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The map label for this gene is ywrD [H]

Identifier: 50083726

GI number: 50083726

Start: 478191

End: 479873

Strand: Reverse

Name: ywrD [H]

Synonym: ACIAD0485

Alternate gene names: 50083726

Gene position: 479873-478191 (Counterclockwise)

Preceding gene: 50083727

Following gene: 50083725

Centisome position: 13.33

GC content: 41.35

Gene sequence:

>1683_bases
GTGTATGCAGAGCAATCTCCAAGTAAGTATTGCAATACAGCATCGGCCTGCCTCGATCCCATGCTAACCAATGCGGCAGT
TACTACACCAAACTATTTAGCAACACAGGCAGCTGTCGAGACTTTACAAAAAGGTGGTAATGCCGTCGATGCTGCGATTT
CTGCTGCTGCAACTTTAGCAGTCGTTTATCCGCAGATGAATACGATTGGTGGGGATAACTTCTGGCTCATTTATAACGCC
AAAACGAAGCAGGTACGTGCCTTAAATGCCAGTGGTCGTGCTGGAGAAAATGTCAGCATCGATTTTTATAAATCCAGAGG
TTATGACAAAATTCCAAGCCGTGGTTATTTAGCTGCCAACACCGTGCCAGGAATCGTTTCAGGATGGGATCAAGCTTATC
AATATGCATCTGGCTCCATGACCAACAAAGGTTTGGCTTGGAAAGATTTATTTAATAAACCCATCATGTATGCATCTCAA
GGTTTTGCAGTTACGCCCTCTTTAGCACGTTGGGAAGCAATCAATACAGATACTAAAGACTCTGTTGCACGTAATTTACA
ACGCTTCGATGAGTTTAAACGAGTTTACCTTAAATCTGATGGTTCACCTTATCAGGTAGGTGACCTATTTAAACAACCCG
ATTTAGCAAAAACACTGGATATTATTGCGACTAAAGGTTCAAAAGAGTTTTACCAAGGTTCAATTGCTAAAGCAATTGTG
CAAGATTTACAGGCAAATGGTGGTGTCTTAACCTTAAATGACTTCAAGCAACATACTGCCGATTGGGTTGATCCATTATC
AGTCAAATATCGTCAATATACCGCTTATAATTTGCCGCCCAATACACAAGGAATGGCTTCTTTAGAAATTTTAAATATTC
TTAATAATTTTAATGTCAGTGCAATTCCTGAAGGTTCAGCAGATTATTATCATCTATTAGTTGAAGCCACCAAAGAAGCC
TTTATTGATCGAGATAAATATTTAACCGATCCAAAATTTTCTCCAATTCCACTAAAGTTTTTGCTTTCAGAACAACACGG
TAAAGATCAAGCTCAACGCATTGATATGAGCAAAGCCGCAGGCAAAAATCCACCTCTTGAACCCAAAGGTGATACAGTTT
GGCTTGGTGTAATTGATAAAGATGGCAATGCTGTTTCTCTAATTCAGAGTATTTATCACGATTTTGGCTCTGCCGTTGTA
GCGAAGGGTACAGGCGTACTTTTACAAAATCGAGGAAGCTTTTTCTCCCTTGATCCGAACCACGTCAATCATTTAGAGCC
CCAAAAGCGTACTTTTCATACCTTAAATGCAGCAATGATGCTCGATCAAAACAACCAGCCTGTTTTAATTTATGGCACGA
TGGGCGGTGAAGGACAGCCTCAAACTCAAGCCGCTATTGCTACACGAGTCGTTGATTATGGAATGAGTGTACAAGAAGCT
GTGGCAGCACCACGCTGGTTATATGGACGAACTTGGGGTGCCGAATCTAACACCTTAAAACTTGAAGGACGTATTACAAG
CGATGTCGCTAAAACACTTAAAGATCGTGGGCAACCTGTTGAAATACTAGATGACTATACGGATACGATGGGACATGCAG
GTGCTATTGCAATTAACCGAAAAACAGGTGTGATTAGTGCCGCAACAGATCCGCGTAGCGATGGACTTGCAGCAGGTTAT
TAA

Upstream 100 bases:

>100_bases
TGATTTGTTGCCATAAATATATTTTATGGTAATCGGTATAATGATTAGACTCTCGCTTCTTTCTGCATCACTTTTTTTAA
CGGTAATCAGTAATAGTACA

Downstream 100 bases:

>100_bases
AATTATATGGACAACAAGATGACCTATTTTAAAAAATAGGTCATCTTTAGAATAAAGATCTGTTTGAAACAATTTCCCCT
ACAAAAATTATCATTTTTTA

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 560; Mature: 560

Protein sequence:

>560_residues
MYAEQSPSKYCNTASACLDPMLTNAAVTTPNYLATQAAVETLQKGGNAVDAAISAAATLAVVYPQMNTIGGDNFWLIYNA
KTKQVRALNASGRAGENVSIDFYKSRGYDKIPSRGYLAANTVPGIVSGWDQAYQYASGSMTNKGLAWKDLFNKPIMYASQ
GFAVTPSLARWEAINTDTKDSVARNLQRFDEFKRVYLKSDGSPYQVGDLFKQPDLAKTLDIIATKGSKEFYQGSIAKAIV
QDLQANGGVLTLNDFKQHTADWVDPLSVKYRQYTAYNLPPNTQGMASLEILNILNNFNVSAIPEGSADYYHLLVEATKEA
FIDRDKYLTDPKFSPIPLKFLLSEQHGKDQAQRIDMSKAAGKNPPLEPKGDTVWLGVIDKDGNAVSLIQSIYHDFGSAVV
AKGTGVLLQNRGSFFSLDPNHVNHLEPQKRTFHTLNAAMMLDQNNQPVLIYGTMGGEGQPQTQAAIATRVVDYGMSVQEA
VAAPRWLYGRTWGAESNTLKLEGRITSDVAKTLKDRGQPVEILDDYTDTMGHAGAIAINRKTGVISAATDPRSDGLAAGY

Sequences:

>Translated_560_residues
MYAEQSPSKYCNTASACLDPMLTNAAVTTPNYLATQAAVETLQKGGNAVDAAISAAATLAVVYPQMNTIGGDNFWLIYNA
KTKQVRALNASGRAGENVSIDFYKSRGYDKIPSRGYLAANTVPGIVSGWDQAYQYASGSMTNKGLAWKDLFNKPIMYASQ
GFAVTPSLARWEAINTDTKDSVARNLQRFDEFKRVYLKSDGSPYQVGDLFKQPDLAKTLDIIATKGSKEFYQGSIAKAIV
QDLQANGGVLTLNDFKQHTADWVDPLSVKYRQYTAYNLPPNTQGMASLEILNILNNFNVSAIPEGSADYYHLLVEATKEA
FIDRDKYLTDPKFSPIPLKFLLSEQHGKDQAQRIDMSKAAGKNPPLEPKGDTVWLGVIDKDGNAVSLIQSIYHDFGSAVV
AKGTGVLLQNRGSFFSLDPNHVNHLEPQKRTFHTLNAAMMLDQNNQPVLIYGTMGGEGQPQTQAAIATRVVDYGMSVQEA
VAAPRWLYGRTWGAESNTLKLEGRITSDVAKTLKDRGQPVEILDDYTDTMGHAGAIAINRKTGVISAATDPRSDGLAAGY
>Mature_560_residues
MYAEQSPSKYCNTASACLDPMLTNAAVTTPNYLATQAAVETLQKGGNAVDAAISAAATLAVVYPQMNTIGGDNFWLIYNA
KTKQVRALNASGRAGENVSIDFYKSRGYDKIPSRGYLAANTVPGIVSGWDQAYQYASGSMTNKGLAWKDLFNKPIMYASQ
GFAVTPSLARWEAINTDTKDSVARNLQRFDEFKRVYLKSDGSPYQVGDLFKQPDLAKTLDIIATKGSKEFYQGSIAKAIV
QDLQANGGVLTLNDFKQHTADWVDPLSVKYRQYTAYNLPPNTQGMASLEILNILNNFNVSAIPEGSADYYHLLVEATKEA
FIDRDKYLTDPKFSPIPLKFLLSEQHGKDQAQRIDMSKAAGKNPPLEPKGDTVWLGVIDKDGNAVSLIQSIYHDFGSAVV
AKGTGVLLQNRGSFFSLDPNHVNHLEPQKRTFHTLNAAMMLDQNNQPVLIYGTMGGEGQPQTQAAIATRVVDYGMSVQEA
VAAPRWLYGRTWGAESNTLKLEGRITSDVAKTLKDRGQPVEILDDYTDTMGHAGAIAINRKTGVISAATDPRSDGLAAGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=565, Percent_Identity=28.4955752212389, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI73915090, Length=565, Percent_Identity=28.4955752212389, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI73915096, Length=565, Percent_Identity=28.4955752212389, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI73915094, Length=565, Percent_Identity=28.4955752212389, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI113429324, Length=563, Percent_Identity=28.2415630550622, Blast_Score=159, Evalue=8e-39,
Organism=Homo sapiens, GI113429326, Length=563, Percent_Identity=27.886323268206, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI153266885, Length=564, Percent_Identity=27.1276595744681, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI153266901, Length=565, Percent_Identity=27.2566371681416, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI153266907, Length=560, Percent_Identity=26.25, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI109148539, Length=568, Percent_Identity=26.056338028169, Blast_Score=111, Evalue=2e-24,
Organism=Escherichia coli, GI1789856, Length=556, Percent_Identity=32.5539568345324, Blast_Score=240, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17542894, Length=491, Percent_Identity=28.1059063136456, Blast_Score=144, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17506189, Length=537, Percent_Identity=25.8845437616387, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI212646519, Length=512, Percent_Identity=25.9765625, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI72000294, Length=512, Percent_Identity=25.9765625, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI193208245, Length=510, Percent_Identity=25.4901960784314, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI193208247, Length=510, Percent_Identity=25.4901960784314, Blast_Score=125, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6323330, Length=502, Percent_Identity=23.7051792828685, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45551474, Length=562, Percent_Identity=26.3345195729537, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24642670, Length=562, Percent_Identity=26.3345195729537, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24642666, Length=562, Percent_Identity=26.3345195729537, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI161077878, Length=562, Percent_Identity=25.9786476868327, Blast_Score=153, Evalue=4e-37,
Organism=Drosophila melanogaster, GI161077880, Length=562, Percent_Identity=25.9786476868327, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI18859893, Length=490, Percent_Identity=26.734693877551, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI18859741, Length=525, Percent_Identity=24.952380952381, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI161077496, Length=474, Percent_Identity=25.1054852320675, Blast_Score=103, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 61019; Mature: 61019

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYAEQSPSKYCNTASACLDPMLTNAAVTTPNYLATQAAVETLQKGGNAVDAAISAAATLA
CCCCCCCHHHHHHHHHHHHHHHHCCEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHEEE
VVYPQMNTIGGDNFWLIYNAKTKQVRALNASGRAGENVSIDFYKSRGYDKIPSRGYLAAN
EEECCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCEEEEC
TVPGIVSGWDQAYQYASGSMTNKGLAWKDLFNKPIMYASQGFAVTPSLARWEAINTDTKD
CCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCEEEECCCCEECCCHHHHEECCCCCHH
SVARNLQRFDEFKRVYLKSDGSPYQVGDLFKQPDLAKTLDIIATKGSKEFYQGSIAKAIV
HHHHHHHHHHHHHHEEECCCCCCEEHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHH
QDLQANGGVLTLNDFKQHTADWVDPLSVKYRQYTAYNLPPNTQGMASLEILNILNNFNVS
HHHHCCCCEEEECHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCE
AIPEGSADYYHLLVEATKEAFIDRDKYLTDPKFSPIPLKFLLSEQHGKDQAQRIDMSKAA
ECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHEEECCCCCCHHHHHHCHHHHC
GKNPPLEPKGDTVWLGVIDKDGNAVSLIQSIYHDFGSAVVAKGTGVLLQNRGSFFSLDPN
CCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCEEEECCCEEEEECCCCEEEECCC
HVNHLEPQKRTFHTLNAAMMLDQNNQPVLIYGTMGGEGQPQTQAAIATRVVDYGMSVQEA
CCCCCCCHHHHHHHHEEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHH
VAAPRWLYGRTWGAESNTLKLEGRITSDVAKTLKDRGQPVEILDDYTDTMGHAGAIAINR
HCCCCCEECEECCCCCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEC
KTGVISAATDPRSDGLAAGY
CCCEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MYAEQSPSKYCNTASACLDPMLTNAAVTTPNYLATQAAVETLQKGGNAVDAAISAAATLA
CCCCCCCHHHHHHHHHHHHHHHHCCEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHEEE
VVYPQMNTIGGDNFWLIYNAKTKQVRALNASGRAGENVSIDFYKSRGYDKIPSRGYLAAN
EEECCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCEEEEC
TVPGIVSGWDQAYQYASGSMTNKGLAWKDLFNKPIMYASQGFAVTPSLARWEAINTDTKD
CCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCEEEECCCCEECCCHHHHEECCCCCHH
SVARNLQRFDEFKRVYLKSDGSPYQVGDLFKQPDLAKTLDIIATKGSKEFYQGSIAKAIV
HHHHHHHHHHHHHHEEECCCCCCEEHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHH
QDLQANGGVLTLNDFKQHTADWVDPLSVKYRQYTAYNLPPNTQGMASLEILNILNNFNVS
HHHHCCCCEEEECHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCE
AIPEGSADYYHLLVEATKEAFIDRDKYLTDPKFSPIPLKFLLSEQHGKDQAQRIDMSKAA
ECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHEEECCCCCCHHHHHHCHHHHC
GKNPPLEPKGDTVWLGVIDKDGNAVSLIQSIYHDFGSAVVAKGTGVLLQNRGSFFSLDPN
CCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCEEEECCCEEEEECCCCEEEECCC
HVNHLEPQKRTFHTLNAAMMLDQNNQPVLIYGTMGGEGQPQTQAAIATRVVDYGMSVQEA
CCCCCCCHHHHHHHHEEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHH
VAAPRWLYGRTWGAESNTLKLEGRITSDVAKTLKDRGQPVEILDDYTDTMGHAGAIAINR
HCCCCCEECEECCCCCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEC
KTGVISAATDPRSDGLAAGY
CCCEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]