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The map label for this gene is lrp [H]

Identifier: 50083403

GI number: 50083403

Start: 115051

End: 115521

Strand: Reverse

Name: lrp [H]

Synonym: ACIAD0114

Alternate gene names: 50083403

Gene position: 115521-115051 (Counterclockwise)

Preceding gene: 50083414

Following gene: 50083402

Centisome position: 3.21

GC content: 41.83

Gene sequence:

>471_bases
ATGCGTGCATTAGACCGAATTGATCGGCAGATTCTGGATATTTTGCAAAAGGAAGGCCGTATTGCAATTAGTGAGCTGGC
CTCCAGAGTCAATCTATCAACTACCCCTTGCTCGGAGCGGGTGAAACGTCTGGAACGGGATGGCATTATTACAGGCTATC
ATGCACGCCTGAATCCAATCTATGTAGATCGTAATTTGTTGGTATTTCTGGAAATCAAACTTTCGGCAAAGTCTGGAGAT
GTATTTGATCAGGTGGCACGTGATTTAGTGGAAATTCCAGAGGTGCTCGAATGTCATCTTATTTCAGGTGAATTTGATTA
CCTAGTCAAAGCACGCCTGAAAGAAATGAGTGCTTACCGACGTCTTTTGGGAGATCTGCTCAAAAAATTGCCTTCTTCTG
CATCGTCGCATAGTTATATTGTGATGGAAGAAATCAAGGAAACATTATTTTTGGATGTGATCAAATCATAA

Upstream 100 bases:

>100_bases
ATATTTCCGCATCAATAGTTTATTTCACTATTTTTAAAGCTATAATCCAGTTAAATCTTAAATTTTGTCGTGCCAAAAAT
CGAAAAGAAGGAAATTTTTC

Downstream 100 bases:

>100_bases
TCTCGTTAAGTTTTATTTAAGTTTGATCAACTATTTTTCTAATATCCTAAACAGATCATTTTTGCCACACATCCCTGTGT
GGTTTTTTTTGGTTTAAATA

Product: branched chain amino acid ABC transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MRALDRIDRQILDILQKEGRIAISELASRVNLSTTPCSERVKRLERDGIITGYHARLNPIYVDRNLLVFLEIKLSAKSGD
VFDQVARDLVEIPEVLECHLISGEFDYLVKARLKEMSAYRRLLGDLLKKLPSSASSHSYIVMEEIKETLFLDVIKS

Sequences:

>Translated_156_residues
MRALDRIDRQILDILQKEGRIAISELASRVNLSTTPCSERVKRLERDGIITGYHARLNPIYVDRNLLVFLEIKLSAKSGD
VFDQVARDLVEIPEVLECHLISGEFDYLVKARLKEMSAYRRLLGDLLKKLPSSASSHSYIVMEEIKETLFLDVIKS
>Mature_156_residues
MRALDRIDRQILDILQKEGRIAISELASRVNLSTTPCSERVKRLERDGIITGYHARLNPIYVDRNLLVFLEIKLSAKSGD
VFDQVARDLVEIPEVLECHLISGEFDYLVKARLKEMSAYRRLLGDLLKKLPSSASSHSYIVMEEIKETLFLDVIKS

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=153, Percent_Identity=55.5555555555556, Blast_Score=169, Evalue=5e-44,
Organism=Escherichia coli, GI87081742, Length=150, Percent_Identity=36.6666666666667, Blast_Score=104, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 17845; Mature: 17845

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALDRIDRQILDILQKEGRIAISELASRVNLSTTPCSERVKRLERDGIITGYHARLNPI
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCEECCCCCCCEE
YVDRNLLVFLEIKLSAKSGDVFDQVARDLVEIPEVLECHLISGEFDYLVKARLKEMSAYR
EECCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
RLLGDLLKKLPSSASSHSYIVMEEIKETLFLDVIKS
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRALDRIDRQILDILQKEGRIAISELASRVNLSTTPCSERVKRLERDGIITGYHARLNPI
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCEECCCCCCCEE
YVDRNLLVFLEIKLSAKSGDVFDQVARDLVEIPEVLECHLISGEFDYLVKARLKEMSAYR
EECCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
RLLGDLLKKLPSSASSHSYIVMEEIKETLFLDVIKS
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]