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The map label for this gene is guaA

Identifier: 50083437

GI number: 50083437

Start: 150400

End: 152052

Strand: Direct

Name: guaA

Synonym: ACIAD0151

Alternate gene names: 50083437

Gene position: 150400-152052 (Clockwise)

Preceding gene: 50083436

Following gene: 50083439

Centisome position: 4.18

GC content: 45.07

Gene sequence:

>1653_bases
TTGCTGATTGAAAGAACGTGCGCGATACTTGGAAAAATGCTAGAATATTGCGCTTCTCTCGTTGCCTTGCATAGTTGCGT
AATCATGACAACCAATACTCACATTACTGATGATCGTATCTTAATTCTGGATTTCGGATCTCAATACAGCCAGCTCATTG
CACGTCGTGTACGTGAAGCGGGTGTATATTCTGAAATGTATGCTTTTGATATGTCTGAAGAAGACATTCGTGCATTTAAT
CCAAATGGCATTATTTTGTCAGGTGGGCCTGAAAGCGTGCATGAAGAAGGCAGCCCGCGTGCGCCACAAGTGGTGTTTGA
GCTTGGTGTACCTGTCTTAGGGATTTGTTATGGTTTTCAAACCATGTCTGAGCAGTTGGGCGGAAAAGTTGAGCCTGGTA
CTGTACATGAGTTTGGCTATGCCGAAGTGGATATTCAGCAGCGCGACCAACTTGTTGGAAACTTGCAAGATCGTGAGAAT
CAACTGCATGTCTGGATGAGCCATGGCGACAAAGTTAGTCGTTTACCAGAAGGTTTTAGTACCACTGCAAGTACCCCAAG
CTGTCCATTCGCAGCAGCATCGGATGAAGCTCGCCGTTTTTACGGTGTGCAGTTCCATCCTGAAGTCACGCATACAGCGA
AAGGTGCCGAGTTACTGGCAAACTTTGTGCATAAAATCTGTGGTTGTGGCGGTCTTTGGACACCAGAACACATTATCGAT
TTGCGTGTAGAACAGTTACGCGCCCAAATTGGTGACGAAAAAGTTTTACTTGGCCTATCGGGTGGTGTGGATTCATCTGT
CGTTGCTGCATTGTTGCATAAAGCCATTGGTGATCAGTTGACTTGCGTATTTGTGGACAATGGTTTGCTTCGTTTAAACG
AAGGTGACCAAGTGATGCAAATGTTTGCTGATAACATGGGGATTCGTGTGATCCGTGCAGATGCAGAAGAACGTTTCTTG
ACTGCGCTTGCAGGTGAAGTTGATCCTGAGAAAAAACGTAAGATCATTGGTCGTGAATTTATTGAAGTATTTGCAGAAGA
AGCACGCAAACTGGATGGCGTGAAATTCTTGGCACAAGGTACGATTTATCCTGACGTGATTGAATCTGCTGCAAGCAAAC
AGGGTAAAGCACACGTGATTAAATCACACCATAATGTGGGTGGTTTACCTGATGATTTAGAATTTGAATTGGTTGAGCCA
TTACGTGATTTATTCAAAGATGAAGTGCGTAAATTGGGTACCACACTCGGCTTGCCGCACAGCATGATTTACCGTCATCC
GTTCCCAGGTCCAGGTTTGGGCGTGCGTATTTTGGGTGAAGTGAAAAAAGAATATGCAGATATTCTTCGCCTTGCCGATG
ACATCTTTATGCAAGAGCTTCGCGCAAGTGGTTGGTATGACAAAACTGCGCAAGCCTTTGCAGTATTCCAACCTGTAAAA
TCTGTGGGTGTGGTCGGTGATGGTCGTCGTTATGCATGGGTGATCGCACTTCGTGCAGTTGAGACTGTTGACTTTATGAC
AGCGCGTTTCGCTCACTTGCCATACGAGTTGGTGGATAAAATCTCAACCCGTATCATGAATGAAATCAAAGATGTTTCAC
GTGTTGTGTATGACGTGTCATCTAAGCCACCAGCAACGATTGAGTGGGAGTAA

Upstream 100 bases:

>100_bases
AACCTACAGATATTGAAGTGGTTAAGATTGAAAAAATTCAACACTAAACTAAAAGGCACGAATCAAGTGCCTTTTTTTAA
TGCTGCTTTTTTGATAACTT

Downstream 100 bases:

>100_bases
AACTGGGGGTTCAAGCATCAACCTGCTTGCCAGTTTTACATCAAGCGAGCGCTCTGAGCGCGGTCTGATTTAAGACATAT
AAAAAAGGGCGCTGAAGCGT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 550; Mature: 550

Protein sequence:

>550_residues
MLIERTCAILGKMLEYCASLVALHSCVIMTTNTHITDDRILILDFGSQYSQLIARRVREAGVYSEMYAFDMSEEDIRAFN
PNGIILSGGPESVHEEGSPRAPQVVFELGVPVLGICYGFQTMSEQLGGKVEPGTVHEFGYAEVDIQQRDQLVGNLQDREN
QLHVWMSHGDKVSRLPEGFSTTASTPSCPFAAASDEARRFYGVQFHPEVTHTAKGAELLANFVHKICGCGGLWTPEHIID
LRVEQLRAQIGDEKVLLGLSGGVDSSVVAALLHKAIGDQLTCVFVDNGLLRLNEGDQVMQMFADNMGIRVIRADAEERFL
TALAGEVDPEKKRKIIGREFIEVFAEEARKLDGVKFLAQGTIYPDVIESAASKQGKAHVIKSHHNVGGLPDDLEFELVEP
LRDLFKDEVRKLGTTLGLPHSMIYRHPFPGPGLGVRILGEVKKEYADILRLADDIFMQELRASGWYDKTAQAFAVFQPVK
SVGVVGDGRRYAWVIALRAVETVDFMTARFAHLPYELVDKISTRIMNEIKDVSRVVYDVSSKPPATIEWE

Sequences:

>Translated_550_residues
MLIERTCAILGKMLEYCASLVALHSCVIMTTNTHITDDRILILDFGSQYSQLIARRVREAGVYSEMYAFDMSEEDIRAFN
PNGIILSGGPESVHEEGSPRAPQVVFELGVPVLGICYGFQTMSEQLGGKVEPGTVHEFGYAEVDIQQRDQLVGNLQDREN
QLHVWMSHGDKVSRLPEGFSTTASTPSCPFAAASDEARRFYGVQFHPEVTHTAKGAELLANFVHKICGCGGLWTPEHIID
LRVEQLRAQIGDEKVLLGLSGGVDSSVVAALLHKAIGDQLTCVFVDNGLLRLNEGDQVMQMFADNMGIRVIRADAEERFL
TALAGEVDPEKKRKIIGREFIEVFAEEARKLDGVKFLAQGTIYPDVIESAASKQGKAHVIKSHHNVGGLPDDLEFELVEP
LRDLFKDEVRKLGTTLGLPHSMIYRHPFPGPGLGVRILGEVKKEYADILRLADDIFMQELRASGWYDKTAQAFAVFQPVK
SVGVVGDGRRYAWVIALRAVETVDFMTARFAHLPYELVDKISTRIMNEIKDVSRVVYDVSSKPPATIEWE
>Mature_550_residues
MLIERTCAILGKMLEYCASLVALHSCVIMTTNTHITDDRILILDFGSQYSQLIARRVREAGVYSEMYAFDMSEEDIRAFN
PNGIILSGGPESVHEEGSPRAPQVVFELGVPVLGICYGFQTMSEQLGGKVEPGTVHEFGYAEVDIQQRDQLVGNLQDREN
QLHVWMSHGDKVSRLPEGFSTTASTPSCPFAAASDEARRFYGVQFHPEVTHTAKGAELLANFVHKICGCGGLWTPEHIID
LRVEQLRAQIGDEKVLLGLSGGVDSSVVAALLHKAIGDQLTCVFVDNGLLRLNEGDQVMQMFADNMGIRVIRADAEERFL
TALAGEVDPEKKRKIIGREFIEVFAEEARKLDGVKFLAQGTIYPDVIESAASKQGKAHVIKSHHNVGGLPDDLEFELVEP
LRDLFKDEVRKLGTTLGLPHSMIYRHPFPGPGLGVRILGEVKKEYADILRLADDIFMQELRASGWYDKTAQAFAVFQPVK
SVGVVGDGRRYAWVIALRAVETVDFMTARFAHLPYELVDKISTRIMNEIKDVSRVVYDVSSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=562, Percent_Identity=35.2313167259786, Blast_Score=293, Evalue=3e-79,
Organism=Escherichia coli, GI1788854, Length=527, Percent_Identity=66.2239089184061, Blast_Score=730, Evalue=0.0,
Organism=Caenorhabditis elegans, GI133901714, Length=571, Percent_Identity=36.6024518388792, Blast_Score=300, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI71992710, Length=571, Percent_Identity=36.6024518388792, Blast_Score=300, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI71992717, Length=571, Percent_Identity=36.6024518388792, Blast_Score=300, Evalue=2e-81,
Organism=Saccharomyces cerevisiae, GI6323873, Length=520, Percent_Identity=48.4615384615385, Blast_Score=513, Evalue=1e-146,
Organism=Drosophila melanogaster, GI281365319, Length=562, Percent_Identity=35.5871886120996, Blast_Score=289, Evalue=3e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_ACIAD (Q6FFN2)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_044947.1
- ProteinModelPortal:   Q6FFN2
- SMR:   Q6FFN2
- STRING:   Q6FFN2
- GeneID:   2879247
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD0151
- NMPDR:   fig|62977.3.peg.181
- eggNOG:   COG0519
- HOGENOM:   HBG391775
- OMA:   MKLVEPL
- PhylomeDB:   Q6FFN2
- ProtClustDB:   PRK00074
- BioCyc:   ASP62977:ACIAD0151-MONOMER
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 61033; Mature: 61033

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 116-116 ACT_SITE 206-206 ACT_SITE 208-208

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIERTCAILGKMLEYCASLVALHSCVIMTTNTHITDDRILILDFGSQYSQLIARRVREA
CCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEECCCEEEEEECCCHHHHHHHHHHHHC
GVYSEMYAFDMSEEDIRAFNPNGIILSGGPESVHEEGSPRAPQVVFELGVPVLGICYGFQ
CCHHHHHHCCCCCCHHHEECCCEEEECCCCHHHHCCCCCCCCHHHHHHCCCHHHHHHHHH
TMSEQLGGKVEPGTVHEFGYAEVDIQQRDQLVGNLQDRENQLHVWMSHGDKVSRLPEGFS
HHHHHHCCCCCCCCEECCCCCEECHHHHHHHHHCCCCCCCEEEEEECCCCHHHHCCCCCC
TTASTPSCPFAAASDEARRFYGVQFHPEVTHTAKGAELLANFVHKICGCGGLWTPEHIID
CCCCCCCCCCCCCCCHHHHHCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHH
LRVEQLRAQIGDEKVLLGLSGGVDSSVVAALLHKAIGDQLTCVFVDNGLLRLNEGDQVMQ
HHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEECCEEEECCCHHHHH
MFADNMGIRVIRADAEERFLTALAGEVDPEKKRKIIGREFIEVFAEEARKLDGVKFLAQG
HHHCCCCEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHEECCC
TIYPDVIESAASKQGKAHVIKSHHNVGGLPDDLEFELVEPLRDLFKDEVRKLGTTLGLPH
CCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
SMIYRHPFPGPGLGVRILGEVKKEYADILRLADDIFMQELRASGWYDKTAQAFAVFQPVK
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
SVGVVGDGRRYAWVIALRAVETVDFMTARFAHLPYELVDKISTRIMNEIKDVSRVVYDVS
HHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
SKPPATIEWE
CCCCCEECCC
>Mature Secondary Structure
MLIERTCAILGKMLEYCASLVALHSCVIMTTNTHITDDRILILDFGSQYSQLIARRVREA
CCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEECCCEEEEEECCCHHHHHHHHHHHHC
GVYSEMYAFDMSEEDIRAFNPNGIILSGGPESVHEEGSPRAPQVVFELGVPVLGICYGFQ
CCHHHHHHCCCCCCHHHEECCCEEEECCCCHHHHCCCCCCCCHHHHHHCCCHHHHHHHHH
TMSEQLGGKVEPGTVHEFGYAEVDIQQRDQLVGNLQDRENQLHVWMSHGDKVSRLPEGFS
HHHHHHCCCCCCCCEECCCCCEECHHHHHHHHHCCCCCCCEEEEEECCCCHHHHCCCCCC
TTASTPSCPFAAASDEARRFYGVQFHPEVTHTAKGAELLANFVHKICGCGGLWTPEHIID
CCCCCCCCCCCCCCCHHHHHCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHH
LRVEQLRAQIGDEKVLLGLSGGVDSSVVAALLHKAIGDQLTCVFVDNGLLRLNEGDQVMQ
HHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEECCEEEECCCHHHHH
MFADNMGIRVIRADAEERFLTALAGEVDPEKKRKIIGREFIEVFAEEARKLDGVKFLAQG
HHHCCCCEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHEECCC
TIYPDVIESAASKQGKAHVIKSHHNVGGLPDDLEFELVEPLRDLFKDEVRKLGTTLGLPH
CCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
SMIYRHPFPGPGLGVRILGEVKKEYADILRLADDIFMQELRASGWYDKTAQAFAVFQPVK
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
SVGVVGDGRRYAWVIALRAVETVDFMTARFAHLPYELVDKISTRIMNEIKDVSRVVYDVS
HHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
SKPPATIEWE
CCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA