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The map label for this gene is atpB

Identifier: 50083463

GI number: 50083463

Start: 179044

End: 179919

Strand: Direct

Name: atpB

Synonym: ACIAD0180

Alternate gene names: 50083463

Gene position: 179044-179919 (Clockwise)

Preceding gene: 50083462

Following gene: 50083464

Centisome position: 4.98

GC content: 43.26

Gene sequence:

>876_bases
ATGGCTGCTGAAGAACATGCCCTTACTTCGACAGAGTATATCAAGCATCACTTGACCAATTTGACCTATGGCAAAATGCC
GGACGGAACTTGGAAATTGGCTGAGAATGCAAAAGAAGCTCAAGAAATGGGGTTTTCTGCTATTCACTTGGACTCGATGG
GTTGGTCAATCGGACTTGGTATCATTTTTTGTTTGGTTTTTTGGTGTGCTGCAAAAGCTGCAAAAGCGGATGTTCCATCA
AAATTCCAATCGGCAATCGAAATGATTATCGAGTTTGTTGATTCCAGCGTTCGCGATACCTTTCATGGTAAATCACGTCT
TATTGCACCTCTTGCTTTGACCATTTTTGTGTGGATTTTCCTCATGAACTTGATGGACCTTATCCCTGTGGATTGGGTGC
CGATGCTGGCTCAAATTGTTGGTGCGCACGTGTTTGGCATGGATCCTCACCATGTGTATTTCAAAATCGTTCCGTCTACA
GATCCGAACATTACCTTAGGTATGTCATTGTCTGTATTCGTACTGATTCTGTTTTACAGCATTCGTGAGAAAGGCATTGG
TGGATTCGTTGGTGAATTGGCGCTCAACCCATTTAACCCAAGTAACCCAGTTGCAAAAGCGTTATTGATTCCTGTGAACT
TGATTCTGGAATTGGTAACTTTCCTTGCACGACCAATTTCATTGGCGCTACGACTTTTCGGTAACATGTATGCGGGCGAG
TTAATCTTTATCTTGATCGCACTTTTACCGTTTTGGATTCAATGGGCGTTGTCTGTGCCTTGGGCAATCTTCCACATTCT
CGTCATCACGTTGCAGGCATTTATCTTTATGATGCTGACCATCGTGTACTTGAGCATGGCAAGCGAAAAGCATTAA

Upstream 100 bases:

>100_bases
CATCAAAAGTTGAAAAATTTTTTGAGTGTGACGAGATATCAGGCAGCACGCGATATTCGTCCTGCTCTTTTTAGTAATTG
ACATTGACCAGGTGTGATTT

Downstream 100 bases:

>100_bases
TGGTTTTTGCCTGACTATCAAAGGGATGGTTGGGCACATTTTTTAGTTTAATTTGGTAATAACCTAACCTCTGAGGAATT
TTTCATGGAACTCACTTTAG

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MAAEEHALTSTEYIKHHLTNLTYGKMPDGTWKLAENAKEAQEMGFSAIHLDSMGWSIGLGIIFCLVFWCAAKAAKADVPS
KFQSAIEMIIEFVDSSVRDTFHGKSRLIAPLALTIFVWIFLMNLMDLIPVDWVPMLAQIVGAHVFGMDPHHVYFKIVPST
DPNITLGMSLSVFVLILFYSIREKGIGGFVGELALNPFNPSNPVAKALLIPVNLILELVTFLARPISLALRLFGNMYAGE
LIFILIALLPFWIQWALSVPWAIFHILVITLQAFIFMMLTIVYLSMASEKH

Sequences:

>Translated_291_residues
MAAEEHALTSTEYIKHHLTNLTYGKMPDGTWKLAENAKEAQEMGFSAIHLDSMGWSIGLGIIFCLVFWCAAKAAKADVPS
KFQSAIEMIIEFVDSSVRDTFHGKSRLIAPLALTIFVWIFLMNLMDLIPVDWVPMLAQIVGAHVFGMDPHHVYFKIVPST
DPNITLGMSLSVFVLILFYSIREKGIGGFVGELALNPFNPSNPVAKALLIPVNLILELVTFLARPISLALRLFGNMYAGE
LIFILIALLPFWIQWALSVPWAIFHILVITLQAFIFMMLTIVYLSMASEKH
>Mature_290_residues
AAEEHALTSTEYIKHHLTNLTYGKMPDGTWKLAENAKEAQEMGFSAIHLDSMGWSIGLGIIFCLVFWCAAKAAKADVPSK
FQSAIEMIIEFVDSSVRDTFHGKSRLIAPLALTIFVWIFLMNLMDLIPVDWVPMLAQIVGAHVFGMDPHHVYFKIVPSTD
PNITLGMSLSVFVLILFYSIREKGIGGFVGELALNPFNPSNPVAKALLIPVNLILELVTFLARPISLALRLFGNMYAGEL
IFILIALLPFWIQWALSVPWAIFHILVITLQAFIFMMLTIVYLSMASEKH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Escherichia coli, GI1790176, Length=292, Percent_Identity=57.8767123287671, Blast_Score=293, Evalue=1e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_ACIAD (Q6FFK6)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_044973.1
- ProteinModelPortal:   Q6FFK6
- SMR:   Q6FFK6
- STRING:   Q6FFK6
- GeneID:   2878477
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD0180
- NMPDR:   fig|62977.3.peg.268
- eggNOG:   COG0356
- HOGENOM:   HBG734175
- OMA:   AGELVFM
- PhylomeDB:   Q6FFK6
- ProtClustDB:   PRK05815
- BioCyc:   ASP62977:ACIAD0180-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 32511; Mature: 32380

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x14d60c1c)-; HASH(0x14f3a3ac)-; HASH(0x14f34990)-; HASH(0x153a63e0)-; HASH(0x1524e498)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAEEHALTSTEYIKHHLTNLTYGKMPDGTWKLAENAKEAQEMGFSAIHLDSMGWSIGLG
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHEEECCCCHHHHHH
IIFCLVFWCAAKAAKADVPSKFQSAIEMIIEFVDSSVRDTFHGKSRLIAPLALTIFVWIF
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LMNLMDLIPVDWVPMLAQIVGAHVFGMDPHHVYFKIVPSTDPNITLGMSLSVFVLILFYS
HHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCEEECHHHHHHHHHHHHH
IREKGIGGFVGELALNPFNPSNPVAKALLIPVNLILELVTFLARPISLALRLFGNMYAGE
HHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIFILIALLPFWIQWALSVPWAIFHILVITLQAFIFMMLTIVYLSMASEKH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure 
AAEEHALTSTEYIKHHLTNLTYGKMPDGTWKLAENAKEAQEMGFSAIHLDSMGWSIGLG
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHEEECCCCHHHHHH
IIFCLVFWCAAKAAKADVPSKFQSAIEMIIEFVDSSVRDTFHGKSRLIAPLALTIFVWIF
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LMNLMDLIPVDWVPMLAQIVGAHVFGMDPHHVYFKIVPSTDPNITLGMSLSVFVLILFYS
HHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCEEECHHHHHHHHHHHHH
IREKGIGGFVGELALNPFNPSNPVAKALLIPVNLILELVTFLARPISLALRLFGNMYAGE
HHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIFILIALLPFWIQWALSVPWAIFHILVITLQAFIFMMLTIVYLSMASEKH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA