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The map label for this gene is gltP [H]

Identifier: 50083723

GI number: 50083723

Start: 474293

End: 475597

Strand: Direct

Name: gltP [H]

Synonym: ACIAD0481

Alternate gene names: 50083723

Gene position: 474293-475597 (Clockwise)

Preceding gene: 50083722

Following gene: 50083729

Centisome position: 13.18

GC content: 41.53

Gene sequence:

>1305_bases
ATGAAAAATTTTAAAATTAGCCTCGCATGGCAAATTTTAATTGCGTTGATTCTAGGGGTTGTGGTTGGGGCTATTTTACA
TAATCAGCCTGAATATAAAGATTTCATGGTCAATAACGTTCTGAAGCCATTGGGCCAGATCTTTATTAGCCTGATCAAAA
TGATTGTGATCCCCATTGTTTTCTCTACCCTGATTCTGGGAATTGCAGGGGTTGGAACAACTAAAAGTTTAGGTCGTTTA
GGTTTTAAAACGATTTTATACTTTGAAATTATTACCACAATTGCGATTATTGTGGGATTAATTGCAGCGAATGTCTTCCA
GCCTGGTGCGGGCGTTGATAAAGCCATGTTGGTGATGAGTGATATTTCACAATATCAACACACTGCTCAAGAAGTCGACT
CTCAATCACATGGCCTGATCCAGACCATTCTGGCGCTGATTCCGACCAACATTATCAACTCTATGGCGCATGGTGAAATG
TTGCCAGTCATTTTCTTTGCGGTATTGTTTGGTATTGGATTGTCTTCATTGCCAACGACCACCAAAGAGCCATTGTTGCA
TGTATTCCATGCTGTGTCTGAAACCATGTTTCGTGTAACACACATCATCATGAAATACGCGCCAATTGGTGTGTTTGGCT
TGATCGCGGTGACTGTCGCCAATTTTGGTTTTGCATCGCTGATCCCGCTGGGTAAGTTGGTGGTCTTGGTTTACGCAGCA
ATCTTTTTCTTTGCTTTTGTTGTATTGGGGATTACAGCAAGAATCTTTAAAATTAATATCTTGACGGTGATGCGTATCCT
CAAGGATGAATTGATTTTAGCGTATTCAACTGCAAGTTCTGAAACTGTACTTCCACGTATCATGCAAAAAATGGAAGCAT
ACGGTGCACCTAAAGCAATCACAAGTTTTGTGATTCCAACTGGTTATTCATTTAATCTTGACGGTTCGACCTTGTACCAA
AGTATTGCCGCGATCTTTATTGCACAGCTTTACGGGATTGAGTTGTCGTTGACACAGCAGATTATTCTGGTCGTTACCCT
GATGATTACTTCAAAAGGGATTGCGGGTGTACCTGGCGTATCGTTTGTCGTGCTCCTTGCTACATTGCACACGGTAGGTA
TTCCACTTGAAGGTTTGGCATTTATTGCGGGTGTCGACCGTATCATGGATATGGCACGTACTGCATTGAATGTTGTAGGT
AATGCGCTTGCAGTACTGGTGATCAGTAAGTGGGAAAATGCCTATGATTTTGAGAAAGCCAAAGAATATGAAGCGTCTCT
GAATCAACCCAAAGCTGATGCTTAA

Upstream 100 bases:

>100_bases
TTAAGATGACATAAAAGGAGTTTTATGAACGAACTATTTGCAATGCAAGTGGTTTTCTCCCGTTCTAAATTAAATGCTTG
CCAAGCATAAGGATTGTCTT

Downstream 100 bases:

>100_bases
ATCGCATCAATAAACCTGATTCAAAAAACAGGAAGCCAAAGCTTCCTGTTTTTTACTTTAAGTTATCTGCGATTCACGAC
AGATTGGTATAAATCTAAGG

Product: glutamate/aspartate:proton symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MKNFKISLAWQILIALILGVVVGAILHNQPEYKDFMVNNVLKPLGQIFISLIKMIVIPIVFSTLILGIAGVGTTKSLGRL
GFKTILYFEIITTIAIIVGLIAANVFQPGAGVDKAMLVMSDISQYQHTAQEVDSQSHGLIQTILALIPTNIINSMAHGEM
LPVIFFAVLFGIGLSSLPTTTKEPLLHVFHAVSETMFRVTHIIMKYAPIGVFGLIAVTVANFGFASLIPLGKLVVLVYAA
IFFFAFVVLGITARIFKINILTVMRILKDELILAYSTASSETVLPRIMQKMEAYGAPKAITSFVIPTGYSFNLDGSTLYQ
SIAAIFIAQLYGIELSLTQQIILVVTLMITSKGIAGVPGVSFVVLLATLHTVGIPLEGLAFIAGVDRIMDMARTALNVVG
NALAVLVISKWENAYDFEKAKEYEASLNQPKADA

Sequences:

>Translated_434_residues
MKNFKISLAWQILIALILGVVVGAILHNQPEYKDFMVNNVLKPLGQIFISLIKMIVIPIVFSTLILGIAGVGTTKSLGRL
GFKTILYFEIITTIAIIVGLIAANVFQPGAGVDKAMLVMSDISQYQHTAQEVDSQSHGLIQTILALIPTNIINSMAHGEM
LPVIFFAVLFGIGLSSLPTTTKEPLLHVFHAVSETMFRVTHIIMKYAPIGVFGLIAVTVANFGFASLIPLGKLVVLVYAA
IFFFAFVVLGITARIFKINILTVMRILKDELILAYSTASSETVLPRIMQKMEAYGAPKAITSFVIPTGYSFNLDGSTLYQ
SIAAIFIAQLYGIELSLTQQIILVVTLMITSKGIAGVPGVSFVVLLATLHTVGIPLEGLAFIAGVDRIMDMARTALNVVG
NALAVLVISKWENAYDFEKAKEYEASLNQPKADA
>Mature_434_residues
MKNFKISLAWQILIALILGVVVGAILHNQPEYKDFMVNNVLKPLGQIFISLIKMIVIPIVFSTLILGIAGVGTTKSLGRL
GFKTILYFEIITTIAIIVGLIAANVFQPGAGVDKAMLVMSDISQYQHTAQEVDSQSHGLIQTILALIPTNIINSMAHGEM
LPVIFFAVLFGIGLSSLPTTTKEPLLHVFHAVSETMFRVTHIIMKYAPIGVFGLIAVTVANFGFASLIPLGKLVVLVYAA
IFFFAFVVLGITARIFKINILTVMRILKDELILAYSTASSETVLPRIMQKMEAYGAPKAITSFVIPTGYSFNLDGSTLYQ
SIAAIFIAQLYGIELSLTQQIILVVTLMITSKGIAGVPGVSFVVLLATLHTVGIPLEGLAFIAGVDRIMDMARTALNVVG
NALAVLVISKWENAYDFEKAKEYEASLNQPKADA

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=457, Percent_Identity=25.8205689277899, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI194239697, Length=469, Percent_Identity=25.7995735607676, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI40254478, Length=456, Percent_Identity=26.0964912280702, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI21314632, Length=428, Percent_Identity=26.1682242990654, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI66773030, Length=441, Percent_Identity=26.3038548752834, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI4827012, Length=361, Percent_Identity=28.808864265928, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI223468564, Length=279, Percent_Identity=30.1075268817204, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI223468566, Length=278, Percent_Identity=30.2158273381295, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI5032093, Length=408, Percent_Identity=27.4509803921569, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI262359914, Length=400, Percent_Identity=24.75, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI301601644, Length=152, Percent_Identity=34.2105263157895, Blast_Score=89, Evalue=9e-18,
Organism=Escherichia coli, GI1790514, Length=424, Percent_Identity=71.6981132075472, Blast_Score=624, Evalue=1e-180,
Organism=Escherichia coli, GI1789947, Length=431, Percent_Identity=40.6032482598608, Blast_Score=324, Evalue=8e-90,
Organism=Escherichia coli, GI1788024, Length=387, Percent_Identity=25.3229974160207, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1789473, Length=365, Percent_Identity=23.5616438356164, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17537407, Length=419, Percent_Identity=27.9236276849642, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71983099, Length=436, Percent_Identity=25.9174311926606, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71983106, Length=436, Percent_Identity=25.9174311926606, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI193206505, Length=423, Percent_Identity=27.6595744680851, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI71996953, Length=457, Percent_Identity=24.0700218818381, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI193206654, Length=448, Percent_Identity=26.7857142857143, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17541374, Length=447, Percent_Identity=24.8322147651007, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24583025, Length=432, Percent_Identity=25.9259259259259, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI17137668, Length=432, Percent_Identity=25.9259259259259, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24583023, Length=432, Percent_Identity=25.9259259259259, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI281360481, Length=450, Percent_Identity=23.5555555555556, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI281360483, Length=450, Percent_Identity=23.5555555555556, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17137666, Length=450, Percent_Identity=23.5555555555556, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46951; Mature: 46951

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHCCCCCCCC
>Mature Secondary Structure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HHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]