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The map label for this gene is argH

Identifier: 50083557

GI number: 50083557

Start: 281279

End: 282712

Strand: Reverse

Name: argH

Synonym: ACIAD0283

Alternate gene names: 50083557

Gene position: 282712-281279 (Counterclockwise)

Preceding gene: 50083582

Following gene: 50083556

Centisome position: 7.86

GC content: 44.07

Gene sequence:

>1434_bases
ATGACCACATCTTCTCATTCCTCTGAACAGCCAACCTCAACCCAGACCTCTGGTATGTGGGGCGGTCGCTTTACTGAAGC
GACCGATGCCTTTGTTGCTGAATTTACCGCATCTGTGCAATTCGACCAACGTTTTTATAAACAAGATATTGCTGGTTCAA
TCGCACATGCCACAATGTTGGCTAAAGTAGGCGTACTCACCGAAGCAGAGCGTGATGACATCATTCAGGGCCTGAGCGCA
ATCAAATCAGAAATCGAAGCAGGTCAATTTGAATGGCGTATTGATTTAGAAGATGTTCATATGAATATTGAGTCTCGCTT
GACTCAACGCATTGGTATTACAGGTAAAAAATTACATACGGGCCGTAGCCGTAACGATCAGGTTGCGACCGATATCCGCC
TGTATCTCAGAGATGAAATCGATGACATTTTGACGATTTTATTACGTCTACAAAAGGGTTTGCTTGGATTAGCAGCGCAA
AATACCCAAACGATCATGCCAGGGTTTACTCACCTGCAAACAGCACAGCCTGTCACGTTTGGTCATCATCTAATGGCTTG
GTTTGAAATGTTTGTGCGTGATACCGAACGTCTACAAGACTGCCGTAAGCGCGTCAATCGTATGCCACTGGGTTCGGCAG
CACTTGCTGGAACCACTTACCCGATTGACCGTGCTTTTACTGCGGAATTACTCGGTTTTGAAGCAGTATCAGAAAACTCG
CTAGATGCTGTATCTGATCGTGATTTTGCCATTGAGTTTAATGCAGCTGCATCGTTGATCATGATGCATTTATCAAGAAT
GTCTGAAGAACTTATTCTATGGACATCAGCACAGTTCAAGTTTGTAAATATTCCTGACCGATTCTGCACAGGCTCATCGA
TTATGCCTCAGAAGAAAAACCCAGATGTGCCTGAGTTAATTCGTGGTAAATCTGGACGTGTTTTTGGTGATCTCATCAGC
TTATTGACACTCATGAAAGGTCAGCCTTTGGCTTACAACAAAGACAATCAGGAAGACAAAGAGCCTTTATTTGATGCTAT
TGATACAGTTCGTGGCTCACTGATGGCATTTGCAGATATGGTCCCAGCATTAGGTCCAAATATTGAAATTATGCGCGAAG
CTGCATTGCGTGGTTTCTCAACTGCAACCGACCTTGCAGATTATTTGGTTAAAAAAGGCGTCGCTTTCCGTGATGCACAT
GAAATTGTGGGGAAAGCCGTTGCGTTAGGCGTGCAGGAAGAAAAAGATCTTTCTGAACTTTCGCTTGAGCAGCTTCAACA
ATTCTCAGATCTCATTACTGCGGATGTCTTTGATAAAGCACTGACTTTAGAAGCTTCTGTCAATGCACGTGATCACATTG
GTGGAACGTCACCAAAGCAGGTAGAAGCCGCGATTGCACGTGCCTATGATCGTCTCGAAAAACTTTATGCTTAA

Upstream 100 bases:

>100_bases
TTTGTCGTAGTGATATATCCTCGACCAAGTTTCTTGTCACGCGATGCGTCGGCAAGTGCAGCAGAATTTGTTATACTCTT
TTTTATTTTACCGAGCCGAC

Downstream 100 bases:

>100_bases
GGAAACATCATGACACGTCTTGTATTTTGTCGAAAATATCAACAGGAAATGGAAGGCTTGGATTTTGCGCCATTCCCTGG
AGCAAAAGGTCAGGAGTTTT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 477; Mature: 476

Protein sequence:

>477_residues
MTTSSHSSEQPTSTQTSGMWGGRFTEATDAFVAEFTASVQFDQRFYKQDIAGSIAHATMLAKVGVLTEAERDDIIQGLSA
IKSEIEAGQFEWRIDLEDVHMNIESRLTQRIGITGKKLHTGRSRNDQVATDIRLYLRDEIDDILTILLRLQKGLLGLAAQ
NTQTIMPGFTHLQTAQPVTFGHHLMAWFEMFVRDTERLQDCRKRVNRMPLGSAALAGTTYPIDRAFTAELLGFEAVSENS
LDAVSDRDFAIEFNAAASLIMMHLSRMSEELILWTSAQFKFVNIPDRFCTGSSIMPQKKNPDVPELIRGKSGRVFGDLIS
LLTLMKGQPLAYNKDNQEDKEPLFDAIDTVRGSLMAFADMVPALGPNIEIMREAALRGFSTATDLADYLVKKGVAFRDAH
EIVGKAVALGVQEEKDLSELSLEQLQQFSDLITADVFDKALTLEASVNARDHIGGTSPKQVEAAIARAYDRLEKLYA

Sequences:

>Translated_477_residues
MTTSSHSSEQPTSTQTSGMWGGRFTEATDAFVAEFTASVQFDQRFYKQDIAGSIAHATMLAKVGVLTEAERDDIIQGLSA
IKSEIEAGQFEWRIDLEDVHMNIESRLTQRIGITGKKLHTGRSRNDQVATDIRLYLRDEIDDILTILLRLQKGLLGLAAQ
NTQTIMPGFTHLQTAQPVTFGHHLMAWFEMFVRDTERLQDCRKRVNRMPLGSAALAGTTYPIDRAFTAELLGFEAVSENS
LDAVSDRDFAIEFNAAASLIMMHLSRMSEELILWTSAQFKFVNIPDRFCTGSSIMPQKKNPDVPELIRGKSGRVFGDLIS
LLTLMKGQPLAYNKDNQEDKEPLFDAIDTVRGSLMAFADMVPALGPNIEIMREAALRGFSTATDLADYLVKKGVAFRDAH
EIVGKAVALGVQEEKDLSELSLEQLQQFSDLITADVFDKALTLEASVNARDHIGGTSPKQVEAAIARAYDRLEKLYA
>Mature_476_residues
TTSSHSSEQPTSTQTSGMWGGRFTEATDAFVAEFTASVQFDQRFYKQDIAGSIAHATMLAKVGVLTEAERDDIIQGLSAI
KSEIEAGQFEWRIDLEDVHMNIESRLTQRIGITGKKLHTGRSRNDQVATDIRLYLRDEIDDILTILLRLQKGLLGLAAQN
TQTIMPGFTHLQTAQPVTFGHHLMAWFEMFVRDTERLQDCRKRVNRMPLGSAALAGTTYPIDRAFTAELLGFEAVSENSL
DAVSDRDFAIEFNAAASLIMMHLSRMSEELILWTSAQFKFVNIPDRFCTGSSIMPQKKNPDVPELIRGKSGRVFGDLISL
LTLMKGQPLAYNKDNQEDKEPLFDAIDTVRGSLMAFADMVPALGPNIEIMREAALRGFSTATDLADYLVKKGVAFRDAHE
IVGKAVALGVQEEKDLSELSLEQLQQFSDLITADVFDKALTLEASVNARDHIGGTSPKQVEAAIARAYDRLEKLYA

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=453, Percent_Identity=43.4878587196468, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI68303542, Length=453, Percent_Identity=43.4878587196468, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI68303547, Length=453, Percent_Identity=41.280353200883, Blast_Score=338, Evalue=9e-93,
Organism=Homo sapiens, GI68303549, Length=453, Percent_Identity=40.8388520971302, Blast_Score=328, Evalue=5e-90,
Organism=Escherichia coli, GI1790398, Length=455, Percent_Identity=48.5714285714286, Blast_Score=424, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6321806, Length=468, Percent_Identity=45.7264957264957, Blast_Score=375, Evalue=1e-105,
Organism=Drosophila melanogaster, GI221473854, Length=443, Percent_Identity=39.9548532731377, Blast_Score=317, Evalue=1e-86,
Organism=Drosophila melanogaster, GI78706858, Length=443, Percent_Identity=39.9548532731377, Blast_Score=317, Evalue=1e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_ACIAD (Q6FFB2)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_045067.1
- ProteinModelPortal:   Q6FFB2
- SMR:   Q6FFB2
- STRING:   Q6FFB2
- GeneID:   2877980
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD0283
- NMPDR:   fig|62977.3.peg.621
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   EDIHTVI
- PhylomeDB:   Q6FFB2
- ProtClustDB:   PRK00855
- BioCyc:   ASP62977:ACIAD0283-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 52920; Mature: 52789

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSSHSSEQPTSTQTSGMWGGRFTEATDAFVAEFTASVQFDQRFYKQDIAGSIAHATML
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKVGVLTEAERDDIIQGLSAIKSEIEAGQFEWRIDLEDVHMNIESRLTQRIGITGKKLHT
HHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHCHHHHHHHHHCCCCCCCCC
GRSRNDQVATDIRLYLRDEIDDILTILLRLQKGLLGLAAQNTQTIMPGFTHLQTAQPVTF
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCHHHCCCCCCHH
GHHLMAWFEMFVRDTERLQDCRKRVNRMPLGSAALAGTTYPIDRAFTAELLGFEAVSENS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHCCCC
LDAVSDRDFAIEFNAAASLIMMHLSRMSEELILWTSAQFKFVNIPDRFCTGSSIMPQKKN
CCCCCCCCEEEEEHHHHHHHHHHHHHCCCCEEEEECCCEEEEECCHHHCCCCCCCCCCCC
PDVPELIRGKSGRVFGDLISLLTLMKGQPLAYNKDNQEDKEPLFDAIDTVRGSLMAFADM
CCHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VPALGPNIEIMREAALRGFSTATDLADYLVKKGVAFRDAHEIVGKAVALGVQEEKDLSEL
HHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHH
SLEQLQQFSDLITADVFDKALTLEASVNARDHIGGTSPKQVEAAIARAYDRLEKLYA
HHHHHHHHHHHHHHHHHHHHEEEEECCCCHHCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTSSHSSEQPTSTQTSGMWGGRFTEATDAFVAEFTASVQFDQRFYKQDIAGSIAHATML
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKVGVLTEAERDDIIQGLSAIKSEIEAGQFEWRIDLEDVHMNIESRLTQRIGITGKKLHT
HHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHCHHHHHHHHHCCCCCCCCC
GRSRNDQVATDIRLYLRDEIDDILTILLRLQKGLLGLAAQNTQTIMPGFTHLQTAQPVTF
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCHHHCCCCCCHH
GHHLMAWFEMFVRDTERLQDCRKRVNRMPLGSAALAGTTYPIDRAFTAELLGFEAVSENS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHCCCC
LDAVSDRDFAIEFNAAASLIMMHLSRMSEELILWTSAQFKFVNIPDRFCTGSSIMPQKKN
CCCCCCCCEEEEEHHHHHHHHHHHHHCCCCEEEEECCCEEEEECCHHHCCCCCCCCCCCC
PDVPELIRGKSGRVFGDLISLLTLMKGQPLAYNKDNQEDKEPLFDAIDTVRGSLMAFADM
CCHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VPALGPNIEIMREAALRGFSTATDLADYLVKKGVAFRDAHEIVGKAVALGVQEEKDLSEL
HHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHH
SLEQLQQFSDLITADVFDKALTLEASVNARDHIGGTSPKQVEAAIARAYDRLEKLYA
HHHHHHHHHHHHHHHHHHHHEEEEECCCCHHCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA