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The map label for this gene is hemD [H]

Identifier: 50083561

GI number: 50083561

Start: 285688

End: 286458

Strand: Direct

Name: hemD [H]

Synonym: ACIAD0287

Alternate gene names: 50083561

Gene position: 285688-286458 (Clockwise)

Preceding gene: 50083560

Following gene: 50083562

Centisome position: 7.94

GC content: 43.97

Gene sequence:

>771_bases
ATGCTGCTGATTAATACACGACCCGCAGATCGTGCAGATGAACTGACACAGGCTGTATCTGCACAGGGTTATCGTGTAGA
AAATCTTCCTTTATTGGTGCTTAAAAAGAAACCATTTTCAGCGCACCTGAAACAACTGTATCAGCAGCTTGACCAGAGTC
AACTGATCGTGGTGGTTAGTCCGACAGCAGTTGAAATTGGAATGCAATATTTGCAAAAAGCCAATATTTCACTGAGCAGC
TTGAGTCATATACGCTGGGTTGCTGTGGGAAAAAGCACGGCCAAAGCGCTGCAATACTACGGCATATCTGCCGAGATTCC
ACAGGTTGAAACCTCAGAAGGCATGTTGCAGCTTCCAGTATTCCAGATGCTTAAATCGTTTAGGCAAGTGGCGTTCTGGC
GTGGAGAGGGAGGGCGTCAATTGATGATGCAGCAGCTCATAGATCAGGGTGTGCACCTACTTAATTTTATTTTATATGAT
CGGCAGTGTCCCGAGTCTGCAACGCAAAAAATATTGTCGATAGCGCATGATATTGTTCAAGACAAGCAACCTGTCTGGGT
CCTGATAACTAGTGAGGCAAGCTGGTTGAACTGGTTAAGTTTAATTCAGCCACATGCTGGATTATTTCAGGATTGTCATT
ACCTCGTATTGGGTGAGCGCTTAGAACAAATTTTAACGATCTATCAGAACCAGCATCAGCTCAGTTTTAATATGATACGT
CTTGAGAATCTGAAAGCCTCAAGCATAGTGCAGCACTTAGACGCATTATAA

Upstream 100 bases:

>100_bases
TCATGCAGATCAGGCTGAGGTGCTTGGTGTGCAATTGGCGAAGCAGTTACTTGCACAGGGTGCAGGCGAATTGCTGCGTG
ATTTATATCAATAAACTACC

Downstream 100 bases:

>100_bases
GGAATCTTATGAGAAAAATTTTATTTGTTAGCTTGTTATTGGTTTTAGGCTGGATCATAAAGCTGAGCTATGACATGTTT
CAAATCTCTCAGCAGATTCC

Product: uroporphyrinogen-III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MLLINTRPADRADELTQAVSAQGYRVENLPLLVLKKKPFSAHLKQLYQQLDQSQLIVVVSPTAVEIGMQYLQKANISLSS
LSHIRWVAVGKSTAKALQYYGISAEIPQVETSEGMLQLPVFQMLKSFRQVAFWRGEGGRQLMMQQLIDQGVHLLNFILYD
RQCPESATQKILSIAHDIVQDKQPVWVLITSEASWLNWLSLIQPHAGLFQDCHYLVLGERLEQILTIYQNQHQLSFNMIR
LENLKASSIVQHLDAL

Sequences:

>Translated_256_residues
MLLINTRPADRADELTQAVSAQGYRVENLPLLVLKKKPFSAHLKQLYQQLDQSQLIVVVSPTAVEIGMQYLQKANISLSS
LSHIRWVAVGKSTAKALQYYGISAEIPQVETSEGMLQLPVFQMLKSFRQVAFWRGEGGRQLMMQQLIDQGVHLLNFILYD
RQCPESATQKILSIAHDIVQDKQPVWVLITSEASWLNWLSLIQPHAGLFQDCHYLVLGERLEQILTIYQNQHQLSFNMIR
LENLKASSIVQHLDAL
>Mature_256_residues
MLLINTRPADRADELTQAVSAQGYRVENLPLLVLKKKPFSAHLKQLYQQLDQSQLIVVVSPTAVEIGMQYLQKANISLSS
LSHIRWVAVGKSTAKALQYYGISAEIPQVETSEGMLQLPVFQMLKSFRQVAFWRGEGGRQLMMQQLIDQGVHLLNFILYD
RQCPESATQKILSIAHDIVQDKQPVWVLITSEASWLNWLSLIQPHAGLFQDCHYLVLGERLEQILTIYQNQHQLSFNMIR
LENLKASSIVQHLDAL

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 29145; Mature: 29145

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLINTRPADRADELTQAVSAQGYRVENLPLLVLKKKPFSAHLKQLYQQLDQSQLIVVVS
CEEECCCCCCHHHHHHHHHHCCCEEECCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEEC
PTAVEIGMQYLQKANISLSSLSHIRWVAVGKSTAKALQYYGISAEIPQVETSEGMLQLPV
CHHHHHHHHHHHHCCCCHHHHHHEEEEEECHHHHHHHHHCCCCCCCCCCCCCCCEEECHH
FQMLKSFRQVAFWRGEGGRQLMMQQLIDQGVHLLNFILYDRQCPESATQKILSIAHDIVQ
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
DKQPVWVLITSEASWLNWLSLIQPHAGLFQDCHYLVLGERLEQILTIYQNQHQLSFNMIR
CCCCEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEE
LENLKASSIVQHLDAL
ECCCCHHHHHHHHHCC
>Mature Secondary Structure
MLLINTRPADRADELTQAVSAQGYRVENLPLLVLKKKPFSAHLKQLYQQLDQSQLIVVVS
CEEECCCCCCHHHHHHHHHHCCCEEECCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEEC
PTAVEIGMQYLQKANISLSSLSHIRWVAVGKSTAKALQYYGISAEIPQVETSEGMLQLPV
CHHHHHHHHHHHHCCCCHHHHHHEEEEEECHHHHHHHHHCCCCCCCCCCCCCCCEEECHH
FQMLKSFRQVAFWRGEGGRQLMMQQLIDQGVHLLNFILYDRQCPESATQKILSIAHDIVQ
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
DKQPVWVLITSEASWLNWLSLIQPHAGLFQDCHYLVLGERLEQILTIYQNQHQLSFNMIR
CCCCEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEE
LENLKASSIVQHLDAL
ECCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8159168; 10984043 [H]