Click here to switch to the map view.

The map label for this gene is mdtD [H]

Identifier: 50083507

GI number: 50083507

Start: 226650

End: 228047

Strand: Reverse

Name: mdtD [H]

Synonym: ACIAD0228

Alternate gene names: 50083507

Gene position: 228047-226650 (Counterclockwise)

Preceding gene: 50083508

Following gene: 50083506

Centisome position: 6.34

GC content: 44.28

Gene sequence:

>1398_bases
TTGACTATGAATGCTACTCCATCGCACCAACGCTTACAGCCTGAATTCAGACTTTTGGTCTTGTTGGTTTCGATCGGTTT
TTTCATGCAGGCACTGGATACCACTATTGTCAATACCGCACTTCCTGCAATGGCTCGCCATCTTAATGAAGATCCACTTC
ACATGCACGGCGTGGTGGTCGCTTATGTGCTGTCTGTCGCAGCCTTTATTCCCCTCAGTGGCTGGCTGGCCGATCGTTTT
GGCGTGCGTAATACCTACTTTGCCGCTATTGTGATCTTTACCTTAGCCTCTTTGGGTTGTGGATTATCGCAATCTCTGAA
TCAATTGATTTTCTTCCGTGTGATTCAAGGACTAGGCGGTGCATTATTGCTTCCCGTGGGACGTTTGGCGATGCTCAAAC
TGATCCCACGGACCCAATTTCTTTCTGCGATGAGCCTGATGAGTCTGGCTGGCCTCATTGGGCCGCTGATTGGCCCAACC
CTAGGCGGTTGGCTGGTCGAAGTGGCAACTTGGCACTGGGTATTTTTAATTAATATTCCAATGGGACTTTTGGGGATTTT
GGTGACCTTTAAGGCCATGCCAAATGTCAAACAAAAAGAAGTAAAGTCCTTCGATTTAAGTGGTTTTGTTCTATTGATGG
TCGCAATGATTGGTCTATCTTTGGGCATCGAACAACTCTCTAGTCGTGAATACCCACAATGGGTGAGTATTTCTCTACTC
ATTGCAGGTATTTTGGCAACCATCATTTATGCTTACCATTCACACATGCATGAAAATGCCTTATTTCGCAGCACGCTATT
TAAAAACAAAATTTATGCAATTGGCGTATTGGGTAACTTTTTTGCGCGCTTTGGCGGCAATGCTGTCCCATTCATTTTGC
CGCTGATGCTTCAGGTTGCATTTGGATTTGAACCGTTTTATACAGGACTGATGATGATTCCATTGGTTTTGGGTTCATTA
TTTTCAAAACCGATTGTGCGTCCGATTATTCAGCGTCTGGGATACCGCAACGTATTATTAACCAACACCATACTGGTCGG
CTGCTGTATTGCCAGTTTCTCTCTCACAACTGCCGAAACCCCAGAATGGTTACGCGCGATTCACTTTTTTATTTTTGGAA
CTCTCAATTCGATTCAGTTTGTTTCCATGAATACCCTTACCTTAAAGGATTTGTCACAACAACAAGCCAGTAGTGGTAAC
AGTTTTCTTTCCATGATCATGATGCTCTCGATGAGTATTGGGGTGGCGCTGGCAGGCACACTGGTCAATATGTTTAGTCA
TTATTTTGGACCACAACACATGGCAACCACGTTCCATGCCACTTTAATTTGTATGGGCTGCATTAATGTGGTCACAGCTT
TAATTTTTTCAAGAATTCCTCGCAACATCCCTGTATGA

Upstream 100 bases:

>100_bases
TGGCAACCTGGCTACAAAAACAAAGCAGCCCCTGTTTAAAAGATATTACTACAGTACGTTTCATGTTAGTTTTTGAGTTA
AGTTCTACACACACCATGTA

Downstream 100 bases:

>100_bases
GCATTGCATTTTGAACATGGTGCGATGCGCTGCTTCACGTTATGATAAGACAAATTATCCATCACAAAGTCGGAATGAAA
TTACCTCATCAACTTAGATT

Product: MFS family transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MTMNATPSHQRLQPEFRLLVLLVSIGFFMQALDTTIVNTALPAMARHLNEDPLHMHGVVVAYVLSVAAFIPLSGWLADRF
GVRNTYFAAIVIFTLASLGCGLSQSLNQLIFFRVIQGLGGALLLPVGRLAMLKLIPRTQFLSAMSLMSLAGLIGPLIGPT
LGGWLVEVATWHWVFLINIPMGLLGILVTFKAMPNVKQKEVKSFDLSGFVLLMVAMIGLSLGIEQLSSREYPQWVSISLL
IAGILATIIYAYHSHMHENALFRSTLFKNKIYAIGVLGNFFARFGGNAVPFILPLMLQVAFGFEPFYTGLMMIPLVLGSL
FSKPIVRPIIQRLGYRNVLLTNTILVGCCIASFSLTTAETPEWLRAIHFFIFGTLNSIQFVSMNTLTLKDLSQQQASSGN
SFLSMIMMLSMSIGVALAGTLVNMFSHYFGPQHMATTFHATLICMGCINVVTALIFSRIPRNIPV

Sequences:

>Translated_465_residues
MTMNATPSHQRLQPEFRLLVLLVSIGFFMQALDTTIVNTALPAMARHLNEDPLHMHGVVVAYVLSVAAFIPLSGWLADRF
GVRNTYFAAIVIFTLASLGCGLSQSLNQLIFFRVIQGLGGALLLPVGRLAMLKLIPRTQFLSAMSLMSLAGLIGPLIGPT
LGGWLVEVATWHWVFLINIPMGLLGILVTFKAMPNVKQKEVKSFDLSGFVLLMVAMIGLSLGIEQLSSREYPQWVSISLL
IAGILATIIYAYHSHMHENALFRSTLFKNKIYAIGVLGNFFARFGGNAVPFILPLMLQVAFGFEPFYTGLMMIPLVLGSL
FSKPIVRPIIQRLGYRNVLLTNTILVGCCIASFSLTTAETPEWLRAIHFFIFGTLNSIQFVSMNTLTLKDLSQQQASSGN
SFLSMIMMLSMSIGVALAGTLVNMFSHYFGPQHMATTFHATLICMGCINVVTALIFSRIPRNIPV
>Mature_464_residues
TMNATPSHQRLQPEFRLLVLLVSIGFFMQALDTTIVNTALPAMARHLNEDPLHMHGVVVAYVLSVAAFIPLSGWLADRFG
VRNTYFAAIVIFTLASLGCGLSQSLNQLIFFRVIQGLGGALLLPVGRLAMLKLIPRTQFLSAMSLMSLAGLIGPLIGPTL
GGWLVEVATWHWVFLINIPMGLLGILVTFKAMPNVKQKEVKSFDLSGFVLLMVAMIGLSLGIEQLSSREYPQWVSISLLI
AGILATIIYAYHSHMHENALFRSTLFKNKIYAIGVLGNFFARFGGNAVPFILPLMLQVAFGFEPFYTGLMMIPLVLGSLF
SKPIVRPIIQRLGYRNVLLTNTILVGCCIASFSLTTAETPEWLRAIHFFIFGTLNSIQFVSMNTLTLKDLSQQQASSGNS
FLSMIMMLSMSIGVALAGTLVNMFSHYFGPQHMATTFHATLICMGCINVVTALIFSRIPRNIPV

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=435, Percent_Identity=44.367816091954, Blast_Score=391, Evalue=1e-110,
Organism=Escherichia coli, GI1788392, Length=469, Percent_Identity=46.6950959488273, Blast_Score=378, Evalue=1e-106,
Organism=Escherichia coli, GI1789042, Length=421, Percent_Identity=27.0783847980998, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI1788710, Length=406, Percent_Identity=27.3399014778325, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI87081983, Length=421, Percent_Identity=27.3159144893112, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1790794, Length=272, Percent_Identity=26.8382352941176, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87082320, Length=185, Percent_Identity=28.6486486486486, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322958, Length=179, Percent_Identity=30.7262569832402, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6319770, Length=275, Percent_Identity=25.0909090909091, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6321663, Length=150, Percent_Identity=30, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6325455, Length=131, Percent_Identity=28.2442748091603, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 51085; Mature: 50954

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TMNATPSHQRLQPEFRLLVLLVSIGFFMQALDTTIVNTALPAMARHLNEDPLHMHGVVV
CCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH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HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA