTTTTCATCGGCAACTCTCGCAGCAATCAAAGA
GTATCATCTCAACATTGATGAGCAAATTATTGATCTTACAGGGAAGCCGACGAAAAAAATCACGGTAAATGGACAGTTCC
CTGCACCACTACTCGAATTTGAGGAAGGCGATGAGGCCGTTATTCATGTCCATAATGCCTTGAAAGATCGTGATACCTCT
TTACATTGGCATGGTTTATTGTTACCAGGCCTAATGGATGGTGTACCTGGTTTTAACGGATTCCGTGGCATCAAGCCTCA
TGCAGATTTTGAATATCGTTTCAAGATTCGGCAAAGTGGAACTTACTGGTATCATGCCCATAGCCAAGGACAGGAACAAG
ACGGCTTATATGGCGCACTTGTGATTTATCCCAAAAATAAAAAACCGATTGTCTCTTATGAGCAAGTTGATCGGGATTAC
GTGGTCATGTTGTCTGATTTTCATCATTCATCTAGTGATCAGATCATGAAAAATCTGAAAAAGTCTTCCGAGTATTATCA
AAATCAGCGTGAAACAATAAAAGACGTTTGGCATCAGCTTCAGCAACAGGGATTTAAGGCAACCTGGCAAGACCGTAAAA
TGTGGAATCAGATGCGAATGCTCAAAACCGATTTATCTGATGTCACTGATTATACATTTCTGGTCAATGGAAAAACACTT
GAACAAAACTGGACAGCGATGTTTAAGCCCAACGAAAAAGTTCGATTGCGTTTTATTAATGCTTCAGCCATGTCTTTTTT
CGATGTCAGGATTCCACAACTACGAATGACAGTGGTAAGTGCCGATGGTCAGCCAGTAAAACCTGTGCAGATTGATGAGT
TTAGAATAGGTGCTGCTGAAACCTACGATGTAATTGTAGAGCCTCAGCAAGCGCATTATCAGATTCAAGCTGAATCGATT
GACCGAAGTGGTTTTGCACTGGCCAGTTTACAAAATGAGTTATTACCAGCACCACCACAGATTCAGGTTCCTACAGCACG
TCCACGTAGTGTTTTAACAATGGAGGATATGGGGCATCATCCTATGGATGTTGAATCAGATAGCTCTTCGATGCAGCATG
AGATGCCGAATGATGATCATGCCATGTCACATAATATGATGCAGCATGATGTGATGAGTCATGAGATGCAACCAAGTCCT
CAGTATAAATCGAGCCAGCAGTCACCAGAAGGGTGGGCAAATGCTTCTACGCCAATGGGTTTAAAAGCATTGCAATATAC
CGATTTAAAATCTTTGTTTCCTCAGTCCGACCTGCGTCAACCTGACCGTGAGATTGTCATCCATCTTGGTGGAAACATGG
AGCGATATATCTGGACCATGAATGGCAAAAAGTTTAGTGAGGCATCGCCTTTAACATTGAAATATGGAGAGCGAGTCAGG
CTCAAATTTGTGAATGATTCCATGATGGCACATCCCATGCATTTACATGGCATGTTTGTACAACTGGAAAATGGTCAGGC
GATGGAGCGTTTACCGAATAAACATACTTTGATCGTGCCGCCTGGCAAAACTGTAACGGCTTTGTTGACCGCAGATGAAG
TAGGAGAGTGGGCGATACATTGTCATTTGCTCTATCACATGACCGCTGGAATGATGAATAAGCTCGTGGTCGCGCATACC
GAAGTTCCAATGCCGAGCACATTAAAGACGAATGAAAACAGTACTCAGGAAGTGAAAGGAGAACATCATGCGCATCACTA
A

Upstream 100 bases:

>100_bases
AAAGGATATTGGCAAGAAATATTACGTCCACCCAAAGCTTAACCTGAATTTAGATACATCACGTTTAACGTAAAGTGTTT
TTAAAATTTAGAGGTTAAGT

Downstream 100 bases:

>100_bases
GGTCACCTTTTACCTGACTGGCGTTCTGATGAATGCTTCGGTATATGCACATGATGCACATGCTATGAACACGATGGTAT
CCAGTGATCATCATATGCAG

Product: copper resistance protein A precursor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 586; Mature: 586

Protein sequence:

>586_residues
MRRVLQQLWAVGICLTFSSATLAAIKEYHLNIDEQIIDLTGKPTKKITVNGQFPAPLLEFEEGDEAVIHVHNALKDRDTS
LHWHGLLLPGLMDGVPGFNGFRGIKPHADFEYRFKIRQSGTYWYHAHSQGQEQDGLYGALVIYPKNKKPIVSYEQVDRDY
VVMLSDFHHSSSDQIMKNLKKSSEYYQNQRETIKDVWHQLQQQGFKATWQDRKMWNQMRMLKTDLSDVTDYTFLVNGKTL
EQNWTAMFKPNEKVRLRFINASAMSFFDVRIPQLRMTVVSADGQPVKPVQIDEFRIGAAETYDVIVEPQQAHYQIQAESI
DRSGFALASLQNELLPAPPQIQVPTARPRSVLTMEDMGHHPMDVESDSSSMQHEMPNDDHAMSHNMMQHDVMSHEMQPSP
QYKSSQQSPEGWANASTPMGLKALQYTDLKSLFPQSDLRQPDREIVIHLGGNMERYIWTMNGKKFSEASPLTLKYGERVR
LKFVNDSMMAHPMHLHGMFVQLENGQAMERLPNKHTLIVPPGKTVTALLTADEVGEWAIHCHLLYHMTAGMMNKLVVAHT
EVPMPSTLKTNENSTQEVKGEHHAHH

Sequences:

>Translated_586_residues
MRRVLQQLWAVGICLTFSSATLAAIKEYHLNIDEQIIDLTGKPTKKITVNGQFPAPLLEFEEGDEAVIHVHNALKDRDTS
LHWHGLLLPGLMDGVPGFNGFRGIKPHADFEYRFKIRQSGTYWYHAHSQGQEQDGLYGALVIYPKNKKPIVSYEQVDRDY
VVMLSDFHHSSSDQIMKNLKKSSEYYQNQRETIKDVWHQLQQQGFKATWQDRKMWNQMRMLKTDLSDVTDYTFLVNGKTL
EQNWTAMFKPNEKVRLRFINASAMSFFDVRIPQLRMTVVSADGQPVKPVQIDEFRIGAAETYDVIVEPQQAHYQIQAESI
DRSGFALASLQNELLPAPPQIQVPTARPRSVLTMEDMGHHPMDVESDSSSMQHEMPNDDHAMSHNMMQHDVMSHEMQPSP
QYKSSQQSPEGWANASTPMGLKALQYTDLKSLFPQSDLRQPDREIVIHLGGNMERYIWTMNGKKFSEASPLTLKYGERVR
LKFVNDSMMAHPMHLHGMFVQLENGQAMERLPNKHTLIVPPGKTVTALLTADEVGEWAIHCHLLYHMTAGMMNKLVVAHT
EVPMPSTLKTNENSTQEVKGEHHAHH
>Mature_586_residues
MRRVLQQLWAVGICLTFSSATLAAIKEYHLNIDEQIIDLTGKPTKKITVNGQFPAPLLEFEEGDEAVIHVHNALKDRDTS
LHWHGLLLPGLMDGVPGFNGFRGIKPHADFEYRFKIRQSGTYWYHAHSQGQEQDGLYGALVIYPKNKKPIVSYEQVDRDY
VVMLSDFHHSSSDQIMKNLKKSSEYYQNQRETIKDVWHQLQQQGFKATWQDRKMWNQMRMLKTDLSDVTDYTFLVNGKTL
EQNWTAMFKPNEKVRLRFINASAMSFFDVRIPQLRMTVVSADGQPVKPVQIDEFRIGAAETYDVIVEPQQAHYQIQAESI
DRSGFALASLQNELLPAPPQIQVPTARPRSVLTMEDMGHHPMDVESDSSSMQHEMPNDDHAMSHNMMQHDVMSHEMQPSP
QYKSSQQSPEGWANASTPMGLKALQYTDLKSLFPQSDLRQPDREIVIHLGGNMERYIWTMNGKKFSEASPLTLKYGERVR
LKFVNDSMMAHPMHLHGMFVQLENGQAMERLPNKHTLIVPPGKTVTALLTADEVGEWAIHCHLLYHMTAGMMNKLVVAHT
EVPMPSTLKTNENSTQEVKGEHHAHH

Specific function: Could be involved in copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Caenorhabditis elegans, GI17539950, Length=312, Percent_Identity=23.0769230769231, Blast_Score=93, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6323703, Length=302, Percent_Identity=28.1456953642384, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6321067, Length=340, Percent_Identity=24.1176470588235, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI28574104, Length=637, Percent_Identity=22.7629513343799, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24585842, Length=619, Percent_Identity=23.7479806138934, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI281360167, Length=310, Percent_Identity=26.4516129032258, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI221329998, Length=310, Percent_Identity=26.4516129032258, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI221330000, Length=312, Percent_Identity=27.2435897435897, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI18859919, Length=554, Percent_Identity=20.5776173285199, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 67029; Mature: 67029

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVLQQLWAVGICLTFSSATLAAIKEYHLNIDEQIIDLTGKPTKKITVNGQFPAPLLEF
CHHHHHHHHHHEEEEEECCHHHHHHHHHHCCCCHHEEECCCCCCEEEEECCCCCCCCEEC
EEGDEAVIHVHNALKDRDTSLHWHGLLLPGLMDGVPGFNGFRGIKPHADFEYRFKIRQSG
CCCCCEEEEEEHHHCCCCCCEEEEEEEHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECC
TYWYHAHSQGQEQDGLYGALVIYPKNKKPIVSYEQVDRDYVVMLSDFHHSSSDQIMKNLK
EEEEEECCCCCCCCCCEEEEEEEECCCCCEECHHHCCCCEEEEEECCCCCCHHHHHHHHH
KSSEYYQNQRETIKDVWHQLQQQGFKATWQDRKMWNQMRMLKTDLSDVTDYTFLVNGKTL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCEE
EQNWTAMFKPNEKVRLRFINASAMSFFDVRIPQLRMTVVSADGQPVKPVQIDEFRIGAAE
CCCCEEEECCCCEEEEEEEECCCEEEEEEECCEEEEEEEECCCCCCCCEEECCEECCCCC
TYDVIVEPQQAHYQIQAESIDRSGFALASLQNELLPAPPQIQVPTARPRSVLTMEDMGHH
EEEEEECCCHHEEEEEEECCCCCCEEHHHHHHHHCCCCCCEECCCCCCCEEEEHHHCCCC
PMDVESDSSSMQHEMPNDDHAMSHNMMQHDVMSHEMQPSPQYKSSQQSPEGWANASTPMG
CCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
LKALQYTDLKSLFPQSDLRQPDREIVIHLGGNMERYIWTMNGKKFSEASPLTLKYGERVR
CEEEEHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCCCCCCCEEEECCCEEE
LKFVNDSMMAHPMHLHGMFVQLENGQAMERLPNKHTLIVPPGKTVTALLTADEVGEWAIH
EEEECCCHHCCCEEEEEEEEEECCCCHHHHCCCCCEEEECCCCCEEEEEECCCCCCEEEE
CHLLYHMTAGMMNKLVVAHTEVPMPSTLKTNENSTQEVKGEHHAHH
EHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCHHHHCCCCCCCC
>Mature Secondary Structure
MRRVLQQLWAVGICLTFSSATLAAIKEYHLNIDEQIIDLTGKPTKKITVNGQFPAPLLEF
CHHHHHHHHHHEEEEEECCHHHHHHHHHHCCCCHHEEECCCCCCEEEEECCCCCCCCEEC
EEGDEAVIHVHNALKDRDTSLHWHGLLLPGLMDGVPGFNGFRGIKPHADFEYRFKIRQSG
CCCCCEEEEEEHHHCCCCCCEEEEEEEHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECC
TYWYHAHSQGQEQDGLYGALVIYPKNKKPIVSYEQVDRDYVVMLSDFHHSSSDQIMKNLK
EEEEEECCCCCCCCCCEEEEEEEECCCCCEECHHHCCCCEEEEEECCCCCCHHHHHHHHH
KSSEYYQNQRETIKDVWHQLQQQGFKATWQDRKMWNQMRMLKTDLSDVTDYTFLVNGKTL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCEE
EQNWTAMFKPNEKVRLRFINASAMSFFDVRIPQLRMTVVSADGQPVKPVQIDEFRIGAAE
CCCCEEEECCCCEEEEEEEECCCEEEEEEECCEEEEEEEECCCCCCCCEEECCEECCCCC
TYDVIVEPQQAHYQIQAESIDRSGFALASLQNELLPAPPQIQVPTARPRSVLTMEDMGHH
EEEEEECCCHHEEEEEEECCCCCCEEHHHHHHHHCCCCCCEECCCCCCCEEEEHHHCCCC
PMDVESDSSSMQHEMPNDDHAMSHNMMQHDVMSHEMQPSPQYKSSQQSPEGWANASTPMG
CCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
LKALQYTDLKSLFPQSDLRQPDREIVIHLGGNMERYIWTMNGKKFSEASPLTLKYGERVR
CEEEEHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCCCCCCCEEEECCCEEE
LKFVNDSMMAHPMHLHGMFVQLENGQAMERLPNKHTLIVPPGKTVTALLTADEVGEWAIH
EEEECCCHHCCCEEEEEEEEEECCCCHHHHCCCCCEEEECCCCCEEEEEECCCCCCEEEE
CHLLYHMTAGMMNKLVVAHTEVPMPSTLKTNENSTQEVKGEHHAHH
EHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]