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The map label for this gene is parC [H]

Identifier: 50083513

GI number: 50083513

Start: 233653

End: 235869

Strand: Direct

Name: parC [H]

Synonym: ACIAD0234

Alternate gene names: 50083513

Gene position: 233653-235869 (Clockwise)

Preceding gene: 50083512

Following gene: 50083514

Centisome position: 6.49

GC content: 42.58

Gene sequence:

>2217_bases
ATGACCAGCCTTGCGCATCATGCGACTGAAAACCGTTCCGTTGCCGAATTTACAGAACAAGCGTATCTCAACTATGCCAT
GTACGTGATTATGGATCGTGCATTGCCTCATATTAGTGATGGTTTAAAGCCTGTACAGCGCCGTATTGTATATGCAATGA
GTGAGTTGGGCCTAAAATCAACAGGAAAACCCAAAAAGTCAGCACGTACTGTGGGTGATGTACTGGGTAAATATCATCCT
CATGGTGATTCGGCCTGTTATGAAGCCATGGTTTTGATGGCACAGCCATTTAGTTATCGTTATCCTTTGGTGGAAGGGCA
AGGAAACTGGGGTTCTCCTGATGATCCTAAATCTTTTGCTGCGATGCGTTATACCGAAGCCAAACTGTCGGCGTATAGCG
AACTGTTATTGAGTGAATTGGGGCAGGGAACCGTAGACTGGCAAGATAACTTTGATGGATCGTTAAAAGAACCGATCAAT
TTACCTGCGCGCGTGCCTAATATTTTATTAAATGGCACTATGGGAATTGCAGTGGGCATGGCCACGGATATTCCACCCCA
TAATTTACGTGAAGTGGTCAAAGGGACCATTGCCCTGATTCGTAACCCTGAAACCACAGATGAGAAACTGGCAGAATATA
TTCCAGCACCCGACTTGCCGACCAAGGCAGAGATTATTACCCCAAAGGATGAGTTACTTAAAATTCAGACCACTGGGCGT
GGTAGTTATCGTGCTAGGGCGGTTTATCACATTGATAAAAACGAGATCGTCATTACTGAGCTACCGTATCAGGTATCTGG
CTCAAAAGTCATTACTCAGATTGCAGATCAGATGCAGGCCAAAAAACTACCGCTGGTCAGTGATGTCCGTGATGAATCAG
ATCATCGTAATCCAACGCGTTTGGTCATTGTATTACGTTCAAACCGTGTAGATGCTGCGGCTGTGATGAGCCATTTATTT
GCAACCACCGATCTTGAAACCAGTTATCGGGTCAATTTGAATATGATTGGTTCAGATGGTCGTCCTCAGGTGAAATCAAT
TCGCCGAATTTTGCTGGAATGGATTGAAATCCGTAAAACGACTGTGACACGTCGTTTGCAATATCATTTGAATAAAATTG
AAAAACGCTTACATATTCTGGCTGGTTTGCTGATTGCGTATTTGGATATTGATACCGTGATCAAGATCATTCGTGAAGAA
GATCAGCCCAAACCTGTCCTGATGCAACATTTTAATATTGATGAAATTCAGGCAGAAGCCATTTTGGAACTTAAATTGCG
CCATTTGGCAAAATTAGAAGAAATGGAAATTCGCCGTGAACAAGAAGAGCTTGAAGCCAGAGCTGCAGTTATTCGTGAAC
AATTGGGTAATCCAGAATCGTTAAAAAATCTGATTATCAATGAACTTAAGGAAGATGCTAAAAAATTTGGTGATGATCGA
CGTTCTCCAATCGTACAGCGTGAAGAAGCCGTACAGATTCGTGAACAGGATTTGCTACCAGCAGAGACGGTGACAGTTGT
TCTATCTGAGGCAGGCTGGATTCGTTCTGCCAAAGGTGAAGTCGATGCAGAAAATCTAAATTATCGTGCAGGTGACCAGT
ACCAAAGTCATGCCATTGGTAAGTCAAATCAGCGTGTTTATGTACTTGATGAAACCGGGCGAAGCTATGCGCTTAGTATT
GGCAACCTACCTTCTGCACGTGGACTCGGCGAGCCGTTAAGTTCAAAACTGTCGCCTGCCAATGGTGTCTCCTTTATTCA
AGTGTATATCAATGATGAGGAATCTGAACTGATTGCAGTAAGTGATGCAGGTTATGGCTTTAAAACGCAGACCAAGCAAC
TAGATACCAATGCCAAAGCAGGCAAAGCATTTCTGAGTGTTCCAGAGGGCGCCAAAGCATTGCCATTATTGACGATACGT
GATGCGACGCATCTGGCTATGCTTAGTTCGTCTGGTCGTTTACTGATTGTAGATTTGTCAGAATTACCAATATTAAACAA
AGGTAAGGGTAATAAGTTGATACAACTTGATGATAAAGATCAAATTTTATCCATGACATTGCTCAGCTTAAATGAAATAA
TTCAGGTGGTTGCGGGACAGCAACATTTAAAAATAAAAGGTGATGACCTTCAAAAATATATGGGTAAGCGTGCGACAAAA
GGGCAACTCTTACCACGAGGTTATCAAAAAGCAAATAGACTGTTGATTCAGAGATAA

Upstream 100 bases:

>100_bases
ATTTGACGCAGAGCATATAGACATTCCCTTGTGTCTATATGTCTGGCGACATAGGATAACCAATAAGACAAAACATATTA
ATTTAGGATGATTCGTTGTT

Downstream 100 bases:

>100_bases
TGCTCGCATCGGTTATCTAAAATACGTTATATATGAAAAGCAATGTAGGAAATAGATGACATGATGGGGCAGCAGAAACC
AATAATAGGCTCGATCATTG

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 738; Mature: 737

Protein sequence:

>738_residues
MTSLAHHATENRSVAEFTEQAYLNYAMYVIMDRALPHISDGLKPVQRRIVYAMSELGLKSTGKPKKSARTVGDVLGKYHP
HGDSACYEAMVLMAQPFSYRYPLVEGQGNWGSPDDPKSFAAMRYTEAKLSAYSELLLSELGQGTVDWQDNFDGSLKEPIN
LPARVPNILLNGTMGIAVGMATDIPPHNLREVVKGTIALIRNPETTDEKLAEYIPAPDLPTKAEIITPKDELLKIQTTGR
GSYRARAVYHIDKNEIVITELPYQVSGSKVITQIADQMQAKKLPLVSDVRDESDHRNPTRLVIVLRSNRVDAAAVMSHLF
ATTDLETSYRVNLNMIGSDGRPQVKSIRRILLEWIEIRKTTVTRRLQYHLNKIEKRLHILAGLLIAYLDIDTVIKIIREE
DQPKPVLMQHFNIDEIQAEAILELKLRHLAKLEEMEIRREQEELEARAAVIREQLGNPESLKNLIINELKEDAKKFGDDR
RSPIVQREEAVQIREQDLLPAETVTVVLSEAGWIRSAKGEVDAENLNYRAGDQYQSHAIGKSNQRVYVLDETGRSYALSI
GNLPSARGLGEPLSSKLSPANGVSFIQVYINDEESELIAVSDAGYGFKTQTKQLDTNAKAGKAFLSVPEGAKALPLLTIR
DATHLAMLSSSGRLLIVDLSELPILNKGKGNKLIQLDDKDQILSMTLLSLNEIIQVVAGQQHLKIKGDDLQKYMGKRATK
GQLLPRGYQKANRLLIQR

Sequences:

>Translated_738_residues
MTSLAHHATENRSVAEFTEQAYLNYAMYVIMDRALPHISDGLKPVQRRIVYAMSELGLKSTGKPKKSARTVGDVLGKYHP
HGDSACYEAMVLMAQPFSYRYPLVEGQGNWGSPDDPKSFAAMRYTEAKLSAYSELLLSELGQGTVDWQDNFDGSLKEPIN
LPARVPNILLNGTMGIAVGMATDIPPHNLREVVKGTIALIRNPETTDEKLAEYIPAPDLPTKAEIITPKDELLKIQTTGR
GSYRARAVYHIDKNEIVITELPYQVSGSKVITQIADQMQAKKLPLVSDVRDESDHRNPTRLVIVLRSNRVDAAAVMSHLF
ATTDLETSYRVNLNMIGSDGRPQVKSIRRILLEWIEIRKTTVTRRLQYHLNKIEKRLHILAGLLIAYLDIDTVIKIIREE
DQPKPVLMQHFNIDEIQAEAILELKLRHLAKLEEMEIRREQEELEARAAVIREQLGNPESLKNLIINELKEDAKKFGDDR
RSPIVQREEAVQIREQDLLPAETVTVVLSEAGWIRSAKGEVDAENLNYRAGDQYQSHAIGKSNQRVYVLDETGRSYALSI
GNLPSARGLGEPLSSKLSPANGVSFIQVYINDEESELIAVSDAGYGFKTQTKQLDTNAKAGKAFLSVPEGAKALPLLTIR
DATHLAMLSSSGRLLIVDLSELPILNKGKGNKLIQLDDKDQILSMTLLSLNEIIQVVAGQQHLKIKGDDLQKYMGKRATK
GQLLPRGYQKANRLLIQR
>Mature_737_residues
TSLAHHATENRSVAEFTEQAYLNYAMYVIMDRALPHISDGLKPVQRRIVYAMSELGLKSTGKPKKSARTVGDVLGKYHPH
GDSACYEAMVLMAQPFSYRYPLVEGQGNWGSPDDPKSFAAMRYTEAKLSAYSELLLSELGQGTVDWQDNFDGSLKEPINL
PARVPNILLNGTMGIAVGMATDIPPHNLREVVKGTIALIRNPETTDEKLAEYIPAPDLPTKAEIITPKDELLKIQTTGRG
SYRARAVYHIDKNEIVITELPYQVSGSKVITQIADQMQAKKLPLVSDVRDESDHRNPTRLVIVLRSNRVDAAAVMSHLFA
TTDLETSYRVNLNMIGSDGRPQVKSIRRILLEWIEIRKTTVTRRLQYHLNKIEKRLHILAGLLIAYLDIDTVIKIIREED
QPKPVLMQHFNIDEIQAEAILELKLRHLAKLEEMEIRREQEELEARAAVIREQLGNPESLKNLIINELKEDAKKFGDDRR
SPIVQREEAVQIREQDLLPAETVTVVLSEAGWIRSAKGEVDAENLNYRAGDQYQSHAIGKSNQRVYVLDETGRSYALSIG
NLPSARGLGEPLSSKLSPANGVSFIQVYINDEESELIAVSDAGYGFKTQTKQLDTNAKAGKAFLSVPEGAKALPLLTIRD
ATHLAMLSSSGRLLIVDLSELPILNKGKGNKLIQLDDKDQILSMTLLSLNEIIQVVAGQQHLKIKGDDLQKYMGKRATKG
QLLPRGYQKANRLLIQR

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=337, Percent_Identity=25.8160237388724, Blast_Score=75, Evalue=3e-13,
Organism=Homo sapiens, GI19913406, Length=390, Percent_Identity=25.1282051282051, Blast_Score=71, Evalue=4e-12,
Organism=Escherichia coli, GI1789396, Length=736, Percent_Identity=58.9673913043478, Blast_Score=876, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=750, Percent_Identity=33.7333333333333, Blast_Score=373, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI212645845, Length=494, Percent_Identity=25.7085020242915, Blast_Score=81, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324241, Length=356, Percent_Identity=26.123595505618, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17136538, Length=176, Percent_Identity=29.5454545454545, Blast_Score=70, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 82459; Mature: 82328

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLAHHATENRSVAEFTEQAYLNYAMYVIMDRALPHISDGLKPVQRRIVYAMSELGLKS
CCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHCCHHHHHHHHHHHHHHCCCCC
TGKPKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVEGQGNWGSPDDPKSFA
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCHHHH
AMRYTEAKLSAYSELLLSELGQGTVDWQDNFDGSLKEPINLPARVPNILLNGTMGIAVGM
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEC
ATDIPPHNLREVVKGTIALIRNPETTDEKLAEYIPAPDLPTKAEIITPKDELLKIQTTGR
CCCCCCHHHHHHHHHHHHEECCCCCCHHHHHHHCCCCCCCCCCEEECCHHHEEEEEECCC
GSYRARAVYHIDKNEIVITELPYQVSGSKVITQIADQMQAKKLPLVSDVRDESDHRNPTR
CCEEEEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCEE
LVIVLRSNRVDAAAVMSHLFATTDLETSYRVNLNMIGSDGRPQVKSIRRILLEWIEIRKT
EEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
TVTRRLQYHLNKIEKRLHILAGLLIAYLDIDTVIKIIREEDQPKPVLMQHFNIDEIQAEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHH
ILELKLRHLAKLEEMEIRREQEELEARAAVIREQLGNPESLKNLIINELKEDAKKFGDDR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCC
RSPIVQREEAVQIREQDLLPAETVTVVLSEAGWIRSAKGEVDAENLNYRAGDQYQSHAIG
CCCCCCHHHHHHHHHHCCCCHHHHHEEECCCCCEECCCCCCCCCCCCCCCCCCHHHHCCC
KSNQRVYVLDETGRSYALSIGNLPSARGLGEPLSSKLSPANGVSFIQVYINDEESELIAV
CCCCEEEEEECCCCEEEEEECCCCCCCCCCCCHHHCCCCCCCCEEEEEEEECCCCCEEEE
SDAGYGFKTQTKQLDTNAKAGKAFLSVPEGAKALPLLTIRDATHLAMLSSSGRLLIVDLS
ECCCCCCCCCCHHCCCCCCCCCEEEECCCCCCCCCEEEECCCHHEEEECCCCCEEEEEHH
ELPILNKGKGNKLIQLDDKDQILSMTLLSLNEIIQVVAGQQHLKIKGDDLQKYMGKRATK
HCCCEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHCCCCCC
GQLLPRGYQKANRLLIQR
CCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
TSLAHHATENRSVAEFTEQAYLNYAMYVIMDRALPHISDGLKPVQRRIVYAMSELGLKS
CCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHCCHHHHHHHHHHHHHHCCCCC
TGKPKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVEGQGNWGSPDDPKSFA
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCHHHH
AMRYTEAKLSAYSELLLSELGQGTVDWQDNFDGSLKEPINLPARVPNILLNGTMGIAVGM
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEC
ATDIPPHNLREVVKGTIALIRNPETTDEKLAEYIPAPDLPTKAEIITPKDELLKIQTTGR
CCCCCCHHHHHHHHHHHHEECCCCCCHHHHHHHCCCCCCCCCCEEECCHHHEEEEEECCC
GSYRARAVYHIDKNEIVITELPYQVSGSKVITQIADQMQAKKLPLVSDVRDESDHRNPTR
CCEEEEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCEE
LVIVLRSNRVDAAAVMSHLFATTDLETSYRVNLNMIGSDGRPQVKSIRRILLEWIEIRKT
EEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
TVTRRLQYHLNKIEKRLHILAGLLIAYLDIDTVIKIIREEDQPKPVLMQHFNIDEIQAEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHH
ILELKLRHLAKLEEMEIRREQEELEARAAVIREQLGNPESLKNLIINELKEDAKKFGDDR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCC
RSPIVQREEAVQIREQDLLPAETVTVVLSEAGWIRSAKGEVDAENLNYRAGDQYQSHAIG
CCCCCCHHHHHHHHHHCCCCHHHHHEEECCCCCEECCCCCCCCCCCCCCCCCCHHHHCCC
KSNQRVYVLDETGRSYALSIGNLPSARGLGEPLSSKLSPANGVSFIQVYINDEESELIAV
CCCCEEEEEECCCCEEEEEECCCCCCCCCCCCHHHCCCCCCCCEEEEEEEECCCCCEEEE
SDAGYGFKTQTKQLDTNAKAGKAFLSVPEGAKALPLLTIRDATHLAMLSSSGRLLIVDLS
ECCCCCCCCCCHHCCCCCCCCCEEEECCCCCCCCCEEEECCCHHEEEECCCCCEEEEEHH
ELPILNKGKGNKLIQLDDKDQILSMTLLSLNEIIQVVAGQQHLKIKGDDLQKYMGKRATK
HCCCEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHCCCCCC
GQLLPRGYQKANRLLIQR
CCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]