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The map label for this gene is fghA [H]

Identifier: 50083909

GI number: 50083909

Start: 674124

End: 674954

Strand: Direct

Name: fghA [H]

Synonym: ACIAD0682

Alternate gene names: 50083909

Gene position: 674124-674954 (Clockwise)

Preceding gene: 50083908

Following gene: 50083911

Centisome position: 18.73

GC content: 41.88

Gene sequence:

>831_bases
CTGCAAAAAAACAAGTGTTATGAAGGTGAACAACGCATTTATCAGATAACATCAAGTTTTTTAAATGGAAAAACCAAGTT
TGGTATTTTTCTGCCTCCTGCTGCCTTGCAAGGTGAACAGTGTTCAACTTTATTTTATCTCGCAGGATTGACCTGTACAG
AAGAAACATTTGCCATTAAAGCGCATGCGCAGCGTCTGGCTGCACAGCTCAATCTCATTTTAATTACACCAGATACTTCA
CCACGCGGAGATGATGTGGCACAAGGCGATCATTGGGATATTGGTCAGGGCGCTAGTTTTTATATCAACGCGACGCAAGC
CCCGTGGAAAGCACATTATCAGATGGAAAGTTATCTTATTGATGAGTTGTACACTTTGATCCAAACGGAATTTCCTGCTC
ATCCAGATCAGATCGGGATAATGGGGCATTCAATGGGTGGTCATGGCGCGCTAACCCTTGCGTTCAAATACCCAGAAAAA
TTTAAGTCAGTTTCTGCATTTGCACCGATTTGTGAGCCATCACAGTGTCCTTGGGGTGAAAAGGCCTTTTCAAATTATCT
TGGTAATGATCAATCAGTTTGGAAAAGCCACGATGCAACTGCACTGATCCGTCAAAAGGGGATGCTGTTTAAAGATATTT
TAATTGATCAAGGATTAGATGATCAGTTCTTAAGTCAGCTTCACCCCGATCAATTTGAGCAGGCATGTGAAGCAGCCCAG
CAGCCATTATCGCTGAGAAAGCATGCAGGATATGATCATGGTTATTACTTTATTCAAAGTTTCATGGATGATCATTTGCA
ATTTCATGCAGTACAGCTTGAACACGCCTAA

Upstream 100 bases:

>100_bases
ATGGAACTGATGCTGCCACAACTAGAGCAGCATTTATTTCCACAGCAAACTTTACCGCAAGCTACCGCCATTTCGCATGA
GGAAAAAACACATGGAACTT

Downstream 100 bases:

>100_bases
ACAAATTTATTCAAATGAGAGGTCGTTTAAGAACAAAATAGCGAAGTAGAACGCTTCGCTGTTTCACTGAGATCACACCT
GAGACCACGTTACATTAAAC

Product: esterase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MQKNKCYEGEQRIYQITSSFLNGKTKFGIFLPPAALQGEQCSTLFYLAGLTCTEETFAIKAHAQRLAAQLNLILITPDTS
PRGDDVAQGDHWDIGQGASFYINATQAPWKAHYQMESYLIDELYTLIQTEFPAHPDQIGIMGHSMGGHGALTLAFKYPEK
FKSVSAFAPICEPSQCPWGEKAFSNYLGNDQSVWKSHDATALIRQKGMLFKDILIDQGLDDQFLSQLHPDQFEQACEAAQ
QPLSLRKHAGYDHGYYFIQSFMDDHLQFHAVQLEHA

Sequences:

>Translated_276_residues
MQKNKCYEGEQRIYQITSSFLNGKTKFGIFLPPAALQGEQCSTLFYLAGLTCTEETFAIKAHAQRLAAQLNLILITPDTS
PRGDDVAQGDHWDIGQGASFYINATQAPWKAHYQMESYLIDELYTLIQTEFPAHPDQIGIMGHSMGGHGALTLAFKYPEK
FKSVSAFAPICEPSQCPWGEKAFSNYLGNDQSVWKSHDATALIRQKGMLFKDILIDQGLDDQFLSQLHPDQFEQACEAAQ
QPLSLRKHAGYDHGYYFIQSFMDDHLQFHAVQLEHA
>Mature_276_residues
MQKNKCYEGEQRIYQITSSFLNGKTKFGIFLPPAALQGEQCSTLFYLAGLTCTEETFAIKAHAQRLAAQLNLILITPDTS
PRGDDVAQGDHWDIGQGASFYINATQAPWKAHYQMESYLIDELYTLIQTEFPAHPDQIGIMGHSMGGHGALTLAFKYPEK
FKSVSAFAPICEPSQCPWGEKAFSNYLGNDQSVWKSHDATALIRQKGMLFKDILIDQGLDDQFLSQLHPDQFEQACEAAQ
QPLSLRKHAGYDHGYYFIQSFMDDHLQFHAVQLEHA

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate (Probable) [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=277, Percent_Identity=50.9025270758123, Blast_Score=290, Evalue=1e-78,
Organism=Escherichia coli, GI1788477, Length=272, Percent_Identity=50, Blast_Score=265, Evalue=2e-72,
Organism=Escherichia coli, GI1786551, Length=275, Percent_Identity=44.7272727272727, Blast_Score=254, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI17510185, Length=273, Percent_Identity=42.1245421245421, Blast_Score=232, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6322393, Length=252, Percent_Identity=41.2698412698413, Blast_Score=186, Evalue=3e-48,
Organism=Drosophila melanogaster, GI45551932, Length=277, Percent_Identity=46.5703971119134, Blast_Score=268, Evalue=3e-72,
Organism=Drosophila melanogaster, GI24648347, Length=277, Percent_Identity=46.5703971119134, Blast_Score=267, Evalue=7e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 31060; Mature: 31060

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKNKCYEGEQRIYQITSSFLNGKTKFGIFLPPAALQGEQCSTLFYLAGLTCTEETFAIK
CCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCHHCCCCCCCEEEEECCCCCCCHHHHHH
AHAQRLAAQLNLILITPDTSPRGDDVAQGDHWDIGQGASFYINATQAPWKAHYQMESYLI
HHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHH
DELYTLIQTEFPAHPDQIGIMGHSMGGHGALTLAFKYPEKFKSVSAFAPICEPSQCPWGE
HHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEEEECCHHHHHHHHHCCCCCCCCCCCCH
KAFSNYLGNDQSVWKSHDATALIRQKGMLFKDILIDQGLDDQFLSQLHPDQFEQACEAAQ
HHHHHHCCCCHHHHHCCCHHHHHHHCCCHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHH
QPLSLRKHAGYDHGYYFIQSFMDDHLQFHAVQLEHA
CCHHHHHHCCCCCHHHHHHHHHHHHHEEEEEEEECC
>Mature Secondary Structure
MQKNKCYEGEQRIYQITSSFLNGKTKFGIFLPPAALQGEQCSTLFYLAGLTCTEETFAIK
CCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCHHCCCCCCCEEEEECCCCCCCHHHHHH
AHAQRLAAQLNLILITPDTSPRGDDVAQGDHWDIGQGASFYINATQAPWKAHYQMESYLI
HHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHH
DELYTLIQTEFPAHPDQIGIMGHSMGGHGALTLAFKYPEKFKSVSAFAPICEPSQCPWGE
HHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEEEECCHHHHHHHHHCCCCCCCCCCCCH
KAFSNYLGNDQSVWKSHDATALIRQKGMLFKDILIDQGLDDQFLSQLHPDQFEQACEAAQ
HHHHHHCCCCHHHHHCCCHHHHHHHCCCHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHH
QPLSLRKHAGYDHGYYFIQSFMDDHLQFHAVQLEHA
CCHHHHHHCCCCCHHHHHHHHHHHHHEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8892832 [H]