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The map label for this gene is ubiE [H]

Identifier: 50083643

GI number: 50083643

Start: 378075

End: 379043

Strand: Reverse

Name: ubiE [H]

Synonym: ACIAD0384

Alternate gene names: 50083643

Gene position: 379043-378075 (Counterclockwise)

Preceding gene: 50083644

Following gene: 50083642

Centisome position: 10.53

GC content: 43.45

Gene sequence:

>969_bases
GTGTTTACATTCAGGAGCGACAACATGTCTAACGAAAATCAAAAGCCACAAACTCCTACTGAGCAGGCCCAGCGTTCAGA
CACTCAAAGTCCTTTCCTGAATCAACCACTTCCTCAAGGTACCCCACAAGGTCAGCAGCAATCCTTACAACAAGACCTAA
CCAATTCTTCTACTCGTGCTGTTCCAAAATATAACTTGCCGCGTGGTGCTGGAAAAACAGGCAATGTCGGAGAAACAACG
CACTTTGGCTACCAAACTGTCAATGCCGATGACAAAGCACAAAAAGTTGCAGAAGTTTTTCATTCGGTTGCCAGTAAATA
CGACATCATGAATGACTTAATGTCTTTTGGTATCCATCGCCTATGGAAGCGTTTTGCAATCAATATGTCAGGTGTACGTC
GTGGTCAGCATGTGCTGGATATTGCGGGTGGTACGGGTGATCTGGCGAAAGTTTTTAGTCGCGAAGTTGGCCCACAAGGT
CATGTGGTGTTATCCGATATCAATGAATCCATGCTGAATGTAGGTCGTGACCGTCTCATTGACGCGGGATGTACCAATGT
GGATTTTGTGCTGGCAAATGCTGAAACTTTAGAACCTTTTGCAGATAATAGCTTTGATCTGGTGACCATTAGTTTTGGTT
TGCGTAATGTAACCGATAAAGATGCAGCACTTGAAGCCATGTATCGCGTATTAAAGCCAGGTGGTCGCTTATTAGTGCTC
GAGTTTTCTAAGCCAGTTTTCGAGCCATTTTCAAAACTTTATGACTTTTACTCGTTCACAGCTTTACCTCTTATGGGTAA
ACTTGTGGCAAATGATTCTGAAAGTTATAAATACCTAGCCGAATCGATTCGTATGCATCCAGATCAACGTACACTCAAGG
GCATGATGGAGCAGGCAGGATTCCAGAATTGTGATTATCATAATTTAACAGGCGGTATCGTTGCCGTTCATCGTGGCTTC
AAACTTTAA

Upstream 100 bases:

>100_bases
GTCTGGTTTTATGTATAGTATTAATAACAATTGCATCGTGACGGCTGTAAAACCATACCAAACTCTGTCATGATGCACAG
CCATAATTACTTGATAATGT

Downstream 100 bases:

>100_bases
AAGGTTCAAACCATGTGGTCGATTCTTGCGCTTGGTGCAGTCGAACGCTGTATCCACCATATCATTGATCTGGATGCCAT
CACACGCATTCAGACCAATC

Product: S-adenosylmethionine: 2-DMK methyltransferase and 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MFTFRSDNMSNENQKPQTPTEQAQRSDTQSPFLNQPLPQGTPQGQQQSLQQDLTNSSTRAVPKYNLPRGAGKTGNVGETT
HFGYQTVNADDKAQKVAEVFHSVASKYDIMNDLMSFGIHRLWKRFAINMSGVRRGQHVLDIAGGTGDLAKVFSREVGPQG
HVVLSDINESMLNVGRDRLIDAGCTNVDFVLANAETLEPFADNSFDLVTISFGLRNVTDKDAALEAMYRVLKPGGRLLVL
EFSKPVFEPFSKLYDFYSFTALPLMGKLVANDSESYKYLAESIRMHPDQRTLKGMMEQAGFQNCDYHNLTGGIVAVHRGF
KL

Sequences:

>Translated_322_residues
MFTFRSDNMSNENQKPQTPTEQAQRSDTQSPFLNQPLPQGTPQGQQQSLQQDLTNSSTRAVPKYNLPRGAGKTGNVGETT
HFGYQTVNADDKAQKVAEVFHSVASKYDIMNDLMSFGIHRLWKRFAINMSGVRRGQHVLDIAGGTGDLAKVFSREVGPQG
HVVLSDINESMLNVGRDRLIDAGCTNVDFVLANAETLEPFADNSFDLVTISFGLRNVTDKDAALEAMYRVLKPGGRLLVL
EFSKPVFEPFSKLYDFYSFTALPLMGKLVANDSESYKYLAESIRMHPDQRTLKGMMEQAGFQNCDYHNLTGGIVAVHRGF
KL
>Mature_322_residues
MFTFRSDNMSNENQKPQTPTEQAQRSDTQSPFLNQPLPQGTPQGQQQSLQQDLTNSSTRAVPKYNLPRGAGKTGNVGETT
HFGYQTVNADDKAQKVAEVFHSVASKYDIMNDLMSFGIHRLWKRFAINMSGVRRGQHVLDIAGGTGDLAKVFSREVGPQG
HVVLSDINESMLNVGRDRLIDAGCTNVDFVLANAETLEPFADNSFDLVTISFGLRNVTDKDAALEAMYRVLKPGGRLLVL
EFSKPVFEPFSKLYDFYSFTALPLMGKLVANDSESYKYLAESIRMHPDQRTLKGMMEQAGFQNCDYHNLTGGIVAVHRGF
KL

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=277, Percent_Identity=44.7653429602888, Blast_Score=232, Evalue=3e-61,
Organism=Escherichia coli, GI48994983, Length=246, Percent_Identity=71.5447154471545, Blast_Score=366, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17557039, Length=253, Percent_Identity=44.2687747035573, Blast_Score=219, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6323526, Length=261, Percent_Identity=44.4444444444444, Blast_Score=192, Evalue=6e-50,
Organism=Drosophila melanogaster, GI24641702, Length=271, Percent_Identity=47.2324723247232, Blast_Score=242, Evalue=3e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 35798; Mature: 35798

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTFRSDNMSNENQKPQTPTEQAQRSDTQSPFLNQPLPQGTPQGQQQSLQQDLTNSSTRA
CCEECCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCC
VPKYNLPRGAGKTGNVGETTHFGYQTVNADDKAQKVAEVFHSVASKYDIMNDLMSFGIHR
CCCCCCCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LWKRFAINMSGVRRGQHVLDIAGGTGDLAKVFSREVGPQGHVVLSDINESMLNVGRDRLI
HHHHHHCCHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCCCEEHHHHHHHHHHCCHHHHH
DAGCTNVDFVLANAETLEPFADNSFDLVTISFGLRNVTDKDAALEAMYRVLKPGGRLLVL
HCCCCCEEEEEECCHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEE
EFSKPVFEPFSKLYDFYSFTALPLMGKLVANDSESYKYLAESIRMHPDQRTLKGMMEQAG
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHCC
FQNCDYHNLTGGIVAVHRGFKL
CCCCCCCCCCCCHHEECCCCCC
>Mature Secondary Structure
MFTFRSDNMSNENQKPQTPTEQAQRSDTQSPFLNQPLPQGTPQGQQQSLQQDLTNSSTRA
CCEECCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCC
VPKYNLPRGAGKTGNVGETTHFGYQTVNADDKAQKVAEVFHSVASKYDIMNDLMSFGIHR
CCCCCCCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LWKRFAINMSGVRRGQHVLDIAGGTGDLAKVFSREVGPQGHVVLSDINESMLNVGRDRLI
HHHHHHCCHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCCCEEHHHHHHHHHHCCHHHHH
DAGCTNVDFVLANAETLEPFADNSFDLVTISFGLRNVTDKDAALEAMYRVLKPGGRLLVL
HCCCCCEEEEEECCHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEE
EFSKPVFEPFSKLYDFYSFTALPLMGKLVANDSESYKYLAESIRMHPDQRTLKGMMEQAG
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHCC
FQNCDYHNLTGGIVAVHRGFKL
CCCCCCCCCCCCHHEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA