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The map label for this gene is atpA

Identifier: 50083467

GI number: 50083467

Start: 181338

End: 182897

Strand: Direct

Name: atpA

Synonym: ACIAD0185

Alternate gene names: 50083467

Gene position: 181338-182897 (Clockwise)

Preceding gene: 50083466

Following gene: 50083468

Centisome position: 5.04

GC content: 45.83

Gene sequence:

>1560_bases
TTGAGGAATAGCGCAATGCAACAACTGAATCCATCCGAGATCAGTGCGCTCATTAAACAGCGTATCGGCGATCTGGACAC
CAGCGCGACCGCGAAGAATGAAGGTACCATTGTTATGGTATCTGACGGTATCGTGCGCATTCACGGTCTTGCTGATGCAA
TGTACGGTGAAATGATCGAATTCGACGGCGGCTTATTTGGTATGGCACTGAACCTAGAACAGGATTCAGTGGGTGCCGTT
GTTTTAGGTAACTACCTAAGCCTTCAAGAAGGTCAAAAAGCGCGTTGTACAGGTCGTGTACTTGAAGTACCAGTGGGTCC
TGAACTACTTGGCCGTGTGGTCGATGCTTTGGGTAACCCGATTGATGGTAAAGGCCCTATTGATGCAAAACTTACTGATG
CTGTTGAAAAAGTAGCACCAGGTGTAATTTGGCGTCAGTCAGTCGACGAACCTGTTCAAACTGGTTATAAATCAGTGGAT
ACCATGATCCCTGTAGGTCGTGGTCAGCGTGAGTTGATCATTGGTGACCGCCAAACTGGTAAAACAGCAATGGCGATCGA
TGCGATCATCGCTCAGAAACACTCTGGCATTAAATGCGTATATGTTGCAATTGGTCAAAAACAATCGACCATCGCAAACG
TGGTACGTAAGCTTGAAGAAACTGGCGCTATGGCGTATACCACTGTTGTCGCGGCTGCGGCGGCTGATCCTGCTGCAATG
CAGTATCTTGCTCCGTATTCTGGCTGTACTATGGGTGAATACTTCCGTGACCGCGGTGAAGATGCGTTGATCATTTATGA
TGATTTGTCTAAACAAGCTGTTGCTTACCGTCAAATCTCATTGCTTCTACGTCGTCCACCAGGTCGTGAAGCATATCCAG
GTGACGTATTCTATCTTCACTCACGTCTTCTTGAGCGTGCTTCGCGCGTTTCAGCAGATTATGTTGAGAAATTCACGAAT
GGCGCAGTAACAGGTCAAACTGGTTCTTTGACTGCATTGCCAATCATTGAAACTCAAGCGGGTGACGTATCTGCATTCGT
ACCAACCAACGTAATTTCGATTACTGATGGTCAGATCTTCCTTGAAACATCATTGTTCAACGCGGGTATTCGTCCTGCTG
TGAACGCGGGTATTTCGGTATCGCGTGTTGGTGGTTCAGCTCAAACCAAGATCATCAAGAAGTTGTCTGGTGGTATCCGT
ACCGCTCTTGCGCAATACCGTGAATTGGCTGCGTTTGCTCAGTTTGCTTCTGACCTTGACGAAGCAACACGTAAACAGCT
TGAACATGGTCAACGTGTAACTGAGTTAATGAAGCAAAAGCAATATGCTCCTTACTCAATTGCTGACCAAGCTGTTTCTG
TTTATGCATCTAATGAAGGCTATATGGCTGACGTAGAAGTGAAGAAAATCGTAGACTTTGATGCTGCGCTAATTTCTTAC
TTCCGTTCTGAATATGCGCCTTTAATGAAACAGATCGATGAAACTGGTGATTACAACAAAGACATCGAAGCAGCAATCAA
ATCAGGTATTGAGAGCTTCAAAGCGACTCAAACTTACTAA

Upstream 100 bases:

>100_bases
AGGCGATCAAGTGATAGATGATTCTGCGCTGAACAAGCTTGAAAAAATGCGGACTCGTCTTCTTGCATAATGCATTAAAG
AAGACTGAACTTTAAAAAGA

Downstream 100 bases:

>100_bases
GTTTATCTTTAGTTAAGTTTGGTTCACGGATCAACCTTCGAAGGCTCGAAAGAGCTTTCGACTACTAGGTTAAGCGTATG
GCAAATTTAAAAGAAATTCG

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha

Number of amino acids: Translated: 519; Mature: 519

Protein sequence:

>519_residues
MRNSAMQQLNPSEISALIKQRIGDLDTSATAKNEGTIVMVSDGIVRIHGLADAMYGEMIEFDGGLFGMALNLEQDSVGAV
VLGNYLSLQEGQKARCTGRVLEVPVGPELLGRVVDALGNPIDGKGPIDAKLTDAVEKVAPGVIWRQSVDEPVQTGYKSVD
TMIPVGRGQRELIIGDRQTGKTAMAIDAIIAQKHSGIKCVYVAIGQKQSTIANVVRKLEETGAMAYTTVVAAAAADPAAM
QYLAPYSGCTMGEYFRDRGEDALIIYDDLSKQAVAYRQISLLLRRPPGREAYPGDVFYLHSRLLERASRVSADYVEKFTN
GAVTGQTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLETSLFNAGIRPAVNAGISVSRVGGSAQTKIIKKLSGGIR
TALAQYRELAAFAQFASDLDEATRKQLEHGQRVTELMKQKQYAPYSIADQAVSVYASNEGYMADVEVKKIVDFDAALISY
FRSEYAPLMKQIDETGDYNKDIEAAIKSGIESFKATQTY

Sequences:

>Translated_519_residues
MRNSAMQQLNPSEISALIKQRIGDLDTSATAKNEGTIVMVSDGIVRIHGLADAMYGEMIEFDGGLFGMALNLEQDSVGAV
VLGNYLSLQEGQKARCTGRVLEVPVGPELLGRVVDALGNPIDGKGPIDAKLTDAVEKVAPGVIWRQSVDEPVQTGYKSVD
TMIPVGRGQRELIIGDRQTGKTAMAIDAIIAQKHSGIKCVYVAIGQKQSTIANVVRKLEETGAMAYTTVVAAAAADPAAM
QYLAPYSGCTMGEYFRDRGEDALIIYDDLSKQAVAYRQISLLLRRPPGREAYPGDVFYLHSRLLERASRVSADYVEKFTN
GAVTGQTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLETSLFNAGIRPAVNAGISVSRVGGSAQTKIIKKLSGGIR
TALAQYRELAAFAQFASDLDEATRKQLEHGQRVTELMKQKQYAPYSIADQAVSVYASNEGYMADVEVKKIVDFDAALISY
FRSEYAPLMKQIDETGDYNKDIEAAIKSGIESFKATQTY
>Mature_519_residues
MRNSAMQQLNPSEISALIKQRIGDLDTSATAKNEGTIVMVSDGIVRIHGLADAMYGEMIEFDGGLFGMALNLEQDSVGAV
VLGNYLSLQEGQKARCTGRVLEVPVGPELLGRVVDALGNPIDGKGPIDAKLTDAVEKVAPGVIWRQSVDEPVQTGYKSVD
TMIPVGRGQRELIIGDRQTGKTAMAIDAIIAQKHSGIKCVYVAIGQKQSTIANVVRKLEETGAMAYTTVVAAAAADPAAM
QYLAPYSGCTMGEYFRDRGEDALIIYDDLSKQAVAYRQISLLLRRPPGREAYPGDVFYLHSRLLERASRVSADYVEKFTN
GAVTGQTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLETSLFNAGIRPAVNAGISVSRVGGSAQTKIIKKLSGGIR
TALAQYRELAAFAQFASDLDEATRKQLEHGQRVTELMKQKQYAPYSIADQAVSVYASNEGYMADVEVKKIVDFDAALISY
FRSEYAPLMKQIDETGDYNKDIEAAIKSGIESFKATQTY

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=521, Percent_Identity=56.6218809980806, Blast_Score=586, Evalue=1e-167,
Organism=Homo sapiens, GI4757810, Length=521, Percent_Identity=56.6218809980806, Blast_Score=586, Evalue=1e-167,
Organism=Homo sapiens, GI19913428, Length=317, Percent_Identity=28.391167192429, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI32189394, Length=398, Percent_Identity=24.6231155778894, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI19913426, Length=323, Percent_Identity=27.5541795665635, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI19913424, Length=334, Percent_Identity=26.3473053892216, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1790172, Length=512, Percent_Identity=74.609375, Blast_Score=793, Evalue=0.0,
Organism=Escherichia coli, GI1790170, Length=388, Percent_Identity=26.0309278350515, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI1788251, Length=425, Percent_Identity=26.8235294117647, Blast_Score=115, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI71988063, Length=513, Percent_Identity=55.7504873294347, Blast_Score=572, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI71988080, Length=513, Percent_Identity=55.7504873294347, Blast_Score=571, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI71988074, Length=513, Percent_Identity=52.2417153996101, Blast_Score=523, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI17510931, Length=381, Percent_Identity=26.509186351706, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI25144756, Length=412, Percent_Identity=24.2718446601942, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17570191, Length=305, Percent_Identity=27.2131147540984, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17565854, Length=251, Percent_Identity=27.4900398406374, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=62, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71988068, Length=73, Percent_Identity=42.4657534246575, Blast_Score=69, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6319370, Length=523, Percent_Identity=53.5372848948375, Blast_Score=575, Evalue=1e-165,
Organism=Saccharomyces cerevisiae, GI6319603, Length=306, Percent_Identity=30.0653594771242, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6322581, Length=397, Percent_Identity=25.6926952141058, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320016, Length=164, Percent_Identity=31.0975609756098, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24658560, Length=513, Percent_Identity=55.7504873294347, Blast_Score=566, Evalue=1e-161,
Organism=Drosophila melanogaster, GI281361666, Length=308, Percent_Identity=29.2207792207792, Blast_Score=119, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24646341, Length=308, Percent_Identity=29.2207792207792, Blast_Score=119, Evalue=7e-27,
Organism=Drosophila melanogaster, GI17136796, Length=308, Percent_Identity=29.2207792207792, Blast_Score=119, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24638766, Length=425, Percent_Identity=24.9411764705882, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28574560, Length=322, Percent_Identity=25.1552795031056, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24583992, Length=320, Percent_Identity=26.25, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24583988, Length=248, Percent_Identity=28.6290322580645, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24583986, Length=248, Percent_Identity=28.6290322580645, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24583984, Length=248, Percent_Identity=28.6290322580645, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI20129479, Length=320, Percent_Identity=26.5625, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA_ACIAD (Q6FFK2)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_044977.1
- ProteinModelPortal:   Q6FFK2
- SMR:   Q6FFK2
- STRING:   Q6FFK2
- GeneID:   2878476
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD0185
- NMPDR:   fig|62977.3.peg.272
- eggNOG:   COG0056
- HOGENOM:   HBG565875
- OMA:   GSDRDIK
- PhylomeDB:   Q6FFK2
- ProtClustDB:   PRK09281
- BioCyc:   ASP62977:ACIAD0185-MONOMER
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 55999; Mature: 55999

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNSAMQQLNPSEISALIKQRIGDLDTSATAKNEGTIVMVSDGIVRIHGLADAMYGEMIE
CCCCHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCEEEEEHHHHHHHHHHHH
FDGGLFGMALNLEQDSVGAVVLGNYLSLQEGQKARCTGRVLEVPVGPELLGRVVDALGNP
CCCCEEEEEEECCCCCCCEEEECCHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHCCC
IDGKGPIDAKLTDAVEKVAPGVIWRQSVDEPVQTGYKSVDTMIPVGRGQRELIIGDRQTG
CCCCCCCCHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCC
KTAMAIDAIIAQKHSGIKCVYVAIGQKQSTIANVVRKLEETGAMAYTTVVAAAAADPAAM
CHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHH
QYLAPYSGCTMGEYFRDRGEDALIIYDDLSKQAVAYRQISLLLRRPPGREAYPGDVFYLH
HHHCCCCCCCHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
SRLLERASRVSADYVEKFTNGAVTGQTGSLTALPIIETQAGDVSAFVPTNVISITDGQIF
HHHHHHHHHCCHHHHHHHCCCCEECCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEE
LETSLFNAGIRPAVNAGISVSRVGGSAQTKIIKKLSGGIRTALAQYRELAAFAQFASDLD
EEEEHHCCCCCHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EATRKQLEHGQRVTELMKQKQYAPYSIADQAVSVYASNEGYMADVEVKKIVDFDAALISY
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEEEECCCCEEEECHHHHHHHHHHHHHHH
FRSEYAPLMKQIDETGDYNKDIEAAIKSGIESFKATQTY
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRNSAMQQLNPSEISALIKQRIGDLDTSATAKNEGTIVMVSDGIVRIHGLADAMYGEMIE
CCCCHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCEEEEEHHHHHHHHHHHH
FDGGLFGMALNLEQDSVGAVVLGNYLSLQEGQKARCTGRVLEVPVGPELLGRVVDALGNP
CCCCEEEEEEECCCCCCCEEEECCHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHCCC
IDGKGPIDAKLTDAVEKVAPGVIWRQSVDEPVQTGYKSVDTMIPVGRGQRELIIGDRQTG
CCCCCCCCHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCC
KTAMAIDAIIAQKHSGIKCVYVAIGQKQSTIANVVRKLEETGAMAYTTVVAAAAADPAAM
CHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHH
QYLAPYSGCTMGEYFRDRGEDALIIYDDLSKQAVAYRQISLLLRRPPGREAYPGDVFYLH
HHHCCCCCCCHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
SRLLERASRVSADYVEKFTNGAVTGQTGSLTALPIIETQAGDVSAFVPTNVISITDGQIF
HHHHHHHHHCCHHHHHHHCCCCEECCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEE
LETSLFNAGIRPAVNAGISVSRVGGSAQTKIIKKLSGGIRTALAQYRELAAFAQFASDLD
EEEEHHCCCCCHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EATRKQLEHGQRVTELMKQKQYAPYSIADQAVSVYASNEGYMADVEVKKIVDFDAALISY
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEEEECCCCEEEECHHHHHHHHHHHHHHH
FRSEYAPLMKQIDETGDYNKDIEAAIKSGIESFKATQTY
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA