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The map label for this gene is edd [H]

Identifier: 50083780

GI number: 50083780

Start: 532423

End: 534270

Strand: Direct

Name: edd [H]

Synonym: ACIAD0542

Alternate gene names: 50083780

Gene position: 532423-534270 (Clockwise)

Preceding gene: 50083777

Following gene: 50083781

Centisome position: 14.8

GC content: 47.46

Gene sequence:

>1848_bases
ATGGACTTGCTGAATCCGATATTAGTAAAAGTGACCGAACGTGTGACTGCACGTAGTCAAAAAACCCGTGCCGCATATTT
AAAGCGTATTGAACATGCGCAAGGTAAATTTCCTGCTCGTGGTGCACTTTCATGTGCCAACTTGGCGCATGGCTTTGCCA
GTATGGATAATTCAGAAAAACTAATTATTAAGGTTGGGCGTGAGCCAAATATTGGCATTGTATCTTCTTATAATGAAATG
CTTTCCGCGCATGCACCTTATAAATCATTTCCAGATTTAATCAAAACAGCCGCTCGAGAAAATGGCGGTGTGGCACAATT
TGCCGGCGGTGTACCCGCCATGTGTGATGGTATTACGCAGGGCAATGCGGGAATGGAACTCTCATTGTTTTCTCGTGAAA
CGATTGCAATGAGTACCGCAATTGCATTGTCACACAATATGTTTGATGCAGCATTGTGTCTGGGCGTTTGCGACAAGATC
GTACCGGGCTTATTGATTGGTGCTTTGCAATTTGGGTATTTACCCACCATTTTTGTACCTGCTGGTCCAATGACCAGTGG
TTTGTCGAATGATGACAAGGCCAAGATTCGTCAACAGTTTGCAACTGGTCAGGTGGGACGCGATGTTTTGTTAGAGGCTG
AGTCTGCTGCTTATCATGGACAAGGGACTTGTACATTTTACGGTACCGCGAACAGCAACCAAATGCTGATGGAAGTCATG
GGCTTGCATTTACCGAGTGCGGCATTTGTTCATCCTCATACGCCACTGCGTGATGCGCTCACCGCAGAAGCAGCCATTCG
TGTACTCGATTTAACCGTTGAACGTGGAAACTATACGCCTATTGGTCATGTGGTGGATGAGAAAGCAATTATCAACGGCA
TTGTCGCTTTGCTCGCTACAGGTGGATCAACCAACCATACCTTGCATTTAATTGCCATAGCCCGTGCCGCTGGCATCTTG
ATTGACTGGGACGACTTTGATGAATTGTCGGCTGTTGTGCCGCTGCTTGCAAAAATCTATCCAAATGGCAAAGCTGATGT
TAATCATTTTCAGGCTGCGGGTGGTGTTGCTTTCCTCATTCGTAATTTGCTTGAGGCTGGATTGTTGCATAACGACGTCA
ATACGGTAGCGGGCAAAGGTTTGCAGCATTACACCAAAGAACCGAAATTGATTGATGGCAAGCTGATTTGGGTGGATGCG
GTCGCTCATAGTTTGGATGAAAAAGTATTACGCAGCATTGAAGCACCATTTCAACCTGATGGTGGCTTGCGTCTAATGCA
AGGTCGCCTTGGCCGAGGTGTGATTAAGATTTCTGCTGTTGCGCCAGAACATCGCAAAGTAAAAGCACCTGCAATTGTGT
TTGATTCTCAAGAAGCCGTACAGGCGGCGTTTGATCGTGGTGAATTACATCGAGATTTTATTGCAGTTGTTCGTTTCCAG
GGTGCACGTGCAAATGGTATGCCTGAATTGCATCGCTTAACTCCTGTATTGGGTGTTTTACAAGATCAAGGTTTTCATGT
GGCCTTGGTCACCGATGGGCGCATGTCGGGTGCATCGGGCAAAGTTCCAGCCGTGATTCATTTGTCTCCAGAAGCCTTAC
TCAATGGTCCGATTGCCAAGGTACAAACCGGCGATATGCTGATCATCGATGCTGAGGCTGGCGTACTTGAGGTAGAGCTT
GACGAGCAGGTCTGGCAGGTACGTCCTGTTGCCCAGCCAGCGCATCAGGCGGAAAACGAAGTTGGTTTTGGTCGTGAGTT
GTTTGGTGTGTTCCGTGCGGCGGCTGCACCTGCTGAGCATGGCGCTTCTGTATTTGGTGCCTTGGTCGATGAAAACGTTC
AAGTTTAG

Upstream 100 bases:

>100_bases
CTTTTGCCTCAATAATATTATTTATTTTTTTCAAATGATCATGAAATCATTTGGTCTATTTTGTTTGCCAGCTTATCCAG
TTGTAAAAGGAGTGCTTAGC

Downstream 100 bases:

>100_bases
CGTTGAAGAATAAATAATAGGAACATAAAAGTAATGATCAAGATGGAAGATGTTGTTCAATTAGGGCCTGTGATTCCTGT
ACTGGCATTCGATTCGGCGG

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 615; Mature: 615

Protein sequence:

>615_residues
MDLLNPILVKVTERVTARSQKTRAAYLKRIEHAQGKFPARGALSCANLAHGFASMDNSEKLIIKVGREPNIGIVSSYNEM
LSAHAPYKSFPDLIKTAARENGGVAQFAGGVPAMCDGITQGNAGMELSLFSRETIAMSTAIALSHNMFDAALCLGVCDKI
VPGLLIGALQFGYLPTIFVPAGPMTSGLSNDDKAKIRQQFATGQVGRDVLLEAESAAYHGQGTCTFYGTANSNQMLMEVM
GLHLPSAAFVHPHTPLRDALTAEAAIRVLDLTVERGNYTPIGHVVDEKAIINGIVALLATGGSTNHTLHLIAIARAAGIL
IDWDDFDELSAVVPLLAKIYPNGKADVNHFQAAGGVAFLIRNLLEAGLLHNDVNTVAGKGLQHYTKEPKLIDGKLIWVDA
VAHSLDEKVLRSIEAPFQPDGGLRLMQGRLGRGVIKISAVAPEHRKVKAPAIVFDSQEAVQAAFDRGELHRDFIAVVRFQ
GARANGMPELHRLTPVLGVLQDQGFHVALVTDGRMSGASGKVPAVIHLSPEALLNGPIAKVQTGDMLIIDAEAGVLEVEL
DEQVWQVRPVAQPAHQAENEVGFGRELFGVFRAAAAPAEHGASVFGALVDENVQV

Sequences:

>Translated_615_residues
MDLLNPILVKVTERVTARSQKTRAAYLKRIEHAQGKFPARGALSCANLAHGFASMDNSEKLIIKVGREPNIGIVSSYNEM
LSAHAPYKSFPDLIKTAARENGGVAQFAGGVPAMCDGITQGNAGMELSLFSRETIAMSTAIALSHNMFDAALCLGVCDKI
VPGLLIGALQFGYLPTIFVPAGPMTSGLSNDDKAKIRQQFATGQVGRDVLLEAESAAYHGQGTCTFYGTANSNQMLMEVM
GLHLPSAAFVHPHTPLRDALTAEAAIRVLDLTVERGNYTPIGHVVDEKAIINGIVALLATGGSTNHTLHLIAIARAAGIL
IDWDDFDELSAVVPLLAKIYPNGKADVNHFQAAGGVAFLIRNLLEAGLLHNDVNTVAGKGLQHYTKEPKLIDGKLIWVDA
VAHSLDEKVLRSIEAPFQPDGGLRLMQGRLGRGVIKISAVAPEHRKVKAPAIVFDSQEAVQAAFDRGELHRDFIAVVRFQ
GARANGMPELHRLTPVLGVLQDQGFHVALVTDGRMSGASGKVPAVIHLSPEALLNGPIAKVQTGDMLIIDAEAGVLEVEL
DEQVWQVRPVAQPAHQAENEVGFGRELFGVFRAAAAPAEHGASVFGALVDENVQV
>Mature_615_residues
MDLLNPILVKVTERVTARSQKTRAAYLKRIEHAQGKFPARGALSCANLAHGFASMDNSEKLIIKVGREPNIGIVSSYNEM
LSAHAPYKSFPDLIKTAARENGGVAQFAGGVPAMCDGITQGNAGMELSLFSRETIAMSTAIALSHNMFDAALCLGVCDKI
VPGLLIGALQFGYLPTIFVPAGPMTSGLSNDDKAKIRQQFATGQVGRDVLLEAESAAYHGQGTCTFYGTANSNQMLMEVM
GLHLPSAAFVHPHTPLRDALTAEAAIRVLDLTVERGNYTPIGHVVDEKAIINGIVALLATGGSTNHTLHLIAIARAAGIL
IDWDDFDELSAVVPLLAKIYPNGKADVNHFQAAGGVAFLIRNLLEAGLLHNDVNTVAGKGLQHYTKEPKLIDGKLIWVDA
VAHSLDEKVLRSIEAPFQPDGGLRLMQGRLGRGVIKISAVAPEHRKVKAPAIVFDSQEAVQAAFDRGELHRDFIAVVRFQ
GARANGMPELHRLTPVLGVLQDQGFHVALVTDGRMSGASGKVPAVIHLSPEALLNGPIAKVQTGDMLIIDAEAGVLEVEL
DEQVWQVRPVAQPAHQAENEVGFGRELFGVFRAAAAPAEHGASVFGALVDENVQV

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=602, Percent_Identity=57.1428571428571, Blast_Score=700, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=549, Percent_Identity=30.4189435336976, Blast_Score=191, Evalue=2e-49,
Organism=Escherichia coli, GI2367371, Length=543, Percent_Identity=30.2025782688766, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI1786464, Length=538, Percent_Identity=29.368029739777, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6322476, Length=589, Percent_Identity=27.6740237691002, Blast_Score=178, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 65559; Mature: 65559

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLLNPILVKVTERVTARSQKTRAAYLKRIEHAQGKFPARGALSCANLAHGFASMDNSEK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCE
LIIKVGREPNIGIVSSYNEMLSAHAPYKSFPDLIKTAARENGGVAQFAGGVPAMCDGITQ
EEEEECCCCCCCEEECHHHHHHCCCCCHHHHHHHHHHHHCCCCEEECCCCCCHHHCCCCC
GNAGMELSLFSRETIAMSTAIALSHNMFDAALCLGVCDKIVPGLLIGALQFGYLPTIFVP
CCCCCEEEEECCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEC
AGPMTSGLSNDDKAKIRQQFATGQVGRDVLLEAESAAYHGQGTCTFYGTANSNQMLMEVM
CCCCCCCCCCCHHHHHHHHHHCCCCCCHHEEEECCCCCCCCCEEEEEECCCCCHHHHHHH
GLHLPSAAFVHPHTPLRDALTAEAAIRVLDLTVERGNYTPIGHVVDEKAIINGIVALLAT
HCCCCCCEEECCCCCHHHHHHHHHHEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCC
GGSTNHTLHLIAIARAAGILIDWDDFDELSAVVPLLAKIYPNGKADVNHFQAAGGVAFLI
CCCCCCEEEEEEEEHHCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHH
RNLLEAGLLHNDVNTVAGKGLQHYTKEPKLIDGKLIWVDAVAHSLDEKVLRSIEAPFQPD
HHHHHHHHHHCCHHHHHCCCHHHHCCCCCEECCEEEEHHHHHHHHHHHHHHHHCCCCCCC
GGLRLMQGRLGRGVIKISAVAPEHRKVKAPAIVFDSQEAVQAAFDRGELHRDFIAVVRFQ
CCCEEECCCCCCCEEEEEEECCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHEEC
GARANGMPELHRLTPVLGVLQDQGFHVALVTDGRMSGASGKVPAVIHLSPEALLNGPIAK
CCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECHHHHHCCCCCE
VQTGDMLIIDAEAGVLEVELDEQVWQVRPVAQPAHQAENEVGFGRELFGVFRAAAAPAEH
EECCCEEEEECCCCEEEEEECHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHHCCCHHH
GASVFGALVDENVQV
HHHHHHHHHCCCCCC
>Mature Secondary Structure
MDLLNPILVKVTERVTARSQKTRAAYLKRIEHAQGKFPARGALSCANLAHGFASMDNSEK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCE
LIIKVGREPNIGIVSSYNEMLSAHAPYKSFPDLIKTAARENGGVAQFAGGVPAMCDGITQ
EEEEECCCCCCCEEECHHHHHHCCCCCHHHHHHHHHHHHCCCCEEECCCCCCHHHCCCCC
GNAGMELSLFSRETIAMSTAIALSHNMFDAALCLGVCDKIVPGLLIGALQFGYLPTIFVP
CCCCCEEEEECCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEC
AGPMTSGLSNDDKAKIRQQFATGQVGRDVLLEAESAAYHGQGTCTFYGTANSNQMLMEVM
CCCCCCCCCCCHHHHHHHHHHCCCCCCHHEEEECCCCCCCCCEEEEEECCCCCHHHHHHH
GLHLPSAAFVHPHTPLRDALTAEAAIRVLDLTVERGNYTPIGHVVDEKAIINGIVALLAT
HCCCCCCEEECCCCCHHHHHHHHHHEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCC
GGSTNHTLHLIAIARAAGILIDWDDFDELSAVVPLLAKIYPNGKADVNHFQAAGGVAFLI
CCCCCCEEEEEEEEHHCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHH
RNLLEAGLLHNDVNTVAGKGLQHYTKEPKLIDGKLIWVDAVAHSLDEKVLRSIEAPFQPD
HHHHHHHHHHCCHHHHHCCCHHHHCCCCCEECCEEEEHHHHHHHHHHHHHHHHCCCCCCC
GGLRLMQGRLGRGVIKISAVAPEHRKVKAPAIVFDSQEAVQAAFDRGELHRDFIAVVRFQ
CCCEEECCCCCCCEEEEEEECCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHEEC
GARANGMPELHRLTPVLGVLQDQGFHVALVTDGRMSGASGKVPAVIHLSPEALLNGPIAK
CCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECHHHHHCCCCCE
VQTGDMLIIDAEAGVLEVELDEQVWQVRPVAQPAHQAENEVGFGRELFGVFRAAAAPAEH
EECCCEEEEECCCCEEEEEECHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHHCCCHHH
GASVFGALVDENVQV
HHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8045900; 10984043 [H]